A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B.

abstract：BACKGROUND & AIMS:Hepatitis C virus (HCV) infection is a leading cause of end-stage liver disease. Interferon-α (IFNα) is an important component of anti-HCV therapy; it up-regulates transcription of IFN-stimulated genes, many of which have been investigated for their antiviral effects. However, all of the genes require...

journal_title：Gastroenterology

authors： Fusco DN,Brisac C,John SP,Huang YW,Chin CR,Xie T,Zhao H,Jilg N,Zhang L,Chevaliez S,Wambua D,Lin W,Peng L,Chung RT,Brass AL

更新日期：2013-06-01 00:00:00

abstract：:Monocytopoietic proliferation activity was determined in 8 patients during severe attacks of Crohn's disease and in 6 patients with ulcerative colitis. Similar results were obtained in both groups of patients. A moderate but significant hyperproliferation of monocytopoiesis was found to be present in about half of the...

journal_title：Gastroenterology

authors： Meuret G,Bitzi A,Hammer B

更新日期：1978-03-01 00:00:00

abstract：:In addition to the previously described molecular forms of gastrin, a new component has been found in high concentrations in the serum of 6 patients with Zollinger-Ellison syndrome. Serum was fractionated by gel filtration, and ion exchange chromatography, and the new component was identified in eluates by radioimmuno...

journal_title：Gastroenterology

authors： Dockray GJ,Walsh JH

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND & AIMS:Caspases are critical mediators of apoptosis and proliferation of peripheral blood T cells (PBT), but their role in lamina propria T cells (LPT), a cell population highly susceptible to apoptosis, has not been explored. METHODS:RA(+), RO(+) PBT, and LPT were activated with CD3, CD2, and CD28 antibodi...

journal_title：Gastroenterology

authors： Sturm A,Mohr S,Fiocchi C

更新日期：2002-05-01 00:00:00

abstract：:An animal model for giardiasis was developed using Giardia muris in Swiss albino mice. Intraesophageal inoculation of G. muris cysts caused a reproducible pattern of infection, with trophozoite and cyst counts reaching a maximum on days 5 to 14 after cyst inoculation and thereafter showing a progressive decline. Spont...

journal_title：Gastroenterology

authors： Roberts-Thomson IC,Stevens DP,Mahmoud AA,Warren KS

更新日期：1976-07-01 00:00:00

abstract：:Hepatic morphology and immunocytology were evaluated in 4 children with clinical and immunologic characteristics of the acquired immune deficiency syndrome or acquired immune deficiency syndrome related complex. All 4 children had hepatomegaly and increased serum alanine and aspartate aminotransferase activity. Both l...

journal_title：Gastroenterology

authors： Duffy LF,Daum F,Kahn E,Teichberg S,Pahwa R,Fagin J,Kenigsberg K,Kaplan M,Fisher SE,Pahwa S

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of anal cancer is higher in patients with anal canal condyloma, a sexually transmitted disease, than in the general population. We determined the prevalence of anal dysplasia and cancer in patients with anal canal condyloma with respect to human immunodeficiency virus (HIV) status, immun...

journal_title：Gastroenterology

authors： Sobhani I,Vuagnat A,Walker F,Vissuzaine C,Mirin B,Hervatin F,Marmuse JP,Crémieux AC,Carbon C,Henin D,Lehy T,Mignon M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND & AIMS:Most colon cancers arise from polypoid adenomas, but how these benign lesions develop into malignant neoplasms is not understood. This study examined the migration of epithelial cells within human adenomatous polyps by determining the distribution of proliferating and apoptotic cells and immunoreactiv...

journal_title：Gastroenterology

authors： Moss SF,Liu TC,Petrotos A,Hsu TM,Gold LI,Holt PR

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND & AIMS:Mutational inactivation of adenomatous polyposis coli (APC) is an early event in colorectal cancer (CRC) progression that affects the stability and increases the activity of β-catenin, a mediator of Wnt signaling. Progression of CRC also involves inactivation of signaling via transforming growth facto...

journal_title：Gastroenterology

authors： Freeman TJ,Smith JJ,Chen X,Washington MK,Roland JT,Means AL,Eschrich SA,Yeatman TJ,Deane NG,Beauchamp RD

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND & AIMS:Endoscopic and Histologic remission are important goals in the treatment of ulcerative colitis (UC). We investigated the correlation of the recently developed Paddington International Virtual ChromoendoScopy ScOre( PICaSSO) and other established endoscopic scores against multiple histological indices ...

journal_title：Gastroenterology

authors： Iacucci M,Smith SC,Bazarova A,Shivaji UN,Bhandari P,Cannatelli R,Daperno M,Ferraz J,Goetz M,Gui X,Hayee B,De Hertogh G,Lazarev M,Li J,Nardone OM,Parra-Blanco A,Pastorelli L,Panaccione R,Occhipinti V,Rath T,Tontini

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND & AIMS:Although protein kinase C (PKC) alterations may play a role in the abnormal reactivity of cirrhotic rat aortas, its isoforms and cellular distribution are unknown. We therefore studied the protein expression and cellular distribution of PKC isoforms and their activation in cirrhotic rat aortas. METHO...

journal_title：Gastroenterology

authors： Tazi KA,Moreau R,Heller J,Poirel O,Lebrec D

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanism regulating cholecystokinin (CCK) secretion during prolonged diversion of bile pancreatic juice (BPJ) is unknown. We examined the hypothesis that the decrease of plasma CCK levels after prolonged diversion of BPJ is mediated by an increase in plasma somatostatin levels evoked by hyperchol...

journal_title：Gastroenterology

authors： Li Y,Hao Y,Owyang C

更新日期：1995-07-01 00:00:00

abstract：:A possible role of insulinlike growth factor I (IGF-I) and IGF-I receptors in the proliferation of human colon cancer has, to the best of the authors' knowledge, not been examined as yet. To determine a role of IGF-I in colon cancer, several human colon cancer cell lines and colon cancers were screened for specific bi...

journal_title：Gastroenterology

authors： Guo YS,Narayan S,Yallampalli C,Singh P

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND & AIMS:Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the pancreas during pancreatitis may contribute to such activation. METHODS:To cause experimental pancreatitis, rats and mice were treated with ...

journal_title：Gastroenterology

authors： Gukovskaya AS,Vaquero E,Zaninovic V,Gorelick FS,Lusis AJ,Brennan ML,Holland S,Pandol SJ

更新日期：2002-04-01 00:00:00

abstract：:This study was performed to determine the relationship between net ion fluxes across the rat gastric mucosa and gastric mucosal damage after gastric ischemia and after intravenous administration of acetylsalicylic acid, and to determine the effect of cimetidine on these parameters. Gastric mucosal blood, albumin, and ...

journal_title：Gastroenterology

authors： Pipkin G,Price CA,Parsons ME

更新日期：1984-12-01 00:00:00

abstract：:Gastrointestinal loss of plasma is usually measured with radiolabeled macromolecules. These methods are expensive and cumbersome. The use of alpha 1-antitrypsin as an endogenous marker and the determination of alpha 1-antitrypsin fecal clearance enable the diagnosis of protein-losing enteropathy. alpha 1-Antitrypsin i...

journal_title：Gastroenterology

authors： Florent C,L'Hirondel C,Desmazures C,Aymes C,Bernier JJ

更新日期：1981-10-01 00:00:00

abstract：:A case of acute hypervitaminosis A complicating viral hepatitis is reported. Twenty days after presenting with hepatitis B, a 42-yr-old vegetarian developed acute hypervitaminosis A in the absence of recent, massive exposure to the vitamin. Findings included headache, confusion, skin desquamation, and hypercalcemia. P...

journal_title：Gastroenterology

authors： Hatoff DE,Gertler SL,Miyai K,Parker BA,Weiss JB

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND & AIMS:We investigated the expression of estrogen receptor (ER) alpha and beta subtypes in cholangiocytes of normal and bile duct-ligated (BDL) rats and evaluated the role and mechanisms of estrogens in the modulation of cholangiocyte proliferation. METHODS:ER-alpha and ER-beta were analyzed by immunohistoc...

journal_title：Gastroenterology

authors： Alvaro D,Alpini G,Onori P,Perego L,Svegliata Baroni G,Franchitto A,Baiocchi L,Glaser SS,Le Sage G,Folli F,Gaudio E

更新日期：2000-12-01 00:00:00

abstract：:The effect of local intraarterial infusion of arginine vasopressin was studied in a vascularly perfused segment of cat ileum. Systemic arterial pressure (Pa), superior mesenteric arterial pressure (Pma), superior mesenteric venous pressure (Pv), blood flow (QB) and intestinal volume (V) were continuously monitored. In...

journal_title：Gastroenterology

authors： Quillen EW,Granger DN,Taylor AE

更新日期：1977-12-01 00:00:00

abstract：:Pancreatic blood flow and its relationship to pancreatic interstitial pressure were investigated in a model of chronic pancreatitis in cats using a hydrogen gas-clearance technique with an intraductal electrode. The intraductal technique correlated well with blood flow measurements made using gamma-labeled microsphere...

journal_title：Gastroenterology

authors： Reber HA,Karanjia ND,Alvarez C,Widdison AL,Leung FW,Ashley SW,Lutrin FJ

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND & AIMS:Increase of T cells expressing CD4 and T-cell receptor (TCR) alpha- beta+ (beta[dim]) was observed in the mucosal and peripheral lymphoid tissues of TCR alpha-/- mice with inflammatory bowel disease (IBD). The aim of this study was to characterize the CD4+ TCR alpha-beta+ T cells. METHODS:Cytokine pr...

journal_title：Gastroenterology

authors： Takahashi I,Kiyono H,Hamada S

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND & AIMS:Gastroesophageal reflux disease (GERD) interferes with the quality of life and carries an increased risk for esophageal adenocarcinoma. We investigated genetic influence in the development of reflux. METHODS:We compared concordance for reflux in monozygotic (MZ) and dizygotic (DZ) twins. All twins ag...

journal_title：Gastroenterology

authors： Cameron AJ,Lagergren J,Henriksson C,Nyren O,Locke GR 3rd,Pedersen NL

更新日期：2002-01-01 00:00:00

abstract：:The presence of autoimmune gastritis was investigated in 54 women with postpartum thyroiditis. Parietal cell antibodies (PCA) specific against H+, K(+)-adenosine triphosphatase (EC 3.6.1.36) were found in 18 women during pregnancy; in 10 of them, a 2-9-fold increase in the PCA level was observed in the postpartum peri...

journal_title：Gastroenterology

authors： Burman P,Kämpe O,Kraaz W,Lööf L,Smolka A,Karlsson A,Karlsson-Parra A

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND & AIMS:Screening colonoscopy is an effective method to reduce the incidence of and mortality from colorectal cancer (CRC). There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with...

journal_title：Gastroenterology

authors： Brenner H,Haug U,Arndt V,Stegmaier C,Altenhofen L,Hoffmeister M

更新日期：2010-03-01 00:00:00

abstract：:Chloroquine and metronidazole were compared in a randomized trial for the treatment of amoebic liver abscess in 36 patients. An additional 30 patients were treated without randomization. Chloroquine was given according to the standard protocol at Los tangeles County-University of Southern California Medical Center, wh...

journal_title：Gastroenterology

authors： Cohen HG,Reynolds TB

更新日期：1975-07-01 00:00:00

abstract：:Aspartame [Nutrasweet, Equal (Searle Consumer Products, Chicago, Ill.)] is the methyl ester of the dipeptide aspartylphenylalanine (Asp-Phe). After hydrolysis of the ester bond in the intestinal lumen, the dipeptide is apparently absorbed and digested in the same manner as dipeptides derived from protein digestion. We...

journal_title：Gastroenterology

authors： Tobey NA,Heizer WD

更新日期：1986-10-01 00:00:00

abstract：:This study of ischemic and postischemic reperfusion intestinal injury in rats evaluates the potential therapeutic value of fructose 1-6 diphosphate on the basis of its ability to enhance anaerobic carbohydrate metabolism during ischemia and to prevent additional tissue injury after reestablishing blood flow by inhibit...

journal_title：Gastroenterology

authors： Sun JX,Farias LA,Markov AK

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Antibodies directed against oligomannose sequences alpha-1,3 Man (alpha-1,2 Man alpha-1,2 Man)(n) (n = 1 or 2), termed anti-Saccharomyces cerevisiae antibodies (ASCAs) are markers of Crohn's disease (CD). S. cerevisiae mannan, which expresses these haptens, is used to detect ASCA, but the exact immu...

journal_title：Gastroenterology

authors： Standaert-Vitse A,Jouault T,Vandewalle P,Mille C,Seddik M,Sendid B,Mallet JM,Colombel JF,Poulain D

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND & AIMS:The interactions among pre-S deletion, precore (PC) mutation, and basal core promoter (BCP) mutation in various stages of chronic hepatitis B virus (HBV) infection remain unclear and were thus investigated in this study. METHODS:The sequences of the pre-S region and the BCP (A1762T, G1764A) and PC (G...

journal_title：Gastroenterology

authors： Chen BF,Liu CJ,Jow GM,Chen PJ,Kao JH,Chen DS

更新日期：2006-04-01 00:00:00

abstract：:S-Adenosylmethionine (800 mg i.v. per day) was used to treat two brothers and a brother and sister from each of two kindreds with benign recurrent intrahepatic cholestasis. Symptoms, routine tests of liver function, concentrations of total bile acids, and the oral clearances of [11,12-2H]chenodeoxycholic acid and [24-...

journal_title：Gastroenterology

authors： Everson GT,Ahnen D,Harper PC,Krawitt EL

更新日期：1989-05-01 00:00:00