Behavioral management of fecal incontinence in adults.

Abstract:

:Biofeedback has been advocated as first-line therapy for patients whose symptoms of mild to moderate fecal incontinence have not responded to simple dietary advice or medication. Three main modalities have been described: (1) use of an intra-anal electromyographic sensor, a probe to measure intra-anal pressure, or perianal surface electromyographic electrodes to teach the patient how to exercise the anal sphincter; (2) use of a 3-balloon system to train the patient to correctly identify the stimulus of rectal distention and to respond without delay; and (3) use of a rectal balloon to retrain the rectal sensory threshold, usually with the aim of enabling the patient to discriminate and respond to smaller rectal volumes. Although a systematic review found that biofeedback eliminated symptoms in up to one half of patients and decreased symptoms in up to two thirds, these studies suffered from methodological problems, a lack of controls, and a lack of validated outcome measures. No studies have compared different exercise instructions, measured patient compliance with those instructions, or determined any trends in symptom response to the exercises prescribed. A recent study by the author suggests that patient-therapist interaction and patient coping strategies may be more important in improving continence than performing exercises or receiving physiological feedback on sphincter function. Better-designed randomized, controlled trials are needed to evaluate different exercise programs and different elements of biofeedback. Development and validation of outcome measures are important, and predictors of outcome and effects in patient subgroups, especially elderly and neurologically impaired patients, should also be investigated.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Norton C

doi

10.1053/j.gastro.2003.10.058

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

S64-70

issue

1 Suppl 1

eissn

0016-5085

issn

1528-0012

pii

S0016508503017268

journal_volume

126

pub_type

杂志文章,评审
  • A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia.

    abstract:BACKGROUND & AIMS:The metaplastic process in which the normal squamous epithelium of the distal esophagus is replaced by columnar-lined epithelium, known as Barrett's esophagus (BE), is poorly understood. The aim of this study was to define, analyze, and compare transcription profiles of BE, normal cardia epithelium, a...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2005.07.026

    authors: van Baal JW,Milano F,Rygiel AM,Bergman JJ,Rosmolen WD,van Deventer SJ,Wang KK,Peppelenbosch MP,Krishnadath KK

    更新日期:2005-10-01 00:00:00

  • Hyponatremia and arginine vasopressin secretion in patients with refractory hepatic ascites undergoing peritoneovenous shunting.

    abstract::Seven patients with persistent hyponatremia but normal or elevated serum arginine vasopressin levels and refractory ascites undergoing peritoneovenous shunting were studied in a Metabolic Unit on a 20 mEq sodium 1200 ml fluid-restricted diet to elucidate the mechanism of this response. The intravascular volume expansi...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Reznick RK,Langer B,Taylor BR,Seif S,Blendis LM

    更新日期:1983-04-01 00:00:00

  • Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice.

    abstract:BACKGROUND & AIMS:Sjögren's syndrome and autoimmune pancreatitis are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. Nonobese diabetic/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren's syndrome and chronic pancreatitis and MRL/Mp mice are models of autoi...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2017.06.011

    authors: Zeng M,Szymczak M,Ahuja M,Zheng C,Yin H,Swaim W,Chiorini JA,Bridges RJ,Muallem S

    更新日期:2017-10-01 00:00:00

  • Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice.

    abstract:BACKGROUND & AIMS:The physiologic significance of the M(3) muscarinic receptor is unclear due to an absence of specific ligand. In the present study, M(3) receptor knockout (KO) mice were used to elucidate the role of M(3) receptors in gastric acid secretion and gastric mucosal integrity. METHODS:M(3) KO versus wild-t...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2003.09.018

    authors: Aihara T,Fujishita T,Kanatani K,Furutani K,Nakamura E,Taketo MM,Matsui M,Chen D,Okabe S

    更新日期:2003-12-01 00:00:00

  • American gastroenterological association institute medical position statement on the use of gastrointestinal medications in pregnancy.

    abstract::This document presents the official recommendations of the American Gastroenterological Association (AGA) Institute on "Use of Gastrointestinal Medications in Pregnancy." It was approved by the Clinical Practice and Economics Committee on February 22, 2006, and by the AGA Institute Governing Board on April 20, 2006. ...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2006.04.048

    authors: Mahadevan U,Kane S

    更新日期:2006-07-01 00:00:00

  • Evidence for exacerbation of irritable bowel syndrome during menses.

    abstract::Many women report that bowel symptoms are associated with menstruation, but neither the prevalence of these complaints nor their physiological basis is known. This study aimed to estimate prevalence, to determine whether patients with irritable bowel syndrome are more likely to make such complaints, and to determine w...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(90)91079-l

    authors: Whitehead WE,Cheskin LJ,Heller BR,Robinson JC,Crowell MD,Benjamin C,Schuster MM

    更新日期:1990-06-01 00:00:00

  • Relationship of serum alpha-fetoprotein to the severity and duration of illness in patients with viral hepatitis.

    abstract::Using a radioimmunoassay which detect concentrations of alpha-fetoprotein as low as 5 ng per ml, 38% of 176 patients with viral hepatitis compared with health volunteers and patients with chronic diseases not affecting the liver. When separated into two groups based on histological classification of liver biopsy speci...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Bloomer JR,Waldmann TA,McIntire R,Klatskin G

    更新日期:1975-02-01 00:00:00

  • Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis.

    abstract:BACKGROUND & AIMS:Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2014.08.028

    authors: Schoepfer AM,Straumann A,Panczak R,Coslovsky M,Kuehni CE,Maurer E,Haas NA,Romero Y,Hirano I,Alexander JA,Gonsalves N,Furuta GT,Dellon ES,Leung J,Collins MH,Bussmann C,Netzer P,Gupta SK,Aceves SS,Chehade M,Moawad F

    更新日期:2014-12-01 00:00:00

  • Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C.

    abstract:BACKGROUND & AIMS:Iron overload may cause or contribute to hepatic injury and fibrosis. Mutations in the HFE gene may influence development or progression of chronic liver disease by increasing iron stores or modulating immune responses. The aim of this work was to assess the influence of HFE mutations and serum and he...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1053/j.gastro.2006.08.036

    authors: Bonkovsky HL,Naishadham D,Lambrecht RW,Chung RT,Hoefs JC,Nash SR,Rogers TE,Banner BF,Sterling RK,Donovan JA,Fontana RJ,Di Bisceglie AM,Ghany MG,Morishima C,HALT-C Trial Group.

    更新日期:2006-11-01 00:00:00

  • Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.

    abstract:BACKGROUND & AIMS:Progressive familial intrahepatic cholestasis can be caused by mutations in ABCB4 or ATP8B1; each encodes a protein that translocates phospholipids, but in opposite directions. ABCB4 flops phosphatidylcholine from the inner to the outer leaflet, where it is extracted by bile salts. ATP8B1, in complex ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2011.07.042

    authors: Groen A,Romero MR,Kunne C,Hoosdally SJ,Dixon PH,Wooding C,Williamson C,Seppen J,Van den Oever K,Mok KS,Paulusma CC,Linton KJ,Oude Elferink RP

    更新日期:2011-11-01 00:00:00

  • Sustained remission after corticosteroid therapy of severe hepatitis B surface antigen-negative chronic active hepatitis.

    abstract::To determine the frequency of a sustained remission and to assess the long-term prognosis of relapse and retreatment, 66 patients with severe hepatitis B surface antigen-negative chronic active hepatitis and prolonged follow-up after initial corticosteroid withdrawal (mean, 10 +/- 0.4 yr) were evaluated. Selection of ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(87)90862-6

    authors: Czaja AJ,Beaver SJ,Shiels MT

    更新日期:1987-01-01 00:00:00

  • High-dose pegylated interferon-α and ribavirin in nonresponder hepatitis C patients and relationship with IL-28B genotype (SYREN trial).

    abstract:BACKGROUND & AIMS:In patients with chronic hepatitis C who failed to respond to standard therapy, high-dose pegylated interferon (IFN)-α and/or ribavirin could induce a stronger antiviral response and prevent treatment failure and HCV resistance when combined with direct-acting antivirals. The influence of genetic dete...

    journal_title:Gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1053/j.gastro.2011.03.039

    authors: Chevaliez S,Hézode C,Soulier A,Costes B,Bouvier-Alias M,Rouanet S,Foucher J,Bronowicki JP,Tran A,Rosa I,Mathurin P,Alric L,Leroy V,Couzigou P,Mallat A,Charaf-Eddine M,Babany G,Pawlotsky JM

    更新日期:2011-07-01 00:00:00

  • A study of the association between Crohn's disease and psychiatric illness.

    abstract::This study is an examination of the association between Crohn's disease and psychiatric illness using careful gastrointestinal evaluation, a structured psychiatric interview of known reliability and validity, and explicit diagnostic criteria for psychiatric illness. A proband sample of 50 subjects with Crohn's disease...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Helzer JE,Chammas S,Norland CC,Stillings WA,Alpers DH

    更新日期:1984-02-01 00:00:00

  • LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

    abstract:BACKGROUND & AIMS:One approach to the development of targeted cancer chemotherapy exploits increased uptake of the agent into neoplastic cells. In this scenario, higher concentrations of the agent in cancer cells are responsible for differential killing, whereas the low concentration in normal human cells decreases sid...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2001.24804

    authors: Abe T,Unno M,Onogawa T,Tokui T,Kondo TN,Nakagomi R,Adachi H,Fujiwara K,Okabe M,Suzuki T,Nunoki K,Sato E,Kakyo M,Nishio T,Sugita J,Asano N,Tanemoto M,Seki M,Date F,Ono K,Kondo Y,Shiiba K,Suzuki M,Ohtani H,S

    更新日期:2001-06-01 00:00:00

  • Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation.

    abstract:BACKGROUND & AIMS:Nuclear factor kappaB (NF-kappaB) is the master regulator of tumor necrosis factor (TNF) susceptibility. Although mitochondrial glutathione (mGSH) depletion was shown to sensitize hepatocytes to TNF despite NF-kappaB activation, the mechanisms involved, particularly the role of Bax oligomerization and...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2008.01.073

    authors: Marí M,Colell A,Morales A,Caballero F,Moles A,Fernández A,Terrones O,Basañez G,Antonsson B,García-Ruiz C,Fernández-Checa JC

    更新日期:2008-05-01 00:00:00

  • Application of the crypt-isolation technique to flow-cytometric analysis of DNA content in colorectal neoplasms.

    abstract:BACKGROUND/AIMS:Conventional flow-cytometric analysis of colorectal tumor DNA content includes both tumor and stromal cell DNA. To improve the method, we evaluated the DNA content of purified epithelial cells using the crypt-isolation technique. METHODS:Normal and neoplastic crypts were isolated from fresh resected co...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(94)94651-5

    authors: Nakamura S,Goto J,Kitayama M,Kino I

    更新日期:1994-01-01 00:00:00

  • Lipase and pepsin activity in the gastric mucosa of infants, children, and adults.

    abstract::The range of activity and the location of lipase and pepsin were determined in the stomach and duodenum of infants, children, and adults. The range of lipase activity in biopsy specimens from the gastric body, in 29 subjects aged from 3 months to 26 years, was 1.8-5.3 U/mg protein (1 U is 1 mumol [3H]oleic acid releas...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(91)90467-y

    authors: DiPalma J,Kirk CL,Hamosh M,Colon AR,Benjamin SB,Hamosh P

    更新日期:1991-07-01 00:00:00

  • Rotaviruses: from pathogenesis to vaccination.

    abstract::Rotaviruses cause life-threatening gastroenteritis in children worldwide; the enormous disease burden has focused efforts to develop vaccines and led to the discovery of novel mechanisms of gastrointestinal virus pathogenesis and host responses to infection. Two live-attenuated vaccines for gastroenteritis (Rotateq [M...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2009.02.076

    authors: Greenberg HB,Estes MK

    更新日期:2009-05-01 00:00:00

  • Pentane clearance from inspired air by the rat: dependence on the liver.

    abstract::Pentane, a volatile hydrocarbon, is cleared from inspired air by the rat. We have studied this clearance to learn whether or not it is a function of the liver. Rats were put individually into airtight chambers which contained CO2 absorbent and were connected to an O2 reservoir. Pentane was injected into each chamber a...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Burk RJ,Ludden TM,Lane JM

    更新日期:1983-01-01 00:00:00

  • Acute hemorrhagic incarceration of prolapsed gastric mucosa.

    abstract::In some patients with hiatus hernia, vomiting may propel a plug of redundant gastric mucosa into the distal esophagus, where it becomes incarcerated and engorged. Significant bleeding may result. Reduction of the hernia controls the hemorrhage. Endoscopy after the acute episode may demonstrate a gastric mucosal lesion...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Laforet EG

    更新日期:1976-04-01 00:00:00

  • Characterization of insulinlike growth factor I receptors in human colon cancer.

    abstract::A possible role of insulinlike growth factor I (IGF-I) and IGF-I receptors in the proliferation of human colon cancer has, to the best of the authors' knowledge, not been examined as yet. To determine a role of IGF-I in colon cancer, several human colon cancer cell lines and colon cancers were screened for specific bi...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Guo YS,Narayan S,Yallampalli C,Singh P

    更新日期:1992-04-01 00:00:00

  • From Birth to Overweight and Atopic Disease: Multiple and Common Pathways of the Infant Gut Microbiome.

    abstract:BACKGROUND & AIMS:Few studies, even those with cohort designs, test the mediating effects of infant gut microbes and metabolites on the onset of disease. We undertook such a study. METHODS:Using structural equation modeling path analysis, we tested directional relationships between first pregnancy, birth mode, prolong...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2020.08.053

    authors: Vu K,Lou W,Tun HM,Konya TB,Morales-Lizcano N,Chari RS,Field CJ,Guttman DS,Mandal R,Wishart DS,Azad MB,Becker AB,Mandhane PJ,Moraes TJ,Lefebvre DL,Sears MR,Turvey SE,Subbarao P,Scott JA,Kozyrskyj AL

    更新日期:2021-01-01 00:00:00

  • The genetically programmed down-regulation of lactase in children.

    abstract:BACKGROUND & AIMS:Intestinal lactase activity is high in all healthy human babies, but in adults a genetic polymorphism, which acts in cis to the lactase gene, determines high or low messenger RNA (mRNA) expression and activity (lactase persistence and nonpersistence, respectively). Our aim was to investigate the onset...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(98)70429-9

    authors: Wang Y,Harvey CB,Hollox EJ,Phillips AD,Poulter M,Clay P,Walker-Smith JA,Swallow DM

    更新日期:1998-06-01 00:00:00

  • Somatostatin inhibits secretin-induced canine pancreatic response via a cholinergic mechanism.

    abstract:BACKGROUND:Somatostatin inhibits pancreatic exocrine secretion in intact animals but not in vitro, suggesting an indirect effect. The present study examined the influence of extrapancreatic nerves and intrapancreatic cholinergic activity on somatostatin-induced inhibition of pancreatic exocrine secretion in conscious d...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(93)90732-r

    authors: Kuvshinoff BW,Brodish RJ,James L,McFadden DW,Fink AS

    更新日期:1993-08-01 00:00:00

  • Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2.

    abstract:BACKGROUND & AIMS:Development of pancreatic ductal adenocarcinoma (PDA) involves acinar to ductal metaplasia and genesis of tuft cells. It has been a challenge to study these rare cells because of the lack of animal models. We investigated the role of tuft cells in pancreatic tumorigenesis. METHODS:We performed studie...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2020.07.037

    authors: DelGiorno KE,Chung CY,Vavinskaya V,Maurer HC,Novak SW,Lytle NK,Ma Z,Giraddi RR,Wang D,Fang L,Naeem RF,Andrade LR,Ali WH,Tseng H,Tsui C,Gubbala VB,Ridinger-Saison M,Ohmoto M,Erikson GA,O'Connor C,Shokhirev MN,Hah

    更新日期:2020-11-01 00:00:00

  • Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics.

    abstract:BACKGROUND & AIMS:In 1988, we reported the first twin study in inflammatory bowel disease. The aim of the current study was to follow up these twins regarding new cases of inflammatory bowel disease and Crohn's disease characteristics using the Vienna classification. METHODS:The official Swedish population register an...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(03)00385-8

    authors: Halfvarson J,Bodin L,Tysk C,Lindberg E,Järnerot G

    更新日期:2003-06-01 00:00:00

  • Primary hepatic actinomycosis.

    abstract::Fever of 10 mo duration in a man of 35 yr was discovered at the time of a second laparatomy to be caused by actinomycotic infection of the liver. Actinomycosis of the liver usually presents as large single or as multiple abscesses. In this patient only nonspecific cellular infiltrates of the liver were found in liver ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Meade RH 3rd

    更新日期:1980-02-01 00:00:00

  • Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins.

    abstract:BACKGROUND & AIMS:Cyclosporin A specifically suppresses hepatitis C virus (HCV) replication in vitro at clinically achievable concentrations. In this study, we investigated the mechanisms of action of cyclosporin A against HCV replication. METHODS:The in vitro effects of cyclosporin A on HCV replication were analyzed ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2005.06.031

    authors: Nakagawa M,Sakamoto N,Tanabe Y,Koyama T,Itsui Y,Takeda Y,Chen CH,Kakinuma S,Oooka S,Maekawa S,Enomoto N,Watanabe M

    更新日期:2005-09-01 00:00:00

  • Heartburn of pregnancy.

    abstract::Lower esophageal sphincter pressure, basal gastric pH, fasting plasma gastrin, and plasma concentrations of estrone, estradiol, and progesterone were measured in pregnant volunteers at 12, 24, and 36 weeks of gestation, and again at 1 to 4 weeks postpartum. In addition, basal and pentagastrin-stimulated acid secretory...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Van Thiel DH,Gavaler JS,Joshi SN,Sara RK,Stremple J

    更新日期:1977-04-01 00:00:00

  • Mast cells are closely apposed to nerves in the human gastrointestinal mucosa.

    abstract::Mast cell/nerve associations have been recorded in several publications; however, the human gastrointestinal tract has received little attention. Accordingly, mucosal samples from small bowel, appendix, and large bowel were studied. Combined histochemical/immunocytochemical techniques revealed that the proportion of m...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(89)90627-6

    authors: Stead RH,Dixon MF,Bramwell NH,Riddell RH,Bienenstock J

    更新日期:1989-09-01 00:00:00