Somatostatin inhibits secretin-induced canine pancreatic response via a cholinergic mechanism.

abstract：:The intracellular pH (pHi) of isolated hamster intestinal cells was determined with three techniques: the null-point method with digitonin, the distribution of the weak acid 5,5-dimethyloxazolidine-2,4-dione, and the trapped fluorescent indicator 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. In physiologic saline, ...

journal_title：Gastroenterology

authors： Goré J,Hoinard C

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Studies in gastrin-deficient mice have demonstrated critical roles for gastrin peptides in the regulation of gastric acid secretion, but the relative contributions of amidated (G-17) and glycine-extended (G17-Gly) gastrin remain unclear. We examined the effects of these 2 forms of gastrin on acid secr...

journal_title：Gastroenterology

authors： Chen D,Zhao CM,Dockray GJ,Varro A,Van Hoek A,Sinclair NF,Wang TC,Koh TJ

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND & AIMS:Infection with Helicobacter pylori is associated with reduced risk of esophageal adenocarcinoma (EAC), but it is not clear whether this reduction is modified by genotype, other host characteristics, or environmental factors. Furthermore, little is known about the association between H pylori and adeno...

journal_title：Gastroenterology

authors： Whiteman DC,Parmar P,Fahey P,Moore SP,Stark M,Zhao ZZ,Montgomery GW,Green AC,Hayward NK,Webb PM,Australian Cancer Study.

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:Type 2 diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC); it is not clear if this association varies by sex or other factors. Insulin use might also be associated with CRC risk. We investigated associations of type 2 DM and insulin use with CRC risk. METHODS:The C...

journal_title：Gastroenterology

authors： Campbell PT,Deka A,Jacobs EJ,Newton CC,Hildebrand JS,McCullough ML,Limburg PJ,Gapstur SM

更新日期：2010-10-01 00:00:00

abstract：:Numerous epidemiologic studies suggest a relationship between lung cancer and peptic ulcer disease. Furthermore, various lung cancers synthesize and release a number of peptides such as gastrin and gastrin-releasing peptide that could cause acid hypersecretion; however, Zollinger-Ellison syndrome (ZES), because of a l...

journal_title：Gastroenterology

authors： Abou-Saif A,Lei J,McDonald TJ,Chakrabarti S,Waxman IF,Shojamanesh H,Schrump DS,Kleiner DE,Gibril F,Jensen RT

更新日期：2001-04-01 00:00:00

abstract：:The purpose of this study is to determine whether lower esophageal sphincter (LES) incompetency is a common occurrence in patients with liver cirrhosis and contributes to the development of variceal bleeding. Resting LES pressure (17.8 +/- 1.1 mm Hg) in 35 patients with cirrhosis was similar to that of our control pop...

journal_title：Gastroenterology

authors： Eckardt VF,Grace ND,Kantrowitz PA

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND & AIMS:Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and weight loss with sibutramine. METHODS:We conducted a randomized, double-blind, pharmacogenetic study...

journal_title：Gastroenterology

authors： Grudell AB,Sweetser S,Camilleri M,Eckert DJ,Vazquez-Roque MI,Carlson PJ,Burton DD,Braddock AE,Clark MM,Graszer KM,Kalsy SA,Zinsmeister AR

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic mucinous cystic neoplasm (MCN), a cystic tumor of the pancreas that develops most frequently in women, is a potential precursor to pancreatic ductal adenocarcinoma. MCNs develop primarily in the body and tail of the pancreas and are characterized by the presence of a mucinous epithelium and...

journal_title：Gastroenterology

authors： Sano M,Driscoll DR,De Jesus-Monge WE,Klimstra DS,Lewis BC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND & AIMS:This longitudinal study investigated the interactions and roles of hepatitis B virus (HBV) genotypes, pre-S deletions, and core promoter and precore mutations on the progression of liver disease in hepatitis B e antigen (HBeAg)-negative patients. METHODS:A total of 141 HBeAg-negative patients without...

journal_title：Gastroenterology

authors： Chen CH,Hung CH,Lee CM,Hu TH,Wang JH,Wang JC,Lu SN,Changchien CS

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Fiber and water-holding agents are used for the treatment of constipation. In what may appear to be a paradox, they are sometimes also used for the treatment of diarrhea; it has been proposed that they sequester water from liquid stools and/or increase the ratio of fecal solids to fecal water and thereby imp...

journal_title：Gastroenterology

authors： Eherer AJ,Santa Ana CA,Porter J,Fordtran JS

更新日期：1993-04-01 00:00:00

abstract：:A multicenter study was conducted on 173 patients with active, endoscopically proven duodenal ulcers (158 men, 15 women). They were randomly assigned, in a double-blind manner, to two groups: those receiving placebo capsules (91 patients) and those receiving capsules containing 100 microgram of 15(R)-15-methyl prostag...

journal_title：Gastroenterology

authors： Vantrappen G,Janssens J,Popiela T,Kulig J,Tytgat GN,Huibregtse K,Lambert R,Pauchard JP,Robert A

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND & AIMS:Small epithelial wounds heal by purse-string contraction of an actomyosin ring that is regulated by myosin light chain (MLC) kinase (MLCK) and rho kinase (ROCK). These studies aimed to define the roles of these kinases in purse-string wound closure. METHODS:Oligocellular and single-cell wounds were c...

journal_title：Gastroenterology

authors： Russo JM,Florian P,Shen L,Graham WV,Tretiakova MS,Gitter AH,Mrsny RJ,Turner JR

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND & AIMS:A single nucleotide polymorphism (SNP) upstream of the IL28B gene has been associated with response of patients with chronic hepatitis C to therapy with pegylated interferon and ribavirin and also with spontaneous clearance of acute hepatitis C in a heterogeneous population. We analyzed the associatio...

journal_title：Gastroenterology

authors： Tillmann HL,Thompson AJ,Patel K,Wiese M,Tenckhoff H,Nischalke HD,Lokhnygina Y,Kullig U,Göbel U,Capka E,Wiegand J,Schiefke I,Güthoff W,Grüngreiff K,König I,Spengler U,McCarthy J,Shianna KV,Goldstein DB,McHutchison JG

更新日期：2010-11-01 00:00:00

abstract：:We have been able to isolate mycobacteria from intestinal specimens obtained by surgical resection or endoscopic biopsy from patients with Crohn's disease, ulcerative colitis, and noninflammatory bowel diseases. Nineteen slow-growing (Runyon groups I and III) and 17 rapid-growing (Runyon group IV) mycobacterial isolat...

journal_title：Gastroenterology

authors： Graham DY,Markesich DC,Yoshimura HH

更新日期：1987-02-01 00:00:00

abstract：:We investigated the possibility that monocyte suppressor cells play a role in the peripheral lymphocyte hyporesponsiveness of chronic liver disease by utilizing assays of monocyte-mediated suppressor activity in 46 patients with chronic liver disease and 46 controls. The percent change achieved by the addition of indo...

journal_title：Gastroenterology

authors： Holdstock G,Chastenay BF,Krawitt EL

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND & AIMS:The physiologic significance of the M(3) muscarinic receptor is unclear due to an absence of specific ligand. In the present study, M(3) receptor knockout (KO) mice were used to elucidate the role of M(3) receptors in gastric acid secretion and gastric mucosal integrity. METHODS:M(3) KO versus wild-t...

journal_title：Gastroenterology

authors： Aihara T,Fujishita T,Kanatani K,Furutani K,Nakamura E,Taketo MM,Matsui M,Chen D,Okabe S

更新日期：2003-12-01 00:00:00

abstract：:Raised plasma carcinoembryonic antigen (CEA) levels were found in over 90% of 71 patients with chronic liver disease and 50% of 16 patients with acute liver damage. Levels increasing chronicity and clinical severity of disease. In individual patients, the plasma CEA level fluctuated with the clinical condition. Persis...

journal_title：Gastroenterology

authors： Bullen AW,Losowsky MS,Carter S,Patel S,Neville AM

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:Nitric oxide acts as a neurotransmitter of nonadrenergic, noncholinergic pathways. The present study examined the role of the L-arginine/NO pathway on sphincter of Oddi motility. METHODS:In anesthetized guinea pigs and rabbits, intracholedochal pressure was recorded by a perfused catheter whose open tip was...

journal_title：Gastroenterology

authors： Mourelle M,Guarner F,Moncada S,Malagelada JR

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND & AIMS:Prostacyclin and nitric oxide have been involved in the hyperkinetic syndrome in portal hypertension. The aim of this study was to investigate the relative contribution and possible interaction between prostacyclin and NO in this circulatory abnormality. METHODS:Portal vein-ligated and sham-operated ...

journal_title：Gastroenterology

authors： Fernández M,García-Pagán JC,Casadevall M,Mourelle MI,Piqué JM,Bosch J,Rodés J

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND/AIMS:Helicobacter felis colonizes the gastric mucosa of rodents. Preliminary studies showed differences in the distribution of the organism in different parts of the stomach that seemed related to the secretory capacity of the mucosa. The aim of this study was to determine the localization of H. felis in the...

journal_title：Gastroenterology

authors： Danon SJ,O'Rourke JL,Moss ND,Lee A

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Mutations in HFE are the most common cause of the iron-overload disorder hereditary hemochromatosis. Levels of the main iron regulatory hormone, hepcidin, are inappropriately low in hereditary hemochromatosis mouse models and patients with HFE mutations, indicating that HFE regulates hepcidin. The b...

journal_title：Gastroenterology

authors： Corradini E,Garuti C,Montosi G,Ventura P,Andriopoulos B Jr,Lin HY,Pietrangelo A,Babitt JL

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND & AIMS:Few data are available concerning the long-term prognosis of chronic liver disease associated with hepatitis C virus infection. This study examined the morbidity and survival of patients with compensated cirrhosis type C. METHODS:A cohort of 384 European cirrhotic patients was enrolled at seven terti...

journal_title：Gastroenterology

authors： Fattovich G,Giustina G,Degos F,Tremolada F,Diodati G,Almasio P,Nevens F,Solinas A,Mura D,Brouwer JT,Thomas H,Njapoum C,Casarin C,Bonetti P,Fuschi P,Basho J,Tocco A,Bhalla A,Galassini R,Noventa F,Schalm SW,Realdi

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have shown that psychological factors play a role in symptom perception among patients with gastroesophageal reflux disease. This report describes the first controlled study showing the effects of relaxation training on symptom reports and esophageal acid exposure in patients with reflu...

journal_title：Gastroenterology

authors： McDonald-Haile J,Bradley LA,Bailey MA,Schan CA,Richter JE

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND & AIMS:beta3 Adrenoceptor (beta3-AR) is expressed on adipocytes and enteric neurons. GW427353 is a human selective beta3-AR agonist with visceral analgesic effects. Some of its effects may involve release of somatostatin (SST) and actions on enteric neurons. The aim of this study was to investigate the mode ...

journal_title：Gastroenterology

authors： Schemann M,Hafsi N,Michel K,Kober OI,Wollmann J,Li Q,Zeller F,Langer R,Lee K,Cellek S

更新日期：2010-01-01 00:00:00

abstract：:Electronic (video) endoscopes are a significant new development in gastroenterology, offering the potential of enhanced teaching and permanent storage of pictorial data. The primary concern of gastroenterologists is the resolution and color performance of these instruments, as these parameters have important bearings ...

journal_title：Gastroenterology

authors： Knyrim K,Seidlitz H,Vakil N,Hagenmüller F,Classen M

更新日期：1989-03-01 00:00:00

abstract：:Superficially invasive squamous cell carcinoma of the esophagus, defined as carcinoma with invasion limited to the mucosa or submucosa regardless of the presence of lymph node metastasis, is being increasingly recognized. We found 7 cases (13%) of this entity among 54 cases of esophageal squamous cancer resected betwe...

journal_title：Gastroenterology

authors： Schmidt LW,Dean PJ,Wilson RT

更新日期：1986-12-01 00:00:00

abstract：:Using flowing isotonic NaCl or flowing molar KCl electrodes, the magnitude of liquid junction potentials between the electrode tip and gastric juice was measured directly, and calculated from electrolyte concentrations in gastric juice according to standard formulas. Gastric transepithelial potential difference was ob...

journal_title：Gastroenterology

authors： Read NW,Fordtran JS

更新日期：1979-05-01 00:00:00

abstract：:In order to discover the effect of bile acid synthesis on cholesterol secretion into the bile, 7 rhesus monkeys were studied at various stable interruptions of the enterohepatic circulation of bile acids. In 4 animals, 2.5 and 7.5% interruptions were compared; 2.5 and 15% interruptions were compared in 5 animals. Ther...

journal_title：Gastroenterology

authors： Strasberg SM,Petrunka CN,Ilson RG

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND & AIMS:New serologic markers of inflammatory bowel disease may be useful for differentiating between Crohn's disease and ulcerative colitis and for disease stratification. We profiled sugar-binding antibodies to identify novel antiglycan antibodies that may be associated with inflammatory bowel disease. MET...

journal_title：Gastroenterology

authors： Dotan I,Fishman S,Dgani Y,Schwartz M,Karban A,Lerner A,Weishauss O,Spector L,Shtevi A,Altstock RT,Dotan N,Halpern Z

更新日期：2006-08-01 00:00:00

abstract：:We have previously demonstrated circulating and tissue-fixed immune complexes containing the small cytoplasmic ribonucleoprotein antigen Ro and immunoglobulin G (IgG) in a case of sicca syndrome associated with primary biliary cirrhosis. To establish the overall prevalence of such complexes in liver disease, we perfor...

journal_title：Gastroenterology

authors： Penner E

更新日期：1986-03-01 00:00:00