Does lower esophageal sphincter incompetency contribute to esophageal bleeding?

abstract：BACKGROUND & AIMS:The secretion and function of antral histamine are not known. The aims of this study were to characterize the mechanisms of histamine release from the gastric antrum of humans, dogs, and rats and to determine whether histamine can influence the secretion of somatostatin and gastrin. METHODS:Somatosta...

journal_title：Gastroenterology

authors： Vuyyuru L,Schubert ML,Harrington L,Arimura A,Makhlouf GM

更新日期：1995-11-01 00:00:00

abstract：:By speeding the fragmentation of meat, peptic digestion might accelerate gastric emptying. To examine this possibility, mongrel dogs prepared with chronic duodenal fistulas were fed steak and 99mTc-labeled chicken liver, measuring 99mTc in all chyme exiting from the stomach out the duodenal fistula allowed quantitatio...

journal_title：Gastroenterology

authors： Ohashi H,Meyer JH

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND & AIMS:To investigate the peripheral sensory effects of repeated stress in patients with postinfectious irritable bowel syndrome (IBS), we tested whether stress following self-limiting bacterial colitis increases colonic dorsal root ganglia (DRG) nociceptive signaling. METHODS:C57BL/6 mice were infected wit...

journal_title：Gastroenterology

authors： Ibeakanma C,Ochoa-Cortes F,Miranda-Morales M,McDonald T,Spreadbury I,Cenac N,Cattaruzza F,Hurlbut D,Vanner S,Bunnett N,Vergnolle N,Vanner S

更新日期：2011-12-01 00:00:00

abstract：:The occurrence of inflammatory bowel disease in all three members of one family is described. Studies of white blood cell chromosomes, histocompatibility antigens, and cellular and humoral immunity failed to explain this unusual phenomenon. However, the appearance of inflammatory bowel disease in an entire family reem...

journal_title：Gastroenterology

authors： Rosenberg JL,Kraft SC,Kirsner JB

更新日期：1976-05-01 00:00:00

abstract：:The effect of furosemide on secretin-stimulated pancreatic secretion was examined in 12 normal subjects using a perfusion method to quantitate pancreatic output. During continuous secretin infusion (0.9 U per kg per hr), secretory volume rose to a steady state level of 32.5 +/- 10.2 ml per min. When a bolus injection ...

journal_title：Gastroenterology

authors： Thomas FB,Sinar D,Caldwell JH,Mekhjian HS,Falko JM

更新日期：1977-08-01 00:00:00

abstract：:We have previously shown that in pregnancy fasting gallbladder volume is increased and emptying after a small volume liquid meal is incomplete. In this study we measured gallbladder volume throughout day and night in healthy women ingesting regular meals. Pregnant women, postpartum women, contraceptive-steroid users, ...

journal_title：Gastroenterology

authors： Everson GT,McKinley C,Lawson M,Johnson M,Kern F Jr

更新日期：1982-04-01 00:00:00

abstract：:We tested the hypothesis that the hepatic siderosis that characterizes sporadic porphyria cutanea tarda is due to the presence of HLA-linked hemochromatosis alleles. We studied 21 probands with sporadic porphyria cutanea tarda and 135 of their relatives by determining HLA haplotypes and measuring transferrin saturatio...

journal_title：Gastroenterology

authors： Edwards CQ,Griffen LM,Goldgar DE,Skolnick MH,Kushner JP

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Despite high morbidity and mortality of alcoholic liver disease worldwide, the molecular mechanisms underlying alcohol-induced liver cell death are not fully understood. Transglutaminase 2 (TG2) is a cross-linking enzyme implicated in apoptosis. TG2 levels and activity are increased in association wit...

journal_title：Gastroenterology

authors： Tatsukawa H,Fukaya Y,Frampton G,Martinez-Fuentes A,Suzuki K,Kuo TF,Nagatsuma K,Shimokado K,Okuno M,Wu J,Iismaa S,Matsuura T,Tsukamoto H,Zern MA,Graham RM,Kojima S

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND & AIMS:Defects in the epithelial tight junction (TJ) barrier contribute to development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) increases intestinal permeability in mice. We investigated microRNAs that are regulated by IL1B and their effects on expression of TJ proteins ...

journal_title：Gastroenterology

authors： Rawat M,Nighot M,Al-Sadi R,Gupta Y,Viszwapriya D,Yochum G,Koltun W,Ma TY

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND & AIMS:In human and canine colon, both slow (slow waves, 2-8/min) and fast (myenteric potential oscillations [MPOs]; 16-20/min) electrical rhythms in the smooth muscle originate at the submucosal and myenteric borders, respectively. We used Ca(2+) imaging to investigate whether interstitial cells of Cajal (I...

journal_title：Gastroenterology

authors： Lee HT,Hennig GW,Park KJ,Bayguinov PO,Ward SM,Sanders KM,Smith TK

更新日期：2009-06-01 00:00:00

abstract：:The aim of the present study was to characterize rat mucosal colonic cells harvested from the crypt continuum during differentiation and dimethylhydrazine-induced neoplasia. The collection of colonocytes was performed using a modified nonenzymatic isolation procedure based on Ca2+ chelation and gentle mechanical disso...

journal_title：Gastroenterology

authors： Schwartz B,Avivi C,Lamprecht SA

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND & AIMS:Reduced generation of all-trans retinoic acid (RA) by CD103(+) intestinal dendritic cells (DCs) is linked to intestinal inflammation in mice. However, the role of RA in intestinal inflammation in humans is unclear. We investigated which antigen-presenting cells (APCs) produce RA in the human intestine...

journal_title：Gastroenterology

authors： Sanders TJ,McCarthy NE,Giles EM,Davidson KL,Haltalli ML,Hazell S,Lindsay JO,Stagg AJ

更新日期：2014-05-01 00:00:00

abstract：:Frequent occurrence of post-transfusion hepatitis continues despite screening for Australia antigen in blood before transfusion and elimination of commercial donor sources. The majority of these cases appears unrelated to hepatitis B virus. Preoperative, acute, and convalescent serra were screened for evidence of hepa...

journal_title：Gastroenterology

authors： Knodell RG,Conrad ME,Dienstag JL,Bell CJ

更新日期：1975-12-01 00:00:00

abstract：:First, and most importantly, the standard of care for treating adenomatous polyps is polypectomy and not therapy with NSAIDs. The initial clinical observation by Waddell and Loughry in 1983 that sulindac treatment influenced rectal polyps in patients with FAP has led to a considerable amount of research, commentary, a...

journal_title：Gastroenterology

authors： DuBois RN

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND & AIMS:Despite inducing an inflammatory response, Helicobacter pylori can persist in the gastric mucosa for decades. H pylori expression of cholesterol-α-glucosyltransferase (encoded by cgt) is required for gastric colonization and T-cell activation. We investigated how cgt affects gastric epithelial cells a...

journal_title：Gastroenterology

authors： Morey P,Pfannkuch L,Pang E,Boccellato F,Sigal M,Imai-Matsushima A,Dyer V,Koch M,Mollenkopf HJ,Schlaermann P,Meyer TF

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The chemokines CCL19 and CCL21 bind CCR7, which is involved in the organization of secondary lymphoid tissue and is expressed during chronic tissue inflammation. We investigated the expression of CCL21 and CCR7 in chronic hepatitis C. The effects of CCL21 on hepatic stellate cells (HSCs) were also s...

journal_title：Gastroenterology

authors： Bonacchi A,Petrai I,Defranco RM,Lazzeri E,Annunziato F,Efsen E,Cosmi L,Romagnani P,Milani S,Failli P,Batignani G,Liotta F,Laffi G,Pinzani M,Gentilini P,Marra F

更新日期：2003-10-01 00:00:00

abstract：:Circulating precursors of mucosal immunoglobulin A plasma cells and T-cell immunoblasts migrate selectively into mucosal sites from the blood, but the mechanisms controlling this selective trafficking have not been determined. One possibility is that the site-specific extravasation of circulating effector cell populat...

journal_title：Gastroenterology

authors： Schmitz M,Nunez D,Butcher EC

更新日期：1988-03-01 00:00:00

abstract：:The symptoms of urgency, diarrhea, and abdominal discomfort are exaggerated after a meal in inflammatory disorders of the colon, such as ulcerative colitis. The possible motor correlates of these symptoms were investigated in a model of acute colitis in six dogs. Each dog was instrumented with seven strain gauge trans...

journal_title：Gastroenterology

authors： Sethi AK,Sarna SK

更新日期：1991-12-01 00:00:00

abstract：:Antibody prevalence and titer to rotavirus and Norwalk virus were studied in Crohn's disease patients and in age-, sex-, and time-matched controls. There were no significant antibody differences between the groups studied. ...

journal_title：Gastroenterology

authors： Greenberg HB,Gebhard RL,McClain CJ,Soltis RD,Kapikian AZ

更新日期：1979-02-01 00:00:00

abstract：:Obese subjects are prone to supersaturated bile, which is maintained or increased during weight loss. In this report, two related studies were carried out on obese subjects to investigate effects of bile acid feeding on biliary lipid metabolism before and during weight reduction. In one study, chenodeoxycholic acid (...

journal_title：Gastroenterology

authors： Mok HY,von Bergmann K,Crouse JR,Grundy SM

更新日期：1979-03-01 00:00:00

abstract：BACKGROUND & AIMS:A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted vs random biopsies in patients with UC. METHODS:W...

journal_title：Gastroenterology

authors： Watanabe T,Ajioka Y,Mitsuyama K,Watanabe K,Hanai H,Nakase H,Kunisaki R,Matsuda K,Iwakiri R,Hida N,Tanaka S,Takeuchi Y,Ohtsuka K,Murakami K,Kobayashi K,Iwao Y,Nagahori M,Iizuka B,Hata K,Igarashi M,Hirata I,Kudo S

更新日期：2016-12-01 00:00:00

abstract：:In vitro neurite outgrowth and neuronal survival are promoted by laminin, and neuronal migration is promoted by collagen type IV. This led to the hypothesis that Hirschsprung's disease (HD) could be the result of an abnormal extracellular matrix microenvironment in the affected bowel during embryogenesis. Using indire...

journal_title：Gastroenterology

authors： Parikh DH,Tam PK,Van Velzen D,Edgar D

更新日期：1992-04-01 00:00:00

abstract：:Wilson's disease may present with severe acute hepatocellular failure. The only effective treatment for fulminant Wilson's disease is liver transplantation, which may lead to reversal of the underlying disease. Some patients with cirrhosis who are too ill to undergo orthotopic liver transplantation have been treated w...

journal_title：Gastroenterology

authors： Stampfl DA,Muñoz SJ,Moritz MJ,Rubin R,Armenti VT,Jarrell BE,Maddrey WC

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND & AIMS:Prior thermal stress induces heat shock protein 70 (HSP70) expression in the pancreas and protects against secretagogue-induced pancreatitis, but it is not clear that this thermal stress-induced protection is actually mediated by HSP70 since thermal stress may have other, non-HSP related, effects. ME...

journal_title：Gastroenterology

authors： Bhagat L,Singh VP,Song AM,van Acker GJ,Agrawal S,Steer ML,Saluja AK

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND & AIMS:Unlike adult antral cells, feline newborn antral cells are unable to contract in response to agonists in the absence of extracellular calcium or in response to exogenous inositol 1,4,5-triphosphate (IP3) after permeabilization. Changes in intracellular pathways that are associated with these differenc...

journal_title：Gastroenterology

authors： Hillemeier AC,Deutsch DE,Bitar KN

更新日期：1997-08-01 00:00:00

abstract：:Abdominal cramps and urgent defecation are common side effects of clinical doses of arginine vasopressin, indicating that the drug may have stimulating effects on colonic motor activity. Four strain-gauge transducers were implanted on the colon in six monkeys. A blood flow probe was fixed on the inferior mesenteric ar...

journal_title：Gastroenterology

authors： Zhu YR,Cowles VE,Herranz ES,Schulte WJ,Condon RE

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND & AIMS:The risk of colorectal neoplasms among siblings of patients with advanced adenomas is not clear. We determined the prevalence of advanced adenomas in the siblings of patients with advanced adenomas and compared it with that of siblings of individuals without these lesions. METHODS:In a blinded, cross...

journal_title：Gastroenterology

authors： Ng SC,Lau JY,Chan FK,Suen BY,Tse YK,Hui AJ,Leung-Ki EL,Ching JY,Chan AW,Wong MC,Ng SS,To KF,Wu JC,Sung JJ

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND & AIMS:In the Active Ulcerative Colitis Trial (ACT)-1 and ACT-2, patients with ulcerative colitis treated with infliximab were more likely than those given placebo to have a clinical response, undergo remission, and have mucosal healing. We investigated the association between early improvement (based on end...

journal_title：Gastroenterology

authors： Colombel JF,Rutgeerts P,Reinisch W,Esser D,Wang Y,Lang Y,Marano CW,Strauss R,Oddens BJ,Feagan BG,Hanauer SB,Lichtenstein GR,Present D,Sands BE,Sandborn WJ

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND & AIMS:Ethanol impairs the mitochondrial transport of reduced glutathione (GSH), resulting in lower mitochondrial GSH (mGSH) levels. Our purpose was to evaluate the role of acetaldehyde on the regulation of mGSH in HepG2 cells. METHODS:mGSH levels and transport, mitochondrial membrane microviscosity, and li...

journal_title：Gastroenterology

authors： Lluis JM,Colell A,García-Ruiz C,Kaplowitz N,Fernández-Checa JC

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND & AIMS:Increase of T cells expressing CD4 and T-cell receptor (TCR) alpha- beta+ (beta[dim]) was observed in the mucosal and peripheral lymphoid tissues of TCR alpha-/- mice with inflammatory bowel disease (IBD). The aim of this study was to characterize the CD4+ TCR alpha-beta+ T cells. METHODS:Cytokine pr...

journal_title：Gastroenterology

authors： Takahashi I,Kiyono H,Hamada S

更新日期：1997-06-01 00:00:00