Effect of hydroxypropylmethylcellulose on gastrointestinal transit and luminal viscosity in dogs.

abstract：BACKGROUND & AIMS:Steatosis in patients with nonalcoholic fatty liver disease (NAFLD) is due to an imbalance between intrahepatic triglyceride (IHTG) production and export. The purpose of this study was to evaluate TG metabolism in adipose tissue and liver in NAFLD. METHODS:Fatty acid, VLDL-TG, and VLDL-apolipoprotein...

journal_title：Gastroenterology

authors： Fabbrini E,Mohammed BS,Magkos F,Korenblat KM,Patterson BW,Klein S

更新日期：2008-02-01 00:00:00

abstract：:Median nerve somatosensory evoked potentials were recorded from 33 patients with various degrees of hepatic failure and from 10 age-matched controls. Within 20 ms poststimulation, one negative peak (N13) could be recorded from the middle of the back of the patient's neck at the C2 vertebral level. Within 150 ms, three...

journal_title：Gastroenterology

authors： Yang SS,Chu NS,Liaw YF

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The chemokines CCL19 and CCL21 bind CCR7, which is involved in the organization of secondary lymphoid tissue and is expressed during chronic tissue inflammation. We investigated the expression of CCL21 and CCR7 in chronic hepatitis C. The effects of CCL21 on hepatic stellate cells (HSCs) were also s...

journal_title：Gastroenterology

authors： Bonacchi A,Petrai I,Defranco RM,Lazzeri E,Annunziato F,Efsen E,Cosmi L,Romagnani P,Milani S,Failli P,Batignani G,Liotta F,Laffi G,Pinzani M,Gentilini P,Marra F

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND & AIMS:Thromboxane levels correlate with severity of liver injury in rats given alcohol. The aim of this study was to evaluate the effect of thromboxane inhibitors on pathological changes in experimental alcoholic liver disease. METHODS:Male Wistar rats were given a liquid diet and ethanol intragastrically ...

journal_title：Gastroenterology

authors： Nanji AA,Khwaja S,Rahemtulla A,Miao L,Zhao S,Tahan SR

更新日期：1997-01-01 00:00:00

abstract：:In vitro studies have shown that some bile salts inhibit the growth of intestinal bacteria. We investigated the possibility that bile salts might have a similar action in vivo in the ileum by performing serial anaerobic cultures and bile salt analyses on postprandial ileal fluid obtained anaerobically via intestinal t...

journal_title：Gastroenterology

authors： Williams RC,Showalter R,Kern F Jr

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND & AIMS:HCV nonstructural protein 5A (NS5A) has been implicated in regulating cell growth and interferon response. The NS5A protein contains proline-rich regions that are highly conserved among HCV genotypes and match Src homology 3 (SH3)-binding motifs (PxxP) found in various cellular signaling molecules. M...

journal_title：Gastroenterology

authors： Nanda SK,Herion D,Liang TJ

更新日期：2006-03-01 00:00:00

abstract：:The polypeptide core of mucin glycoprotein subunits resists cleavage by proteases. To determine if the carbohydrate side chains of these subunits protect the underlying polypeptide core from proteolytic cleavage, we compared the effect of pancreatic proteases on hog gastric mucin before and after cleavage of its carbo...

journal_title：Gastroenterology

authors： Variyam EP,Hoskins LC

更新日期：1983-03-01 00:00:00

abstract：:The prevalence of gastroesophageal varices and gastrointestinal hemorrhage was determined in 124 patients with severe chronic active liver disease (CALD) receiving prednisone and followed regularly for up to 10 yr. Varices were demonstrated by contrast radiography in only 19 patients (15%). Ten had varices before ther...

journal_title：Gastroenterology

authors： Czaja AJ,Wolf AM,Summerskill WH

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND & AIMS:The revised Bethesda guidelines for Lynch syndrome recommend microsatellite instability (MSI) testing all colorectal cancers in patients diagnosed before age 50 years and colorectal cancers diagnosed in patients between ages 50 and 59 years with particular pathology features. Our aim was to identify p...

journal_title：Gastroenterology

authors： Jenkins MA,Hayashi S,O'Shea AM,Burgart LJ,Smyrk TC,Shimizu D,Waring PM,Ruszkiewicz AR,Pollett AF,Redston M,Barker MA,Baron JA,Casey GR,Dowty JG,Giles GG,Limburg P,Newcomb P,Young JP,Walsh MD,Thibodeau SN,Lindor NM

更新日期：2007-07-01 00:00:00

abstract：:A case of enterogenous cysts of the duodenum in a 44-yr-old man complicated by duodenal obstruction and relapsing pancreatitis is presented. The cystic duodenal lesions were visualized by endoscopic retrograde cholangiopancreatography and for the first time by computed tomography and abdominal sonography. Thus, the di...

journal_title：Gastroenterology

authors： Holstege A,Barner S,Brambs HJ,Wenz W,Gerok W,Farthmann EH

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND & AIMS:The liver has high regenerative potential. We attempted to establish a novel culture system for extensive expansion of fetal mouse hepatic stem/progenitor cells and to characterize cultured cells. METHODS:Hepatic spheroids collected from 6-day floating cultures were cultured on collagen-coated dishes...

journal_title：Gastroenterology

authors： Tsuchiya A,Heike T,Fujino H,Shiota M,Umeda K,Yoshimoto M,Matsuda Y,Ichida T,Aoyagi Y,Nakahata T

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND & AIMS:Induction of heat-shock protein 72 is associated with enhanced tolerance to subsequent nonthermal stresses. This study evaluated whether induction of heat-shock protein 72 protects against intestinal ischemia/reperfusion injury. METHODS:Groups of nonheated and heated rats underwent sham operation, 30...

journal_title：Gastroenterology

authors： Stojadinovic A,Kiang J,Smallridge R,Galloway R,Shea-Donohue T

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND & AIMS:The relationship between the sensation of bloating, often ranked as the most bothersome symptom by patients with irritable bowel syndrome (IBS), and actual distention manifest as an increase in abdominal girth is controversial. Investigation of this problem has been hampered by the lack of a reliable ...

journal_title：Gastroenterology

authors： Houghton LA,Lea R,Agrawal A,Reilly B,Whorwell PJ

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND/AIMS:Antifungal therapy cures esophageal candidiasis in most patients with acquired immunodeficiency syndrome, but the subsequent course of these patients is not established. This study examines the natural history of esophageal candidiasis after successful treatment. METHODS:Patients with endoscopic and cl...

journal_title：Gastroenterology

authors： Laine L

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Mutations in HFE are the most common cause of the iron-overload disorder hereditary hemochromatosis. Levels of the main iron regulatory hormone, hepcidin, are inappropriately low in hereditary hemochromatosis mouse models and patients with HFE mutations, indicating that HFE regulates hepcidin. The b...

journal_title：Gastroenterology

authors： Corradini E,Garuti C,Montosi G,Ventura P,Andriopoulos B Jr,Lin HY,Pietrangelo A,Babitt JL

更新日期：2009-10-01 00:00:00

abstract：:A 14-yr-old girl presented with long-standing symptoms of partial gastric outlet obstruction due to an antral mucosal diaphragm that had a central aperture of 4-5 mm. The literature of this congenital malformation is reviewed with respect to diagnostic criteria and feasibility of endoscopic transection. The procedure ...

journal_title：Gastroenterology

authors： Berr F,Rienmueller R,Sauerbruch T

更新日期：1985-11-01 00:00:00

abstract：:A newly recognized clinical and morphologic pattern of acute alcoholic liver disease is described. Twenty-one patients, having the hepatic morphologic features of alcoholic foamy degeneration, were retrospectively analyzed. All patients had a significant history of chronic alcoholism. Jaundice and hepatomegaly were us...

journal_title：Gastroenterology

authors： Uchida T,Kao H,Quispe-Sjogren M,Peters RL

更新日期：1983-04-01 00:00:00

abstract：:Encephalopathy in liver disease may be unresponsive to protein restriction, lactulose, and neomycin. Zinc supplements have been reported to improve psychometric performance in liver cirrhosis, but the importance of zinc deficiency in overt hepatic encephalopathy has not yet been clearly established. A patient with sev...

journal_title：Gastroenterology

authors： Van der Rijt CC,Schalm SW,Schat H,Foeken K,De Jong G

更新日期：1991-04-01 00:00:00

abstract：:To find a possible explanation for the selective hepatic conjugation of bile acids with glycine or taurine, the N-acyl amidates of cholic acid and a number of amino acids and amino acid analogues were synthesized, and their susceptibility to hydrolysis by pancreatic juice, gastric juice, serum, or small intestinal muc...

journal_title：Gastroenterology

authors： Huijghebaert SM,Hofmann AF

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND & AIMS:Liver fibrosis, hepatocellular necrosis, inflammation, and proliferation of liver progenitor cells are features of chronic liver injury. Mouse models have been used to study the end-stage pathophysiology of chronic liver injury. However, little is known about differences in the mechanisms of liver inj...

journal_title：Gastroenterology

authors： Pradhan-Sundd T,Vats R,Russell JO,Singh S,Michael AA,Molina L,Kakar S,Cornuet P,Poddar M,Watkins SC,Nejak-Bowen KN,Monga SP,Sundd P

更新日期：2018-10-01 00:00:00

abstract：:A method of measuring gastric secretions and emptying rates after ingestion of an ordinary (solid-liquid) meal has been developed and validated. The technique quantifies movements of volume across the pylorus using constant duodenal perfusion with a nonabsorbable marker, polyethylene glycol (PEG), which, in turn, quan...

journal_title：Gastroenterology

authors： Malagelada JR,Longstreth GF,Summerskill WH,Go VL

更新日期：1976-02-01 00:00:00

abstract：:We studied intestinal function and hepatic microsomal phase I monooxygenase function in healthy, free-living subjects, aged 19-91 yr. In subjects (n = 114) given a diet including 100 g/day of fat, fecal fat in a 72-h collection did not increase with advancing age. D-Xylose excretion (n = 54) following a 25-g oral load...

journal_title：Gastroenterology

authors： Arora S,Kassarjian Z,Krasinski SD,Croffey B,Kaplan MM,Russell RM

更新日期：1989-06-01 00:00:00

abstract：:A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursor-product relationship betwe...

journal_title：Gastroenterology

authors： Schwartz CC,Vlahcevic ZR,Halloran LG,Gregory DH,Meek JB,Swell L

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND & AIMS:Based on experimental and epidemiologic studies, we investigated whether coffee and caffeine consumption reduced the risk of elevated alanine aminotransferase (ALT) activity in persons at high risk for liver injury in a national, population-based study. METHODS:Participants were 5944 adults in the Th...

journal_title：Gastroenterology

authors： Ruhl CE,Everhart JE

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND & AIMS:Abdominal bloating is a frequent complaint in irritable bowel syndrome (IBS), but its underlying mechanism remains uncertain. Our aim was to determine whether the abdominal wall, specifically its adaptation to intra-abdominal volumes, plays a role. METHODS:In 12 patients complaining of abdominal bloa...

journal_title：Gastroenterology

authors： Tremolaterra F,Villoria A,Azpiroz F,Serra J,Aguadé S,Malagelada JR

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND & AIMS:Triage of patients with acute upper gastrointestinal hemorrhage (UGIH) has traditionally required urgent upper endoscopy. The aim of this study is to evaluate the use of artificial neural network for nonendoscopic triage. METHODS:A cohort of 387 patients was used to train (n = 194) and internally val...

journal_title：Gastroenterology

authors： Das A,Ben-Menachem T,Farooq FT,Cooper GS,Chak A,Sivak MV Jr,Wong RC

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND & AIMS:Krüppel-like factor 5 (KLF5) is a transcription factor that promotes proliferation, is highly expressed in dividing crypt cells of the gastrointestinal epithelium, and is induced by various stress stimuli. We sought to determine the role of KLF5 in colonic inflammation and recovery by studying mice wi...

journal_title：Gastroenterology

authors： McConnell BB,Kim SS,Bialkowska AB,Yu K,Sitaraman SV,Yang VW

更新日期：2011-02-01 00:00:00

abstract：:We compared the inhibition of food-stimulated gastric acid secretion and changes in serum concentrations of immunoreactive gastric inhibitory polypeptide and gastrin caused by: (a) duodenal perfusion of oleic acid, and (b) intravenous infusion of pure, natural, porcine gastric inhibitory, polypeptide in dogs with gast...

journal_title：Gastroenterology

authors： Yamagishi T,Debas HT

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND & AIMS:Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are potent antiviral agents that might have additive or synergistic antiviral activity in treatment of patients with chronic hepatitis B (CHB). We compared the efficacy and safety of ETV monotherapy with those of a combination of ETV and TDF. ME...

journal_title：Gastroenterology

authors： Lok AS,Trinh H,Carosi G,Akarca US,Gadano A,Habersetzer F,Sievert W,Wong D,Lovegren M,Cohen D,Llamoso C

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND & AIMS:The finding of bone morphogenetic protein (BMP) receptor 1a mutations in juvenile polyposis suggests that BMPs are important in colorectal cancer (CRC). We investigated the BMP pathway in sporadic CRC. METHODS:We investigated BMP receptor (BMPR) expression using immunoblotting and sequenced BMPR2 in ...

journal_title：Gastroenterology

authors： Kodach LL,Wiercinska E,de Miranda NF,Bleuming SA,Musler AR,Peppelenbosch MP,Dekker E,van den Brink GR,van Noesel CJ,Morreau H,Hommes DW,Ten Dijke P,Offerhaus GJ,Hardwick JC

更新日期：2008-05-01 00:00:00