Abstract:
:A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursor-product relationship between biliary cholesterol, plasma free cholesterol and bile acids. Both the constant infusion and pulse labeling data indicated that the bile acid precursor had a more rapid rate of turnover than plasma or biliary cholesterol; the biliary cholesterol precursor turned over more rapidly than plasma cholesterol. The data suggest the presence of multiple hepatic cholesterol precursor compartments. Bile acids may be derived predominantly from newly synthesized cholesterol in man.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Schwartz CC,Vlahcevic ZR,Halloran LG,Gregory DH,Meek JB,Swell Lkeywords:
subject
Has Abstractpub_date
1975-12-01 00:00:00pages
1379-82issue
6eissn
0016-5085issn
1528-0012pii
S0016508575002454journal_volume
69pub_type
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