Abstract：
BACKGROUND & AIMS:Corticofugal pathways to the human esophagus have been recently identified in humans using transcranial magnetic stimulation. The aim of this study was to determine the topographic representation of the esophagus on the cerebral cortex. METHODS:Focal magnetic stimulation of 1-cm areas was performed over both hemispheres in 10 healthy subjects. Esophageal electromyographic responses were recorded 2 cm below the upper esophageal sphincter. The studies were repeated to determine reproducibility in 3 subjects; in 2 subjects, esophageal topography was compared with thenar muscle topography. RESULTS:In all subjects, esophageal electromyographic responses were evoked by stimulation of either the right or left hemisphere. Largest amplitude responses were obtained anterior to those of the thenar muscles, indicating that the esophagus may be represented on either the anterior aspect of the motor cortex or on the premotor cortex. In all subjects, the area of response was asymmetric, being more extensive on the right hemisphere than on the left hemisphere in 8 subjects. In 2 subjects, the area of response on the left hemisphere was more extensive than on the right. Repeat studies showed that this asymmetry was consistent. CONCLUSIONS:Esophageal motor function shows bilateral cortical representation with consistent interhemispheric asymmetry.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Aziz Q,Rothwell JC,Hamdy S,Barlow J,Thompson DGdoi
10.1016/s0016-5085(96)70053-7subject
Has Abstractpub_date
1996-10-01 00:00:00pages
855-62issue
4eissn
0016-5085issn
1528-0012pii
S0016-5085(96)70053-7journal_volume
111pub_type
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