Impaired mixed-lymphocyte culture reactions in patients with inflammatory bowel disease.

abstract：:Detailed porphyrin analysis and additional ultrastructural abnormalities of liver cells are described in a patient with features of Rotor's syndrome. Normal values of porphyrin precursors, delta-aminolevulinic acid and porphobilinogen, and porphyrins were found in plasma, urine, and erythrocytes. However, fecal porphy...

journal_title：Gastroenterology

authors： Evans J,Lefkowitch J,Lim CK,Billing B

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND & AIMS:Carcinomas of the extrahepatic bile ducts, ampulla of Vater, and duodenum are uncommon, and their epigenetic and genetic alterations are not well characterized. METHODS:We therefore compared the methylation profile and genetic alterations in 18 extrahepatic biliary, 9 ampullary, and 12 duodenal carci...

journal_title：Gastroenterology

authors： Kim SG,Chan AO,Wu TT,Issa JP,Hamilton SR,Rashid A

更新日期：2003-05-01 00:00:00

abstract：:A patient with a lifelong history of asthma and hay fever was investigated because of symptoms of esophageal spasm. Esophageal biopsies revealed elongated papillae and basal zone hyperplasia of the epithelial layer with eosinophilic infiltration of the lamina propria and muscularis mucosae. There was no evidence of re...

journal_title：Gastroenterology

authors： Dobbins JW,Sheahan DG,Behar J

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND & AIMS:A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted vs random biopsies in patients with UC. METHODS:W...

journal_title：Gastroenterology

authors： Watanabe T,Ajioka Y,Mitsuyama K,Watanabe K,Hanai H,Nakase H,Kunisaki R,Matsuda K,Iwakiri R,Hida N,Tanaka S,Takeuchi Y,Ohtsuka K,Murakami K,Kobayashi K,Iwao Y,Nagahori M,Iizuka B,Hata K,Igarashi M,Hirata I,Kudo S

更新日期：2016-12-01 00:00:00

abstract：:Antibody prevalence and titer to rotavirus and Norwalk virus were studied in Crohn's disease patients and in age-, sex-, and time-matched controls. There were no significant antibody differences between the groups studied. ...

journal_title：Gastroenterology

authors： Greenberg HB,Gebhard RL,McClain CJ,Soltis RD,Kapikian AZ

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic mucinous cystic neoplasm (MCN), a cystic tumor of the pancreas that develops most frequently in women, is a potential precursor to pancreatic ductal adenocarcinoma. MCNs develop primarily in the body and tail of the pancreas and are characterized by the presence of a mucinous epithelium and...

journal_title：Gastroenterology

authors： Sano M,Driscoll DR,De Jesus-Monge WE,Klimstra DS,Lewis BC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND & AIMS:Methionine adenosyltransferase (MAT) catalyzes S-adenosylmethionine biosynthesis. Two genes (MAT1A and MAT2A) encode for the catalytic subunit of MAT, while a third gene (MAT2beta) encodes for a regulatory subunit that modulates the activity of MAT2A-encoded isoenzyme. We uncovered multiple splicing v...

journal_title：Gastroenterology

authors： Yang H,Ara AI,Magilnick N,Xia M,Ramani K,Chen H,Lee TD,Mato JM,Lu SC

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND & AIMS:Although the cell of origin for pancreatic cancer remains unknown, prior studies have suggested that pancreatic neoplasia may be initiated in progenitor-like cells. To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of b...

journal_title：Gastroenterology

authors： Park SW,Davison JM,Rhee J,Hruban RH,Maitra A,Leach SD

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND & AIMS:Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia. However, the possible effect these medications may have on the risk of esophageal adenocarcinoma (EAC) in patients w...

journal_title：Gastroenterology

authors： Nguyen DM,Richardson P,El-Serag HB

更新日期：2010-06-01 00:00:00

abstract：:For decades, interactions between the enteric neuromuscular apparatus and the central nervous system have served as the primary focus of pathophysiological research in the functional gastrointestinal disorders. The accumulation of patient reports, as well as clinical observations, has belatedly led to an interest in t...

journal_title：Gastroenterology

authors： Barbara G,Feinle-Bisset C,Ghoshal UC,Quigley EM,Santos J,Vanner S,Vergnolle N,Zoetendal EG

更新日期：2016-02-18 00:00:00

abstract：BACKGROUND & AIMS:Keratins 8 and 18 (K8/K18) provide anti-apoptotic functions upon liver injury. The cytoprotective function of keratins explains the overrepresentation of K8/K18 variants in patients with cirrhosis. However, K8/K18 variant-associated susceptibility to acute liver injury, which is well-described in anim...

journal_title：Gastroenterology

authors： Strnad P,Zhou Q,Hanada S,Lazzeroni LC,Zhong BH,So P,Davern TJ,Lee WM,Acute Liver Failure Study Group.,Omary MB

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND & AIMS:Little is known about the prevalence of nonalcoholic fatty liver disease (NAFLD) among severely obese adolescents or factors that determine its development. We investigated the prevalence of NAFLD in a multicenter cohort of adolescents undergoing bariatric surgery and the factors associated with it. ...

journal_title：Gastroenterology

authors： Xanthakos SA,Jenkins TM,Kleiner DE,Boyce TW,Mourya R,Karns R,Brandt ML,Harmon CM,Helmrath MA,Michalsky MP,Courcoulas AP,Zeller MH,Inge TH,Teen-LABS Consortium.

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AND AIMS:In stomach, metaplasia can arise from differentiated chief cells that become mitotic via paligenosis, a stepwise program. In paligenosis, mitosis initiation requires reactivation of the cellular energy hub mTORC1 after initial mTORC1 suppression by DNA damage induced transcript 4 (DDIT4 aka REDD1). ...

journal_title：Gastroenterology

authors： Miao ZF,Sun JX,Adkins-Threats M,Pang MJ,Zhao JH,Wang X,Tang KW,Wang ZN,Mills JC

更新日期：2021-01-01 00:00:00

abstract：:A 17-yr-old boy developed acute proctosigmoiditis after the institution of isotretinoin for the treatment of cystic acne vulgaris. Painless diarrhea, accompanied by mucus and eventually blood, began within days of commencing treatment and persisted while the drug was administered. At sigmoidoscopy patchy mucosal infla...

journal_title：Gastroenterology

authors： Martin P,Manley PN,Depew WT,Blakeman JM

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND & AIMS:Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota, and T cells in the development and progression of colitis in mice. METHODS:All mice were maintained on...

journal_title：Gastroenterology

authors： Chen L,He Z,Iuga AC,Martins Filho SN,Faith JJ,Clemente JC,Deshpande M,Jayaprakash A,Colombel JF,Lafaille JJ,Sachidanandam R,Furtado GC,Lira SA

更新日期：2018-10-01 00:00:00

abstract：:The fibrinolytic activity of blood draining from the stomachs of patients with gastroduodenal disease has been compared with the fibrinolytic activity of blood in the systemic venous circulation and with the blood draining from normal stomachs. Gastric venous blood from normal and diseased stomachs contains greater am...

journal_title：Gastroenterology

authors： O'Brien TE,Hadley H,Irving MH

更新日期：1979-03-01 00:00:00

abstract：BACKGROUND & AIMS:The emergence of oxyntic atrophy and metaplastic cell lineages in response to chronic Helicobacter pylori infection predisposes to gastric neoplasia. We have described a trefoil factor family 2 (TFF2; spasmolytic polypeptide) expressing metaplasia (SPEM) associated with gastric neoplasia in both roden...

journal_title：Gastroenterology

authors： Nomura S,Baxter T,Yamaguchi H,Leys C,Vartapetian AB,Fox JG,Lee JR,Wang TC,Goldenring JR

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of Barrett's esophagus and esophageal adenocarcinoma has increased despite surveillance of patients with Barrett's esophagus. Limited data indicate that nonsteroidal anti-inflammatory drug (NSAID) and statin use reduce the risk for esophageal adenocarcinoma. We investigated whether NSAID...

journal_title：Gastroenterology

authors： Kastelein F,Spaander MC,Biermann K,Steyerberg EW,Kuipers EJ,Bruno MJ,Probar-study Group.

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND/AIMS:Diarrhea is a significant problem in patients with acquired immunodeficiency syndrome (AIDS). The aim of this study was to determine octreotide effectiveness in refractory AIDS-associated diarrhea. METHODS:In a 3-week protocol, 129 patients with a stool weight of > 500 g/day despite standard antidiarrh...

journal_title：Gastroenterology

authors： Simon DM,Cello JP,Valenzuela J,Levy R,Dickerson G,Goodgame R,Brown M,Lyche K,Fessel WJ,Grendell J

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND & AIMS:Corticotropin-releasing factor (CRF) signaling pathways play a key role in the stress response through the activation of CRF(1) and CRF(2) receptors. We investigated the CRF receptor subtypes involved in gastric postoperative ileus. METHODS:Adult male mice (C57BL/6, CRF(1)-deficient, and wild-type), ...

journal_title：Gastroenterology

authors： Luckey A,Wang L,Jamieson PM,Basa NR,Million M,Czimmer J,Vale W,Taché Y

更新日期：2003-09-01 00:00:00

abstract：:Fetal bile salt metabolism was assessed by the intravenous infusion of e114C]cholate into 6 monkey fetuses. The placental transfer, fetal plasma clearance, and fetal hepatic excretion of the administered radiolabeled bile salt were measured. Placental transfer averaged 30% of the injected dose, while biliary excretion...

journal_title：Gastroenterology

authors： Little JM,Smallwood RA,Lester R,Piasecki GJ,Jackson BT

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND & AIMS:Postprandial glycemia excursions increase after gastric bypass surgery; this effect is even greater among patients with recurrent hypoglycemia. These patients also have increased postprandial levels of insulin and glucagon-like peptide 1 (GLP-1). We performed a clinical trial to determine the role of ...

journal_title：Gastroenterology

authors： Salehi M,Gastaldelli A,D'Alessio DA

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND & AIMS:Trinitrobenzene sulfonic acid (TNBS)-induced colitis is a T-helper 1 (Th1) T cell-mediated inflammation that is rapidly reversed by administration of anti-interleukin (IL) 12. This study sought to define the mechanism of this curative effect. METHODS:Cells and tissue from mice with TNBS colitis recei...

journal_title：Gastroenterology

authors： Fuss IJ,Marth T,Neurath MF,Pearlstein GR,Jain A,Strober W

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND & AIMS:Type 2 diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC); it is not clear if this association varies by sex or other factors. Insulin use might also be associated with CRC risk. We investigated associations of type 2 DM and insulin use with CRC risk. METHODS:The C...

journal_title：Gastroenterology

authors： Campbell PT,Deka A,Jacobs EJ,Newton CC,Hildebrand JS,McCullough ML,Limburg PJ,Gapstur SM

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND/AIMS:Clinical and experimental studies suggest a link between nutritional status and the recovery of hepatic function after hypoxic and hypothermic insults. This study aimed at determining the metabolic pathways involved in such recovery as a function of nutrition. METHODS:Livers from fed and fasted mice we...

journal_title：Gastroenterology

authors： Dimicoli JL,Patry J,Adam R,Dennison A,Nedelec JF,Bismuth H

更新日期：1994-12-01 00:00:00

abstract：:Eleven infants born to mothers with acute hepatitis B during the third trimester of pregnancy who were hepatitis B surface antigen-positive at delivery were treated with hepatitis B immune globulin within 24-48 h of birth. Five infants received one dose of hepatitis B immune globulin and 6 infants received a second do...

journal_title：Gastroenterology

authors： Tong MJ,Nair PV,Thursby M,Schweitzer IL

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND & AIMS:Recently, the immediate early gene h-sgk was cloned as a hypertonicity-induced gene from human hepatoma cells. The aim of this study was to localize h-sgk messenger RNA (mRNA) expression in normal and inflamed intestinal mucosa and to identify potential transcriptional regulators. METHODS:h-sgk mRNA ...

journal_title：Gastroenterology

authors： Waldegger S,Klingel K,Barth P,Sauter M,Rfer ML,Kandolf R,Lang F

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND & AIMS:We assessed the influence of genetic variants in the hepatitis B virus (HBV) core, which is a principal immunologic target, on the progression to hepatocellular carcinoma (HCC) in a cohort of 4841 male HBV carriers followed up for 16 years. METHODS:First, baseline sera from 116 HCC cases and 154 cont...

journal_title：Gastroenterology

authors： Sung FY,Jung CM,Wu CF,Lin CL,Liu CJ,Liaw YF,Tsai KS,Yu MW

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND & AIMS:Studies in gastrin-deficient mice have demonstrated critical roles for gastrin peptides in the regulation of gastric acid secretion, but the relative contributions of amidated (G-17) and glycine-extended (G17-Gly) gastrin remain unclear. We examined the effects of these 2 forms of gastrin on acid secr...

journal_title：Gastroenterology

authors： Chen D,Zhao CM,Dockray GJ,Varro A,Van Hoek A,Sinclair NF,Wang TC,Koh TJ

更新日期：2000-09-01 00:00:00

abstract：:To study directly the functions of the cells that line the bile ducts inside the liver, we developed a new technique for isolating intrahepatic bile duct epithelial cells (IBDECs) from normal rat liver. Parenchymal and nonparenchymal cells were separated from whole liver by enzymatic digestion and mechanical disruptio...

journal_title：Gastroenterology

authors： Ishii M,Vroman B,LaRusso NF

更新日期：1989-11-01 00:00:00