Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression.

abstract：BACKGROUND & AIMS:Drug-induced cholestasis is a frequent form of acquired liver disease. To elucidate the molecular pathogenesis of drug-induced cholestasis, we investigated the effects of prototypic cholestatic drugs on the canalicular bile salt export pump (Bsep) of rat liver. METHODS:Vesicles were isolated from Bse...

journal_title：Gastroenterology

authors： Stieger B,Fattinger K,Madon J,Kullak-Ublick GA,Meier PJ

更新日期：2000-02-01 00:00:00

abstract：:Urokinase, the plasminogen activator from human urine, produces a dose-dependent increase in blood flow in the canine superior mesenteric artery when injected intraarterially at doses from 10(-1) to 10(3) units kg-1. This vasodilation persists despite blockade of beta-adrenergic and histamine H1 and H2 receptors as we...

journal_title：Gastroenterology

authors： Gurll N,Zinner MJ,Turtinen L,Reynolds DG

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatitis is the most important risk factor for pancreatic ductal adenocarcinoma (PDAC). Pancreatitis predisposes to PDAC because it induces a process of acinar cell reprogramming known as acinar-to-ductal metaplasia (ADM)-a precursor of pancreatic intraepithelial neoplasia lesions that can progres...

journal_title：Gastroenterology

authors： Gruber R,Panayiotou R,Nye E,Spencer-Dene B,Stamp G,Behrens A

更新日期：2016-09-01 00:00:00

abstract：:The effects of a variety of substances influencing the initiation of cyclic motor events at the gastroduodenal junction were studied in conscious sheep. A significant and long-lasting decrease in the frequency of cyclic events from approximately 100 min to 30-40 min was elicited by the intraduodenal bulb administratio...

journal_title：Gastroenterology

authors： Ruckebusch Y

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:Recurrent hepatitis B after liver transplantation may be complicated by fibrosing cholestatic hepatitis. This syndrome is associated with rapid graft failure and is characterized by ballooning degeneration of hepatocytes and abundant viral antigen expression. METHODS:To study this disorder further, in situ ...

journal_title：Gastroenterology

authors： Mason AL,Wick M,White HM,Benner KG,Lee RG,Regenstein F,Riely CA,Bain VG,Campbell C,Perrillo RP

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND/AIMS:Cytokines are thought to be important in mediating tissue damage in inflammatory bowel disease (IBD). Many of the in vivo activities of tumor necrosis factor alpha (TNF-alpha) match the changes found in IBD, but its importance is controversial. METHODS:A sensitive, reverse hemolytic plaque assay was us...

journal_title：Gastroenterology

authors： Breese EJ,Michie CA,Nicholls SW,Murch SH,Williams CB,Domizio P,Walker-Smith JA,MacDonald TT

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND & AIMS:Recurrence of varices and rebleeding after endoscopic therapy is very common. Data on the prediction of recurrent varices after initial obliteration by endoscopic therapy are few. The aim of this study was to correlate the presence and the size of paraesophageal varices (PEVs) in patients after endosc...

journal_title：Gastroenterology

authors： Leung VK,Sung JJ,Ahuja AT,Tumala IE,Lee YT,Lau JY,Chung SC

更新日期：1997-06-01 00:00:00

abstract：:Furosemide occasionally causes azotemia in patients with ascites, independently of induced volume depletion. To define this effect, we measured renal clearances in patients with chronic liver disease and ascites and in nonascitic controls. Furosemide (80 mg i.v.) transiently increased p-aminohippurate clearance in con...

journal_title：Gastroenterology

authors： Daskalopoulos G,Laffi G,Morgan T,Pinzani M,Harley H,Reynolds T,Zipser RD

更新日期：1987-06-01 00:00:00

abstract：:Esophageal ligation in the pylorus-ligated rat significantly inhibited volume, titratable acidity, and titratable acid output and reduced the incidence of ulcers, perforations, and death of 18-hr pylorus-ligated rats. Draining the saliva outside the body of the rat by esophageal cannulation produced a significant incr...

journal_title：Gastroenterology

authors： Brodie DA,Knapp PG

更新日期：1966-06-01 00:00:00

abstract：BACKGROUND & AIMS:Conventional transarterial chemoembolization (cTACE) is used to treat patients with hepatocellular carcinoma (HCC). Radioembolization is a minimally invasive procedure that involves implantation of radioactive micron-sized particles loaded with yttrium-90 (Y90) inside the blood vessels that supply a t...

journal_title：Gastroenterology

authors： Salem R,Gordon AC,Mouli S,Hickey R,Kallini J,Gabr A,Mulcahy MF,Baker T,Abecassis M,Miller FH,Yaghmai V,Sato K,Desai K,Thornburg B,Benson AB,Rademaker A,Ganger D,Kulik L,Lewandowski RJ

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND & AIMS:Regeneration from cerulein-induced pancreatitis is accompanied by a transient synthesis and deposition of extracellular matrix components in the rat pancreas. The pleiotropic transforming growth factor (TGF)-beta1 has been suggested to regulate extracellular matrix remodeling during regeneration from ...

journal_title：Gastroenterology

authors： Menke A,Yamaguchi H,Gress TM,Adler G

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND & AIMS:Galectin-3 is a beta-galactoside-binding protein implicated in tumor progression and metastasis of colorectal cancers. To determine whether circulating galectin-3 ligands are related to the presence of colon cancer, we sought to identify and quantify ligands in serum that bind to galectin-3. METHODS:...

journal_title：Gastroenterology

authors： Bresalier RS,Byrd JC,Tessler D,Lebel J,Koomen J,Hawke D,Half E,Liu KF,Mazurek N,Great Lakes-New England Clinical and Epidemiology Center of the Early Detection Research Network.

更新日期：2004-09-01 00:00:00

abstract：:The effect of local intraarterial infusion of arginine vasopressin was studied in a vascularly perfused segment of cat ileum. Systemic arterial pressure (Pa), superior mesenteric arterial pressure (Pma), superior mesenteric venous pressure (Pv), blood flow (QB) and intestinal volume (V) were continuously monitored. In...

journal_title：Gastroenterology

authors： Quillen EW,Granger DN,Taylor AE

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic encephalopathy (HE) is associated with typical changes of cerebral metabolite pattern observed by proton magnetic resonance (MR) spectroscopy consisting of a depletion of myo-inositol and an increase of glutamine. The aim of this study was to determine whether abnormalities in brain metabolism...

journal_title：Gastroenterology

authors： Laubenberger J,Häussinger D,Bayer S,Gufler H,Hennig J,Langer M

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND & AIMS:Visceral hypersensitivity plays a major role in the pathophysiology of inflammatory bowel syndrome (IBS). Opioid kappa receptors on afferent nerves may modulate it and may be the target of new IBS treatments. The aim of this study was to evaluate the effects of fedotozine, a potent and selective kappa...

journal_title：Gastroenterology

authors： Delvaux M,Louvel D,Lagier E,Scherrer B,Abitbol JL,Frexinos J

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic osmoreceptors are sensitive to changes in portal blood osmolality and cause variations in plasma antidiuretic hormone and water diuresis, which prevent major systemic osmotic changes. Insensitivity of hepatic osmoreceptors might contribute to maintaining increased plasma levels of antidiuretic h...

journal_title：Gastroenterology

authors： Castellano G,Solis-Herruzo JA,Gonzalez A,Morillas JD,Moreno D,Muñoz T,Larrodera L

更新日期：1994-03-01 00:00:00

abstract：:The efficacy of various adsorbents for endotoxin was tested in vitro and in vivo using a murine experimental model of gut-derived endotoxemia. A quantitative limulus amebocyte lysate microtiter test and the limulus amebocyte lysate tube test were used to determine intestinal and circulating levels of endotoxin. Kaopec...

journal_title：Gastroenterology

authors： Ditter B,Urbaschek R,Urbaschek B

更新日期：1983-06-01 00:00:00

abstract：:Hepatic cytochrome P450 levels in male rats fall after portal vein ligation, a procedure that produces total hepatic bypass of portal blood. The present study was undertaken to examine whether changes in sex hormone metabolism could account for these lowered cytochrome P450 levels. Portal vein ligation resulted in tes...

journal_title：Gastroenterology

authors： Farrell GC,Koltai A,Zaluzny L,Murray M

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Mutations in HFE are the most common cause of the iron-overload disorder hereditary hemochromatosis. Levels of the main iron regulatory hormone, hepcidin, are inappropriately low in hereditary hemochromatosis mouse models and patients with HFE mutations, indicating that HFE regulates hepcidin. The b...

journal_title：Gastroenterology

authors： Corradini E,Garuti C,Montosi G,Ventura P,Andriopoulos B Jr,Lin HY,Pietrangelo A,Babitt JL

更新日期：2009-10-01 00:00:00

abstract：:This study was performed to ascertain whether testosterone metabolism is altered in male rats with portal bypass, and whether such changes could contribute to the reduction in serum testosterone concentration and raised serum estrogen levels that are observed in this situation. The metabolic clearance rate of testoste...

journal_title：Gastroenterology

authors： Farrell G,Koltai A

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of Barrett's esophagus and esophageal adenocarcinoma has increased despite surveillance of patients with Barrett's esophagus. Limited data indicate that nonsteroidal anti-inflammatory drug (NSAID) and statin use reduce the risk for esophageal adenocarcinoma. We investigated whether NSAID...

journal_title：Gastroenterology

authors： Kastelein F,Spaander MC,Biermann K,Steyerberg EW,Kuipers EJ,Bruno MJ,Probar-study Group.

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:Although dextran sodium sulfate (DSS)-induced colitis is a commonly used model of colonic injury, the mechanism of this model is not understood. The aim of this study was to determine the contribution of prostaglandins to the mechanism of DSS-induced epithelial injury. METHODS:Mice were treated with ...

journal_title：Gastroenterology

authors： Tessner TG,Cohn SM,Schloemann S,Stenson WF

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND & AIMS:Corticotropin-releasing factor (CRF) signaling pathways play a key role in the stress response through the activation of CRF(1) and CRF(2) receptors. We investigated the CRF receptor subtypes involved in gastric postoperative ileus. METHODS:Adult male mice (C57BL/6, CRF(1)-deficient, and wild-type), ...

journal_title：Gastroenterology

authors： Luckey A,Wang L,Jamieson PM,Basa NR,Million M,Czimmer J,Vale W,Taché Y

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Diffuse-type gastric cancer (GC) is currently subdivided into signet-ring cell carcinoma (SRCC) and non-SRCC, referred to as poorly cohesive carcinoma not otherwise specified (PCC-NOS). Although these subtypes are considered to be independent, they often coexist in the same tumors, raising a questio...

journal_title：Gastroenterology

authors： Togasaki K,Sugimoto S,Ohta Y,Nanki K,Matano M,Takahashi S,Fujii M,Kanai T,Sato T

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND & AIMS:Screening for colorectal cancer (CRC) with sigmoidoscopy reduces CRC incidence by detecting and removing adenomas. The number needed to screen is a measure of screening efficiency, but is not directly associated with adenoma removal. We propose the following 2 new metrics for quantifying the relations...

journal_title：Gastroenterology

authors： Pinsky PF,Loberg M,Senore C,Wooldrage K,Atkin W,Bretthauer M,Cross AJ,Hoff G,Holme O,Kalager M,Segnan N,Schoen RE

更新日期：2018-10-01 00:00:00

abstract：:Osteopenia in the form of osteoporosis is a common clinical problem associated with chronic cholestatic liver disease, and clinical morbidity from atraumatic fractures is increasing as more patients with PBC and PSC undergo successful liver transplantation. In the absence of symptomatic fractures, the clinical diagnos...

journal_title：Gastroenterology

authors： Hay JE

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND & AIMS:Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci ...

journal_title：Gastroenterology

authors： Dong J,Maj C,Tsavachidis S,Ostrom QT,Gharahkhani P,Anderson LA,Wu AH,Ye W,Bernstein L,Borisov O,Schröder J,Chow WH,Gammon MD,Liu G,Caldas C,Pharoah PD,Risch HA,May A,Gerges C,Anders M,Venerito M,Schmidt T,Izbi

更新日期：2020-12-01 00:00:00

abstract：:Gastric ulcers have been thought to occur only in the pyloric gland area. However, endoscopic examinations using the Congo red test showed that 18 of the ulcers examined (7.8%) were surrounded by an acid-secreting area, and so were in the fundic gland area. Histological examination of specimens obtained by gastrectomy...

journal_title：Gastroenterology

authors： Tatsuta M,Okuda S

更新日期：1976-07-01 00:00:00

abstract：:The human gastrointestinal tract contains distinct microbial communities that differ in composition and function based on their location, as well as age, sex, race/ethnicity, and diet of their host. We describe the bacterial taxa present in different locations of the GI tract, and their specific metabolic features. Th...

journal_title：Gastroenterology

authors： Hollister EB,Gao C,Versalovic J

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND & AIMS:It has been proposed that activation of the sympathetic nervous system causes a rightward shift in the renal autoregulatory curve such that renal blood flow is critically dependent on renal perfusion pressure and that this contributes to the development of the hepatorenal syndrome. The aims of the stu...

journal_title：Gastroenterology

authors： Stadlbauer V,Wright GA,Banaji M,Mukhopadhya A,Mookerjee RP,Moore K,Jalan R

更新日期：2008-01-01 00:00:00