Abstract:
:To look for possible HLA linkage in familial Crohn's disease, HLA haplotype segregation patterns were determined in 70 members of five kindreds, each having 2 or more patients with Crohn's disease (total number: 13 with Crohn's disease, 1 with ulcerative colitis). Concordant segregation of HLA haplotypes and disease was not observed. Study of HLA A and B locus phenotypes in 64 additional patients with documented Crohn's disease failed to show any significant disease association. We conclude that in these kindreds, HLA linkage does not account for the familial susceptibiltiy to Crohn's disease and that HLA A and B locus antigens are not associated with Crohn's disease.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Eade OE,Moulton C,MacPherson BR,Andre-Ukena SS,Albertini RJ,Beeken WLsubject
Has Abstractpub_date
1980-08-01 00:00:00pages
271-5issue
2eissn
0016-5085issn
1528-0012pii
S0016508580001515journal_volume
79pub_type
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