Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice.

abstract：BACKGROUND & AIMS:Human tumors and liver cancer cell lines express the product of a fusion between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and the last 6 exons in the FER tyrosine kinase gene (FER), called MAN2A1-FER. We investigated whether MAN2A1-FER is expressed by human liver tumors ...

journal_title：Gastroenterology

authors： Chen ZH,Yu YP,Tao J,Liu S,Tseng G,Nalesnik M,Hamilton R,Bhargava R,Nelson JB,Pennathur A,Monga SP,Luketich JD,Michalopoulos GK,Luo JH

更新日期：2017-10-01 00:00:00

abstract：:Cholylglycylhistamine, a derivative of cholic acid, has been synthesized and characterized. This derivative has been iodinated using Na125I and chloramine-T and purified free from unlabeled cholylglycylhistamine. Application of this iodinated bile salt derivative to radioimmunoassay of bile salts in human serum is rep...

journal_title：Gastroenterology

authors： Spenney JG,Johnson BJ,Hirschowitz BI,Mihas AA,Gibson R

更新日期：1977-02-01 00:00:00

abstract：:A numerically important group of patients with functional gastrointestinal disorders have chronic symptoms that can be attributed to the gastroduodenal region. Based on the consensus opinion of an international panel of clinical investigators who reviewed the available evidence, a classification of the functional gast...

journal_title：Gastroenterology

authors： Tack J,Talley NJ,Camilleri M,Holtmann G,Hu P,Malagelada JR,Stanghellini V

更新日期：2006-04-01 00:00:00

abstract：:Dioctyl sodium sulfosuccinate (DSS) is an anionic detergent that is used widely as a laxative and promoted as a stool softener. Although many anecdotal reports attest to the laxative and stool softening efficacy of DSS, no controlled trials have been performed to document the effect of DSS on small or large bowel func...

journal_title：Gastroenterology

authors： Chapman RW,Sillery J,Fontana DD,Matthys C,Saunders DR

更新日期：1985-09-01 00:00:00

abstract：:Six patients (4 women, 2 men) with malignant gastrinoma developed multiple bone metastases; osteolytic as well as osteoblastic lesions occurred. All lesions involved the central skeleton, most caused symptoms, and, in 2 cases, there was associated hypercalcemia with normal serum parathormone levels. Poor responses wer...

journal_title：Gastroenterology

authors： Barton JC,Hirschowitz BI,Maton PN,Jensen RT

更新日期：1986-11-01 00:00:00

abstract：:A patient with gastric outlet syndrome (Bouveret's syndrome) caused by a large gallstone impacted in the duodenal bulb was successfully treated by extracorporeal shock-wave lithotripsy. Thus, open abdominal surgery could be avoided. For disintegration of the stone, three consecutive lithotripsy procedures were necessa...

journal_title：Gastroenterology

authors： Holl J,Sackmann M,Hoffmann R,Schüssler P,Sauerbruch T,Jüngst D,Paumgartner G

更新日期：1989-08-01 00:00:00

abstract：:Patients with chronic nausea and vomiting frequently present challenging diagnostic and therapeutic problems. In such patients, gastroparesis of unknown cause, or "idiopathic" gastroparesis, may be the only objective finding. Two middle-aged women with nausea, vomiting, and weight loss of 10 and 26 kg over 6 and 18 mo...

journal_title：Gastroenterology

authors： Liberski SM,Koch KL,Atnip RG,Stern RM

更新日期：1990-07-01 00:00:00

abstract：:An attempt was made to compare various morphometric parameters, including total hepatocyte number, with the in vivo clearances of aminopyrine and antipyrine in 26 cirrhotic and 14 noncirrhotic patients to evaluate the intact hepatocyte theory. Morphometric analysis was performed with a newly developed method using a c...

journal_title：Gastroenterology

authors： Kawasaki S,Imamura H,Bandai Y,Sanjo K,Idezuki Y

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND & AIMS:Viral genotypes have been associated with different severity and outcome of hepatitis C virus (HCV)-related liver disease. The aim of this study was to determine whether HCV genotypes may influence the cirrhosis-related risk of the development of hepatocellular carcinoma (HCC). METHODS:Three groups o...

journal_title：Gastroenterology

authors： Silini E,Bottelli R,Asti M,Bruno S,Candusso ME,Brambilla S,Bono F,Iamoni G,Tinelli C,Mondelli MU,Ideo G

更新日期：1996-07-01 00:00:00

abstract：:The effects of pancreatic duct ligation on the digestion and absorption of a randomly 14C-labeled protein meal has been investigated in the rat. Although there was a significant reduction in luminal digestion and absorption of the protein meal in the pancreatic duct-ligated animals compared with controls, 37% of admin...

journal_title：Gastroenterology

authors： Curtis KJ,Gaines HD,Kim YS

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND & AIMS:A common variant in the solute carrier family 39 member 6 gene (SLC39A6) has been associated with survival times of patients with esophageal squamous cell carcinoma (ESCC). We investigated the function of SLC39A6 and ways in which this variant affects tumor progression by studying ESCC samples and cel...

journal_title：Gastroenterology

authors： Cheng X,Wei L,Huang X,Zheng J,Shao M,Feng T,Li J,Han Y,Tan W,Tan W,Lin D,Wu C

更新日期：2017-06-01 00:00:00

abstract：:Adenylate cyclase activity was measured in rat small intestinal villus and crypt cells after in vivo and in vitro exposure to cholera toxin. The increase in intestinal adenylate cyclase induced by cholera toxin in vivo appeared to be largely confined to the villus cell with the largest increase observed for upper vill...

journal_title：Gastroenterology

authors： Weiser MM,Quill H

更新日期：1975-08-01 00:00:00

abstract：:The liver efficiently transports dimeric immunoglobulin A (dIgA) from blood to bile in a direct, nonlysosomal pathway involving smooth-surfaced vesicles. Secretory component (SC), the plasma membrane receptor for dIgA, is released into bile still bound to its ligand by disulfide bridges. Rabbit IgG antirat SC binds sp...

journal_title：Gastroenterology

authors： Kim E,Hradek GT,Jones AL

更新日期：1985-06-01 00:00:00

abstract：:Endoscopic screening in 123 patients with pernicious anemia (PA) yielded 4 patients with solitary and 1 patient with multiple gastric carcinoid tumors. Quantitative histologic studies of multiple standardized biopsy specimens showed a significantly increased number of fundic mucosal argyrophil endocrine cells in 40 pa...

journal_title：Gastroenterology

authors： Borch K,Renvall H,Liedberg G

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND & AIMS:Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with adverse events in observational studies. We aimed to confirm these findings in an adequately powered randomized trial. METHODS:...

journal_title：Gastroenterology

authors： Moayyedi P,Eikelboom JW,Bosch J,Connolly SJ,Dyal L,Shestakovska O,Leong D,Anand SS,Störk S,Branch KRH,Bhatt DL,Verhamme PB,O'Donnell M,Maggioni AP,Lonn EM,Piegas LS,Ertl G,Keltai M,Bruns NC,Muehlhofer E,Dagenais G

更新日期：2019-09-01 00:00:00

abstract：:To determine the long-term efficacy, safety, and toxicity of omeprazole, we studied 40 patients with Zollinger-Ellison syndrome given omeprazole for 6-51 mo (median 29). The mean daily dose of omeprazole required to control gastric acid secretion was 82 +/- 31 mg. Thirty-one patients required omeprazole once per day. ...

journal_title：Gastroenterology

authors： Maton PN,Vinayek R,Frucht H,McArthur KA,Miller LS,Saeed ZA,Gardner JD,Jensen RT

更新日期：1989-10-01 00:00:00

abstract：:A prospective study of 22 patients with antibiotic-associated pseudomembranous colitis demonstrated that the most distal location of the pseudomembranes was noted from 0 to 25 cm from the anus in 17 patients, from 25 to 60 cm from the anus in 3 patients, and greater than 60 cm from the anus in only 2 patients. These d...

journal_title：Gastroenterology

authors： Tedesco FJ,Corless JK,Brownstein RE

更新日期：1982-12-01 00:00:00

abstract：:To study the relationship between gallstone disease (cholelithiasis and cholecystectomy) and cancer, a case-control study was performed in two Swedish hospitals comparing the prevalence of gallstone disease discovered at necropsy in 1422 subjects who died of cancer and 1205 subjects who did not die of cancer. Gallston...

journal_title：Gastroenterology

authors： Lowenfels AB,Domellöf L,Lindström CG,Bergman F,Monk MA,Sternby NH

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND & AIMS:Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis. Although highly expressed in liver, several studies have reported TfR2 expression in other tissues. To determine the contribution of liver expressed...

journal_title：Gastroenterology

authors： Wallace DF,Summerville L,Subramaniam VN

更新日期：2007-01-01 00:00:00

abstract：:Polyethylene glycol (PEG) is commonly used as a nonabsorbable volume marker in intestinal perfusion and flow studies. It has been assumed that PEG does not affect water and electrolyte movement, but this has not been extensively investigated. Using triple-lumen tube perfusion technique, we examined the effect of vario...

journal_title：Gastroenterology

authors： Davis GR,Santa Ana CA,Morawski SG,Fordtran JS

更新日期：1980-07-01 00:00:00

abstract：:Phospholipases are enzymes that hydrolyze specific portions of phospholipid molecules. Their role in the digestion of exogenous phospholipids and as the active principle in snake and bee venoms has long been appreciated. Interest has increased in phospholipases recently because of new data implicating them in the infl...

journal_title：Gastroenterology

authors： Mansbach CM 2nd

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND & AIMS:We have reported that contrast echocardiography is a sensitive screening test for the hepatopulmonary syndrome (HPS). However, contrast echocardiography lacks specificity because many cirrhotic patients have positive study results with normal arterial blood gases and therefore do not fulfill criteria ...

journal_title：Gastroenterology

authors： Abrams GA,Nanda NC,Dubovsky EV,Krowka MJ,Fallon MB

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND & AIMS:CD8(+) T cells that produce interleukin (IL)-17 (Tc17 cells) promote inflammation and have been identified in tumors. We investigated their role in the pathogenesis of gastric cancer. METHODS:We used flow cytometry analyses to determine levels and phenotype of Tc17 cells in blood and tumor samples fr...

journal_title：Gastroenterology

authors： Zhuang Y,Peng LS,Zhao YL,Shi Y,Mao XH,Chen W,Pang KC,Liu XF,Liu T,Zhang JY,Zeng H,Liu KY,Guo G,Tong WD,Shi Y,Tang B,Li N,Yu S,Luo P,Zhang WJ,Lu DS,Yu PW,Zou QM

更新日期：2012-10-01 00:00:00

abstract：:The effect of atropine (100 micrograms/kg/h, i.v.) on plasma cholecystokinin and pancreatic secretion during diversion of bile and pancreatic juice from the intestine was studied in 8 conscious rats equipped with jugular vein, pancreatic, biliary, and duodenal cannulas, and with pyloric ligation and gastric drainage. ...

journal_title：Gastroenterology

authors： Guan D,Ohta H,Tawil T,Spannagel AW,Liddle RA,Green GM

更新日期：1990-02-01 00:00:00

abstract：:Biofeedback has been advocated as first-line therapy for patients whose symptoms of mild to moderate fecal incontinence have not responded to simple dietary advice or medication. Three main modalities have been described: (1) use of an intra-anal electromyographic sensor, a probe to measure intra-anal pressure, or per...

journal_title：Gastroenterology

authors： Norton C

更新日期：2004-01-01 00:00:00

abstract：:This study shows the distribution of the messenger RNA for lactase-phlorizin hydrolase during postnatal development and along the longitudinal axis of the rat small intestine. At birth, this messenger RNA was present along the whole length of small intestine, and its concentration remained elevated during the suckling...

journal_title：Gastroenterology

authors： Freund JN,Duluc I,Raul F

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND & AIMS:Liver graft dysfunction is related to hypothermic preservation and may implicate altered cell volume homeostasis. The aim of this study was to evaluate how cold preservation and rewarming affect hepatocellular volume regulation and concentrative amino acid uptake. METHODS:Rat hepatocytes suspended fo...

journal_title：Gastroenterology

authors： Serrar H,Haddad P

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND & AIMS:Nuclear factor of activated T cells transcription factors plays a central role in immunity by regulating the expression of multiple cytokines and other regulatory molecules, many of which have been heavily implicated in the pathogenesis of inflammatory bowel disease. However, few studies have directly...

journal_title：Gastroenterology

authors： Gerth AJ,Lin L,Neurath MF,Glimcher LH,Peng SL

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND & AIMS:Most colon cancers arise from polypoid adenomas, but how these benign lesions develop into malignant neoplasms is not understood. This study examined the migration of epithelial cells within human adenomatous polyps by determining the distribution of proliferating and apoptotic cells and immunoreactiv...

journal_title：Gastroenterology

authors： Moss SF,Liu TC,Petrotos A,Hsu TM,Gold LI,Holt PR

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND & AIMS:Manganese (Mn) deposition could be responsible for the T(1)-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional specificity of the Mn increases as well as their relationship to portal-systemic shunting or hepatobili...

journal_title：Gastroenterology

authors： Rose C,Butterworth RF,Zayed J,Normandin L,Todd K,Michalak A,Spahr L,Huet PM,Pomier-Layrargues G

更新日期：1999-09-01 00:00:00