Abstract:
:Adenylate cyclase activity was measured in rat small intestinal villus and crypt cells after in vivo and in vitro exposure to cholera toxin. The increase in intestinal adenylate cyclase induced by cholera toxin in vivo appeared to be largely confined to the villus cell with the largest increase observed for upper villus cells. Crypt cell adenylate cyclase was not responsive to cholera toxin. No response could be demonstrated for isolated villus or crypt cells incubated with cholera toxin in vitro. In vivo incubation with 125I-cholera toxin demonstrated binding to only villus cells. These results suggest that the major effect of cholera toxin was on villus cells rather than crypt cells and this was due to the greater accessibility or binding capacity of the villus cell to luminal cholera toxin.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Weiser MM,Quill Hsubject
Has Abstractpub_date
1975-08-01 00:00:00pages
479-82issue
2eissn
0016-5085issn
1528-0012pii
S0016508575001783journal_volume
69pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract::The target appearance of grey scale ultrasound is thought to be a characteristic sign of gastrointestinal wall thickening. It consists of a strong echogenic center surrounded by a sonolucent rim. In a prospective controlled study, the sensitivity and specificity of the ultrasonic B-scan for Crohn's disease were invest...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND & AIMS:Gastritis is associated with development of stomach cancer, but little is known about changes in microRNA expression patterns during gastric inflammation. Specific changes in gene expression in epithelial cells are difficult to monitor because of the heterogeneity of the tissue. We investigated epithe...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2018.11.059
更新日期:2019-03-01 00:00:00
abstract::The influence of ethinyl estradiol (EE) on the effects of dietary cholesterol on the biliary saturation index and on the rate-limiting hepatic enzymes of cholesterol synthesis, hydroxymethylglutaryl-CoA-reductase, and bile acid synthesis, 7 alpha-hydroxylase, were determined. Four groups of 12 male hamsters were treat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
abstract::Corticotropin-releasing factor (CRF) administered into the lateral cerebral ventricle significantly inhibited gastric emptying and small bowel transit, but most markedly increased large bowel transit in a dose-related fashion in freely moving rats. Inhibition of gastric emptying induced by central administration of CR...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90229-6
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND & AIMS:Biliary atresia (BA) is a rare disease in infants, with unknown mechanisms of pathogenesis. It is characterized by hepatobiliary inflammatory, progressive destruction of the biliary system leading to liver fibrosis, and deterioration of liver function. Interleukin (IL) 17A promotes inflammatory and au...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2015.09.008
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Factors associated with the development and malignant progression of Barrett's esophagus are poorly understood. Gastrin is a mitogen capable of inducing growth in normal and malignant gastrointestinal mucosa. It is unknown whether gastrin can influence cellular events in the esophagus in Barrett's. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2003.50091
更新日期:2003-03-01 00:00:00
abstract::In recent years the hypothesis that the number of villus cells regulates crypt cell proliferation in the epithelium of the small intestine has been brought forward by a number of investigators. To test this hypothesis, the villus cell population was reduced by clamping the superior mesenteric artery and vein in rats f...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND & AIMS:Nitric oxide is a major inhibitory neurotransmitter in the enteric nervous system. Loss or dysfunction of nitrinergic neurons is associated with serious disruptions of motility, intractable symptoms, and long-term suffering. The aim of this study was to evaluate the effect of intrapyloric transplantat...
journal_title:Gastroenterology
pub_type: 评论,杂志文章
doi:10.1053/j.gastro.2005.08.055
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND/AIMS:The role of cholecystokinin (CCK) in the regulation of gastric acid secretion is still controversial. This study examined the effect of the CCK-A receptor antagonist loxiglumide (lox) on gastrin- or CCK-induced gastric acid secretion and meal-stimulated plasma gastrin levels in a placebo-controlled stud...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1016/0016-5085(94)90799-4
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND & AIMS:Because alterations of integrin expression in cancers contribute to cancer cell biology, we analyzed the association between the potential for peritoneal dissemination and integrin expression. METHODS:The dissemination potential of 10 human gastric cancer cell lines in mice with severe combined immun...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(00)70255-1
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND & AIMS:The US Medicare indications for intestinal transplantation are based on failure of home parenteral nutrition. The American Society of Transplantation also includes patients at high risk of death from their primary disease or with high morbidity intestinal failure. A 3-year prospective study evaluated ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.03.043
更新日期:2008-07-01 00:00:00
abstract::The histamine-storing enterochromaffinlike cells, which are numerous in the oxyntic mucosa of the rat stomach, are known to proliferate in response to long-lasting hypergastrinaemia. In addition, portacaval shunting, which is not associated with elevated serum gastrin, causes an increase in enterochromaffinlike cell d...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90948-z
更新日期:1990-09-01 00:00:00
abstract::In seven healthy volunteers pure pancreatic juice was obtained by endoscopic cannulation of the papilla of Vater. Synthetic secretin was intravenously infused in doses doubled every 20 min. The volume of pancreatic juice was proportional to the log of the secretin dose. A significant rise (P less than 0.05) in pancrea...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-04-01 00:00:00
abstract::Hepatocellular carcinoma often affects blacks at an early age. The purpose of this study was to ascertain if the association between chronic hepatitis B virus infection and hepatocellular carcinoma is the same in young and older black patients. Serum markers of hepatitis B infection were measured by radioimmunoassay i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90434-9
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND & AIMS:The finding of bone morphogenetic protein (BMP) receptor 1a mutations in juvenile polyposis suggests that BMPs are important in colorectal cancer (CRC). We investigated the BMP pathway in sporadic CRC. METHODS:We investigated BMP receptor (BMPR) expression using immunoblotting and sequenced BMPR2 in ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.02.059
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND & AIMS:Studies in gastrin-deficient mice have demonstrated critical roles for gastrin peptides in the regulation of gastric acid secretion, but the relative contributions of amidated (G-17) and glycine-extended (G17-Gly) gastrin remain unclear. We examined the effects of these 2 forms of gastrin on acid secr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.16480
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND & AIMS:Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the pancreas during pancreatitis may contribute to such activation. METHODS:To cause experimental pancreatitis, rats and mice were treated with ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.32409
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND & AIMS:Methylation of specific microRNAs (miRNAs) often occurs in an age-dependent manner, as a field defect in some instances, and may be an early event in colitis-associated carcinogenesis. We aimed to determine whether specific mRNA signature patterns (MIR1, MIR9, MIR124, MIR137, MIR34B/C) could be used t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.08.037
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND & AIMS:Predictors of reactivation of hepatitis B following hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B have rarely been reported before and deserve further study. METHODS:A total of 133 HBeAg-positive asymptomatic carriers who have undergone HBeAg seroconversion were studied. Reactiv...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.08.039
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND & AIMS:Paneth cells (PCs) secrete defensins and antimicrobial enzymes that contribute to innate immunity against pathogen infections within the mucosa of the small intestine. We examined the role of colony stimulating factor-1 (CSF-1) in PC development. METHODS:CSF-1-deficient and CSF-1 receptor (CSF-1R)-de...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.03.004
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND & AIMS:Intestinal epithelial cells release antigen-presenting vesicles (exosomes) bearing major histocompatibility complex class II/peptide complexes stimulating specific immune responses in vivo. To characterize further the role of human epithelial exosomes in antigen presentation, their capacity to load an...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.02.043
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND & AIMS:The study and management of reflux esophagitis require an endoscopic classification system founded on esophageal lesions that can be reproducibly identified. The aim of this study was to investigate interobserver agreement for the identification of endoscopic lesions typical of reflux esophagitis. ME...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v111.pm8698230
更新日期:1996-07-01 00:00:00
abstract::Regional specific antibodies and chromatography were used to analyze the distributions and molecular forms of peptide histidine isoleucine (PHI) and vasoactive intestinal peptide (VIP) in the porcine intestine. Both peptides were present along the entire length of the intestine, the highest concentrations occurring in...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90445-7
更新日期:1985-09-01 00:00:00
abstract::Cell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. Although the literature on cell death has grown enormously in size and complexity, a pattern has emerged that each of several distinct organelles (plasma membrane, mitochondrion, nucleu...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2005.06.006
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND & AIMS:A 3-dimensional (3D) culture system for immortalized human hepatocytes (HuS-E/2 cells) recently was shown to support the lifecycle of blood-borne hepatitis C virus (HCV). We used this system to identify proteins that are active during the HCV lifecycle under 3D culture conditions. METHODS:We compared...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.05.014
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND & AIMS:The down-regulated in adenoma (DRA) protein, encoded by SLC26A3, a key intestinal chloride anion exchanger, has recently been identified as a novel susceptibility gene for inflammatory bowel disease (IBD). However, the mechanisms underlying the increased susceptibility to inflammation induced by the l...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2020.11.008
更新日期:2020-11-13 00:00:00
abstract:BACKGROUND:Current information concerning endothelin in cirrhosis is conflicting. Plasma endothelin concentration has been found to be increased in some studies and normal or reduced in others. The present study was aimed to investigate the plasma levels of endothelin in cirrhosis and to assess whether it is involved i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90360-o
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND & AIMS:Colonic crypt elongation occurs during both chronic colitis and in the recovery phase of acute colitis. The impact of these alterations on epithelial cell functions is not fully defined. METHODS:DNA microarray analysis of freshly isolated colonic epithelial cells (CECs) from acute and chronic colitis...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)00665-6
更新日期:2003-07-01 00:00:00
abstract::Eight homosexual men presented with odynophagia. Five had a maculopapular rash and 2 had oral ulcers. Upper panendoscopy revealed the presence of multiple discrete ulcers measuring 3 mm-1.5 cm in diameter in the esophagus of each patient. The intervening mucosa appeared normal. Endoscopic brushings and biopsy specimen...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90257-x
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatic lipid retention (steatosis) predisposes hepatitis. We investigated the mechanisms of lymphocyte homing to fatty liver and the role of lipopolysaccharide (LPS) in the onset of inflammation in ob/ob mice. METHODS:We decreased intestinal bacterial compounds by oral antibiotic treatment to test t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.02.055
更新日期:2008-05-01 00:00:00