Effect of oral dioctyl sodium sulfosuccinate on intake-output studies of human small and large intestine.

abstract：BACKGROUND/AIMS:The mechanisms of chemically induced injury are poorly understood. The purpose of this study was to develop a rapid method for isolation of gastric mucosal cells (GMCs) and sensitive tests for investigating cell damage and protection. METHODS:GMCs were prepared from rat glandular stomach with pronase a...

journal_title：Gastroenterology

authors： Nagy L,Szabo S,Morales RE,Plebani M,Jenkins JM

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND & AIMS:Advanced cirrhosis is associated with impaired leukocyte function, but the mechanism underlying this host defense alteration is unknown. The aim of this study was to investigate the lipoxygenase pathway of arachidonic acid metabolism and its influence in leukocyte trafficking in patients with cirrhosi...

journal_title：Gastroenterology

authors： Clària J,Titos E,Jiménez W,Ros J,Ginès P,Arroyo V,Rivera F,Rodés J

更新日期：1998-07-01 00:00:00

abstract：:This study is an examination of the association between Crohn's disease and psychiatric illness using careful gastrointestinal evaluation, a structured psychiatric interview of known reliability and validity, and explicit diagnostic criteria for psychiatric illness. A proband sample of 50 subjects with Crohn's disease...

journal_title：Gastroenterology

authors： Helzer JE,Chammas S,Norland CC,Stillings WA,Alpers DH

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Tumor necrosis factor (TNF) is a cytokine that promotes inflammation and contributes to pathogenesis of inflammatory bowel diseases. Unlike other cells and tissues, intestinal epithelial cells undergo rapid cell death upon exposure to TNF, by unclear mechanisms. We investigated the roles of inhibito...

journal_title：Gastroenterology

authors： Grabinger T,Bode KJ,Demgenski J,Seitz C,Delgado ME,Kostadinova F,Reinhold C,Etemadi N,Wilhelm S,Schweinlin M,Hänggi K,Knop J,Hauck C,Walles H,Silke J,Wajant H,Nachbur U,W Wei-Lynn W,Brunner T

更新日期：2017-03-01 00:00:00

abstract：:Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease...

journal_title：Gastroenterology

authors： Gukovskaya AS,Gukovsky I,Algül H,Habtezion A

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND & AIMS:Thyroid hormones are implicated in intestinal development. Their effects are mediated by nuclear receptors, which are transcriptional regulators activated upon binding of triiodothyronine. The aim of this study was to define the involvement of the receptor subtypes during intestinal development. METH...

journal_title：Gastroenterology

authors： Plateroti M,Chassande O,Fraichard A,Gauthier K,Freund JN,Samarut J,Kedinger M

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND & AIMS:Studies on the early steps in the life cycle of hepatitis B virus have been hampered by the lack of readily available target cells. In this study, we mapped a defined virus attachment site to primary hepatocytes that is essential for infection. METHODS:We used purified virus particles from human carr...

journal_title：Gastroenterology

authors： Glebe D,Urban S,Knoop EV,Cag N,Krass P,Grün S,Bulavaite A,Sasnauskas K,Gerlich WH

更新日期：2005-07-01 00:00:00

abstract：:The aim of the present study was to characterize rat mucosal colonic cells harvested from the crypt continuum during differentiation and dimethylhydrazine-induced neoplasia. The collection of colonocytes was performed using a modified nonenzymatic isolation procedure based on Ca2+ chelation and gentle mechanical disso...

journal_title：Gastroenterology

authors： Schwartz B,Avivi C,Lamprecht SA

更新日期：1991-03-01 00:00:00

abstract：:The intracellular pH (pHi) of isolated hamster intestinal cells was determined with three techniques: the null-point method with digitonin, the distribution of the weak acid 5,5-dimethyloxazolidine-2,4-dione, and the trapped fluorescent indicator 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. In physiologic saline, ...

journal_title：Gastroenterology

authors： Goré J,Hoinard C

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-beta signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-beta signaling is impaired because of high expression...

journal_title：Gastroenterology

authors： Fantini MC,Rizzo A,Fina D,Caruso R,Sarra M,Stolfi C,Becker C,Macdonald TT,Pallone F,Neurath MF,Monteleone G

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND & AIMS:Men have a higher incidence of hepatocellular carcinoma (HCC) than women, which is believed to partly be because of protective effects of estrogen. We sought to determine whether there were differences in levels of microRNA (miRNA) molecules between male and female HCC samples. METHODS:The expression...

journal_title：Gastroenterology

authors： Liu WH,Yeh SH,Lu CC,Yu SL,Chen HY,Lin CY,Chen DS,Chen PJ

更新日期：2009-02-01 00:00:00

abstract：:The effect of neuropeptide Y on the motor activity of the circular and longitudinal muscle of the guinea pig small intestine was investigated. Neuropeptide Y (0.3-30 nM) inhibited, in a concentration-dependent manner, the ascending enteric reflex contraction of the circular muscle; both the cholinergic and noncholiner...

journal_title：Gastroenterology

authors： Holzer P,Lippe IT,Barthó L,Saria A

更新日期：1987-06-01 00:00:00

abstract：:Twenty-nine patients with esophageal symptoms and contraction abnormalities of the esophageal body completed a 6-wk, double-blind, placebo-controlled trial of trazodone (100-150 mg/day). Measures of esophageal and psychologic symptoms were completed at entry and at each follow-up visit. Esophageal manometry was repeat...

journal_title：Gastroenterology

authors： Clouse RE,Lustman PJ,Eckert TC,Ferney DM,Griffith LS

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND & AIMS:Increase of T cells expressing CD4 and T-cell receptor (TCR) alpha- beta+ (beta[dim]) was observed in the mucosal and peripheral lymphoid tissues of TCR alpha-/- mice with inflammatory bowel disease (IBD). The aim of this study was to characterize the CD4+ TCR alpha-beta+ T cells. METHODS:Cytokine pr...

journal_title：Gastroenterology

authors： Takahashi I,Kiyono H,Hamada S

更新日期：1997-06-01 00:00:00

abstract：:A monoclonal antibody to bromodeoxyuridine was used in tissue specimens previously incubated with bromodeoxyuridine to show S-phase cells by immunohistochemical technique. Biopsy specimens of normal mucosa (n = 10), hyperplastic polyps (n = 10), adenomas with low-grade dysplasia (n = 20), adenomas with high-grade dysp...

journal_title：Gastroenterology

authors： Risio M,Coverlizza S,Ferrari A,Candelaresi GL,Rossini FP

更新日期：1988-04-01 00:00:00

abstract：:Ketoconazole has only recently been recognized as a cause of hepatic injury, with most reports coming from outside the United States. In order to characterize more fully the U.S. experience, we undertook an analysis of 54 reports of alleged ketoconazole-induced liver injury submitted to the Food and Drug Administratio...

journal_title：Gastroenterology

authors： Lewis JH,Zimmerman HJ,Benson GD,Ishak KG

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND & AIMS:Macrophage migration inhibitory factor (MIF) inhibits macrophage migration and has pleiotropic activities on immune and inflammatory responses, cell growth, and glucose metabolism. MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators imp...

journal_title：Gastroenterology

authors： Maaser C,Eckmann L,Paesold G,Kim HS,Kagnoff MF

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND & AIMS:There have been conflicting results on a cell of origin in pancreatic regeneration. These discrepancies predominantly stem from lack of specific markers for the pancreatic precursors/stem cells, as well as differences in the targeted cells and severity of tissue injury in the experimental models so fa...

journal_title：Gastroenterology

authors： Criscimanna A,Speicher JA,Houshmand G,Shiota C,Prasadan K,Ji B,Logsdon CD,Gittes GK,Esni F

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND & AIMS:In human and canine colon, both slow (slow waves, 2-8/min) and fast (myenteric potential oscillations [MPOs]; 16-20/min) electrical rhythms in the smooth muscle originate at the submucosal and myenteric borders, respectively. We used Ca(2+) imaging to investigate whether interstitial cells of Cajal (I...

journal_title：Gastroenterology

authors： Lee HT,Hennig GW,Park KJ,Bayguinov PO,Ward SM,Sanders KM,Smith TK

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND & AIMS:An increased duodenal expression of the iron transporters, divalent-metal-transporter-1, and ferroportin is observed in patients with iron deficiency or hereditary hemochromatosis. Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transpor...

journal_title：Gastroenterology

authors： Zoller H,Theurl I,Koch RO,McKie AT,Vogel W,Weiss G

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND & AIMS:Early embryogenesis involves cell fate decisions that define the body axes and establish pools of progenitor cells. Development does not stop once lineages are specified; cells continue to undergo specific maturation events, and changes in gene expression patterns lead to their unique physiological fu...

journal_title：Gastroenterology

authors： Direnzo D,Hess DA,Damsz B,Hallett JE,Marshall B,Goswami C,Liu Y,Deering T,Macdonald RJ,Konieczny SF

更新日期：2012-08-01 00:00:00

abstract：:The aim of this study was to test in vivo (a) whether the sphincter of Oddi acts as a resistor or also as a pump, (b) the effect of an IV infusion of cholecystokinin (CCK) on choledochoduodenal flow, and (c) the ability of the choledochoduodenal junction to prevent duodenobiliary reflux in two animal species, opossums...

journal_title：Gastroenterology

authors： Calabuig R,Weems WA,Moody FG

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND & AIMS:Studies implicating primary sclerosing cholangitis as a risk factor for colorectal neoplasia in patients with ulcerative colitis have been limited by small sample size and referral bias. The aim of this study was to determine the relative risk and cumulative incidence of colorectal neoplasia in a larg...

journal_title：Gastroenterology

authors： Loftus EV Jr,Sandborn WJ,Tremaine WJ,Mahoney DW,Zinsmeister AR,Offord KP,Melton LJ 3rd

更新日期：1996-02-01 00:00:00

abstract：:The role of adrenal medullary discharge of catecholamines on inhibition of gastric emptying and small intestinal propulsion after laparotomy was examined in rats. The rate of movement of a 51Cr-labeled liquid test meal, which had been introduced by gastric intubation, out of the stomach and through the small intestine...

journal_title：Gastroenterology

authors： Dubois A,Henry DP,Kopin IJ

更新日期：1975-03-01 00:00:00

abstract：BACKGROUND & AIMS:Noninvasive methods are needed to identify clinically significant portal hypertension (CSPH) and esophageal varices (EVs) in patients with compensated cirrhosis. We looked for markers of the presence of CSPH and EVs in patients with cirrhosis. METHODS:We performed a cross-sectional study that include...

journal_title：Gastroenterology

authors： Berzigotti A,Seijo S,Arena U,Abraldes JG,Vizzutti F,García-Pagán JC,Pinzani M,Bosch J

更新日期：2013-01-01 00:00:00

abstract：:The study of cholesterol gallstone disease would be facilitated if the nucleation time of cholesterol crystals could be measured in duodenal bile and was correlated with nucleation occurring in vivo. Therefore, our aims were to determine (a) if nucleation time could be measured in duodenal bile, (b) the effect of bact...

journal_title：Gastroenterology

authors： Marks JW,Broomfield P,Bonorris GG,Schoenfield LJ

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:This study investigated whether obesity, diabetes, and other metabolic factors are independently associated with hepatocellular carcinoma (HCC), stratified by hepatitis B virus (HBV) and hepatitis C virus (HCV) serostatus, and explored the possible joint influence of obesity/diabetes and HBV/HCV infec...

journal_title：Gastroenterology

authors： Chen CL,Yang HI,Yang WS,Liu CJ,Chen PJ,You SL,Wang LY,Sun CA,Lu SN,Chen DS,Chen CJ

更新日期：2008-07-01 00:00:00

abstract：:A patient who developed symptomatic giardiasis after a tour of the Soviet Union is presented. The diagnosis was established by duodenal aspiration. A small intestinal biopsy revealed total villous atrophy in the absence of celiac sprue or a gastrointestinal immunodeficiency syndrome, a finding not previously described...

journal_title：Gastroenterology

authors： Levinson JD,Nastro LJ

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND & AIMS:Abnormal processing of visceral sensation at the level of the central nervous system is believed to be involved in functional dyspepsia. However, compared with studies of stimulation-related changes in brain activity, few studies have focused on resting brain activity, which also is important in patho...

journal_title：Gastroenterology

authors： Zeng F,Qin W,Liang F,Liu J,Tang Y,Liu X,Yuan K,Yu S,Song W,Liu M,Lan L,Gao X,Liu Y,Tian J

更新日期：2011-08-01 00:00:00

abstract：:We describe a 47-year-old patient who developed cholelithiasis in adolescence, followed by recurrent intrahepatic cholestasis of pregnancy, and finally biliary cirrhosis in adulthood. In our patient, the consecutive presentation of the 3 mentioned disorders raised the suspicion of a defect of MDR3, the canalicular pro...

journal_title：Gastroenterology

authors： Lucena JF,Herrero JI,Quiroga J,Sangro B,Garcia-Foncillas J,Zabalegui N,Sola J,Herraiz M,Medina JF,Prieto J

更新日期：2003-04-01 00:00:00