Plasma catecholamines and postoperative gastric emptying and small intestinal propulsion in the rat.

abstract：BACKGROUND & AIMS:Thromboxane levels correlate with severity of liver injury in rats given alcohol. The aim of this study was to evaluate the effect of thromboxane inhibitors on pathological changes in experimental alcoholic liver disease. METHODS:Male Wistar rats were given a liquid diet and ethanol intragastrically ...

journal_title：Gastroenterology

authors： Nanji AA,Khwaja S,Rahemtulla A,Miao L,Zhao S,Tahan SR

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND & AIMS:This study examined the possible role of endotoxinemia (from increased gut permeability) as an additional trigger factor for overt pancreatic disease and as a promoter of chronic pancreatic injury in alcoholics by using a rat model of chronic alcohol feeding and in vitro experiments with cultured panc...

journal_title：Gastroenterology

authors： Vonlaufen A,Xu Z,Daniel B,Kumar RK,Pirola R,Wilson J,Apte MV

更新日期：2007-10-01 00:00:00

abstract：:Serum group I pepsinogen (PG I) levels, basal acid output, and peak acid output (PAO) have been determined in 120 patients, 54 with duodenal ulcer, 14 with prepyloric ulcer, 12 with gastric ulcer, and 40 without ulcer. The correlation between serum PG I and PAO was statistically significant (r = 0.736, P less than 0.0...

journal_title：Gastroenterology

authors： Samloff IM,Secrist DM,Passaro E Jr

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND & AIMS:Accurate biomarkers of disease activity and therapeutic response can be valuable for clinical trials. We performed a post hoc analysis of data from a phase 2 trial to assess the relationship between the concentration of fecal calprotectin (FCP) and clinical and endoscopic outcomes of patients with mod...

journal_title：Gastroenterology

authors： Sandborn WJ,Panés J,Zhang H,Yu D,Niezychowski W,Su C

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND & AIMS:Several randomized population-based studies have shown that screening for colorectal cancer (CRC) by fecal occult blood tests (FOBTs) can reduce CRC mortality. The aim of this French population-based study was to assess whether a similar benefit could be obtained in countries characterized by high per...

journal_title：Gastroenterology

authors： Faivre J,Dancourt V,Lejeune C,Tazi MA,Lamour J,Gerard D,Dassonville F,Bonithon-Kopp C

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND & AIMS:Colonic crypt elongation occurs during both chronic colitis and in the recovery phase of acute colitis. The impact of these alterations on epithelial cell functions is not fully defined. METHODS:DNA microarray analysis of freshly isolated colonic epithelial cells (CECs) from acute and chronic colitis...

journal_title：Gastroenterology

authors： Mizoguchi E,Xavier RJ,Reinecker HC,Uchino H,Bhan AK,Podolsky DK,Mizoguchi A

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND & AIMS:Math1 (Atoh1) is a basic helix-loop-helix transcription factor important for intestinal secretory cell differentiation. We hypothesized that Math1 is important in cell fate commitment, and therefore mediates proliferative homeostasis and the adaptive response following intestinal resection in the adul...

journal_title：Gastroenterology

authors： Shroyer NF,Helmrath MA,Wang VY,Antalffy B,Henning SJ,Zoghbi HY

更新日期：2007-06-01 00:00:00

abstract：:Non-major histocompatibility complex-restricted cytotoxicity triggered by antibodies to the CD3 component of the human T-cell receptor complex is thought to be an indirect measure of in vivo primed cytotoxic T-cell activity. We have used this technique to examine the lytic activity of freshly isolated T cells from non...

journal_title：Gastroenterology

authors： Shanahan F,Deem R,Nayersina R,Leman B,Targan S

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND & AIMS:Although ustekinumab is an effective therapy for moderate to severe Crohn's disease (CD), its effects on the microscopic manifestations of CD are unknown. METHODS:We evaluated the effects of ustekinumab on histologic CD activity in an analysis of data from 251 participants in phase 3 induction and ma...

journal_title：Gastroenterology

authors： Li K,Friedman JR,Chan D,Pollack P,Yang F,Jacobstein D,Brodmerkel C,Gasink C,Feagan BG,Sandborn WJ,Rutgeerts P,De Hertogh G

更新日期：2019-10-01 00:00:00

abstract：:Psycho-neuro-endocrine-immune modulation through the brain-gut axis likely has a key role in the pathogenesis of inflammatory bowel disease (IBD). The brain-gut axis involves interactions among the neural components, including (1) the autonomic nervous system, (2) the central nervous system, (3) the stress system (hyp...

journal_title：Gastroenterology

authors： Bonaz BL,Bernstein CN

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND & AIMS:Type 2 diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC); it is not clear if this association varies by sex or other factors. Insulin use might also be associated with CRC risk. We investigated associations of type 2 DM and insulin use with CRC risk. METHODS:The C...

journal_title：Gastroenterology

authors： Campbell PT,Deka A,Jacobs EJ,Newton CC,Hildebrand JS,McCullough ML,Limburg PJ,Gapstur SM

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND & AIMS:Congenital tufting enteropathy (CTE) is a rare autosomal recessive diarrheal disorder presenting in the neonatal period. CTE is characterized by intestinal epithelial cell dysplasia leading to severe malabsorption and significant morbidity and mortality. The pathogenesis and genetics of this disorder ...

journal_title：Gastroenterology

authors： Sivagnanam M,Mueller JL,Lee H,Chen Z,Nelson SF,Turner D,Zlotkin SH,Pencharz PB,Ngan BY,Libiger O,Schork NJ,Lavine JE,Taylor S,Newbury RO,Kolodner RD,Hoffman HM

更新日期：2008-08-01 00:00:00

abstract：:There is considerable evidence that fluids are removed from the peritoneal cavity by drainage into lymphatics lining the surface of the diaphragm, but there is little quantitative information on the rate of reabsorption as affected by conditions which exist in cirrhotic ascites. In the present study a plethysmographic...

journal_title：Gastroenterology

authors： Zink J,Greenway CV

更新日期：1977-11-01 00:00:00

abstract：:A 76-yr-old male presented with Guillain-Barré syndrome after acute hepatitis B virus infection. Main immunologic features were: (a) high levels of circulating hepatitis B surface antigen-containing immune complexes in serum and cerebrospinal fluid during the acute neurologic syndrome, and (b) clearance of immune-comp...

journal_title：Gastroenterology

authors： Penner E,Maida E,Mamoli B,Gangl A

更新日期：1982-03-01 00:00:00

abstract：:The polypeptide core of mucin glycoprotein subunits resists cleavage by proteases. To determine if the carbohydrate side chains of these subunits protect the underlying polypeptide core from proteolytic cleavage, we compared the effect of pancreatic proteases on hog gastric mucin before and after cleavage of its carbo...

journal_title：Gastroenterology

authors： Variyam EP,Hoskins LC

更新日期：1983-03-01 00:00:00

abstract：:Interstitial pneumonitis is an uncommon complication of low-dose methotrexate therapy in patients with psoriasis but occurs in 3%-5% of patients with rheumatoid arthritis. We found a higher incidence of interstitial pneumonitis in patients with primary biliary cirrhosis (14%) and describe its clinical manifestations, ...

journal_title：Gastroenterology

authors： Sharma A,Provenzale D,McKusick A,Kaplan MM

更新日期：1994-07-01 00:00:00

abstract：:The histamine-storing enterochromaffinlike cells, which are numerous in the oxyntic mucosa of the rat stomach, are known to proliferate in response to long-lasting hypergastrinaemia. In addition, portacaval shunting, which is not associated with elevated serum gastrin, causes an increase in enterochromaffinlike cell d...

journal_title：Gastroenterology

authors： Axelson J,Ekelund M,Sundler F,Håkanson R

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND & AIMS:Intrahepatic bile ducts express a range of lymphocyte adhesion molecules during episodes of inflammation. This may contribute to the susceptibility of biliary epithelium to immunologic damage during liver allograft rejection, graft-versus-host disease, and primary biliary cirrhosis. However, no previo...

journal_title：Gastroenterology

authors： Leon MP,Bassendine MF,Gibbs P,Thick M,Kirby JA

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND/AIMS:The role of cholecystokinin (CCK) in the regulation of gastric acid secretion is still controversial. This study examined the effect of the CCK-A receptor antagonist loxiglumide (lox) on gastrin- or CCK-induced gastric acid secretion and meal-stimulated plasma gastrin levels in a placebo-controlled stud...

journal_title：Gastroenterology

authors： Schmidt WE,Schenk S,Nustede R,Holst JJ,Fölsch UR,Creutzfeldt W

更新日期：1994-12-01 00:00:00

abstract：:To determine the pattern of inheritance of lactase deficiency, we studied 104 American Indian and 2 white subjects in 19 families. Subjects were considered deficient in lactase if breath-hydrogen excretion exceeded 0.20 ml per min above fasting at 2 hr after a lactose load of 2 g per kg of body weight (maximum 50 g). ...

journal_title：Gastroenterology

authors： Newcomer AD,Gordon H,Thomas PJ,McGill DB

更新日期：1977-11-01 00:00:00

abstract：:The efficacy of phenobarbital in altering biliary lipid composition in normal man was investigated by determining parameters of biliary lipid metabolism in 8 human subjects without biliary tract disease before and after oral phenobarbital administration at a dose of approximately 3 mg per kg per day for 25 to 54 days....

journal_title：Gastroenterology

authors： Ginsberg RL,Garnick MB

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND & AIMS:Changes in the properties of visceral sensory neurons contribute to the development of gastrointestinal pain. However, little is known about the molecules involved in mechanosensation from the gastrointestinal tract. We investigated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK...

journal_title：Gastroenterology

authors： Sakurai J,Obata K,Ozaki N,Tokunaga A,Kobayashi K,Yamanaka H,Dai Y,Kondo T,Miyoshi K,Sugiura Y,Matsumoto T,Miwa H,Noguchi K

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Newly synthesized apical membrane proteins in hepatocytes go first to the basolateral membrane, from which they are retrieved and delivered to the apical domain. The goal of the present study was to identify the vesicular carriers of these molecules. METHODS:The common bile duct of rats was ligated for 10-7...

journal_title：Gastroenterology

authors： Barr VA,Hubbard AL

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND & AIMS:Synchronous activation of the Wnt signaling pathway, mostly because of loss of function of the APC tumor suppressor, and of the oncogenic KRAS-signaling pathway is very frequent in colorectal cancer and is associated with poor prognosis. METHODS:We have generated a compound transgenic mouse model, KR...

journal_title：Gastroenterology

authors： Janssen KP,Alberici P,Fsihi H,Gaspar C,Breukel C,Franken P,Rosty C,Abal M,El Marjou F,Smits R,Louvard D,Fodde R,Robine S

更新日期：2006-10-01 00:00:00

abstract：:We have quantified neurotransmitter changes in the rat jejunum in which the myenteric neurons were ablated by serosal application of benzalkonium chloride. Within 2 days after benzalkonium chloride treatment, there was a 40% reduction in the activity of choline acetyltransferase, a specific marker for cholinergic neur...

journal_title：Gastroenterology

authors： Dahl JL,Bloom DD,Epstein ML,Fox DA,Bass P

更新日期：1987-02-01 00:00:00

abstract：:We investigated the ability of isolated human colonic epithelial cells to express the common acute lymphoblastic leukemia antigen (CALLA), the transferrin receptor, and the 4F2 antigen in response to different types of stimuli. The expression of these markers was assessed by immunofluorescence using monoclonal antibod...

journal_title：Gastroenterology

authors： Fais S,Pallone F

更新日期：1989-12-01 00:00:00

abstract：:Celiac sprue and Crohn's disease have very rarely been documented in the same patient. We report a case involving an adolescent male with known Crohn's disease who had extreme wasting, growth retardation, intractable diarrhea, and delay in development of secondary sexual characteristics. Peroral jejunal biopsy showed ...

journal_title：Gastroenterology

authors： Euler AR,Ament ME

更新日期：1977-04-01 00:00:00

abstract：:Initially, scintigraphy was established as a valid method for detecting and quantitating enterogastric reflux. A new, tubeless technique for the measurement of enterogastric reflux was developed. 99mTc bound to [(2,6 dimethylphenylcarbamoylmethyl) iminodiacetic acid] (5 mCi) was administered intravenously to visualize...

journal_title：Gastroenterology

authors： Tolin RD,Malmud LS,Stelzer F,Menin R,Makler PT Jr,Applegate G,Fisher RS

更新日期：1979-11-01 00:00:00

abstract：:An adult patient with chronic idiopathic intestinal pseudo-obstruction maintained on home parenteral nutrition for 6 consecutive years died from cardiomyopathy and ventricular fibrillation. Postmortem examination of the heart revealed widespread myocytolysis and replacement fibrosis similar to that seen in the seleniu...

journal_title：Gastroenterology

authors： Fleming CR,Lie JT,McCall JT,O'Brien JF,Baillie EE,Thistle JL

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND & AIMS:Mucosal cell-mediated immune response is considered the central event in the pathogenesis of celiac disease. In cultured intestinal explants from celiacs in remission, we have characterized the early stages of gliadin-induced immune activation. METHODS:Intestinal biopsy specimens (15 treated celiacs ...

journal_title：Gastroenterology

authors： Maiuri L,Picarelli A,Boirivant M,Coletta S,Mazzilli MC,De Vincenzi M,Londei M,Auricchio S

更新日期：1996-05-01 00:00:00