CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha chain-deficient mice.

abstract：:Immunologic injury in the liver involves immigrant T and B lymphocytes and a resident lymphoid population that comprises distinct lymphocytic cells and accessory cells. The forerunner to autoimmunity is breaching of natural self-tolerance and hence the disruption of a fundamental property of the immune system. Such br...

journal_title：Gastroenterology

authors： Kita H,Mackay IR,Van De Water J,Gershwin ME

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND & AIMS:Cure of Helicobacter pylori infection may lead to complete remission of associated low-grade mucosa-associated lymphoid tissue (MALT) lymphoma in stage EI. This study investigated whether Helicobacter heilmannii infection-associated primary gastric MALT lymphoma will regress after cure of the infectio...

journal_title：Gastroenterology

authors： Morgner A,Lehn N,Andersen LP,Thiede C,Bennedsen M,Trebesius K,Neubauer B,Neubauer A,Stolte M,Bayerdörffer E

更新日期：2000-05-01 00:00:00

abstract：:We studied whether 16,16--dimethyl prostaglandin E2 (dmPGE2) may prevent acute liver damage induced by carbon tetrachloride (CCl4) in the rat. One hundred thirty male rats were divided into the following groups: (1) controls, (2) rats given CCl4 6670 mg/kg body wt subcutaneously, (3) rats pretreated with 5 micrograms/...

journal_title：Gastroenterology

authors： Stachura J,Tarnawski A,Ivey KJ,Mach T,Bogdal J,Szczudrawa J,klimczyk B

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND & AIMS:Estimates of complication rates following elective percutaneous liver biopsy vary and might not accurately reflect current practice. We studied mortality and complication rates, by indication, in patients after they underwent liver biopsies. METHODS:We performed a study using hospital episode statist...

journal_title：Gastroenterology

authors： West J,Card TR

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND & AIMS:This study aimed to determine if hiatal hernia influences vulnerability to reflux and transient lower esophageal sphincter relaxation (tLESR) during gastric distention in patients with gastroesophageal reflux disease (GERD). METHODS:Eight normal subjects and 15 patients with GERD were studied. A meta...

journal_title：Gastroenterology

authors： Kahrilas PJ,Shi G,Manka M,Joehl RJ

更新日期：2000-04-01 00:00:00

abstract：:We studied chronic intake of diets deficient in or supplemented with linoleic acid to determine whether it affects gastric acid secretion, release of prostaglandin E2, and stress-induced lesions. For 8-10 wk rats were fed three dietary regimens supplying 3.5% (control group), 0.3%, and 10% of total calories as linolei...

journal_title：Gastroenterology

authors： Schepp W,Steffen B,Ruoff HJ,Schusdziarra V,Classen M

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND/AIMS:Little is known about the evolution of morphological changes in pelvic ileal-pouch mucosa. This study evaluates prospectively the sequence of early morphological, histochemical, and phenotypic features in pouch mucosal biopsy specimens. METHODS:Twenty-two patients with pelvic ileal pouches constructed ...

journal_title：Gastroenterology

authors： Apel R,Cohen Z,Andrews CW Jr,McLeod R,Steinhart H,Odze RD

更新日期：1994-08-01 00:00:00

abstract：:Hyperplasia of the oxyntic enterochromaffinlike cells in response to long-lasting blockade of acid secretion is closely related to hypergastrinemia. In the present study, the effect of a specific gastrin receptor antagonist on proton pump inhibitor-induced changes on serum gastrin levels, mucosal height, as well as ga...

journal_title：Gastroenterology

authors： Eissele R,Patberg H,Koop H,Krack W,Lorenz W,McKnight AT,Arnold R

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND & AIMS:Histamine-producing enterochromaffin-like (ECL) cells play an integrative role in the regulation of acid secretion. Decreased mucosal histamine concentrations and increased levels of interleukin (IL) 1 beta, IL-6, and IL-8 have been detected in the gastric mucosa inflamed with Helicobacter pylori. The...

journal_title：Gastroenterology

authors： Prinz C,Neumayer N,Mahr S,Classen M,Schepp W

更新日期：1997-02-01 00:00:00

abstract：:The human gastrointestinal tract contains distinct microbial communities that differ in composition and function based on their location, as well as age, sex, race/ethnicity, and diet of their host. We describe the bacterial taxa present in different locations of the GI tract, and their specific metabolic features. Th...

journal_title：Gastroenterology

authors： Hollister EB,Gao C,Versalovic J

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND & AIMS:After liver injury, bone marrow-derived liver sinusoidal endothelial cell progenitor cells (BM SPCs) repopulate the sinusoid as liver sinusoidal endothelial cells (LSECs). After partial hepatectomy, BM SPCs provide hepatocyte growth factor, promote hepatocyte proliferation, and are necessary for norma...

journal_title：Gastroenterology

authors： Wang L,Wang X,Wang L,Chiu JD,van de Ven G,Gaarde WA,Deleve LD

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND & AIMS:Because alterations of integrin expression in cancers contribute to cancer cell biology, we analyzed the association between the potential for peritoneal dissemination and integrin expression. METHODS:The dissemination potential of 10 human gastric cancer cell lines in mice with severe combined immun...

journal_title：Gastroenterology

authors： Ishii Y,Ochiai A,Yamada T,Akimoto S,Yanagihara K,Kitajima M,Hirohashi S

更新日期：2000-03-01 00:00:00

abstract：:In this review, we compared the outcome of 25 studies of experimentally induced pancreatitis in animals with 13 studies of human acute pancreatitis in which the same therapeutic agents were used (aprotinin, glucagon, 5-fluorouracil, somatostatin, peritoneal lavage). Whereas 81% of the animal studies had a positive out...

journal_title：Gastroenterology

authors： Steinberg WM,Schlesselman SE

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND & AIMS:Both androgenic and estrogenic steroids have been implicated in the development and course of several liver diseases, including hepatocellular carcinoma. The aim of this study was to investigate temporal changes in hepatic estrogen and androgen receptors and hormone metabolism in a rat model of liver ...

journal_title：Gastroenterology

authors： Eagon PK,Elm MS,Epley MJ,Shinozuka H,Rao KN

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with limited life expectancy, the risks of colorectal cancer screening may outweigh the benefits. The aim of this study was to quantify risks and benefits of different screening strategies in elderly patients with varying life expectancies. METHODS:We examined risks and benefits of screen...

journal_title：Gastroenterology

authors： Ko CW,Sonnenberg A

更新日期：2005-10-01 00:00:00

abstract：:Helicobacter pylori infects the stomach of half of the human population worldwide and causes chronic active gastritis, which can lead to peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The host immune response to the infection is ineffective, because the bacterium persists...

journal_title：Gastroenterology

authors： Wilson KT,Crabtree JE

更新日期：2007-07-01 00:00:00

abstract：:Human intraepithelial lymphocytes (IEL) are CD8+ T cells located between intestinal epithelial cells, capable of only minimal proliferation to mitogens but brisk proliferation to mitogens combined with sheep red blood cells. This study examines this differential response of IEL. Both IEL and CD8+ T lymphocytes from th...

journal_title：Gastroenterology

authors： Ebert EC

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND & AIMS:The risk of colorectal neoplasms among siblings of patients with advanced adenomas is not clear. We determined the prevalence of advanced adenomas in the siblings of patients with advanced adenomas and compared it with that of siblings of individuals without these lesions. METHODS:In a blinded, cross...

journal_title：Gastroenterology

authors： Ng SC,Lau JY,Chan FK,Suen BY,Tse YK,Hui AJ,Leung-Ki EL,Ching JY,Chan AW,Wong MC,Ng SS,To KF,Wu JC,Sung JJ

更新日期：2016-03-01 00:00:00

abstract：:The published world literature on the efficacy of cimetidine, a histamine H2-receptor antagonist, in the treatment of duodenal ulcer is reviewed. In eight prospective randomized double blind placebo-controlled studies, cimetidine was administered to 348 duodenal ulcer patients with an incidence of endoscopically verif...

journal_title：Gastroenterology

authors： Winship DH

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND & AIMS:Corticosteroids have been shown to significantly decrease short-term mortality in patients with severe alcoholic hepatitis. However, independent factors associated with a favorable outcome and long-term survival are unknown. The aim of this study was to examine prognostic factors and long-term surviva...

journal_title：Gastroenterology

authors： Mathurin P,Duchatelle V,Ramond MJ,Degott C,Bedossa P,Erlinger S,Benhamou JP,Chaput JC,Rueff B,Poynard T

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND & AIMS:The optimal strategy for the detection of hereditary nonpolyposis colorectal cancer (HNPCC) gene carriers remains uncertain. We evaluated whether microsatellite instability (MSI) analysis or MSH2 and MLH1 protein immunostaining of tumors will screen individuals efficiently for germline MSH2 and MLH1 t...

journal_title：Gastroenterology

authors： Terdiman JP,Gum JR Jr,Conrad PG,Miller GA,Weinberg V,Crawley SC,Levin TR,Reeves C,Schmitt A,Hepburn M,Sleisenger MH,Kim YS

更新日期：2001-01-01 00:00:00

abstract：:In 48 patients with obstructive jaundice caused by unresectable lesions, a polyethylene tube was inserted into the biliary tract using a percutaneous transhepatic technique. This endoprosthesis provided permanent internal drainage without an external catheter. In 27 patients, bilirubin declined to anicteric or subicte...

journal_title：Gastroenterology

authors： Burcharth F,Jensen LI,Olesen K

更新日期：1979-07-01 00:00:00

abstract：:We have recently demonstrated that ritanserin, a serotonin 5-hydroxytryptamine receptor antagonist void of systemic effects, caused a significant reduction of portal pressure in conscious cirrhotic dogs. The mechanism by which ritanserin lowers portal pressure is poorly defined. We investigated the splanchnic and syst...

journal_title：Gastroenterology

authors： Mastai R,Giroux L,Semret M,Huet PM

更新日期：1990-01-01 00:00:00

abstract：:In some patients with hiatus hernia, vomiting may propel a plug of redundant gastric mucosa into the distal esophagus, where it becomes incarcerated and engorged. Significant bleeding may result. Reduction of the hernia controls the hemorrhage. Endoscopy after the acute episode may demonstrate a gastric mucosal lesion...

journal_title：Gastroenterology

authors： Laforet EG

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND & AIMS:The physiologic significance of the M(3) muscarinic receptor is unclear due to an absence of specific ligand. In the present study, M(3) receptor knockout (KO) mice were used to elucidate the role of M(3) receptors in gastric acid secretion and gastric mucosal integrity. METHODS:M(3) KO versus wild-t...

journal_title：Gastroenterology

authors： Aihara T,Fujishita T,Kanatani K,Furutani K,Nakamura E,Taketo MM,Matsui M,Chen D,Okabe S

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND & AIMS:Toll-like receptors (TLRs) represent a class of transmembrane pattern recognition receptors essential for microbial recognition and control of innate immune responses. Commensal bacteria play an important role in maintaining tolerance and active stability of the intestinal epithelial barrier by suppre...

journal_title：Gastroenterology

authors： Cario E,Gerken G,Podolsky DK

更新日期：2007-04-01 00:00:00

abstract：:Gastroenterologists frequently encounter pelvic floor disorders, which affect 10% to 15% of the population. The anorectum is a complex organ that collaborates with the pelvic floor muscles to preserve fecal continence and enable defecation. A careful clinical assessment is critical for the diagnosis and management of ...

journal_title：Gastroenterology

authors： Bharucha AE,Rao SS

更新日期：2014-01-01 00:00:00

abstract：:Two infants under 3 mo of age who presented with obstructive jaundice secondary to cholelithiasis are reported. Neither infant had any congenital anatomic abnormality of the biliary tract leading to stasis, yet both had cultures of gallbladder bile that grew abundant bacteria. In both, recovery of gallbladder bile and...

journal_title：Gastroenterology

authors： Treem WR,Malet PF,Gourley GR,Hyams JS

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND & AIMS:Exposure to biologic and immunosuppressant agents during breastfeeding is controversial, and there are limited data on safety. We investigated whether biologics are detectable in breast milk from women receiving treatment for inflammatory bowel diseases (IBDs) and whether breastfeeding while receiving...

journal_title：Gastroenterology

authors： Matro R,Martin CF,Wolf D,Shah SA,Mahadevan U

更新日期：2018-09-01 00:00:00

abstract：:To study directly the functions of the cells that line the bile ducts inside the liver, we developed a new technique for isolating intrahepatic bile duct epithelial cells (IBDECs) from normal rat liver. Parenchymal and nonparenchymal cells were separated from whole liver by enzymatic digestion and mechanical disruptio...

journal_title：Gastroenterology

authors： Ishii M,Vroman B,LaRusso NF

更新日期：1989-11-01 00:00:00