Abstract:
BACKGROUND/AIMS:Little is known about the evolution of morphological changes in pelvic ileal-pouch mucosa. This study evaluates prospectively the sequence of early morphological, histochemical, and phenotypic features in pouch mucosal biopsy specimens. METHODS:Twenty-two patients with pelvic ileal pouches constructed after total colectomy for chronic ulcerative colitis had biopsies performed at the time of ileostomy closure and after 6 weeks and 6 months of pouch function and were evaluated to assess the type and degree of inflammation, villus atrophy, Paneth's cell hyperplasia, mucin histochemical changes, the mucosal proliferative activity using the murine monoclonal antibody 1 (MIB-1), and the expression of the enzyme sucrase-isomaltase. RESULTS:Early changes (6 weeks) were characterized by neutrophilic and eosinophilic inflammation, mild villus atrophy, Paneth's cell hyperplasia, a partial transition to colonic mucin phenotype, and an increased MIB-1 proliferation index. These features remained relatively stable after 6 months, except for a greater degree of mononuclear infiltration, a progressive increase in the degree of eosinophilic inflammation and a new higher steady state level of crypt epithelial kinetics. Expression of sucrase-isomaltase remained stable. CONCLUSIONS:Pelvic ileal pouches develop inflammatory, phenotypic, and kinetic changes early in the course of function but have only a limited potential for colonic type metaplasia. The persistence of these changes is evidence in support of an adaptive response to a new luminal environment.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Apel R,Cohen Z,Andrews CW Jr,McLeod R,Steinhart H,Odze RDdoi
10.1016/0016-5085(94)90169-4subject
Has Abstractpub_date
1994-08-01 00:00:00pages
435-43issue
2eissn
0016-5085issn
1528-0012pii
0016-5085(94)90169-4journal_volume
107pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND & AIMS:Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with constipation (IBS-C). Little is known about the mechanism by which linaclotide reduces abdominal pain in patients with IBS-C. METHODS:We determined t...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2013.08.017
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND/AIMS:The effectiveness of ursodeoxycholic acid in treating biliary liver diseases is limited by low bioavailability and moderate activity. A new analogue of ursodeoxycholic acid was synthesized with a fluorine atom in position 6 because this should have resulted in an analogue more hydrophilic than ursodeoxy...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90221-x
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND & AIMS:Pancreatitis starts with primarily sterile local inflammation that induces systemic inflammatory response syndrome, followed by compensatory anti-inflammatory response syndrome (CARS). We investigated the mechanisms of these processes in mice and human serum. METHODS:We induced severe acute pancreati...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2019.09.040
更新日期:2020-01-01 00:00:00
abstract::Intraarterial vasopressin has been reported to be effective in the treatment of massive upper gastrointestinal hemorrhage. A prospective, controlled clinical trial comparing conventional treatment with conventional therapy plus intraarterial vasopressin was undertaken. Sixty episodes of upper gastrointestinal hemorrha...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1975-02-01 00:00:00
abstract::Hydrolysis of small peptides, like disaccharide hydrolysis, is an important function of the intestinal brush border, but little is known of the individual human peptidases. The purposes of this study were to detect all human brush border enzymes hydrolyzing dipeptides and tripeptides, identify the most discriminating ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(85)80008-1
更新日期:1985-04-01 00:00:00
abstract::Four Puerto Rican sisters had recurrent prolonged cholestasis of pregnancy without preexisting or intercurrent hepatic disorders. Available information was reviewed on the course, mechanism, and sequelae of prolonged recurrent cholestasis after 14 pregnancies in the 4 sisters. Etiologic, clinical, laboratory, radiolog...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70193-8
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND & AIMS:Inflammatory bowel disease (IBD) is a multifactorial disease thought to be caused by alterations in epithelial function, innate and adaptive immunity, and luminal microbiota. The specific role of epithelial barrier function remains undefined, although increased activity of intestinal epithelial myosin...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.10.081
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND & AIMS:Nonalcoholic fatty liver disease (NAFLD) is associated with increased risk of hepatic, cardiovascular, and metabolic diseases. High-protein diets, rich in methionine and branched chain amino acids (BCAAs), apparently reduce liver fat, but can induce insulin resistance. We investigated the effects of d...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2016.10.007
更新日期:2017-02-01 00:00:00
abstract::Infliximab, the chimeric monoclonal immunoglobulin (Ig)G1 antibody to tumor necrosis factor (TNF) has changed our therapy of Crohn's disease. Infliximab is indicated in refractory luminal and fistulizing Crohn's disease. In patients with luminal disease, a single intravenous (i.v.) dose of 5 mg/kg is efficacious; in f...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2004.02.070
更新日期:2004-05-01 00:00:00
abstract::Histologic or ultrastructural evidence of the ability of sucralfate to protect the gastric mucosa against ethanol injury is lacking. Therefore we analyzed morphologic and functional changes in the mucosa of 120 rats receiving, intragastrically, 2 ml of either sucralfate 500 mg/kg body wt or a control solution and 1 h ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(85)80191-8
更新日期:1985-01-01 00:00:00
abstract::An animal model suitable for in vivo studies of interferon-mediated suppression of hepatic oxidative drug metabolism has been developed. Rats were injected with either recombinant human interferon alpha A, recombinant human interferon gamma, recombinant rat interferon gamma, or vehicle and experiments were performed 2...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)91509-6
更新日期:1989-10-01 00:00:00
abstract::It has been suggested that the lower esophageal sphincter (LES) plays an important role in preventing gastroesophageal reflux. This study was designed to determine if abolition of the LES alone is sufficient to induce gastroesophageal reflux and esophagitis. Studies were performed in the Australian brush-tailed possum...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND & AIMS:Cirrhotic liver diseases are associated with abnormalities in cardiac geometry and function in adults (cirrhotic cardiomyopathy) but rarely explored in cirrhotic infants or children. We proposed that features of cirrhotic cardiomyopathy are present in infants with cirrhosis due to biliary atresia (BA)...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.06.082
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND & AIMS:Chronic pancreatitis has been suggested as a causal risk factor for pancreatic cancer in a recent study. The aim of this study was to clarify the relationship between chronic pancreatitis and pancreatic cancer. METHODS:All patients in the Swedish inpatient Register with a discharge diagnosis of pancr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1997.v113.pm9247480
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND & AIMS:Empirical therapy has been proposed for initial management of dyspepsia. The aim of this study was to evaluate initial endoscopy, empirical therapy, and testing for Helicobacter pylori in the management of patients with a new onset of dyspepsia. METHODS:Decision analysis was used to compare the direc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v110.pm8536890
更新日期:1996-01-01 00:00:00
abstract::The purpose of this study was to determine whether gamma-hydroxybutyrate provides protection against intestinal ischemia/reperfusion injury and to compare its effect with that of allopurinol and vitamin E. Thirty minutes of total regional ischemia, followed by 3 hours of reperfusion, produced intestinal damage that wa...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90982-7
更新日期:1990-09-01 00:00:00
abstract::Endoscopic sphincterotomy has proven to be a safe alternative to surgery for selected types of biliary disease. Despite a relatively low morbidity, postprocedure complications are well described. This report presents an experience with three patients in whom acute relapsing pancreatitis developed as a possible complic...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90663-w
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND & AIMS:Abnormal processing of visceral sensation at the level of the central nervous system is believed to be involved in functional dyspepsia. However, compared with studies of stimulation-related changes in brain activity, few studies have focused on resting brain activity, which also is important in patho...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.05.003
更新日期:2011-08-01 00:00:00
abstract::We studied 375 chronic hemodialysis patients for evidence of hepatitis B virus infection using first- and second-generation monoclonal radioimmunoassays. These assays employ high-affinity monoclonal antibodies produced against antigenic determinants that reside on hepatitis B surface antigen. Such assays have a lower ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90187-3
更新日期:1986-12-01 00:00:00
abstract::Sepsis, peritonitis, and gastroenteritis developed in a 45-yr-old homosexual man 1 day after ingestion of raw oysters. The patient had chronic active hepatitis and cirrhosis with hepatitis B virus and delta-infection. He also had persistent generalized lymphadenopathy associated with HTLV-III antibody positivity. Vibr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90035-7
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND & AIMS:The morphology of acid damage to esophageal epithelium is characterized by marked cell (swelling) edema. This observation suggests that, in the process of acid damage, an increase in osmotic forces develops within the cell that accounts for the increase in cell water. The aim of this study was to docu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90328-3
更新日期:1995-08-01 00:00:00
abstract::The growth rate of 31 asymptomatic hepatocellular carcinomas (diameter less than or equal to 5 cm) discovered in 28 patients by a prospective screening program was determined by real-time ultrasonography over 36-860 days. Except for one tumor that shrank on follow-up, the doubling time ranged from 29 to 398 days, with...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90324-5
更新日期:1985-08-01 00:00:00
abstract::The efficacy of phenobarbital in altering biliary lipid composition in normal man was investigated by determining parameters of biliary lipid metabolism in 8 human subjects without biliary tract disease before and after oral phenobarbital administration at a dose of approximately 3 mg per kg per day for 25 to 54 days....
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::Gastroenterologists frequently encounter pelvic floor disorders, which affect 10% to 15% of the population. The anorectum is a complex organ that collaborates with the pelvic floor muscles to preserve fecal continence and enable defecation. A careful clinical assessment is critical for the diagnosis and management of ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2013.10.062
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:Liver fat-storing cells (FSCs) actively proliferate and secrete extracellular matrix during liver injury. Platelet-derived growth factor (PDGF) is a potent mitogen for cultured FSCs. In the present study, we investigated the regulation of PDGF gene expression and production in cultured human liver FSCs....
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90236-4
更新日期:1994-10-01 00:00:00
abstract::Recent data seem to support a tubular defect as the mechanism of the elevated renal clearance of amylase relative to creatinine in acute pancreatitis. Glucagon has been proposed by some to be an important factor in this phenomenon. To examine the role of glucagon as this "tubular dysfunction factor", we investigated t...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract::An enteroscopic method that uses a pediatric colonoscope provides an alternative approach to the diagnostic and management problems arising in the setting of a Roux-en-Y limb hepaticojejunostomy or biliary diversion. Three patients with Roux-en-Y limb reconstructions who experienced recurrent cholangitis, recurrent pa...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90305-8
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND & AIMS:Helicobacter pylori is believed to predispose to gastric cancer by inducing gastric atrophy and hypochlorhydria. First-degree relatives of patients with gastric cancer have an increased risk of developing gastric cancer. The aim of this study was to determine the prevalence of atrophy and hypochlorhyd...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(00)70410-0
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatic iron toxicity may be mediated by free radical species and lipid peroxidation of biological membranes. The antioxidant property of silybin, a main constituent of natural flavonoids, was investigated in vivo during experimental iron overload. METHODS:Rats were fed a 2.5% carbonyl-iron diet and ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90762-9
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND & AIMS:AJM300 is an orally active small-molecule antagonist of the α4 integrin subunit. We performed a randomized trial to investigate the efficacy and safety of AJM300 in patients with active ulcerative colitis (UC). METHODS:In a double-blind, placebo-controlled, phase 2a study, 102 patients with moderatel...
journal_title:Gastroenterology
pub_type: 评论,杂志文章
doi:10.1053/j.gastro.2015.08.044
更新日期:2015-12-01 00:00:00