Helicobacter heilmannii-associated primary gastric low-grade MALT lymphoma: complete remission after curing the infection.

Abstract:

BACKGROUND & AIMS:Cure of Helicobacter pylori infection may lead to complete remission of associated low-grade mucosa-associated lymphoid tissue (MALT) lymphoma in stage EI. This study investigated whether Helicobacter heilmannii infection-associated primary gastric MALT lymphoma will regress after cure of the infection. METHODS:H. heilmannii-induced gastritis was diagnosed histologically, by a new specific immunoglobulin G enzyme-linked immunosorbent assay, and with 16S ribosomal RNA amplification and sequencing in 5 consecutive patients with primary gastric MALT lymphoma clinical stage EI. Patients received 40 mg omeprazole and 750 mg amoxicillin 3 times per day for 14 days. Polymerase chain reaction (PCR) was used to detect rearrangement of immunoglobulin heavy-chain genes before treatment and during follow-up. RESULTS:Five patients (3 men, 2 women; mean age, 65 years; range, 42-79 years) were studied. H. pylori was not detected by culture, histology, serology, or PCR. Treatment resulted in the cure of H. heilmannii infection in each case and complete histological and endoscopic remission of the tumors. Three of 5 patients showed monoclonal B cells before treatment, 2 of whom remained PCR positive. Within a median follow-up period of 24 months, no relapse of the lymphoma or reinfection with H. heilmannii occurred. CONCLUSIONS:These data suggest that gastric MALT lymphoma may arise in patients with H. heilmannii infection. Cure of this infection may lead to complete remission of the MALT lymphoma.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Morgner A,Lehn N,Andersen LP,Thiede C,Bennedsen M,Trebesius K,Neubauer B,Neubauer A,Stolte M,Bayerdörffer E

doi

10.1016/s0016-5085(00)70167-3

keywords:

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

821-8

issue

5

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(00)70167-3

journal_volume

118

pub_type

临床试验,杂志文章
  • Effects of aspirin on pathways of ion permeation in Necturus antrum: role of nutrient HCO3.

    abstract::Intracellular microelectrodes were used to evaluate electrical properties of the cell membranes in Necturus antral mucosa during exposure to luminal acid alone (pH 4) or to 5 mmol/L aspirin [acetylsalicylic acid (ASA)] in the presence of luminal acid. When nutrient solutions were buffered by HCO3- (pH 7.3), ASA modera...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(92)91167-3

    authors: Soybel DI,Davis MB,West AB

    更新日期:1992-11-01 00:00:00

  • Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat.

    abstract:BACKGROUND & AIMS:During hepatic fibrogenesis, the hepatic extracellular matrix changes to fibrillar collagens types I and III, and cirrhosis is believed to produce an irreversible scar. In this study, we investigated whether gene delivery of human matrix metalloproteinase-1, which degrades collagens types I and type I...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2003.50063

    authors: Iimuro Y,Nishio T,Morimoto T,Nitta T,Stefanovic B,Choi SK,Brenner DA,Yamaoka Y

    更新日期:2003-02-01 00:00:00

  • Qualitative and quantitative analysis of muscarinic acetylcholine receptors in the piebald lethal mouse model of Hirschsprung's disease.

    abstract::Cholinergic innervation in the aganglionic bowel of the piebald lethal mouse model of Hirschsprung's disease was investigated by analysis of muscarinic acetylcholine receptors before and after administration of hexamethonium. After hexamethonium administration in the normal rectum, the maximum specific binding (Bmax) ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(85)90008-3

    authors: Ueki S,Okamoto E,Kuwata K,Toyosaka A,Nagai K

    更新日期:1985-06-01 00:00:00

  • Unplanned Hospital Encounters After Endoscopic Retrograde Cholangiopancreatography in 3 Large North American States.

    abstract:BACKGROUND & AIMS:We have few population-level data on the performance of endoscopic retrograde cholangiopancreatography (ERCP) in the United States. We investigated the numbers of unplanned hospital encounters (UHEs), patient and facility factors associated with UHEs, and variation in quality and outcomes in the perfo...

    journal_title:Gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1053/j.gastro.2018.09.037

    authors: Huang RJ,Barakat MT,Girotra M,Lee JS,Banerjee S

    更新日期:2019-01-01 00:00:00

  • Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL.

    abstract:BACKGROUND & AIMS:IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738. In the Spanish white population, we found the IKBL+738(C) allele in haplotypes carrying either HLA-DRB1(*)1501 or -DRB1(*)0103. Because ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2000.20258

    authors: de la Concha EG,Fernandez-Arquero M,Lopez-Nava G,Martin E,Allcock RJ,Conejero L,Paredes JG,Diaz-Rubio M

    更新日期:2000-12-01 00:00:00

  • Decreasing risk of colorectal cancer in patients with inflammatory bowel disease over 30 years.

    abstract:BACKGROUND & AIMS:The risk for colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) could have changed over time, with changes in treatment options. We studied CRC risk in a nationwide cohort of 47,374 Danish patients with IBD over a 30-year period. METHODS:We determined relative risk (RR) values ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2012.04.016

    authors: Jess T,Simonsen J,Jørgensen KT,Pedersen BV,Nielsen NM,Frisch M

    更新日期:2012-08-01 00:00:00

  • p53 point mutations in dysplastic and cancerous ulcerative colitis lesions.

    abstract:BACKGROUND:The molecular basis of colorectal dysplasia and carcinoma arising in ulcerative colitis is poorly understood. Loss of heterozygosity involving the tumor suppressor gene p53 occurs frequently in neoplastic ulcerative colitis lesions. Point mutation affecting p53 is associated with loss of heterozygosity in ot...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(93)90639-t

    authors: Yin J,Harpaz N,Tong Y,Huang Y,Laurin J,Greenwald BD,Hontanosas M,Newkirk C,Meltzer SJ

    更新日期:1993-06-01 00:00:00

  • Effects of fundic distention on pentagastrin-stimulated gastric acid secretion in man.

    abstract::The acid secretory effect of combined stimulation with balloon distention of the fundus and body of the stomach and intravenous infusion of pentagastrin has been studied in patients with duodenal ulcer (DU) and in healthy subjects. In 8 nonoperated DU subjects and in 5 DU patients subjected to proximal gastric vagotom...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Grötzinger U,Bergegårdh S,Olbe L

    更新日期:1977-09-01 00:00:00

  • Pro-angiogenic activity of TLRs and NLRs: a novel link between gut microbiota and intestinal angiogenesis.

    abstract:BACKGROUND & AIMS:In intestinal inflammation the gut microbiota induces an innate immune response by activating epithelial and immune cells that initiate or maintain inflammation. We investigated whether the microbiota also can activate local microvascular cells and induce angiogenesis. METHODS:Human intestinal microv...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2012.11.005

    authors: Schirbel A,Kessler S,Rieder F,West G,Rebert N,Asosingh K,McDonald C,Fiocchi C

    更新日期:2013-03-01 00:00:00

  • Relationship of abdominal bloating to distention in irritable bowel syndrome and effect of bowel habit.

    abstract:BACKGROUND & AIMS:The relationship between the sensation of bloating, often ranked as the most bothersome symptom by patients with irritable bowel syndrome (IBS), and actual distention manifest as an increase in abdominal girth is controversial. Investigation of this problem has been hampered by the lack of a reliable ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2006.07.015

    authors: Houghton LA,Lea R,Agrawal A,Reilly B,Whorwell PJ

    更新日期:2006-10-01 00:00:00

  • Eosinophilic gastroenteritis in extreme allergy. Immunopathological comparison with nonallergic gastrointestinal disease.

    abstract::Intestinal mucosal biopsy immunoglobulin content in a patient with eosinophilia, allergic gastroenteropathy (atopy, food sensitivities, protein-losing enteropathy, iron deficiency anemia, and growth retardation), and hyperimmunoglobulinemia E (68,000 units) was compared with that of a control group and a group with eo...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Caldwell JH,Sharma HM,Hurtubise PE,Colwell DL

    更新日期:1979-09-01 00:00:00

  • Colonic and small intestinal alkaline phosphatase. A histochemical and biochemical study.

    abstract::Colonic and intestinal alkaline phosphatase were studied histoenzymatically and biochemically in normal mucosae from eight hemicolectomy specimens. Histochemically, the most intense reaction was found in the small intestine, followed by vascular endothelium and colonic epithelium, respectively. The reaction was strong...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Lev R,Griffiths WC

    更新日期:1982-06-01 00:00:00

  • Calcium affinity for biliary lipid aggregates in model biles: complementary importance of bile salts and lecithin.

    abstract:BACKGROUND/AIMS:Despite putative roles of calcium in biliary physiology and gallstone formation, quantitative aspects of calcium binding to bile salt (BS) monomers, simple micelles, mixed micelles, and vesicles, which constitute the lipid aggregates in bile, remain unexplored. METHODS:Calcium activity was measured usi...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(94)90134-1

    authors: Donovan JM,Leonard MR,Batta AK,Carey MC

    更新日期:1994-09-01 00:00:00

  • Acute cytomegalovirus infection in a child with Ménétrier's disease.

    abstract::The cause of Ménétrier's disease is unknown, although allergic, autoimmune, and infectious, particularly viral, causes have been postulated. This case report describes a 3-year-old child with Ménétrier's disease in whom evidence of acute cytomegalovirus (CMV) infection was found. To our knowledge, this is the first ca...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(95)90349-6

    authors: Eisenstat DD,Griffiths AM,Cutz E,Petric M,Drumm B

    更新日期:1995-08-01 00:00:00

  • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.

    abstract:BACKGROUND & AIMS:The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS:Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structu...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2002.31001

    authors: Lerat H,Honda M,Beard MR,Loesch K,Sun J,Yang Y,Okuda M,Gosert R,Xiao SY,Weinman SA,Lemon SM

    更新日期:2002-02-01 00:00:00

  • Evidence for autoregulation of cholecystokinin secretion during diversion of bile pancreatic juice in rats.

    abstract:BACKGROUND & AIMS:The mechanism regulating cholecystokinin (CCK) secretion during prolonged diversion of bile pancreatic juice (BPJ) is unknown. We examined the hypothesis that the decrease of plasma CCK levels after prolonged diversion of BPJ is mediated by an increase in plasma somatostatin levels evoked by hyperchol...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(95)90289-9

    authors: Li Y,Hao Y,Owyang C

    更新日期:1995-07-01 00:00:00

  • Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation.

    abstract:BACKGROUND & AIMS:Cell stress signaling pathways result in phosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or EIF2A), which affects regulation of protein translation. Translation reprogramming mitigates stress by activating pathways that result in autophagy and cell death, to eli...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2017.12.016

    authors: Roy S,Esmaeilniakooshkghazi A,Patnaik S,Wang Y,George SP,Ahrorov A,Hou JK,Herron AJ,Sesaki H,Khurana S

    更新日期:2018-04-01 00:00:00

  • Colonic epithelial functional phenotype varies with type and phase of experimental colitis.

    abstract:BACKGROUND & AIMS:Colonic crypt elongation occurs during both chronic colitis and in the recovery phase of acute colitis. The impact of these alterations on epithelial cell functions is not fully defined. METHODS:DNA microarray analysis of freshly isolated colonic epithelial cells (CECs) from acute and chronic colitis...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(03)00665-6

    authors: Mizoguchi E,Xavier RJ,Reinecker HC,Uchino H,Bhan AK,Podolsky DK,Mizoguchi A

    更新日期:2003-07-01 00:00:00

  • Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: a new approach.

    abstract:BACKGROUND & AIMS:We have reported that contrast echocardiography is a sensitive screening test for the hepatopulmonary syndrome (HPS). However, contrast echocardiography lacks specificity because many cirrhotic patients have positive study results with normal arterial blood gases and therefore do not fulfill criteria ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(98)70481-0

    authors: Abrams GA,Nanda NC,Dubovsky EV,Krowka MJ,Fallon MB

    更新日期:1998-02-01 00:00:00

  • Evidence for the existence of definitive hepatic cholesterol precursor compartments for bile acids and biliary cholesterol in man.

    abstract::A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursor-product relationship betwe...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Schwartz CC,Vlahcevic ZR,Halloran LG,Gregory DH,Meek JB,Swell L

    更新日期:1975-12-01 00:00:00

  • Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma.

    abstract:BACKGROUND & AIMS:Conventional transarterial chemoembolization (cTACE) is used to treat patients with hepatocellular carcinoma (HCC). Radioembolization is a minimally invasive procedure that involves implantation of radioactive micron-sized particles loaded with yttrium-90 (Y90) inside the blood vessels that supply a t...

    journal_title:Gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1053/j.gastro.2016.08.029

    authors: Salem R,Gordon AC,Mouli S,Hickey R,Kallini J,Gabr A,Mulcahy MF,Baker T,Abecassis M,Miller FH,Yaghmai V,Sato K,Desai K,Thornburg B,Benson AB,Rademaker A,Ganger D,Kulik L,Lewandowski RJ

    更新日期:2016-12-01 00:00:00

  • Gastric inhibitory polypeptide (GIP) is not the primary mediator of the enterogastrone action of fat in the dog.

    abstract::We compared the inhibition of food-stimulated gastric acid secretion and changes in serum concentrations of immunoreactive gastric inhibitory polypeptide and gastrin caused by: (a) duodenal perfusion of oleic acid, and (b) intravenous infusion of pure, natural, porcine gastric inhibitory, polypeptide in dogs with gast...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Yamagishi T,Debas HT

    更新日期:1980-05-01 00:00:00

  • The gluten-free diet: how to provide effective education and resources.

    abstract::A strict gluten-free diet (GFD) for life is the only treatment for celiac disease (CD). This article reviews (1) the impact of the GFD on the quality of life of individuals with CD and their families; (2) the causes of poorly controlled CD; (3) the access to and source and quality of information provided by health pro...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2005.02.020

    authors: Case S

    更新日期:2005-04-01 00:00:00

  • Regional esophageal distribution and clearance of refluxed gastric acid.

    abstract::Regional differences in the esophageal distribution and clearance of refluxed gastric acid was studied in seven asymptomatic volunteers and seven patients with reflux esophagitis. Intraluminal pH was recorded for 3 postprandial hours from the distal, middle, and proximal esophagus on two separate occasions (with subje...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(91)90011-9

    authors: Shaker R,Dodds WJ,Helm JF,Kern MK,Hogan WJ

    更新日期:1991-08-01 00:00:00

  • Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells.

    abstract:BACKGROUND & AIMS:Helicobacter pylori infection causes inflammation, accumulation of reactive oxygen species, and oxidative DNA damage in the gastric mucosa. Apurinic/apyrimidinic endonuclease-1 (APE-1)/redox factor-1 (Ref-1) repairs damaged DNA and reductively activates transcription factors, including activator prote...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2004.06.017

    authors: Ding SZ,O'Hara AM,Denning TL,Dirden-Kramer B,Mifflin RC,Reyes VE,Ryan KA,Elliott SN,Izumi T,Boldogh I,Mitra S,Ernst PB,Crowe SE

    更新日期:2004-09-01 00:00:00

  • Colorectal Cancer Screening With Repeated Fecal Immunochemical Test Versus Sigmoidoscopy: Baseline Results From a Randomized Trial.

    abstract:BACKGROUND & AIMS:The comparative effectiveness of sigmoidoscopy and fecal immunochemical testing (FIT) for colorectal cancer (CRC) screening is unknown. METHODS:Individuals aged 50-74 years living in Southeast Norway were randomly invited between 2012 and 2019 to either once-only flexible sigmoidoscopy or FIT screeni...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2020.11.037

    authors: Randel KR,Schult AL,Botteri E,Hoff G,Bretthauer M,Ursin G,Natvig E,Berstad P,Jørgensen A,Sandvei PK,Olsen ME,Frigstad SO,Darre-Næss O,Norvard ER,Bolstad N,Kørner H,Wibe A,Wensaas KA,de Lange T,Holme Ø

    更新日期:2020-11-21 00:00:00

  • Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.

    abstract:BACKGROUND & AIMS:Apart from its importance as an acid secretogogue, the role of histamine as a downstream target of gastrin has not been fully explored. Previous studies have shown that the combination of hypergastrinemia and Helicobacter infection resulted in accelerated gastric cancer in mice. We used this model to ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2005.03.027

    authors: Takaishi S,Cui G,Frederick DM,Carlson JE,Houghton J,Varro A,Dockray GJ,Ge Z,Whary MT,Rogers AB,Fox JG,Wang TC

    更新日期:2005-06-01 00:00:00

  • Involvement of tumor necrosis factor-alpha in the pathogenesis of activated macrophage-mediated hepatitis in mice.

    abstract::The possible involvement of tumor necrosis factor-alpha in the pathogenesis of an experimentally induced hepatitis was investigated. Balb/c mice were primed with Propionibacterium acnes to induce the infiltration of mononuclear cells into the liver. Immunohistochemical study showed that most of the accumulated mononuc...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(90)90965-4

    authors: Nagakawa J,Hishinuma I,Hirota K,Miyamoto K,Yamanaka T,Tsukidate K,Katayama K,Yamatsu I

    更新日期:1990-09-01 00:00:00

  • Orthotopic liver transplantation for graft-versus-host disease following bone marrow transplantation.

    abstract::Chronic graft-vs.-host disease occurs in 30%-50% of long-term survivors of allogeneic bone marrow grafts, and may eventuate in cirrhosis. In this study, a young woman, originally diagnosed as having acute myelogenous leukemia, underwent successful bone marrow transplantation but later developed graft-vs.-host disease-...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(90)91039-9

    authors: Rhodes DF,Lee WM,Wingard JR,Pavy MD,Santos GW,Shaw BW,Wood RP,Sorrell MF,Markin RS

    更新日期:1990-08-01 00:00:00

  • In vivo hepatic 31P magnetic resonance spectroscopy in chronic alcohol abusers.

    abstract:BACKGROUND/AIMS:In vivo hepatic 31P magnetic resonance spectroscopy (MRS) can provide information on hepatic energy metabolism, phospholipid substrates, and hepatocyte lipid bilayers. The aim of this study was to ascertain the effects of alcohol ingestion on hepatic 31P spectral variables. METHODS:Twenty-six chronic a...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(95)90451-4

    authors: Menon DK,Harris M,Sargentoni J,Taylor-Robinson SD,Cox IJ,Morgan MY

    更新日期:1995-03-01 00:00:00