Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.

abstract：:The major modes of presentation of patients with celiac disease are the classic diarrhea-predominant form and silent celiac disease. Those with silent celiac disease lack diarrhea, although they may present with manifestations of celiac disease that include an irritable bowel syndrome, anemia, osteoporosis, neurologic...

journal_title：Gastroenterology

authors： Green PH

更新日期：2005-04-01 00:00:00

abstract：:With a worldwide prevalence of 15%, chronic constipation is one of the most frequent gastrointestinal diagnoses made in ambulatory medicine clinics, and is a common source cause for referrals to gastroenterologists and colorectal surgeons in the United States. Symptoms vary among patients; straining, incomplete evacua...

journal_title：Gastroenterology

authors： Bharucha AE,Lacy BE

更新日期：2020-04-01 00:00:00

abstract：:The effects of IV injection of 5-hydroxytryptamine 3 receptor antagonists (BRL 43694 and GR38032F) on gastrointestinal contractile activity were studied in dogs with vagally denervated fundic pouch in the conscious state by means of chronically implanted force transducers in the gastrointestinal tract and the pouch. I...

journal_title：Gastroenterology

authors： Itoh Z,Mizumoto A,Iwanaga Y,Yoshida N,Torii K,Wakabayashi K

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND & AIMS:The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS:Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structu...

journal_title：Gastroenterology

authors： Lerat H,Honda M,Beard MR,Loesch K,Sun J,Yang Y,Okuda M,Gosert R,Xiao SY,Weinman SA,Lemon SM

更新日期：2002-02-01 00:00:00

abstract：:A technique for the direct measurement of portal vein pressure in fully conscious patients is described. This uses a percutaneous transhepatic approach with a thin Chiba needle and is shown to be simple and safe. The technique has been applied to 123 patients with a variety of liver disorders and the pressure measurem...

journal_title：Gastroenterology

authors： Boyer TD,Triger DR,Horisawa M,Redeker AG,Reynolds TB

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:The composition of the extracellular matrix (ECM) as well as insulinlike growth factor I (IGF-I) receptor density vary along the crypt-villus axis. We determined whether components of the ECM influence IGF-I receptor expression in IEC-18 rat small intestine crypt cells. METHODS:IEC-18 cells were cultured on...

journal_title：Gastroenterology

authors： Benya RV,Duncan MD,Mishra L,Bass BL,Voyles NR,Korman LY

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND & AIMS:Epithelial cells of the small intestine migrate to the tip of the villus at which they are shed. It is not understood how the intestinal barrier is maintained during this high cell turnover. The aim of this study was to use high-resolution in vivo light microscopy to investigate the mechanism of epith...

journal_title：Gastroenterology

authors： Watson AJ,Chu S,Sieck L,Gerasimenko O,Bullen T,Campbell F,McKenna M,Rose T,Montrose MH

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND & AIMS:No controlled trial has examined the clinical efficacy of antibiotics in small bowel bacterial overgrowth. METHODS:Ten patients with bacterial overgrowth-related diarrhea underwent the following five 7-day treatment periods: untreated (control period), then placebo, and subsequently, in random order ...

journal_title：Gastroenterology

authors： Attar A,Flourié B,Rambaud JC,Franchisseur C,Ruszniewski P,Bouhnik Y

更新日期：1999-10-01 00:00:00

abstract：:Adenylate cyclase activity was measured in rat small intestinal villus and crypt cells after in vivo and in vitro exposure to cholera toxin. The increase in intestinal adenylate cyclase induced by cholera toxin in vivo appeared to be largely confined to the villus cell with the largest increase observed for upper vill...

journal_title：Gastroenterology

authors： Weiser MM,Quill H

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND AND AIMS:In stomach, metaplasia can arise from differentiated chief cells that become mitotic via paligenosis, a stepwise program. In paligenosis, mitosis initiation requires reactivation of the cellular energy hub mTORC1 after initial mTORC1 suppression by DNA damage induced transcript 4 (DDIT4 aka REDD1). ...

journal_title：Gastroenterology

authors： Miao ZF,Sun JX,Adkins-Threats M,Pang MJ,Zhao JH,Wang X,Tang KW,Wang ZN,Mills JC

更新日期：2021-01-01 00:00:00

abstract：:The conventional method of ascitic fluid culture detects bacteria in only 42%-65% of patients who have neutrocytic ascites and suspected spontaneous bacterial peritonitis. In this study ascitic fluid was cultured by the conventional method as well as by a new method consisting of bedside inoculation of blood culture b...

journal_title：Gastroenterology

authors： Runyon BA,Canawati HN,Akriviadis EA

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND & AIMS:Collagen I deposition contributes to liver fibrosis, yet little is known about other factors that mediate this process. Fibromodulin is a liver proteoglycan that regulates extracellular matrix organization and is induced by fibrogenic stimuli. We propose that fibromodulin contributes to the pathogenes...

journal_title：Gastroenterology

authors： Mormone E,Lu Y,Ge X,Fiel MI,Nieto N

更新日期：2012-03-01 00:00:00

abstract：:Two types of benzodiazepine receptors have been identified in the central nervous system. The aim of these experiments was to determine if ligands for these receptors alter basal water absorption by rat ileum in vivo after central administration. Specifically, the effects on net water flux of the systemic and central ...

journal_title：Gastroenterology

authors： Fogel R,Michelson G,Senler T,Marshall D,Brown T,Gaginella T

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND & AIMS:The molecular features of colorectal tumors differ with their anatomic location. Colorectal tumors are usually classified as proximal or distal. We collected data from 3 cohorts to identify demographic, clinical, anthropometric, lifestyle, and dietary risk factors for colorectal cancer (CRC) at 7 anat...

journal_title：Gastroenterology

authors： Wang L,Lo CH,He X,Hang D,Wang M,Wu K,Chan AT,Ogino S,Giovannucci EL,Song M

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND & AIMS:Stool samples from patients with colorectal cancer (CRC) have a higher abundance of Peptostreptococcus anaerobius than stool from individuals without CRC, based on metagenome sequencing. We investigated whether P anaerobius contributes to colon tumor formation in mice and its possible mechanisms of ca...

journal_title：Gastroenterology

authors： Tsoi H,Chu ESH,Zhang X,Sheng J,Nakatsu G,Ng SC,Chan AWH,Chan FKL,Sung JJY,Yu J

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND & AIMS:Immune-nonimmune cell interactions modulate mucosal immunity. We investigated the expression of adhesion molecules by intestinal fibroblasts, the effect of immune cell-derived factor on fibroblast binding of T cells, and the consequences of interfering with adhesion molecule expression on fibroblast-T...

journal_title：Gastroenterology

authors： Musso A,Condon TP,West GA,De La Motte C,Strong SA,Levine AD,Bennett CF,Fiocchi C

更新日期：1999-09-01 00:00:00

abstract：:The effect of changes in the rate of infusion versus glucose concentration on glucose, water, and sodium absorption was studied in 20 infant miniature pigs using the single-pass small intestinal perfusion technique. During infusions of glucose loads of up to 75.0 mumol/min, glucose absorption increased similarly wheth...

journal_title：Gastroenterology

authors： Shulman RJ,Lifschitz CH

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND & AIMS:Liver graft dysfunction is related to hypothermic preservation and may implicate altered cell volume homeostasis. The aim of this study was to evaluate how cold preservation and rewarming affect hepatocellular volume regulation and concentrative amino acid uptake. METHODS:Rat hepatocytes suspended fo...

journal_title：Gastroenterology

authors： Serrar H,Haddad P

更新日期：1997-04-01 00:00:00

abstract：:Increased type III collagen deposition in all layers of the intestinal tract, including the lamina propria, is a common feature of strictures in Crohn's disease. In the present study, it was found that in comparison with fibroblasts from normal or nonstrictured but inflamed intestinal lamina propria, the fibroblasts i...

journal_title：Gastroenterology

authors： Stallmach A,Schuppan D,Riese HH,Matthes H,Riecken EO

更新日期：1992-06-01 00:00:00

abstract：:Polyethylene glycol (PEG) is commonly used as a nonabsorbable volume marker in intestinal perfusion and flow studies. It has been assumed that PEG does not affect water and electrolyte movement, but this has not been extensively investigated. Using triple-lumen tube perfusion technique, we examined the effect of vario...

journal_title：Gastroenterology

authors： Davis GR,Santa Ana CA,Morawski SG,Fordtran JS

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND & AIMS:Alcoholic hepatitis (AH) is characterized by hepatocellular damage, inflammation, and fibrosis. We performed a prospective study to associate hepatic expression of the CXC subfamily of chemokines with histology findings and prognosis of patients with AH. METHODS:Liver biopsy samples from 105 patients...

journal_title：Gastroenterology

authors： Dominguez M,Miquel R,Colmenero J,Moreno M,García-Pagán JC,Bosch J,Arroyo V,Ginès P,Caballería J,Bataller R

更新日期：2009-05-01 00:00:00

abstract：:The possibility that chronic uremia renders the gastric mucosa more susceptible to acid injury was investigated. A rat model of chronic renal failure was induced by subtotal nephrectomy. [H+] back-diffusion across the mucosa, following intragastric perfusion of 0.15N HCl or 15% ethanol in 0.15N HCl, was significantly ...

journal_title：Gastroenterology

authors： Quintero E,Kaunitz J,Nishizaki Y,De Giorgio R,Sternini C,Guth PH

更新日期：1992-12-01 00:00:00

abstract：:In human cirrhosis, there is evidence that there are considerable alterations in fluid and solute exchange in the hepatic and intestinal microcirculations . Experimental cirrhosis was induced in rats by using oral phenobarbitone and carbon tetrachloride inhalation over an 8-wk period. Portal venous pressure, hepatic a...

journal_title：Gastroenterology

authors： Barrowman JA,Granger DN

更新日期：1984-07-01 00:00:00

abstract：:The effect of substance P (SP) on the release of gastric somatostatinlike immunoreactivity (SLI) was studied. Substance P inhibited both basal SLI release and SLI release stimulated by gastric inhibitory polypeptide or 1-isoproterenol. This inhibitory action of SP was not blocked by atropine or hexamethonium, suggesti...

journal_title：Gastroenterology

authors： Kwok YN,McIntosh CH,Pederson RA,Brown JC

更新日期：1985-01-01 00:00:00

abstract：:The mortality experienced by a cohort of 653 patients with celiac disease in Edinburgh and the Lothian region has been analyzed. Mortality overall was 1.9-fold (95% confidence limits, 1.5-2.2) that of the general population (115 deaths observed, 61.8 expected; p less than 0.0001). The increased mortality was greatest ...

journal_title：Gastroenterology

authors： Logan RF,Rifkind EA,Turner ID,Ferguson A

更新日期：1989-08-01 00:00:00

abstract：:A case of spontaneous rupture of a nonparasitic liver cyst, documented by serial computed tomography scans, is reported. The patient was closely followed clinically after the rupture of the cyst and was treated conservatively, without surgical intervention. No peritonitis developed. This unusual complication of nonpar...

journal_title：Gastroenterology

authors： Akriviadis EA,Steindel H,Ralls P,Redeker AG

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Whether long-term octreotide treatment given to portal hypertensive rats could prevent or ameliorate peripheral vasodilatation and thereby modify sodium retention was investigated. METHODS:Starting at the time of partial portal vein ligation or sham operation, rats received a 4-day course of either octreoti...

journal_title：Gastroenterology

authors： Albillos A,Colombato LA,Lee FY,Groszmann RJ

更新日期：1993-02-01 00:00:00

abstract：:Non-major histocompatibility complex-restricted cytotoxicity triggered by antibodies to the CD3 component of the human T-cell receptor complex is thought to be an indirect measure of in vivo primed cytotoxic T-cell activity. We have used this technique to examine the lytic activity of freshly isolated T cells from non...

journal_title：Gastroenterology

authors： Shanahan F,Deem R,Nayersina R,Leman B,Targan S

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatitis starts with primarily sterile local inflammation that induces systemic inflammatory response syndrome, followed by compensatory anti-inflammatory response syndrome (CARS). We investigated the mechanisms of these processes in mice and human serum. METHODS:We induced severe acute pancreati...

journal_title：Gastroenterology

authors： Sendler M,van den Brandt C,Glaubitz J,Wilden A,Golchert J,Weiss FU,Homuth G,De Freitas Chama LL,Mishra N,Mahajan UM,Bossaller L,Völker U,Bröker BM,Mayerle J,Lerch MM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND & AIMS:Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and weight loss with sibutramine. METHODS:We conducted a randomized, double-blind, pharmacogenetic study...

journal_title：Gastroenterology

authors： Grudell AB,Sweetser S,Camilleri M,Eckert DJ,Vazquez-Roque MI,Carlson PJ,Burton DD,Braddock AE,Clark MM,Graszer KM,Kalsy SA,Zinsmeister AR

更新日期：2008-10-01 00:00:00