当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis.

Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis.

Abstract：

BACKGROUND & AIMS:Alcoholic hepatitis (AH) is characterized by hepatocellular damage, inflammation, and fibrosis. We performed a prospective study to associate hepatic expression of the CXC subfamily of chemokines with histology findings and prognosis of patients with AH. METHODS:Liver biopsy samples from 105 patients with AH and 5 normal liver samples (controls) were evaluated for steatosis, inflammation, fibrosis, and cholestasis. Computer-based morphometric analysis assessed the numbers of infiltrating CD3+ T cells and CD15+ cells (neutrophils); terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling staining was used to quantify apoptosis. Expression of CXC and CC chemokines and selected signaling components were assessed by quantitative reverse-transcription polymerase chain reaction; protein levels of interleukin (IL)-8 and Gro-alpha also were determined by immunohistochemistry. Serum levels of IL-8 and Gro-alpha were measured by enzyme-linked immunosorbent assay. The Cox regression model identified variables associated with mortality. RESULTS:Most patients (75%) had severe AH; their 90-day mortality rate was 21.9%. In AH liver samples, expression of the CXC subfamily members IL-8, Gro-alpha, CXCL5, CXCL6, CXCL10, and platelet factor 4 was up-regulated and compared with controls. The CC chemokine CCL2, but not CCL5, also was up-regulated. Higher expression levels of IL-8, CXCL5, Gro-gamma, and CXCL6 were associated with worse prognosis. Expression of CXC components correlated with neutrophil infiltration and the severity of portal hypertension. In the multivariate analysis, IL-8 protein levels were an independent predictor of 90-day mortality. IL-8 and Gro-alpha serum levels did not correlate with prognosis. CONCLUSIONS:Hepatic expression of CXC components correlates with prognosis of patients with AH. Reagents that target CXC chemokines might be developed as therapeutics.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Dominguez M,Miquel R,Colmenero J,Moreno M,García-Pagán JC,Bosch J,Arroyo V,Ginès P,Caballería J,Bataller R

doi

10.1053/j.gastro.2009.01.056

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

1639-50

issue

5

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(09)00160-7

journal_volume

136

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Effect of deoxycholic acid ingestion on bile acid metabolism and biliary lipid secretion in normal subjects.

    abstract：:The effect of deoxycholate ingestion, 750 mg per day, on bile acid kinetics, biliary bile acid composition, and biliary lipid secretion was studied in 7 healthy volunteers. Bile acid kinetics were measured by isotope dilution, and hourly outputs of bile acid, cholesterol, and phospholipid were quantitated by a duodena...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,评审

    doi：

    authors： LaRusso NF,Szczepanik PA,Hofmann AF

    更新日期：1977-01-01 00:00:00

  • Fundic inhibition of acid secretion and gastrin release in the dog.

    abstract：:In dogs provided with Heidenhain pouch and gastric fistula, we studied the effect of near-total excision of the fundic mucosa of the main stomach on acid secretion and gastrin release. Fundic mucosal excision abolished the mean response of the gastric fistula and reduced its maximal response to pentagastrin and to his...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Soon-Shiong P,Debas HT

    更新日期：1980-11-01 00:00:00

  • Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer.

    abstract：BACKGROUND & AIMS:Germline mutations of DNA mismatch repair genes are responsible for cancer susceptibility in hereditary nonpolyposis colorectal cancer (HNPCC) kindreds. Transforming growth factor beta type II receptor (TGF-beta RII) has been found to be somatically altered in HNPCC. The aim of this study was to clari...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(97)70216-6

    authors： Akiyama Y,Iwanaga R,Saitoh K,Shiba K,Ushio K,Ikeda E,Iwama T,Nomizu T,Yuasa Y

    更新日期：1997-01-01 00:00:00

  • Treatment of hepatocellular carcinoma by percutaneous tumor ablation methods: Ethanol injection therapy and radiofrequency ablation.

    abstract：:In Japan, approximately 30,000 patients died of hepatocellular carcinoma (HCC) in 2003. Ten percent had hepatitis B virus infection and 80% had hepatitis C virus (HCV) infection, indicating that viral hepatitis accounted for >90% of cases of HCC. In comparison, only 3% (1.5%, hepatitis B virus; 1.5%, HCV) of the gener...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2004.09.030

    authors： Omata M,Tateishi R,Yoshida H,Shiina S

    更新日期：2004-11-01 00:00:00

  • A small animal model of human Helicobacter pylori active chronic gastritis.

    abstract：:Isolation of a spiral-shaped bacterium closely related to Helicobacter pylori from the cat stomach made it possible to investigate new small animal models of gastric infection. Pure cultures of this bacterium, provisionally named "Helicobacter felis," were fed to germ-free mice. The organism colonized the stomach in l...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)91156-z

    authors： Lee A,Fox JG,Otto G,Murphy J

    更新日期：1990-11-01 00:00:00

  • Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers.

    abstract：BACKGROUND & AIMS:The accurate identification of inactive (serum HBV-DNA persistently

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.04.052

    authors： Brunetto MR,Oliveri F,Colombatto P,Moriconi F,Ciccorossi P,Coco B,Romagnoli V,Cherubini B,Moscato G,Maina AM,Cavallone D,Bonino F

    更新日期：2010-08-01 00:00:00

  • Pancreatic acinar cell function and morphology in rats fed zinc-deficient and marginal zinc-deficient diets.

    abstract：:The prevalence of marginal zinc nutriture in several populations of people in this country and the lack of reports on the effect of marginal zinc nutriture in experimental animals prompted us to look at pancreatic acinar cell function and morphology in rats fed a zinc-deficient diet ad libitum: 4 and 50 ppm zinc-suppl...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)90872-3

    authors： Perez-Jimenez F,Bockman DE,Singh M

    更新日期：1986-04-01 00:00:00

  • Favorable response to parenteral nutrition and medical therapy in Crohn's colitis. A report of 38 patients comparing severe Crohn's and ulcerative colitis.

    abstract：:The courses of 38 patients with severe, uncomplicated acute colitis (16 with Crohn's colitis and 22 with ulcerative colitis) were analyzed retrospectively. The patients were placed on total parenteral nutrition and treated concomitantly with corticosteroids, antibiotics (often metronidazole), sulfasalazine, and/or aza...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)90470-l

    authors： Sitzmann JV,Converse RL Jr,Bayless TM

    更新日期：1990-12-01 00:00:00

  • Intestinal permeability: an overview.

    abstract：:The noninvasive assessment of intestinal permeability in humans has a 20-year history. Because the tests are increasingly used in clinical practice and research and because there is much controversy, we reviewed the literature and outlined the potential and possible shortcomings of these procedures. Data was obtained ...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1016/0016-5085(95)90708-4

    authors： Bjarnason I,MacPherson A,Hollander D

    更新日期：1995-05-01 00:00:00

  • Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system.

    abstract：BACKGROUND & AIMS:In the intestines, Toll-like receptor 2 (TLR2) mediates immune responses to pathogens and regulates epithelial barrier function; polymorphisms in TLR2 have been associated with inflammatory bowel disease phenotype. We assessed the effects of TLR2 signaling on the enteric nervous system (ENS) in mice. ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2013.08.047

    authors： Brun P,Giron MC,Qesari M,Porzionato A,Caputi V,Zoppellaro C,Banzato S,Grillo AR,Spagnol L,De Caro R,Pizzuti D,Barbieri V,Rosato A,Sturniolo GC,Martines D,Zaninotto G,Palù G,Castagliuolo I

    更新日期：2013-12-01 00:00:00

  • Neurohumoral pathways mediating stress-induced changes in rat gastrointestinal transit.

    abstract：:Pharmacologic and surgical procedures were used to define the neurohumoral pathways that mediate stress-induced changes in gastrointestinal transit in the rat. Physical restraint (a validated stressor) resulted in significant inhibition of gastric emptying and small bowel transit but in stimulation of large bowel tran...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)91439-x

    authors： Lenz HJ

    更新日期：1989-07-01 00:00:00

  • Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis.

    abstract：BACKGROUND & AIMS:Interactions between genetic and environmental factors are believed to be involved in onset and initiation of inflammatory bowel disease. We analyzed the interaction between gastrointestinal mucosal microbiota and host genes in twin pairs discordant for ulcerative colitis (UC) to study the functional ...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1053/j.gastro.2011.04.011

    authors： Lepage P,Häsler R,Spehlmann ME,Rehman A,Zvirbliene A,Begun A,Ott S,Kupcinskas L,Doré J,Raedler A,Schreiber S

    更新日期：2011-07-01 00:00:00

  • Incidence, outcomes, and health services burden of very early onset inflammatory bowel disease.

    abstract：BACKGROUND & AIMS:The Paris pediatric modification of the Montreal classification defines very early onset inflammatory bowel disease (VEO-IBD) as a form of IBD distinct from that of older children. We compared the incidence and outcomes of VEO-IBD with those of IBD in older children. METHODS:We performed a population...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2014.06.023

    authors： Benchimol EI,Mack DR,Nguyen GC,Snapper SB,Li W,Mojaverian N,Quach P,Muise AM

    更新日期：2014-10-01 00:00:00

  • Quantitative endoscopic ultrasound elastography: an accurate method for the differentiation of solid pancreatic masses.

    abstract：BACKGROUND & AIMS:Qualitative endoscopic ultrasound (EUS) elastography is an accurate but subjective tool for the differential diagnosis of solid pancreatic masses. Second-generation EUS elastography allows quantitative analysis of tissue stiffness. We evaluated the accuracy of quantitative, second-generation EUS elast...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.06.059

    authors： Iglesias-Garcia J,Larino-Noia J,Abdulkader I,Forteza J,Dominguez-Munoz JE

    更新日期：2010-10-01 00:00:00

  • Intestinal vessels express a high density of somatostatin receptors in human inflammatory bowel disease.

    abstract：BACKGROUND/AIMS:The neuropeptide somatostatin exerts multiple functions in the gastrointestinal tract and may also play a regulatory role in inflammatory bowel disease, as several other neuropeptides do, e.g., substance P or calcitonin gene-related peptide. Therefore, the expression of somatostatin receptors was evalua...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(94)90754-4

    authors： Reubi JC,Mazzucchelli L,Laissue JA

    更新日期：1994-04-01 00:00:00

  • Hemosiderosis in cirrhosis: a study of 447 native livers.

    abstract：BACKGROUND & AIMS:Hemosiderosis may have a detrimental effect on some chronic liver diseases. The aim of this study was to determine the prevalence and diagnostic implications of hemosiderosis in cirrhosis. METHODS:Tissue iron in 447 cirrhotic livers was studied histologically and chemically. RESULTS:Positive iron st...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v112.pm9041250

    authors： Ludwig J,Hashimoto E,Porayko MK,Moyer TP,Baldus WP

    更新日期：1997-03-01 00:00:00

  • Human intestinal folate transport: cloning, expression, and distribution of complementary RNA.

    abstract：BACKGROUND & AIMS:Despite intensive investigations, very little is known about the molecular identity(ies) of the intestinal folate transport system(s), especially in humans. The aim of this study was to isolate a functional human intestinal folate carrier complementary DNA (cDNA) clone and determine the distribution o...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v112.pm9041240

    authors： Nguyen TT,Dyer DL,Dunning DD,Rubin SA,Grant KE,Said HM

    更新日期：1997-03-01 00:00:00

  • The effect of intrathecal opioid-receptor agonists on visceral noxious stimulation in rabbits.

    abstract：BACKGROUND & AIMS:Conflicting results have been published concerning the effects of different opioid-receptor agonists against visceral noxious stimulation. The introduction of colorectal distention facilitates research in this field. The aim of this study was to examine intrathecally administered opioid agonists again...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1996.v110.pm8536850

    authors： Borgbjerg FM,Frigast C,Madsen JB,Mikkelsen LF

    更新日期：1996-01-01 00:00:00

  • Absorption of short chain fatty acids from the human jejunum.

    abstract：:Jejunal absorption of acetate, propionate, and butyrate--the three predominant short chain fatty acids (SCFA's) in small and large intestinal contents--was studied in 5 volunteer subjects. A triple-lumen perfusion technique was employed; the test solutions were isotonic and contained 0, 5, 10, 25, 40, or 50 mM of a SC...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Schmitt MG Jr,Soergel KH,Wood CM

    更新日期：1976-02-01 00:00:00

  • Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells.

    abstract：BACKGROUND & AIMS:Cell-mediated immunity is a feature of Crohn's disease (CD). The heterodimer interleukin (IL)-12, produced by phagocytes, induces T-cell cytokines, primarily interferon (IFN)-gamma. This study examined whether CD lamina propria mononuclear cells (LPMCs) express and release bioactive IL-12. METHODS:LP...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(97)70128-8

    authors： Monteleone G,Biancone L,Marasco R,Morrone G,Marasco O,Luzza F,Pallone F

    更新日期：1997-04-01 00:00:00

  • Granulocytopenia complicating colchicine therapy for primary biliary cirrhosis.

    abstract：:A case is presented of a 76-yr-old woman with primary biliary cirrhosis and adult polycystic liver disease who developed bone marrow toxicity associated with chronic low-dose colchicine therapy. Two months after starting colchicine therapy (0.6 mg b.i.d. p.o.), the patient developed hematologic toxicity as evidenced b...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(87)90249-6

    authors： Finklestein M,Goldman L,Grace ND,Foley M,Randall N

    更新日期：1987-12-01 00:00:00

  • Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin.

    abstract：:The onset, course, and regression of the biochemical and structural alterations associated with pancreatitis induced by various doses of caerulein were studied in the mouse. In addition, the protective effect of secretin was compared with that of the cholecystokinin-receptor antagonists proglumide and benzotript. Subc...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(85)80079-2

    authors： Niederau C,Ferrell LD,Grendell JH

    更新日期：1985-05-01 00:00:00

  • Bile and stone analysis in two infants with brown pigment gallstones and infected bile.

    abstract：:Two infants under 3 mo of age who presented with obstructive jaundice secondary to cholelithiasis are reported. Neither infant had any congenital anatomic abnormality of the biliary tract leading to stasis, yet both had cultures of gallbladder bile that grew abundant bacteria. In both, recovery of gallbladder bile and...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(89)91579-5

    authors： Treem WR,Malet PF,Gourley GR,Hyams JS

    更新日期：1989-02-01 00:00:00

  • Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis.

    abstract：BACKGROUND & AIMS:The majority of patients with Helicobacter pylori infection have autoantibodies cross-reacting with gastric antigens. In this study, the relation between autoantibody status, histopathology of body mucosa, and antigenic profile of H. pylori was investigated. METHODS:One hundred patients were examined...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1996.v111.pm8780570

    authors： Negrini R,Savio A,Poiesi C,Appelmelk BJ,Buffoli F,Paterlini A,Cesari P,Graffeo M,Vaira D,Franzin G

    更新日期：1996-09-01 00:00:00

  • Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis.

    abstract：BACKGROUND & AIMS:We have shown previously that cure of Helicobacter pylori infection leads to the disappearance of acid-neutralizing substances. Also, patients with ulcer after cure may gain weight. The aim of this study was to investigate whether cure of the infection increases the risk of reflux esophagitis. METHOD...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0016-5085(97)70024-6

    authors： Labenz J,Blum AL,Bayerdörffer E,Meining A,Stolte M,Börsch G

    更新日期：1997-05-01 00:00:00

  • Inward growth of colonic adenomatous polyps.

    abstract：BACKGROUND & AIMS:Most colon cancers arise from polypoid adenomas, but how these benign lesions develop into malignant neoplasms is not understood. This study examined the migration of epithelial cells within human adenomatous polyps by determining the distribution of proliferating and apoptotic cells and immunoreactiv...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(96)70003-3

    authors： Moss SF,Liu TC,Petrotos A,Hsu TM,Gold LI,Holt PR

    更新日期：1996-12-01 00:00:00

  • An international multicenter real-life prospective study of electronic chromoendoscopy score PICaSSO in Ulcerative Colitis.

    abstract：BACKGROUND & AIMS:Endoscopic and Histologic remission are important goals in the treatment of ulcerative colitis (UC). We investigated the correlation of the recently developed Paddington International Virtual ChromoendoScopy ScOre( PICaSSO) and other established endoscopic scores against multiple histological indices ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2020.12.024

    authors： Iacucci M,Smith SC,Bazarova A,Shivaji UN,Bhandari P,Cannatelli R,Daperno M,Ferraz J,Goetz M,Gui X,Hayee B,De Hertogh G,Lazarev M,Li J,Nardone OM,Parra-Blanco A,Pastorelli L,Panaccione R,Occhipinti V,Rath T,Tontini

    更新日期：2020-12-18 00:00:00

  • Abnormal plasma lipoproteins and lecithin-cholesterol acyltransferase deficiency in alcoholic liver disease.

    abstract：:Serial studies of plasma lipids and lipoproteins were performed in 4 patients with acute alcoholic liver disease characterized by a massive fatty liver and laboratory evidence of intrahepatic cholestasis. There were striking alterations in the plasma lipoprotein electrophoretic patterns characterized by the absence of...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Sabesin SM,Hawkins HL,Kuiken L,Ragland JB

    更新日期：1977-03-01 00:00:00

  • Parietal cell antibodies in pernicious anemia inhibit H+, K+-adenosine triphosphatase, the proton pump of the stomach.

    abstract：:Antibodies to a membrane-bound antigen, localized to the canalicular structures of the parietal cell, are found in most sera of patients with chronic atrophic gastritis and pernicious anemia. In the present study immunoglobulins containing parietal cell antibodies were found to inhibit the activity of H+,K+-adenosine ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)90509-x

    authors： Burman P,Mårdh S,Norberg L,Karlsson FA

    更新日期：1989-06-01 00:00:00

  • Spontaneous bacterial empyema in cirrhosis.

    abstract：:Spontaneous bacterial peritonitis in decompensated cirrhotic patients develops when bacteria invade preexising ascites. It is probable that other transudates such as pleural effusions can be afected in a similar manner. This paper describes a cirrhotic patient with long-standing pleural effusion in whom Escherichia co...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Flaum MA

    更新日期：1976-03-01 00:00:00