Abstract：
:Serial studies of plasma lipids and lipoproteins were performed in 4 patients with acute alcoholic liver disease characterized by a massive fatty liver and laboratory evidence of intrahepatic cholestasis. There were striking alterations in the plasma lipoprotein electrophoretic patterns characterized by the absence of alpha- and pre-beta-lipoprotein bands and the presence of a single band of abnormal mobility. These changes were associated with an extreme decrease in plasma lecithin-cholesterol acyltransferase activity, resulting in greatly reduced levels of plasma cholesteryl esters and increased levels of unesterified cholesterol. In 2 patients hypertriglyceridemia and hypercholesterolemia were present, the latter because of an increase in unesterified cholesterol. Lipoproteins were isolated from the plasma by sequential ultracentrifugation at the densities used for separation of normal very low density, low density, and high density lipoproteins; however, the patients' lipoproteins were different from normal in lipid composition and ultrastructure. All of the lipoprotein fractions were decreased in cholesteryl esters and the major lipoprotein was a triglyceride-rich low density lipoprotein. Electron microscopic studies of the low and high density lipoprotein fractions revealed the presence of bilamellar vesicles and stacked discs. All of the changes in lipoprotein composition and ultrastructure gradually returned to normal with clinical improvement. These observations indicate that alcoholic liver injury is associated with profound alterations in lipoprotein composition and metabolism which may be related in part to lecithin-cholesterol acyltransferase deficiency.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Sabesin SM,Hawkins HL,Kuiken L,Ragland JBsubject
Has Abstractpub_date
1977-03-01 00:00:00pages
510-8issue
3eissn
0016-5085issn
1528-0012pii
S0016508577000651journal_volume
72pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：:The human gastrointestinal tract contains distinct microbial communities that differ in composition and function based on their location, as well as age, sex, race/ethnicity, and diet of their host. We describe the bacterial taxa present in different locations of the GI tract, and their specific metabolic features. Th...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2014.01.052
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND & AIMS:Significant improvements in management of hepatocellular carcinoma (HCC) have occurred in the last years, but their impact on surveillance outcome is unknown. To clarify this, we compared survival of HCC patients identified along 3 consecutive quinquennia of surveillance. METHODS:A cohort of 417 HCC-...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2003.12.049
更新日期：2004-04-01 00:00:00
abstract：:Mucins synthesized in colonic cancer are known to be different from those in the normal colon; however, the biochemical differences between these mucins have not been defined. We have purified mucins from samples of nonneoplastic (normal) human colon and colon cancer and found that the carbohydrate content of the canc...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(90)90330-4
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND & AIMS:Prostaglandin-endoperoxide synthase (Ptgs)2 is an enzyme involved in prostaglandin production during the response to mucosal damage. Its expression is regulated, in part, by messenger RNA (mRNA)-binding proteins that control the stability of Ptgs2 mRNA. We used a precise system of colonic injury and r...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2012.03.037
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND/AIMS:Capillarization of the hepatic sinusoid occurs in alcoholic liver disease. Because endothelial cell proliferation is relevant to capillarization, we used the intragastric feeding rat model to evaluate the relationship between pathological liver injury and endothelial cell proliferation. METHODS:Male Wi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(94)90132-5
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND AND AIMS:The mammalian intestinal epithelium self-renews rapidly and homeostasis is preserved via tightly controlled mechanisms. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions, but little is known about their role in maintaining the integrity of the inte...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.10.009
更新日期：2018-02-01 00:00:00
abstract：:Gastric and esophageal emptying were assessed using scintigraphic techniques in 12 patients with progressive systemic sclerosis and 22 normal volunteers. Esophageal emptying was significantly delayed in the patient group, with 7 of the 12 patients beyond the normal range. Gastric emptying was slower in patients than i...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:Abdominal cramps and urgent defecation are common side effects of clinical doses of arginine vasopressin, indicating that the drug may have stimulating effects on colonic motor activity. Four strain-gauge transducers were implanted on the colon in six monkeys. A blood flow probe was fixed on the inferior mesenteric ar...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)90171-t
更新日期：1992-03-01 00:00:00
abstract：:Endogenous pancreatic prostaglandin production in control and obstructive jaundice was investigated using isolated and perfused dog pancreas. In both groups, spontaneous production of prostaglandin E2 and prostaglandin I2 was recorded, and the levels did not change in both groups. The production of both prostaglandins...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(90)90347-4
更新日期：1990-05-01 00:00:00
abstract：:The diagnosis of inflammatory bowel disease (IBD) with its 2 main subforms, Crohn's disease and ulcerative colitis, is based on clinical, endoscopic, radiologic, and histologic criteria. This paradigm remains unchanged despite the advent of new molecular technologies for the examination of serum proteins and genetic s...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2007.09.001
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND & AIMS:Indomethacin impairs liver microsomal monooxygenase activities mediated by cytochrome P450 (CYP). We investigated the inhibition mechanism and the isoform selectivity in vitro and in vivo. METHODS:In an in vitro study, liver microsomes from male Wistar rats were preincubated with indomethacin and a r...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2002.31886
更新日期：2002-03-01 00:00:00
abstract：:A patient who developed symptomatic giardiasis after a tour of the Soviet Union is presented. The diagnosis was established by duodenal aspiration. A small intestinal biopsy revealed total villous atrophy in the absence of celiac sprue or a gastrointestinal immunodeficiency syndrome, a finding not previously described...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1978-02-01 00:00:00
abstract：BACKGROUND:The molecular basis of colorectal dysplasia and carcinoma arising in ulcerative colitis is poorly understood. Loss of heterozygosity involving the tumor suppressor gene p53 occurs frequently in neoplastic ulcerative colitis lesions. Point mutation affecting p53 is associated with loss of heterozygosity in ot...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(93)90639-t
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND & AIMS:Refractory gastroesophageal reflux disease (GERD) reduces quality of life and creates significant financial burden on the health care system. Approximately 30% of patients with GERD who receive label-dose proton pump inhibitors (PPIs) still have symptoms. We performed a trial to evaluate the efficacy ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2020.02.031
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND & AIMS:Protein kinase C (PKC) has been implicated as a mediator of growth control during colorectal carcinogenesis, but the mechanisms involved are still a matter of dispute. The aim of this study was to analyze PKC patterns and tissue distribution to gain further insight in PKC function during tumor develop...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1996.v110.pm8964400
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND & AIMS:Ethanol causes both tolerance and sensitization of Kupffer cells. This study was designed to evaluate temporal effects of ethanol in an attempt to understand this paradox. METHODS:Rats were given ethanol (4 g/kg body wt) intragastrically, and Kupffer cells were isolated 0-48 hours later. After additi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(98)70211-2
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND & AIMS:Reactive oxidative species (ROS) are believed to be involved in the progression of nonalcoholic steatohepatitis (NASH). However, little is known about the sources of ROS in hepatocytes or their role in disease progression. We studied the effects of nicotinamide adenine dinucleotide phosphate reduced o...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2015.04.009
更新日期：2015-08-01 00:00:00
abstract：:One hundred Chinese patients who received induction cytotoxic therapy for malignant lymphoma were prospectively studied to determine the incidence, morbidity, mortality, and predisposing factors for reactivation of hepatitis B virus replication during cytotoxic therapy. In 18 (67%) hepatitis B surface antigen-positive...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90599-g
更新日期：1991-01-01 00:00:00
abstract：:The effects of some newly developed tachykinin antagonists that are selective for the neurokinin (NK)-1 (L 668,169) or the NK-2 (MEN 10,207, L 659,877 and R 396) tachykinin receptor on the cholinergic and noncholinergic contraction and on the nonadrenergic noncholinergic relaxation produced by electrical field stimula...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)91787-5
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND/AIMS:The gastrointestinal tract is a major target of insulinlike growth factor (IGF) I. IGF-I binds to two different receptors and to binding proteins (IGFBPs), which act as carriers and mediators. This study investigated the regulation of IGF-I binding sites in rat colitis. METHODS:Colitis was induced by c...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(95)90435-2
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND & AIMS:We aimed to characterize offers of organs to candidates awaiting liver transplantation (LT). METHODS:We analyzed data from the United Network for Organ Sharing registry on all US LT candidates with nonfulminant disease who were offered livers from February 1, 2005, to January 31, 2010, and ultimately...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2012.07.105
更新日期：2012-11-01 00:00:00
abstract：:In seven healthy volunteers pure pancreatic juice was obtained by endoscopic cannulation of the papilla of Vater. Synthetic secretin was intravenously infused in doses doubled every 20 min. The volume of pancreatic juice was proportional to the log of the secretin dose. A significant rise (P less than 0.05) in pancrea...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
abstract：BACKGROUND & AIMS:The activation of Wnt/beta-catenin signaling causes the development of gastric and colon cancers. Sox17 represses Wnt/beta-catenin signaling and is down-regulated in colon cancer. This study was designed to elucidate the role of Sox17 during the course of gastrointestinal tumorigenesis. METHODS:Sox17...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2009.06.041
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND & AIMS:Lactase-phlorizin hydrolase (LPH) is an intestinal microvillus membrane glycoprotein that hydrolyzes lactose and phlorizin. These enzymatic activities have been assigned to glutamic acid (E) residues 1271 and 1747 in rabbit LPH. The aim of this study was to determine directly if this assignment was co...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(95)90583-9
更新日期：1995-10-01 00:00:00
abstract：BACKGROUND & AIMS:Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2020.08.052
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND/AIMS:Ursodeoxycholic acid (UDCA) and colchicine have beneficial effects in primary biliary cirrhosis (PBC). The efficacy of colchicine and UDCA in PBC was compared in a 2-year placebo-controlled study (n = 90). METHODS:Clinical events, laboratory test results, and liver histology were recorded at the beginn...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/0016-5085(95)90696-7
更新日期：1995-05-01 00:00:00
abstract：:From 1979 to 1984, we followed the cases of 3 men (aged 13, 31, and 75 yr) and 2 women (aged 38 and 45 yr who had never used oral contraceptives) suffering from liver adenomatosis, an uncommon lesion consisting of numerous benign adenomas in an otherwise normal hepatic parenchyma. During the same period, we observed 2...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
abstract：:Although long-term parenteral nutrition is lifesaving in patients with intestinal failure, it is expensive and associated with serious complications such as catheter sepsis, venous occlusions, and liver failure and severely impairs the quality of life in the short bowel patients. Therefore, treatments that increase th...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2005.09.068
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND & AIMS:Capillarization of the sinusoids in cirrhosis is proposed to reduce oxygen availability to the hepatocyte, resulting in the patterns of altered drug metabolism observed in cirrhosis. If this were true, drug metabolism in cirrhotic livers would be expected to be more sensitive to reduced oxygen deliver...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(96)70073-2
更新日期：1996-10-01 00:00:00
abstract：:Methyl tert-butyl ether dissolves cholesterol gallbladder stones when infused through a percutaneous transhepatic catheter. All gallstones, however, contain noncholesterol components that are insoluble in lipid solvents and may be too large to be aspirated through a small catheter or flushed from the gallbladder. To i...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(12)90345-5
更新日期：1990-05-01 00:00:00
