Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control.

abstract：:Random fecal alpha 1-antitrypsin levels were determined in 34 patients, 24 with Crohn's disease, and 10 "controls" having diarrheal illnesses not associated with intestinal protein loss, in an effort to evaluate its usefulness as a measure of Crohn's disease intestinal activity. In the control group, all alpha 1-antit...

journal_title：Gastroenterology

authors： Meyers S,Wolke A,Field SP,Feuer EJ,Johnson JW,Janowitz HD

更新日期：1985-07-01 00:00:00

abstract：:A 45-minute infusion of an octapeptide of cholecystokinin (Kinevac; Squibb Diagnostics, New Brunswick, NJ) was used to measure the gallbladder ejection fraction during cholescintigraphy in 40 normal volunteers. Cholecystokinin cholescintigraphy was shown to be a reproducible test. The maximum mean gallbladder ejection...

journal_title：Gastroenterology

authors： Yap L,Wycherley AG,Morphett AD,Toouli J

更新日期：1991-09-01 00:00:00

abstract：:Thirty-five 1-day-old Pekin-Aylesbury ducks were inoculated intravenously or intraperitoneally with duck hepatitis B virus, and the time-course of infection was examined by Southern-blot, dot-blot, and in situ hybridization and by immunohistochemistry. Randomly scattered single infected hepatocytes were first seen on ...

journal_title：Gastroenterology

authors： Jilbert AR,Freiman JS,Burrell CJ,Holmes M,Gowans EJ,Rowland R,Hall P,Cossart YE

更新日期：1988-11-01 00:00:00

abstract：:In this study, quantitation of the epithelial proliferation status of gastric glands and duodenal crypts was performed using endoscopic biopsy specimens from patients with rheumatological conditions requiring long-term anti-inflammatory and analgesic therapy, testing the hypothesis that long-term administration of non...

journal_title：Gastroenterology

authors： Levi S,Goodlad RA,Lee CY,Walport MJ,Wright NA,Hodgson HJ

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND & AIMS:The goal of the study was to facilitate fat balance measurements with an appropriate intestinal marker for the transit of dietary fat and thereby eliminate the need for complete diet and fecal collections. METHODS:Dietary fat containing 5% sucrose polybehenate was fed in a semisynthetic diet to rats ...

journal_title：Gastroenterology

authors： Jandacek RJ,Heubi JE,Tso P

更新日期：2004-07-01 00:00:00

abstract：:The role of leukotrienes in the pathogenesis of chronic colitis was investigated using a rat model. Ulceration and inflammation of the distal colon was initiated by the intracolonic administration of the hapten trinitrobenzene sulfonic acid in 50% ethanol. Leukotriene B4 synthesis increased significantly within 4 h af...

journal_title：Gastroenterology

authors： Wallace JL,MacNaughton WK,Morris GP,Beck PL

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND & AIMS:Several studies have reported that low doses of interferon can delay the development of hepatocellular carcinoma (HCC) and progression of chronic hepatitis C. We investigated the incidence of clinical events among participants of the Evaluation of PegIntron in Control of Hepatitis C Cirrhosis (EPIC)3 ...

journal_title：Gastroenterology

authors： Bruix J,Poynard T,Colombo M,Schiff E,Burak K,Heathcote EJ,Berg T,Poo JL,Mello CB,Guenther R,Niederau C,Terg R,Bedossa P,Boparai N,Griffel LH,Burroughs M,Brass CA,Albrecht JK,EPIC3 Study Group.

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:The I1307K allele of the APC gene has been shown to confer a modestly elevated risk of colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5-1.7). However, it is unclear whether the alteration predisposes to adenomas and whether the genetic information can be used in clinical practi...

journal_title：Gastroenterology

authors： Stern HS,Viertelhausen S,Hunter AG,O'Rourke K,Cappelli M,Perras H,Serfas K,Blumenthall A,Dewar D,Baumann E,Lagarde AE

更新日期：2001-02-01 00:00:00

abstract：:The aim of the present study was to characterize rat mucosal colonic cells harvested from the crypt continuum during differentiation and dimethylhydrazine-induced neoplasia. The collection of colonocytes was performed using a modified nonenzymatic isolation procedure based on Ca2+ chelation and gentle mechanical disso...

journal_title：Gastroenterology

authors： Schwartz B,Avivi C,Lamprecht SA

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND & AIMS:Dkk1 is a secreted antagonist of the Wnt/β-catenin signaling pathway. It is induced by inflammatory cytokines during colitis and exacerbates tissue damage by promoting apoptosis of epithelial cells. However, little is known about the physiologic role of Dkk1 in normal intestinal homeostasis and during...

journal_title：Gastroenterology

authors： Koch S,Nava P,Addis C,Kim W,Denning TL,Li L,Parkos CA,Nusrat A

更新日期：2011-07-01 00:00:00

abstract：:Circulating precursors of mucosal immunoglobulin A plasma cells and T-cell immunoblasts migrate selectively into mucosal sites from the blood, but the mechanisms controlling this selective trafficking have not been determined. One possibility is that the site-specific extravasation of circulating effector cell populat...

journal_title：Gastroenterology

authors： Schmitz M,Nunez D,Butcher EC

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatopulmonary syndrome (HPS) affects 10%-30% of patients with cirrhosis and portal hypertension and significantly increases mortality. Studies in experimental models indicate that pulmonary angiogenesis contributes to the development of HPS, but pathogenesis in humans is poorly understood. We invest...

journal_title：Gastroenterology

authors： Roberts KE,Kawut SM,Krowka MJ,Brown RS Jr,Trotter JF,Shah V,Peter I,Tighiouart H,Mitra N,Handorf E,Knowles JA,Zacks S,Fallon MB,Pulmonary Vascular Complications of Liver Disease Study Group.

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:High-level coffee consumption has been associated with reduced progression of pre-existing liver diseases and lower risk of hepatocellular carcinoma. However, its relationship with therapy for hepatitis C virus infection has not been evaluated. METHODS:Patients (n=885) from the lead-in phase of the H...

journal_title：Gastroenterology

authors： Freedman ND,Curto TM,Lindsay KL,Wright EC,Sinha R,Everhart JE,HALT-C TRIAL GROUP.

更新日期：2011-06-01 00:00:00

abstract：:We investigated whether intrapancreatic coagulation, with deposition of the fibrinogen-γ dimer (Fib-γD) and hypoxia, affect the severity of acute pancreatitis (AP) in mice. Pancreata of mice with AP induced by administration of cerulein or by L-arginine, or from patients with pancreatitis, had increased deposition of ...

journal_title：Gastroenterology

authors： Park MJ,Iyer S,Xue X,Bragazzi Cunha J,Gu S,Moons D,Pipe SW,Williams JA,Simeone DM,Shah YM,Omary MB

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with chronic hepatitis C and persistently normal alanine aminotransferase (ALT) levels have been routinely excluded from large randomized treatment trials; consequently, the efficacy and safety of antiviral therapy in this population are unknown. METHODS:Patients with at least 3 normal ALT v...

journal_title：Gastroenterology

authors： Zeuzem S,Diago M,Gane E,Reddy KR,Pockros P,Prati D,Shiffman M,Farci P,Gitlin N,O'Brien CB,Lamour F,Lardelli P,PEGASYS Study NR16071 Investigator Group.

更新日期：2004-12-01 00:00:00

abstract：:Endoscopic submucosal dissection was developed in Japan, early in this century, to provide a minimally invasive yet curative treatment for the large numbers of patients with early gastric cancer identified by the national screening program. Previously, the majority of these patients were treated surgically at substant...

journal_title：Gastroenterology

authors： Bourke MJ,Neuhaus H,Bergman JJ

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND & AIMS:Three-dimensional (3D) ultrasound imaging of the total stomach volume has not yet been achieved. The aim of this study was to investigate whether a magnetic position sensor system for acquisition of 3D ultrasonograms could be used to determine gastric emptying rates and intragastric distribution. MET...

journal_title：Gastroenterology

authors： Gilja OH,Detmer PR,Jong JM,Leotta DF,Li XN,Beach KW,Martin R,Strandness DE Jr

更新日期：1997-07-01 00:00:00

abstract：:A monoclonal antibody to bromodeoxyuridine was used in tissue specimens previously incubated with bromodeoxyuridine to show S-phase cells by immunohistochemical technique. Biopsy specimens of normal mucosa (n = 10), hyperplastic polyps (n = 10), adenomas with low-grade dysplasia (n = 20), adenomas with high-grade dysp...

journal_title：Gastroenterology

authors： Risio M,Coverlizza S,Ferrari A,Candelaresi GL,Rossini FP

更新日期：1988-04-01 00:00:00

abstract：:Spontaneous bacterial peritonitis in decompensated cirrhotic patients develops when bacteria invade preexising ascites. It is probable that other transudates such as pleural effusions can be afected in a similar manner. This paper describes a cirrhotic patient with long-standing pleural effusion in whom Escherichia co...

journal_title：Gastroenterology

authors： Flaum MA

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND & AIMS:Elevated hepatic iron concentration may affect the response to antiviral therapy in chronic hepatitis C. This study explored the contribution of genetic hemochromatosis to iron accumulation in chronic hepatitis C. METHODS:HFE mutations (C282Y and H63D) were assessed in 184 patients with chronic hepat...

journal_title：Gastroenterology

authors： Kazemi-Shirazi L,Datz C,Maier-Dobersberger T,Kaserer K,Hackl F,Polli C,Steindl PE,Penner E,Ferenci P

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND & AIMS:Intrahepatic bile ducts express a range of lymphocyte adhesion molecules during episodes of inflammation. This may contribute to the susceptibility of biliary epithelium to immunologic damage during liver allograft rejection, graft-versus-host disease, and primary biliary cirrhosis. However, no previo...

journal_title：Gastroenterology

authors： Leon MP,Bassendine MF,Gibbs P,Thick M,Kirby JA

更新日期：1997-03-01 00:00:00

abstract：:Previous studies suggested that the food-containing canine stomach retains large, nondigestible spheres until all food has emptied; but it is not known whether there is a threshold size or a gradation of sizes that will empty along with food. Further, nothing is known of the effects of such parameters as density, shap...

journal_title：Gastroenterology

authors： Meyer JH,Dressman J,Fink A,Amidon G

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND & AIMS:The comparative effectiveness of sigmoidoscopy and fecal immunochemical testing (FIT) for colorectal cancer (CRC) screening is unknown. METHODS:Individuals aged 50-74 years living in Southeast Norway were randomly invited between 2012 and 2019 to either once-only flexible sigmoidoscopy or FIT screeni...

journal_title：Gastroenterology

authors： Randel KR,Schult AL,Botteri E,Hoff G,Bretthauer M,Ursin G,Natvig E,Berstad P,Jørgensen A,Sandvei PK,Olsen ME,Frigstad SO,Darre-Næss O,Norvard ER,Bolstad N,Kørner H,Wibe A,Wensaas KA,de Lange T,Holme Ø

更新日期：2020-11-21 00:00:00

abstract：:In a series of in vitro studies, both the soluble (plasmatic) coagulation system and the cellular (platelet-mediated) aspect of coagulation were shown to be extremely sensitive to relatively minor increases in hydrogen ion concentration. All studies became abnormal at pH 6.8. At pH 6.4, assays of the intrinsic and ext...

journal_title：Gastroenterology

authors： Green FW Jr,Kaplan MM,Curtis LE,Levine PH

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic and epigenetic alterations contribute to the pathogenesis of colorectal cancer (CRC). There is considerable molecular heterogeneity among colorectal tumors, which appears to arise as polyps progress to cancer. This heterogeneity results in different pathways to tumorigenesis. Although epigenet...

journal_title：Gastroenterology

authors： Luo Y,Wong CJ,Kaz AM,Dzieciatkowski S,Carter KT,Morris SM,Wang J,Willis JE,Makar KW,Ulrich CM,Lutterbaugh JD,Shrubsole MJ,Zheng W,Markowitz SD,Grady WM

更新日期：2014-08-01 00:00:00

abstract：:First, and most importantly, the standard of care for treating adenomatous polyps is polypectomy and not therapy with NSAIDs. The initial clinical observation by Waddell and Loughry in 1983 that sulindac treatment influenced rectal polyps in patients with FAP has led to a considerable amount of research, commentary, a...

journal_title：Gastroenterology

authors： DuBois RN

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND & AIMS:Proinflammatory cytokines alter function in enteric nerves, but little is known about underlying mechanisms. This study was designed to investigate the roles of prostanoids and of macrophage-like cells in cytokine-induced suppression of [3H]norepinephrine release from rat myenteric plexus. METHODS:Th...

journal_title：Gastroenterology

authors： Rühl A,Berezin I,Collins SM

更新日期：1995-12-01 00:00:00

abstract：:We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for d...

journal_title：Gastroenterology

authors： Dedhia PH,Bertaux-Skeirik N,Zavros Y,Spence JR

更新日期：2016-05-01 00:00:00

abstract：:In some patients with hiatus hernia, vomiting may propel a plug of redundant gastric mucosa into the distal esophagus, where it becomes incarcerated and engorged. Significant bleeding may result. Reduction of the hernia controls the hemorrhage. Endoscopy after the acute episode may demonstrate a gastric mucosal lesion...

journal_title：Gastroenterology

authors： Laforet EG

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND & AIMS:Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate into hepatocytes. Little is known about the mechanisms of LPC differentiation. We used zebrafish and mouse models of liver injury to study the ...

journal_title：Gastroenterology

authors： Ko S,Russell JO,Tian J,Gao C,Kobayashi M,Feng R,Yuan X,Shao C,Ding H,Poddar M,Singh S,Locker J,Weng HL,Monga SP,Shin D

更新日期：2019-01-01 00:00:00