Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma.

abstract：BACKGROUND & AIMS:Early growth response gene-1 (Egr-1) is an important inflammatory transcription factor. We hypothesize that leukocyte-derived Egr-1 plays a key inflammatory role in causing postoperative ileus. METHODS:Wild-type, Egr-1 knockout, and chimera mice (constructed by irradiation followed by injection with ...

journal_title：Gastroenterology

authors： Schmidt J,Stoffels B,Moore BA,Chanthaphavong RS,Mazie AR,Buchholz BM,Bauer AJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND & AIMS:: At least half of patients with chronic hepatitis C virus (HCV) fail to respond to interferon or interferon/ribavirin therapy. Histological improvement is observed in some nonresponders. We conducted a randomized, controlled trial to determine if maintenance interferon therapy could prevent histologi...

journal_title：Gastroenterology

authors： Shiffman ML,Hofmann CM,Contos MJ,Luketic VA,Sanyal AJ,Sterling RK,Ferreira-Gonzalez A,Mills AS,Garret C

更新日期：1999-11-01 00:00:00

abstract：:Decreases in arterial pH markedly increase sodium, chloride, and water absorption in the normal ileum and can reverse ongoing cholera toxin-induced secretion. In the current study we examined whether these effects of pH are evident in other models of ileal secretion, and in a model of increased absorption. Rats were a...

journal_title：Gastroenterology

authors： Charney AN,Ingrassia PM,Thaler SM,Keane MG

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND & AIMS:Galectin-3 is a beta-galactoside-binding protein implicated in tumor progression and metastasis of colorectal cancers. To determine whether circulating galectin-3 ligands are related to the presence of colon cancer, we sought to identify and quantify ligands in serum that bind to galectin-3. METHODS:...

journal_title：Gastroenterology

authors： Bresalier RS,Byrd JC,Tessler D,Lebel J,Koomen J,Hawke D,Half E,Liu KF,Mazurek N,Great Lakes-New England Clinical and Epidemiology Center of the Early Detection Research Network.

更新日期：2004-09-01 00:00:00

abstract：:Skin tests and measurement of serum levels of immunoglobulin E do not accurately identify foods for elimination from the diets of patients with eosinophilic esophagitis (EoE). We investigated whether an esophageal prick test, in which the esophageal mucosa is challenged by local injection of allergen extracts, could i...

journal_title：Gastroenterology

authors： Warners MJ,Terreehorst I,van den Wijngaard RM,Akkerdaas J,van Esch BCAM,van Ree R,Versteeg SA,Smout AJPM,Bredenoord AJ

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic variations in proinflammatory and anti-inflammatory cytokine genes influence individual response to carcinogenic exposures. Polymorphisms in interleukin (IL)-1 beta and its endogenous receptor antagonist are associated with risk of Helicobacter pylori-related gastric cancer. The aim of this st...

journal_title：Gastroenterology

authors： El-Omar EM,Rabkin CS,Gammon MD,Vaughan TL,Risch HA,Schoenberg JB,Stanford JL,Mayne ST,Goedert J,Blot WJ,Fraumeni JF Jr,Chow WH

更新日期：2003-05-01 00:00:00

abstract：:With a worldwide prevalence of 15%, chronic constipation is one of the most frequent gastrointestinal diagnoses made in ambulatory medicine clinics, and is a common source cause for referrals to gastroenterologists and colorectal surgeons in the United States. Symptoms vary among patients; straining, incomplete evacua...

journal_title：Gastroenterology

authors： Bharucha AE,Lacy BE

更新日期：2020-04-01 00:00:00

abstract：:Adverse effects associated with nonsteroidal antiinflammatory drug treatment are reported more commonly to regulatory authorities than the adverse effects of any other form of treatment. Epidemiologic evidence in general suggests a doubling or quadrupling of the risk of ulcer complications or death in recipients of su...

journal_title：Gastroenterology

authors： Langman MJ

更新日期：1989-02-01 00:00:00

abstract：:Cholinergic innervation in the aganglionic bowel of the piebald lethal mouse model of Hirschsprung's disease was investigated by analysis of muscarinic acetylcholine receptors before and after administration of hexamethonium. After hexamethonium administration in the normal rectum, the maximum specific binding (Bmax) ...

journal_title：Gastroenterology

authors： Ueki S,Okamoto E,Kuwata K,Toyosaka A,Nagai K

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND & AIMS:Few studies, even those with cohort designs, test the mediating effects of infant gut microbes and metabolites on the onset of disease. We undertook such a study. METHODS:Using structural equation modeling path analysis, we tested directional relationships between first pregnancy, birth mode, prolong...

journal_title：Gastroenterology

authors： Vu K,Lou W,Tun HM,Konya TB,Morales-Lizcano N,Chari RS,Field CJ,Guttman DS,Mandal R,Wishart DS,Azad MB,Becker AB,Mandhane PJ,Moraes TJ,Lefebvre DL,Sears MR,Turvey SE,Subbarao P,Scott JA,Kozyrskyj AL

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND & AIMS:Molecules that regulate T-cell adhesion to hepatic endothelium and thereby recirculation of T cells to the liver are poorly understood. Because the adhesion molecule vascular adhesion protein-1 (VAP-1), which mediates lymphocyte binding to lymph node endothelium, is expressed on hepatic endothelium, i...

journal_title：Gastroenterology

authors： McNab G,Reeves JL,Salmi M,Hubscher S,Jalkanen S,Adams DH

更新日期：1996-02-01 00:00:00

abstract：:A patient who developed symptomatic giardiasis after a tour of the Soviet Union is presented. The diagnosis was established by duodenal aspiration. A small intestinal biopsy revealed total villous atrophy in the absence of celiac sprue or a gastrointestinal immunodeficiency syndrome, a finding not previously described...

journal_title：Gastroenterology

authors： Levinson JD,Nastro LJ

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND & AIMS:Tumors that develop in patients with Crohn's disease tend be multifocal, so field cancerization (the replacement of normal cells with nondysplastic but tumorigenic clones) might contribute to intestinal carcinogenesis. We investigated patterns of tumor development from pretumor intestinal cell clones....

journal_title：Gastroenterology

authors： Galandiuk S,Rodriguez-Justo M,Jeffery R,Nicholson AM,Cheng Y,Oukrif D,Elia G,Leedham SJ,McDonald SA,Wright NA,Graham TA

更新日期：2012-04-01 00:00:00

abstract：:Electronic (video) endoscopes are a significant new development in gastroenterology, offering the potential of enhanced teaching and permanent storage of pictorial data. The primary concern of gastroenterologists is the resolution and color performance of these instruments, as these parameters have important bearings ...

journal_title：Gastroenterology

authors： Knyrim K,Seidlitz H,Vakil N,Hagenmüller F,Classen M

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND & AIMS:The Paris pediatric modification of the Montreal classification defines very early onset inflammatory bowel disease (VEO-IBD) as a form of IBD distinct from that of older children. We compared the incidence and outcomes of VEO-IBD with those of IBD in older children. METHODS:We performed a population...

journal_title：Gastroenterology

authors： Benchimol EI,Mack DR,Nguyen GC,Snapper SB,Li W,Mojaverian N,Quach P,Muise AM

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Mutant hepatitis B virus is often associated with severe liver damage. The purpose of this study is to elucidate the relationship between mutations in hepatitis B precore/core gene and the severity of liver damage. METHODS:The hepatitis B precore/core gene from 20 patients with chronic hepatitis B virus inf...

journal_title：Gastroenterology

authors： Chuang WL,Omata M,Ehata T,Yokosuka O,Ito Y,Imazeki F,Lu SN,Chang WY,Ohto M

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic osmoreceptors are sensitive to changes in portal blood osmolality and cause variations in plasma antidiuretic hormone and water diuresis, which prevent major systemic osmotic changes. Insensitivity of hepatic osmoreceptors might contribute to maintaining increased plasma levels of antidiuretic h...

journal_title：Gastroenterology

authors： Castellano G,Solis-Herruzo JA,Gonzalez A,Morillas JD,Moreno D,Muñoz T,Larrodera L

更新日期：1994-03-01 00:00:00

abstract：:We have examined the possibility that the 33- and 39-amino acid forms of cholecystokinin (CCK) are cleaved to produce CCK-octapeptide (CCK-8) during circulation in humans. When a mixture of the 33- and 39-amino acid forms of porcine CCK was infused at 0.1-2.5 pmol/kg.min into normal subjects, material indistinguishabl...

journal_title：Gastroenterology

authors： Springer CJ,Calam J

更新日期：1988-07-01 00:00:00

abstract：:We studied the appearance of specific secretory immunoglobulin A (IgA) antibody in bile after inoculation of live Giardia lamblia trophozoites into rat intestine. Serial bile specimens collected before and after inoculation of trophozoites were assayed for IgA antibodies by indirect immunofluorescence. Secretory IgA a...

journal_title：Gastroenterology

authors： Loftness TJ,Erlandsen SL,Wilson ID,Meyer EA

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND/AIMS:Cytokines are thought to be important in mediating tissue damage in inflammatory bowel disease (IBD). Many of the in vivo activities of tumor necrosis factor alpha (TNF-alpha) match the changes found in IBD, but its importance is controversial. METHODS:A sensitive, reverse hemolytic plaque assay was us...

journal_title：Gastroenterology

authors： Breese EJ,Michie CA,Nicholls SW,Murch SH,Williams CB,Domizio P,Walker-Smith JA,MacDonald TT

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND & AIMS:Maintenance of acid-base homeostasis is required for normal physiology, metabolism, and development. It is not clear how cell death is activated in response to changes in pH. We performed a screen to identify agents that induce cell death in a pH-dependent manner (we call this alkaliptosis) in pancrea...

journal_title：Gastroenterology

authors： Song X,Zhu S,Xie Y,Liu J,Sun L,Zeng D,Wang P,Ma X,Kroemer G,Bartlett DL,Billiar TR,Lotze MT,Zeh HJ,Kang R,Tang D

更新日期：2018-04-01 00:00:00

abstract：:The interrelationship of the effects of antacids and of rising intragastric pH on serum gastrin levels was examined by comparing the effect of three antacids (Mg(OH)2Al(OH)3, and CaCO3), and their nonbuffering chloride compounds (MgCl2, AlCl3, and CaCl2), on serum gastrin and intragastric pH in duodenal ulcer patients...

journal_title：Gastroenterology

authors： Feurle GE

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND & AIMS:In colorectal adenoma and carcinoma, glutathione S-transferase-pi (GSTP1-1) is highly expressed. K-ras mutation is also known to occur frequently in colorectal adenoma and carcinoma, as well as in the putative precursor of adenoma, aberrant crypt foci (ACF). Further, forced expression of v-H-ras in ra...

journal_title：Gastroenterology

authors： Miyanishi K,Takayama T,Ohi M,Hayashi T,Nobuoka A,Nakajima T,Takimoto R,Kogawa K,Kato J,Sakamaki S,Niitsu Y

更新日期：2001-10-01 00:00:00

abstract：:The bioavailability of parenteral cimetidine was tested in 12 volunteers in a balanced three-way crossover study. Blood levels and urinary excretion were compared after intramuscular and intravenous injection and oral administration of 300 mg of cinetidine. The results indicated that the intramuscular and intravenous ...

journal_title：Gastroenterology

authors： Walkenstein SS,Dubb JW,Randolph WC,Westlake WJ,Stote RM,Intoccia AP

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The peptidyl prolyl isomerase Pin1 frequently is overexpressed in hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1. The role of Pin1 in hepatocarcino...

journal_title：Gastroenterology

authors： Pang R,Lee TK,Poon RT,Fan ST,Wong KB,Kwong YL,Tse E

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND & AIMS:The integrin alpha(4)beta(7) mediates homing of effector/memory lymphocytes to the intestine and the mucosa-associated lymphoid tissue. This study examined the ability of alpha(4)beta(7)(hi) CD4(+) T lymphocytes to home to the stomach and their role in immunization-mediated protection against Helicoba...

journal_title：Gastroenterology

authors： Michetti M,Kelly CP,Kraehenbuhl JP,Bouzourene H,Michetti P

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hydrophobic bile acids have been implicated in the pathogenesis of cholestatic liver injury. The hypothesis that hydrophobic bile acid toxicity is mediated by oxidant stress in an in vivo rat model was tested in this study. METHODS:A dose-response study of bolus intravenous (i.v.) taurochenodeoxychol...

journal_title：Gastroenterology

authors： Sokol RJ,McKim JM Jr,Goff MC,Ruyle SZ,Devereaux MW,Han D,Packer L,Everson G

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The mammalian intestinal epithelium self-renews rapidly and homeostasis is preserved via tightly controlled mechanisms. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions, but little is known about their role in maintaining the integrity of the inte...

journal_title：Gastroenterology

authors： Xiao L,Wu J,Wang JY,Chung HK,Kalakonda S,Rao JN,Gorospe M,Wang JY

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND & AIMS:Gastroesophageal reflux typically occurs after meals. During dual gastric and esophageal pH monitoring, we observed that postprandial refluxate was often more acidic than the gastric contents. This study aimed to investigate this phenomenon. METHODS:Dual gastric and esophageal pH tracings were analyz...

journal_title：Gastroenterology

authors： Fletcher J,Wirz A,Young J,Vallance R,McColl KE

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND & AIMS:Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) lower the risk of colorectal cancer (CRC). We investigated whether plasma inflammatory markers were associated with risk of CRC and if use of anti-inflammatory drugs was differentially associated with risk of CRC according to levels of inflamma...

journal_title：Gastroenterology

authors： Chan AT,Ogino S,Giovannucci EL,Fuchs CS

更新日期：2011-03-01 00:00:00