Abstract：
:In seven healthy volunteers pure pancreatic juice was obtained by endoscopic cannulation of the papilla of Vater. Synthetic secretin was intravenously infused in doses doubled every 20 min. The volume of pancreatic juice was proportional to the log of the secretin dose. A significant rise (P less than 0.05) in pancreatic juice flow was elicited at a dose as low as 8.05 ng per kg per hr. Maximum flow rate approximating 250 mul per 5 min per kg of body weight was attained during infusion of 129 ng per kg per hr. At the same dose maximal bicarbonate outputs averaging 383 muEq per hr per kg of body weight were obtained, whereas bicarbonate ion concentration approached peak values (135 +/- 9 muEq per ml) at 32.2 ng per kg per hr. Bicarbonate concentrations showed a tendency to fall at supramaximal doses. The effect of increasing secretin doses on bicarbonate and cyclic AMP concentrations was remarkably similar (rs = 0.635, P less than 0.001) suggesting the participation of cyclic AMP in human pancreatic bicarbonate secretion.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Domschke S,Domschke W,Rösch W,Konturek SJ,Wünsch E,Demling Lsubject
Has Abstractpub_date
1976-04-01 00:00:00pages
533-6issue
4eissn
0016-5085issn
1528-0012pii
S001650857600084Xjournal_volume
70pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：:Congenital esophageal stenosis (CES) is a rare disorder with narrowed esophageal lumen that presents as dysphagia from childhood and that is often associated with tracheobronchial remnants or webs. The pathogenesis of CES is unknown. The aim of this study was to examine the histological and immunohistochemical feature...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(95)90294-5
更新日期：1995-07-01 00:00:00
abstract：:The diagnosis of inflammatory bowel disease (IBD) with its 2 main subforms, Crohn's disease and ulcerative colitis, is based on clinical, endoscopic, radiologic, and histologic criteria. This paradigm remains unchanged despite the advent of new molecular technologies for the examination of serum proteins and genetic s...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2007.09.001
更新日期：2007-11-01 00:00:00
abstract：:Three cases of Stevens-Johnson syndrome with intestinal involvement are described. Two patients had esophageal involvement, the severity of which paralleled skin lesions and, in 1 case, probably contributed to death. Dysphagia and bleeding were manifestations. The third patient was unique and had gastric, small and la...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(86)90585-8
更新日期：1986-08-01 00:00:00
abstract：:Antibody prevalence and titer to rotavirus and Norwalk virus were studied in Crohn's disease patients and in age-, sex-, and time-matched controls. There were no significant antibody differences between the groups studied. ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1979-02-01 00:00:00
abstract：BACKGROUND & AIMS:Patients with Barrett's esophagus (BE) show increased risk of developing esophageal adenocarcinoma and are routinely examined using upper endoscopy with biopsy to detect neoplastic changes. Angle-resolved low coherence interferometry (a/LCI) uses in vivo depth-resolved nuclear morphology measurements ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.09.008
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND & AIMS:Monocytes/macrophages infiltrate into injured livers. We tried to clarify their roles in inflammation and subsequent fibrogenesis by inhibiting their infiltration with a mutated form (7ND; 7 amino acids at the N-terminal were deleted) of monocyte chemoattractant protein 1, which may function as a domi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2004.10.005
更新日期：2005-01-01 00:00:00
abstract：:Three analogues of the carboxyl-terminal tricosapeptide of secretin (S5-27), one with glutamine replacing glutamic acid in position 9 (9-Gln-S5-27), a second with asparagine substituted for aspartic acid in position 15 (15-Asn-S5-27), and a third with both replacements (9-Gln-15-Asn-S5-27) were tested for their abilit...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-12-01 00:00:00
abstract：:The existence of high- and low-affinity cholecystokinin (CCK)-A receptors on rodent pancreatic acini is well established. Until recently, CCK was believed to act directly on pancreatic acini to stimulate pancreatic secretion in both rodents and humans. However, conclusive evidence that human pancreatic acini lack func...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2004.05.002
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND & AIMS:It is a challenge to deliver nucleic acids to gastrointestinal (GI) tissues due to their size and need for intracellular delivery. They are also extremely susceptible to degradation by nucleases, which are ubiquitous in the GI tract. We investigated whether ultrasound, which can permeabilize tissue th...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.01.002
更新日期：2017-04-01 00:00:00
abstract：:Random fecal alpha 1-antitrypsin levels were determined in 34 patients, 24 with Crohn's disease, and 10 "controls" having diarrheal illnesses not associated with intestinal protein loss, in an effort to evaluate its usefulness as a measure of Crohn's disease intestinal activity. In the control group, all alpha 1-antit...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(85)90739-5
更新日期：1985-07-01 00:00:00
abstract：:To characterize gastric mucosal perfusion in cirrhotic patients with portal hypertensive gastropathy, 34 cirrhotics with this lesion and 24 noncirrhotics were studied by reflectance spectrophotometry and laser-Doppler flowmetry during endoscopy. A significant correlation was observed between the hemoglobin content of ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)91447-c
更新日期：1992-12-01 00:00:00
abstract：:A patient with ulcerative ileojejunitis was studied by determination of HL-A phenotype, by measurement of jejunal IgA synthesis using a labeled amino acid incorporation technique, and by in vitro organ culture. The patient carried the HL-A8 phenotype in common with 87.5% of patients with gluten-sensitive enteropathy. ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：:A patient with gastric outlet syndrome (Bouveret's syndrome) caused by a large gallstone impacted in the duodenal bulb was successfully treated by extracorporeal shock-wave lithotripsy. Thus, open abdominal surgery could be avoided. For disintegration of the stone, three consecutive lithotripsy procedures were necessa...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(89)90086-3
更新日期：1989-08-01 00:00:00
abstract：BACKGROUND & AIMS:Although bacterial bowel flora may be one of the contributing factors in the pathogenesis of chronic mucosal inflammation, antibiotic treatment has no established role in ulcerative colitis. The aim of the study was to evaluate the role of ciprofloxacin in the induction and maintenance of remission in...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0016-5085(98)70076-9
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND & AIMS:Infection with Helicobacter pylori is associated with reduced risk of esophageal adenocarcinoma (EAC), but it is not clear whether this reduction is modified by genotype, other host characteristics, or environmental factors. Furthermore, little is known about the association between H pylori and adeno...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.04.009
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND & AIMS:Outcomes of liver transplantation for hepatocellular carcinoma (HCC) are determined by cancer-related and non-related events. Treatments for hepatitis C virus infection have reduced non-cancer events among patients receiving liver transplants, so reducing HCC-related death might be an actionable end p...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.09.025
更新日期：2018-01-01 00:00:00
abstract：:Approximately 5% of the world's human population have an increased risk for developing liver cancer and cirrhosis as a direct consequence of chronic infection with the hepatitis B virus (HBV). Antiviral chemotherapy remains the only option for controlling infection in these individuals, for whom the current licensed h...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1016/s0016-5085(00)70008-4
更新日期：2000-02-01 00:00:00
abstract：:Phosphatase-mediated hydrolysis is the first step in the intestinal absorption of pyridoxal 5'-phosphate (PLP). Studies presented here evaluated the effects of PLP-protein binding and pH on intestinal hydrolysis in the rat. Models included in vitro PLP decay and in vivo PLP disappearance from perfused jejunal segments...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(86)90567-6
更新日期：1986-08-01 00:00:00
abstract：BACKGROUND & AIMS:In patients with achalasia esophagus, swallows induce simultaneous pressure waves known as esophageal pressurization. We studied the mechanism of esophageal pressurization and bolus flow patterns in patients with type 2 or type 3 achalasia. METHODS:We recorded high-resolution manometry with impedance...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2018.04.033
更新日期：2018-08-01 00:00:00
abstract：:Clonidine hydrochloride (an alpha 2-adrenoceptor agonist) was tested for antisecretory effects in patients with cholera in a randomized controlled trial. Nineteen adults with diarrhea due to Vibrio cholerae were treated with clonidine (0.9 mg/24 h orally for 72 h) and 18 served as controls. During the first 24 h of tr...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0016-5085(89)90067-x
更新日期：1989-08-01 00:00:00
abstract：BACKGROUND & AIMS:Despite inducing an inflammatory response, Helicobacter pylori can persist in the gastric mucosa for decades. H pylori expression of cholesterol-α-glucosyltransferase (encoded by cgt) is required for gastric colonization and T-cell activation. We investigated how cgt affects gastric epithelial cells a...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.12.008
更新日期：2018-04-01 00:00:00
abstract：:The long term administration of chenodeoxycholic acid in man has to be regarded with caution because chenodeoxycholic acid has caused liver damage in various species of animals, including primates. To study the effect of three doses of chenodeoxycholic acid (10, 40, and 100 mg per kg per day) on hepatic function and m...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:The effect of thyroidectomy on the activity of liver alcohol dehydrogenase and on the rate of ethanol elimination was determined in the rat. Thyroidectomy resulted in a marked increase in liver alcohol dehydrogenase activity. Three isoenzymes of alcohol dehydrogenase activity were demonstrated in thyroidectomized anim...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-03-01 00:00:00
abstract：UNLABELLED:We investigated a patient (W.B.) with chronic symptomatic Giardiasis despite seven separate courses of either quinacrine or metronidazole who was cured by combined quinacrine and metronidazole. After isolating Giardia lamblia from W.B., we cultured the trophozoites to make the following observations. In vitr...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：:Concern has arisen about the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection treated with direct-acting antivirals (DAAs). To identify patients at risk for HCC, we evaluated serum levels of immune mediators before, during, and after DAA treatment of HCV infection. Our s...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.10.035
更新日期：2018-02-01 00:00:00
abstract：:The pancreatic secretion of 6 normal human volunteers was collected by endoscopic cannulation of the main pancreatic duct. The appearance of newly synthesized proteins was monitored at 1-min intervals after labeling with [75Se]methionine. The minimum transit time of these proteins from their site of synthesis to the a...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：:The relationship between renal tubular acidosis (RTA) and copper metabolism has been investigated in a group of 18 patients with primary biliary cirrhosis. RTA, considered when urinary pH remained above 5.4 after an oral load of ammonium chloride of 0.1 g/kg body wt, was found in 6 patients (33%). Plasma copper concen...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-04-01 00:00:00
abstract：:Among the components of dietary fiber, the soluble polysaccharides, primarily guaran and pectin, have been found to impair intestinal absorption. Little is known, however, about the mechanism of this effect. The direct action of guaran on small intestinal absorption was evaluated by a single-pass perfusion technique. ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：BACKGROUND & AIMS:The anti-cancer effects of vegetables and fruit have been investigated extensively, but the association between vegetable and fruit consumption and risk of hepatocellular carcinoma (HCC) has not been quantified. We performed a meta-analysis of observational studies to clarify the association. METHODS...
journal_title：Gastroenterology
pub_type： 杂志文章,meta分析,评审
doi：10.1053/j.gastro.2014.08.005
更新日期：2014-11-01 00:00:00
abstract：:To clarify the role of fat maldigestion in the pathogenesis of steatorrhea in patients with ileal resection the total and aqueous phase concentrations of bile acid and fatty acid were characterized in 8 such patients (5 patients with small ileal resection, bile acid diarrhea, and steatorrhea less than 20 g per day; 3 ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
