Effects of fundic distention on pentagastrin-stimulated gastric acid secretion in man.

abstract：BACKGROUND AND AIMS:We have developed a mouse model of gastric cancer that resembles human intestinal-type adenocarcinoma. The aim of this study was to determine the identity and temporal changes in mediators of IL-6 signaling regulating tumor development. METHODS:gp130(757F/F) Mice that lack the SHP2-binding site on ...

journal_title：Gastroenterology

authors： Judd LM,Alderman BM,Howlett M,Shulkes A,Dow C,Moverley J,Grail D,Jenkins BJ,Ernst M,Giraud AS

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND & AIMS:The transcription factor nuclear factor-κB (NF-κB) (a heterodimer of NF-κB1p50 and RelA) is activated rapidly in acute pancreatitis (AP). However, it is not clear whether NF-κB promotes or protects against AP. We used the NF-κB inhibitor protein, inhibitor of κB (IκB)α, to study the roles of NF-κB in ...

journal_title：Gastroenterology

authors： Neuhöfer P,Liang S,Einwächter H,Schwerdtfeger C,Wartmann T,Treiber M,Zhang H,Schulz HU,Dlubatz K,Lesina M,Diakopoulos KN,Wörmann S,Halangk W,Witt H,Schmid RM,Algül H

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND & AIMS:HuR is a RNA-binding factor whose expression is commonly upregulated in some human tumor types. We explored the molecular mechanism underlying HuR elevation and its role in gastric cancer tumorigenesis. METHODS:HuR expression and subcellular localization were determined by polymerase chain reaction, ...

journal_title：Gastroenterology

authors： Kang MJ,Ryu BK,Lee MG,Han J,Lee JH,Ha TK,Byun DS,Chae KS,Lee BH,Chun HS,Lee KY,Kim HJ,Chi SG

更新日期：2008-12-01 00:00:00

abstract：:Interleukin 6 (IL6) is an inflammatory cytokine; signaling via its receptor (IL6R) is believed to contribute to development of inflammatory bowel diseases (IBD). The single nucleotide polymorphism rs2228145 in IL6R associates with increased levels of soluble IL6R (s-IL6R), as well as reduced IL6R signaling and risk of...

journal_title：Gastroenterology

authors： Parisinos CA,Serghiou S,Katsoulis M,George MJ,Patel RS,Hemingway H,Hingorani AD

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND & AIMS:Hirschsprung disease is caused by failure of enteric neural crest cells (ENCCs) to fully colonize the bowel, leading to bowel obstruction and megacolon. Heterozygous mutations in the coding region of the RET gene cause a severe form of Hirschsprung disease (total colonic aganglionosis). However, 80% o...

journal_title：Gastroenterology

authors： Lai FP,Lau ST,Wong JK,Gui H,Wang RX,Zhou T,Lai WH,Tse HF,Tam PK,Garcia-Barcelo MM,Ngan ES

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND & AIMS:Barrett's esophagus-associated high-grade dysplasia is commonly treated by endoscopy. However, most guidelines offer no recommendations for endoscopic treatment of mucosal adenocarcinoma of the esophagus (mAC). We investigated the efficacy and safety of endoscopic resection in a large series of patien...

journal_title：Gastroenterology

authors： Pech O,May A,Manner H,Behrens A,Pohl J,Weferling M,Hartmann U,Manner N,Huijsmans J,Gossner L,Rabenstein T,Vieth M,Stolte M,Ell C

更新日期：2014-03-01 00:00:00

abstract：:Regional differences in the esophageal distribution and clearance of refluxed gastric acid was studied in seven asymptomatic volunteers and seven patients with reflux esophagitis. Intraluminal pH was recorded for 3 postprandial hours from the distal, middle, and proximal esophagus on two separate occasions (with subje...

journal_title：Gastroenterology

authors： Shaker R,Dodds WJ,Helm JF,Kern MK,Hogan WJ

更新日期：1991-08-01 00:00:00

abstract：:The reason why hepatocellular carcinoma occurs less frequently in women than in men is unknown. The possibility that differences in the hepatitis B virus status between men and women with this tumor might be important in this regard was investigated in 75 black women and 75 age- and ethnically-matched men with hepatoc...

journal_title：Gastroenterology

authors： Kew MC,Rossouw E,Paterson A,Hodkinson J,Whitcutt M,Dusheiko G

更新日期：1983-04-01 00:00:00

abstract：:A patient with a lifelong history of asthma and hay fever was investigated because of symptoms of esophageal spasm. Esophageal biopsies revealed elongated papillae and basal zone hyperplasia of the epithelial layer with eosinophilic infiltration of the lamina propria and muscularis mucosae. There was no evidence of re...

journal_title：Gastroenterology

authors： Dobbins JW,Sheahan DG,Behar J

更新日期：1977-06-01 00:00:00

abstract：:We report the case of a patient in whom amitriptyline administration for 5 wk was followed by prolonged cholestasis. Jaundice and pruritus lasted 19 and 20 mo, respectively. Three liver biopsies were performed at different stages of the disease showing the course of liver lesions. Cholestasis initially located in the ...

journal_title：Gastroenterology

authors： Larrey D,Amouyal G,Pessayre D,Degott C,Danne O,Machayekhi JP,Feldmann G,Benhamou JP

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic lipid retention (steatosis) predisposes hepatitis. We investigated the mechanisms of lymphocyte homing to fatty liver and the role of lipopolysaccharide (LPS) in the onset of inflammation in ob/ob mice. METHODS:We decreased intestinal bacterial compounds by oral antibiotic treatment to test t...

journal_title：Gastroenterology

authors： Bigorgne AE,Bouchet-Delbos L,Naveau S,Dagher I,Prévot S,Durand-Gasselin I,Couderc J,Valet P,Emilie D,Perlemuter G

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND & AIMS:Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and weight loss with sibutramine. METHODS:We conducted a randomized, double-blind, pharmacogenetic study...

journal_title：Gastroenterology

authors： Grudell AB,Sweetser S,Camilleri M,Eckert DJ,Vazquez-Roque MI,Carlson PJ,Burton DD,Braddock AE,Clark MM,Graszer KM,Kalsy SA,Zinsmeister AR

更新日期：2008-10-01 00:00:00

abstract：:A patient is described with Campylobacter enteritis complicated by massive lower gastrointestinal bleeding from multiple mucosal ulcers in the terminal ileum and at the ileocecal valve. Repeated stool cultures and antibiotic therapy may be indicated in certain patients to diminish the morbidity arising from what may s...

journal_title：Gastroenterology

authors： Michalak DM,Perrault J,Gilchrist MJ,Dozois RR,Carney JA,Sheedy PF 2nd

更新日期：1980-10-01 00:00:00

abstract：:Prior animal models of cholesterol gallstone formation have been criticized for their dissimilarity to the conditions of humans with gallstones. We present a new hamster model of cholesterol cholelithiasis that more closely approximates the human situation. Sixty female Golden Syrian hamsters (average weight 83.2 +/- ...

journal_title：Gastroenterology

authors： Pearlman BJ,Bonorris GG,Phillips MJ,Chung A,Vimadalal S,Marks JW,Schoenfield LJ

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND & AIMS:Significant improvements in management of hepatocellular carcinoma (HCC) have occurred in the last years, but their impact on surveillance outcome is unknown. To clarify this, we compared survival of HCC patients identified along 3 consecutive quinquennia of surveillance. METHODS:A cohort of 417 HCC-...

journal_title：Gastroenterology

authors： Sangiovanni A,Del Ninno E,Fasani P,De Fazio C,Ronchi G,Romeo R,Morabito A,De Franchis R,Colombo M

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND & AIMS:Galectin-3 is a beta-galactoside-binding protein implicated in tumor progression and metastasis of colorectal cancers. To determine whether circulating galectin-3 ligands are related to the presence of colon cancer, we sought to identify and quantify ligands in serum that bind to galectin-3. METHODS:...

journal_title：Gastroenterology

authors： Bresalier RS,Byrd JC,Tessler D,Lebel J,Koomen J,Hawke D,Half E,Liu KF,Mazurek N,Great Lakes-New England Clinical and Epidemiology Center of the Early Detection Research Network.

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND & AIMS:Acetaminophen toxicity is the most common cause of acute liver failure (ALF) in the United States and Great Britain, but may be underrecognized in certain settings. Acetaminophen-protein adducts are specific biomarkers of drug-related toxicity in animal models and can be measured in tissue or blood sa...

journal_title：Gastroenterology

authors： Davern TJ 2nd,James LP,Hinson JA,Polson J,Larson AM,Fontana RJ,Lalani E,Munoz S,Shakil AO,Lee WM,Acute Liver Failure Study Group.

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND & AIMS:Gastritis is associated with development of stomach cancer, but little is known about changes in microRNA expression patterns during gastric inflammation. Specific changes in gene expression in epithelial cells are difficult to monitor because of the heterogeneity of the tissue. We investigated epithe...

journal_title：Gastroenterology

authors： Han TS,Voon DC,Oshima H,Nakayama M,Echizen K,Sakai E,Yong ZWE,Murakami K,Yu L,Minamoto T,Ock CY,Jenkins BJ,Kim SJ,Yang HK,Oshima M

更新日期：2019-03-01 00:00:00

abstract：:The role of lipoxygenase metabolites in ethanol-induced gastric mucosal injury and submucosal microvascular change in the rat was studied by in vivo microscopy. Intragastric ethanol-instillation caused marked submucosal venular constriction, dilatation of small arterioles, and corpus mucosal gross lesion formation. Th...

journal_title：Gastroenterology

authors： Yonei Y,Guth PH

更新日期：1989-08-01 00:00:00

abstract：:A case of primary liver cell carcinoma is presented in which tumor emboli to the pulmonary microvasculature resulted in pulmonary hypertension, documented by clinical, radiologic, electrocardiographic, and cardiac catheter studies. Emboli arose from tumor invading the portal vein and passed via a patent splenorenal sh...

journal_title：Gastroenterology

authors： Willett IR,Sutherland RC,O'Rourke MF,Dudley FJ

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND/AIMS:Platelet-activating factor (PAF) is involved in the pathophysiology of motility changes induced by intestinal inflammation. The aim of this study was to evaluate a possible desensitization of PAF receptors in guinea pig intestinal smooth muscle cells after experimental inflammation induced by trinitrobe...

journal_title：Gastroenterology

authors： Jeanneton O,Delvaux M,Frexinos J,Bueno L

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...

journal_title：Gastroenterology

authors： Tibble JA,Sigthorsson G,Bridger S,Fagerhol MK,Bjarnason I

更新日期：2000-07-01 00:00:00

abstract：:Ceftriaxone, a semisynthetic third-generation cephalosporin, has recently been associated with biliary sludge formation. Analysis of the biliary concretions induced by this agent shows a calcium salt of ceftriaxone. The present in vitro studies were undertaken to provide insight into the pathogenesis of ceftriaxone-as...

journal_title：Gastroenterology

authors： Shiffman ML,Keith FB,Moore EW

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND & AIMS:The tumor necrosis factor (TNF)-alpha/TNF receptor system is critical for liver development because hepatocytes undergo apoptosis if the antiapoptotic cascades resulting in RelA NF-kappaB activation are not effective. Therefore, we studied the role of TNF-alpha in fulminant hepatic failure (FHF) and d...

journal_title：Gastroenterology

authors： Streetz K,Leifeld L,Grundmann D,Ramakers J,Eckert K,Spengler U,Brenner D,Manns M,Trautwein C

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND/AIMS:Several studies have shown that polymorphonuclear neutrophil leukocyte (PMN) margination is an early and critical event in the pathogenesis of gastric mucosal injury caused by nonsteroidal anti-inflammatory drugs. Tumor necrosis factor (TNF) alpha is a proinflammatory cytokine that causes PMN marginatio...

journal_title：Gastroenterology

authors： Santucci L,Fiorucci S,Di Matteo FM,Morelli A

更新日期：1995-02-01 00:00:00

abstract：:A pancreatic somatostatinoma metastatized to the liver was detected in a 70-yr-old woman presenting with chronic diarrhea, steatorrhea, pancreatic insufficiency, diabetes mellitus, and achlorhydria. At immunocytochemistry, most tumor cells stored both somatostatin and calcitoninlike substances. Chromatography of acid ...

journal_title：Gastroenterology

authors： Galmiche JP,Chayvialle JA,Dubois PM,David L,Descos F,Paulin C,Ducastelle T,Colin R,Geffroy Y

更新日期：1980-06-01 00:00:00

abstract：:Mucins synthesized in colonic cancer are known to be different from those in the normal colon; however, the biochemical differences between these mucins have not been defined. We have purified mucins from samples of nonneoplastic (normal) human colon and colon cancer and found that the carbohydrate content of the canc...

journal_title：Gastroenterology

authors： Boland CR,Deshmukh GD

更新日期：1990-05-01 00:00:00

abstract：:The association of hepatobiliary disorders with colonic inflammation is well recognized. Although the pathophysiology is obscure, increased permeation of toxic bacterial products across the inflamed gut to the portal circulation might be one mechanism. Potentially toxic metabolites include N-formylated chemotactic pep...

journal_title：Gastroenterology

authors： Hobson CH,Butt TJ,Ferry DM,Hunter J,Chadwick VS,Broom MF

更新日期：1988-04-01 00:00:00

abstract：:The emergence of new glycoprotein structures in colonic mucosa from patients with ulcerative colitis (UC) was assessed through the development of monoclonal antibodies (MAbs). Hybridomas were prepared from mice immunized with mucin glycoproteins purified from UC colonic tissue. Supernatants of 11 fusion products among...

journal_title：Gastroenterology

authors： Podolsky DK,Fournier DA

更新日期：1988-08-01 00:00:00

abstract：:Fasting hyperbilirubinemia (FHB) has previously been shown to be rapidly reversed by the ingestion of a mixed diet. This study examines the effect of carbohydrate, fat, amino acids, and noncaloric materials on FHB. After an initial fast of 15 to 39 hr, caloric and noncaloric materials were administered by mouth or vei...

journal_title：Gastroenterology

authors： Barrett PV

更新日期：1975-02-01 00:00:00