当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Variation in Interleukin 6 Receptor Gene Associates With Risk of Crohn's Disease and Ulcerative Colitis.

Variation in Interleukin 6 Receptor Gene Associates With Risk of Crohn's Disease and Ulcerative Colitis.

Abstract：

:Interleukin 6 (IL6) is an inflammatory cytokine; signaling via its receptor (IL6R) is believed to contribute to development of inflammatory bowel diseases (IBD). The single nucleotide polymorphism rs2228145 in IL6R associates with increased levels of soluble IL6R (s-IL6R), as well as reduced IL6R signaling and risk of inflammatory disorders; its effects are similar to those of a therapeutic monoclonal antibody that blocks IL6R signaling. We used the effect of rs2228145 on s-IL6R level as an indirect marker to investigate whether reduced IL6R signaling associates with risk of ulcerative colitis (UC) or Crohn's disease (CD). In a genome-wide meta-analysis of 20,550 patients with CD, 17,647 patients with UC, and more than 40,000 individuals without IBD (controls), we found that rs2228145 (scaled to a 2-fold increase in s-IL6R) was associated with reduced risk of CD (odds ratio 0.876; 95% confidence interval 0.822-0.933; P = .00003) or UC (odds ratio 0.932; 95% confidence interval 0.875-0.996; P = .036). These findings indicate that therapeutics designed to block IL6R signaling might be effective in treatment of IBD.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Parisinos CA,Serghiou S,Katsoulis M,George MJ,Patel RS,Hemingway H,Hingorani AD

doi

10.1053/j.gastro.2018.05.022

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

303-306.e2

issue

2

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(18)34542-6

journal_volume

155

pub_type

杂志文章,meta分析

相关文献

GASTROENTEROLOGY文献大全
  • Effect of the acid secretory state on intramural pH of rabbit gastric mucosa.

    abstract：:Intramural pH of the gastric mucosa was measured using a microelectrode technique in rabbit gastric pouches under different secretory conditions and luminal acidity. Exposure of spontaneously secreting or metiamide-treated fundic pouches to a relatively high concentration of luminal acid. HCl 120 mM, for 60 min, led ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Kivilaakso E,Fromm D,Silen W

    更新日期：1978-10-01 00:00:00

  • High Prevalence of Nonalcoholic Fatty Liver Disease in Adolescents Undergoing Bariatric Surgery.

    abstract：BACKGROUND & AIMS:Little is known about the prevalence of nonalcoholic fatty liver disease (NAFLD) among severely obese adolescents or factors that determine its development. We investigated the prevalence of NAFLD in a multicenter cohort of adolescents undergoing bariatric surgery and the factors associated with it. ...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1053/j.gastro.2015.05.039

    authors： Xanthakos SA,Jenkins TM,Kleiner DE,Boyce TW,Mourya R,Karns R,Brandt ML,Harmon CM,Helmrath MA,Michalsky MP,Courcoulas AP,Zeller MH,Inge TH,Teen-LABS Consortium.

    更新日期：2015-09-01 00:00:00

  • Tropism for Spasmolytic Polypeptide-Expressing Metaplasia Allows Helicobacter pylori to Expand Its Intragastric Niche.

    abstract：BACKGROUND & AIMS:In patients with chronic Helicobacter pylori (H pylori) infection, parietal and chief cell atrophy in the gastric corpus, a process known as spasmolytic polypeptide-expressing metaplasia (SPEM), increases the risk for progression to cancer. The relation between H pylori and these metaplastic changes i...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2018.09.050

    authors： Sáenz JB,Vargas N,Mills JC

    更新日期：2019-01-01 00:00:00

  • Anatomical extent of fiberoptic sigmoidoscopy.

    abstract：:The anatomical extent of fiberoptic sigmoidoscopy was determined by placing a clip on the colonic mucosa and subsequently locating the clip on barium enema. A 60 cm exam viewed the entire sigmoid colon in 81% of patients. Exams of 50-55 cm, 40-45 cm, and 30-35 cm extent viewed the entire sigmoid colon in 68%, 27%, and...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Lehman GA,Buchner DM,Lappas JC

    更新日期：1983-04-01 00:00:00

  • Epidemiologic evidence on the association between peptic ulceration and antiinflammatory drug use.

    abstract：:Adverse effects associated with nonsteroidal antiinflammatory drug treatment are reported more commonly to regulatory authorities than the adverse effects of any other form of treatment. Epidemiologic evidence in general suggests a doubling or quadrupling of the risk of ulcer complications or death in recipients of su...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1016/s0016-5085(89)80060-5

    authors： Langman MJ

    更新日期：1989-02-01 00:00:00

  • Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish.

    abstract：BACKGROUND & AIMS:Biliary epithelial cells (BECs) are considered to be a source of regenerating hepatocytes when hepatocyte proliferation is compromised. However, there is still controversy about the extent to which BECs can contribute to the regenerating hepatocyte population, and thereby to liver recovery. To investi...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2013.10.019

    authors： Choi TY,Ninov N,Stainier DY,Shin D

    更新日期：2014-03-01 00:00:00

  • Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats.

    abstract：BACKGROUND/AIMS:Several studies have shown that polymorphonuclear neutrophil leukocyte (PMN) margination is an early and critical event in the pathogenesis of gastric mucosal injury caused by nonsteroidal anti-inflammatory drugs. Tumor necrosis factor (TNF) alpha is a proinflammatory cytokine that causes PMN marginatio...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90065-9

    authors： Santucci L,Fiorucci S,Di Matteo FM,Morelli A

    更新日期：1995-02-01 00:00:00

  • Symptomatic hepatic disease in cystic fibrosis: incidence, course, and outcome of portal systemic hunting.

    abstract：:Fifteen (2.2%) of 693 patients with cystic fibrosis seen over an 18-year period developed clinical hepatic disease. In 13 patients all symptoms were secondary to portal hypertension. Ten had hypersplenism and 6 had variceal bleeding, including 3 who developed both conditions. All 5 patients who survived the initial ep...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Stern RC,Stevens DP,Boat TF,Doershuk CF,Izant RJ Jr,Matthews LW

    更新日期：1976-05-01 00:00:00

  • Primary malignant melanoma of the gallbladder, metastatic to the common bile duct.

    abstract：:A primary malignant melanoma of the gallbladder, metastatic to the common bile duct, is reported. Both tumor sites were first visualized by abdominal sonography. The presence of the common bile duct metastasis was confirmed by endoscopic retrograde cholangiopancreatography. Histologic evidence is presented that the pr...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)90461-0

    authors： Verbanck JJ,Rutgeerts LJ,van Aelst FJ,Tytgat JH,Decoster JM,Noyez DN,Theunynck PJ,Geboes KJ

    更新日期：1986-07-01 00:00:00

  • YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling.

    abstract：BACKGROUND & AIMS:Pancreatitis is the most important risk factor for pancreatic ductal adenocarcinoma (PDAC). Pancreatitis predisposes to PDAC because it induces a process of acinar cell reprogramming known as acinar-to-ductal metaplasia (ADM)-a precursor of pancreatic intraepithelial neoplasia lesions that can progres...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2016.05.006

    authors： Gruber R,Panayiotou R,Nye E,Spencer-Dene B,Stamp G,Behrens A

    更新日期：2016-09-01 00:00:00

  • Cholangiopancreatography, sphincterotomy, and common duct stone removal via Roux-en-Y limb enteroscopy.

    abstract：:An enteroscopic method that uses a pediatric colonoscope provides an alternative approach to the diagnostic and management problems arising in the setting of a Roux-en-Y limb hepaticojejunostomy or biliary diversion. Three patients with Roux-en-Y limb reconstructions who experienced recurrent cholangitis, recurrent pa...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(88)90305-8

    authors： Gostout CJ,Bender CE

    更新日期：1988-07-01 00:00:00

  • Extracellular matrix composition influences insulinlike growth factor I receptor expression in rat IEC-18 cells.

    abstract：BACKGROUND:The composition of the extracellular matrix (ECM) as well as insulinlike growth factor I (IGF-I) receptor density vary along the crypt-villus axis. We determined whether components of the ECM influence IGF-I receptor expression in IEC-18 rat small intestine crypt cells. METHODS:IEC-18 cells were cultured on...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)90649-w

    authors： Benya RV,Duncan MD,Mishra L,Bass BL,Voyles NR,Korman LY

    更新日期：1993-06-01 00:00:00

  • Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis.

    abstract：BACKGROUND & AIMS:Circulating membrane-shed microparticles (MPs) participate in regulation of vascular tone. We investigated the cellular origins of MPs in plasma from patients with cirrhosis and assessed the contribution of MPs to arterial vasodilation, a mechanism that contributes to portal hypertension. METHODS:We ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2012.03.040

    authors： Rautou PE,Bresson J,Sainte-Marie Y,Vion AC,Paradis V,Renard JM,Devue C,Heymes C,Letteron P,Elkrief L,Lebrec D,Valla D,Tedgui A,Moreau R,Boulanger CM

    更新日期：2012-07-01 00:00:00

  • Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.

    abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is often associated with hepatitis B virus (HBV) infection. Cells of most HBV-related HCCs contain HBV-DNA fragments that do not encode entire HBV antigens. We investigated whether these integrated HBV-DNA fragments encode epitopes that are recognized by T cells and whet...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2019.01.251

    authors： Tan AT,Yang N,Lee Krishnamoorthy T,Oei V,Chua A,Zhao X,Tan HS,Chia A,Le Bert N,Low D,Tan HK,Kumar R,Irani FG,Ho ZZ,Zhang Q,Guccione E,Wai LE,Koh S,Hwang W,Chow WC,Bertoletti A

    更新日期：2019-05-01 00:00:00

  • c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.

    abstract：BACKGROUND & AIMS:In searching for effects of acetaminophen (APAP) on hepatocytes downstream of its metabolism that may participate in hepatotoxicity, we examined the role of stress kinases. METHODS:Mouse hepatocytes and C57BL/6 mice were administered a toxic dose of APAP with or without SP600125, a chemical c-jun N-t...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2006.03.045

    authors： Gunawan BK,Liu ZX,Han D,Hanawa N,Gaarde WA,Kaplowitz N

    更新日期：2006-07-01 00:00:00

  • Circulating levels of endothelin in cirrhosis.

    abstract：BACKGROUND:Current information concerning endothelin in cirrhosis is conflicting. Plasma endothelin concentration has been found to be increased in some studies and normal or reduced in others. The present study was aimed to investigate the plasma levels of endothelin in cirrhosis and to assess whether it is involved i...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)90360-o

    authors： Asbert M,Ginès A,Ginès P,Jiménez W,Clària J,Saló J,Arroyo V,Rivera F,Rodés J

    更新日期：1993-05-01 00:00:00

  • Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

    abstract：BACKGROUND & AIMS:SMAD4 frequently is lost from colorectal cancers (CRCs), which is associated with the development of metastases and a poor prognosis. SMAD4 loss is believed to alter transforming growth factor β signaling to promote tumor progression. However, SMAD4 is also a central component of the bone morphogeneti...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2014.03.052

    authors： Voorneveld PW,Kodach LL,Jacobs RJ,Liv N,Zonnevylle AC,Hoogenboom JP,Biemond I,Verspaget HW,Hommes DW,de Rooij K,van Noesel CJ,Morreau H,van Wezel T,Offerhaus GJ,van den Brink GR,Peppelenbosch MP,Ten Dijke P,Hardwick JC

    更新日期：2014-07-01 00:00:00

  • Liver X receptors inhibit proliferation of human colorectal cancer cells and growth of intestinal tumors in mice.

    abstract：BACKGROUND & AIMS:Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2013.02.005

    authors： Lo Sasso G,Bovenga F,Murzilli S,Salvatore L,Di Tullio G,Martelli N,D'Orazio A,Rainaldi S,Vacca M,Mangia A,Palasciano G,Moschetta A

    更新日期：2013-06-01 00:00:00

  • Rab27b localizes to the tubulovesicle membranes of gastric parietal cells and regulates acid secretion.

    abstract：BACKGROUND & AIMS:Rabs are monomeric guanosine triphosphatases that regulate membrane trafficking and acid secretion in gastric parietal cells. Using a proteomics approach, we identified a new Rab, Rab27b, in tubulovesicle membranes and determined its role in parietal cell activation. METHODS:We used mass spectrometry...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.09.044

    authors： Suda J,Zhu L,Okamoto CT,Karvar S

    更新日期：2011-03-01 00:00:00

  • Acknowledging joint first authors of published work: the time has come.

    abstract：:We are delighted to introduce a new and simple format in the references section of the articles we publish in Gastroenterology that highlights joint first authors of citations. We believe this is an important step to acknowledging equal contribution to published work as research becomes increasingly team-oriented and ...

    journal_title：Gastroenterology

    pub_type： 社论

    doi：10.1053/j.gastro.2012.08.009

    authors： Dubnansky E,Omary MB

    更新日期：2012-10-01 00:00:00

  • Some parameters of large bowel motility in normal man.

    abstract：:This study presents normal values of bowel habits, colonic transit times of radioopaque markers, and anorectal pressure obtained from 114 normal subjects. Their stool frequency ranged from 3 to 11 per 7 days, whereas their diet contained an average of 14.4 g of crude fibers. Radioopaque markers progressed regularly al...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Martelli H,Devroede G,Arhan P,Duguay C,Dornic C,Faverdin C

    更新日期：1978-10-01 00:00:00

  • The role of hepatitis G virus infection in patients with acute posttransfusion hepatitis in Taiwan.

    abstract：BACKGROUND & AIMS:Hepatitis G virus (HGV) has been recently identified as a new transfusion-transmissible agent. This study was performed to evaluate the role of HGV infection in patients with acute posttransfusion hepatitis in Taiwan. METHODS:Sera from 63 patients with acute posttransfusion hepatitis and 61 patients ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(97)70138-0

    authors： Hwang SJ,Lu RH,Chan CY,Wang YJ,Wu JC,Lee SD

    更新日期：1997-04-01 00:00:00

  • Effects of extracellular Ca2+ and HCO3- on epidermal growth factor-induced DNA synthesis in cultured rat hepatocytes.

    abstract：BACKGROUND/AIMS:The elevation of cytosolic free calcium concentration ([Ca2+]i) and intracellular pH mediate the growth factor-initiated proliferation of many cells, but it is not known if they trigger mitosis in resting hepatocytes. The maintenance of [Ca2+]i and intracellular pH depends partly on extracellular calciu...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90077-2

    authors： Zhang BH,Farrell GC

    更新日期：1995-02-01 00:00:00

  • Gastrointestinal transit time in human pregnancy: prolongation in the second and third trimesters followed by postpartum normalization.

    abstract：:Fifty-nine studies of gastrointestinal transit time were performed in 27 healthy women during pregnancy and postpartum. Gastrointestinal transit time was defined as the time of the first sustained rise in breath hydrogen concentration after ingestion of 10 g of lactulose. Gastrointestinal transit time was significantl...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(85)90199-4

    authors： Lawson M,Kern F Jr,Everson GT

    更新日期：1985-11-01 00:00:00

  • Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection.

    abstract：BACKGROUND & AIMS:Cytotoxic T cells have been suggested to be responsible for lysis of hepatitis B virus (HBV)-infected hepatocytes and control of virus infection. The frequency, kinetics, phenotype, and capacity for clonal expansion of circulating HBV-specific CD8 cells were analyzed directly in patients with acute HB...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(99)70289-1

    authors： Maini MK,Boni C,Ogg GS,King AS,Reignat S,Lee CK,Larrubia JR,Webster GJ,McMichael AJ,Ferrari C,Williams R,Vergani D,Bertoletti A

    更新日期：1999-12-01 00:00:00

  • Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene.

    abstract：:We describe 2 siblings with multiple gastrointestinal stromal tumors (GISTs) and cutaneous hyperpigmentation. Both had a point mutation of the c-kit gene. The patients were sisters who had exhibited cutaneous hyperpigmentation since their late teens, but the diagnosis of multiple gastrointestinal submucosal tumors was...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.20880

    authors： Maeyama H,Hidaka E,Ota H,Minami S,Kajiyama M,Kuraishi A,Mori H,Matsuda Y,Wada S,Sodeyama H,Nakata S,Kawamura N,Hata S,Watanabe M,Iijima Y,Katsuyama T

    更新日期：2001-01-01 00:00:00

  • Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice.

    abstract：BACKGROUND & AIMS:Liver fibrosis, hepatocellular necrosis, inflammation, and proliferation of liver progenitor cells are features of chronic liver injury. Mouse models have been used to study the end-stage pathophysiology of chronic liver injury. However, little is known about differences in the mechanisms of liver inj...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2018.06.048

    authors： Pradhan-Sundd T,Vats R,Russell JO,Singh S,Michael AA,Molina L,Kakar S,Cornuet P,Poddar M,Watkins SC,Nejak-Bowen KN,Monga SP,Sundd P

    更新日期：2018-10-01 00:00:00

  • Qualitative and quantitative analysis of muscarinic acetylcholine receptors in the piebald lethal mouse model of Hirschsprung's disease.

    abstract：:Cholinergic innervation in the aganglionic bowel of the piebald lethal mouse model of Hirschsprung's disease was investigated by analysis of muscarinic acetylcholine receptors before and after administration of hexamethonium. After hexamethonium administration in the normal rectum, the maximum specific binding (Bmax) ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(85)90008-3

    authors： Ueki S,Okamoto E,Kuwata K,Toyosaka A,Nagai K

    更新日期：1985-06-01 00:00:00

  • Leukocyte migration inhibition in response to biliary antigens in primary biliary cirrhosis, sclerosing cholangitis, and other chronic liver diseases.

    abstract：:The leukocyte migration inhibition test has been used to investigate cellular immune responses to antigens in a protein fraction (BPF) of normal human gallbladder bile in patients with a variety of intra- and extrahepatic diseases. Inhibition of leukocyte migration in the presence of BPF was observed in 30 (81%) of 37...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： McFarlane IG,Wojcicka BM,Tsantoulas DC,Portmann BC,Eddleston AL,Williams R

    更新日期：1979-06-01 00:00:00

  • A study of the relationship between serum group I pepsinogen levels and gastric acid secretion.

    abstract：:Serum group I pepsinogen (PG I) levels, basal acid output, and peak acid output (PAO) have been determined in 120 patients, 54 with duodenal ulcer, 14 with prepyloric ulcer, 12 with gastric ulcer, and 40 without ulcer. The correlation between serum PG I and PAO was statistically significant (r = 0.736, P less than 0.0...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Samloff IM,Secrist DM,Passaro E Jr

    更新日期：1975-12-01 00:00:00