Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats.

abstract：BACKGROUND & AIMS:Hepatitis C virus (HCV) infection is a leading cause of end-stage liver disease. Interferon-α (IFNα) is an important component of anti-HCV therapy; it up-regulates transcription of IFN-stimulated genes, many of which have been investigated for their antiviral effects. However, all of the genes require...

journal_title：Gastroenterology

authors： Fusco DN,Brisac C,John SP,Huang YW,Chin CR,Xie T,Zhao H,Jilg N,Zhang L,Chevaliez S,Wambua D,Lin W,Peng L,Chung RT,Brass AL

更新日期：2013-06-01 00:00:00

abstract：:This study examines the effects of endotoxin on intestinal water and electrolyte transport in adult male rats. Endotoxin (1.55 mg/kg, intravenously) reduced in vivo colonic saline absorption 61% in 1 hour. In vitro unidirectional and net 22Na and 36Cl fluxes showed that endotoxin significantly decreased net colonic 22...

journal_title：Gastroenterology

authors： Ciancio MJ,Vitiritti L,Dhar A,Chang EB

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:To date, the potential effects of free radicals on the activities of intestinal brush-border membrane enzymes have received little attention. Therefore, we conducted a series of experiments to examine the effects of free radicals on various enzymatic activities of rat small intestinal brush-border membranes....

journal_title：Gastroenterology

authors： Dudeja PK,Brasitus TA

更新日期：1993-08-01 00:00:00

abstract：:Behavioral economic approaches could increase uptake for colorectal cancer screening. We performed a randomized controlled trial of 2245 employees to determine whether an email containing a phone number for scheduling (control), an email with the active choice to opt in or opt out (active choice), or the active choice...

journal_title：Gastroenterology

authors： Mehta SJ,Feingold J,Vandertuyn M,Niewood T,Cox C,Doubeni CA,Volpp KG,Asch DA

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND & AIMS:The Paris pediatric modification of the Montreal classification defines very early onset inflammatory bowel disease (VEO-IBD) as a form of IBD distinct from that of older children. We compared the incidence and outcomes of VEO-IBD with those of IBD in older children. METHODS:We performed a population...

journal_title：Gastroenterology

authors： Benchimol EI,Mack DR,Nguyen GC,Snapper SB,Li W,Mojaverian N,Quach P,Muise AM

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND & AIMS:Congenital tufting enteropathy (CTE) is a rare autosomal recessive diarrheal disorder presenting in the neonatal period. CTE is characterized by intestinal epithelial cell dysplasia leading to severe malabsorption and significant morbidity and mortality. The pathogenesis and genetics of this disorder ...

journal_title：Gastroenterology

authors： Sivagnanam M,Mueller JL,Lee H,Chen Z,Nelson SF,Turner D,Zlotkin SH,Pencharz PB,Ngan BY,Libiger O,Schork NJ,Lavine JE,Taylor S,Newbury RO,Kolodner RD,Hoffman HM

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND & AIMS:Osteoporosis is common in patients with Crohn's disease, but less is known about their risk of actual fractures. METHODS:The medical records of all 238 Olmsted County, Minnesota, residents diagnosed with Crohn's disease between 1940 and 1993 were reviewed for evidence of subsequent fractures compared...

journal_title：Gastroenterology

authors： Loftus EV Jr,Crowson CS,Sandborn WJ,Tremaine WJ,O'Fallon WM,Melton LJ 3rd

更新日期：2002-08-01 00:00:00

abstract：:The role of the endothelium-derived vasodilator, nitric oxide, as a mediator of the increase in gastric mucosal blood flow and as a modulator of the acid secretory response induced by pentagastrin was investigated in the anesthetised rat. Intravenous administration of the selective inhibitor of endogenous nitric oxide...

journal_title：Gastroenterology

authors： Pique JM,Esplugues JV,Whittle BJ

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND & AIMS:Cirrhosis and portal hypertension due to chronic common bile duct ligation reproduce the features of human hepatopulmonary syndrome, whereas portal hypertension alone due to partial portal vein ligation does not. Nitric oxide contributes to experimental hepatopulmonary syndrome, but the nitric oxide s...

journal_title：Gastroenterology

authors： Zhang J,Ling Y,Luo B,Tang L,Ryter SW,Stockard CR,Grizzle WE,Fallon MB

更新日期：2003-11-01 00:00:00

abstract：:Clonidine hydrochloride (an alpha 2-adrenoceptor agonist) was tested for antisecretory effects in patients with cholera in a randomized controlled trial. Nineteen adults with diarrhea due to Vibrio cholerae were treated with clonidine (0.9 mg/24 h orally for 72 h) and 18 served as controls. During the first 24 h of tr...

journal_title：Gastroenterology

authors： Rabbani GH,Butler T,Patte D,Abud RL

更新日期：1989-08-01 00:00:00

abstract：:Short-chain (C2-C5) fatty acids account for 60%-70% of the anions in the colon. Acetate (C2) is nontoxic in contrast to C(3)4-C5 fatty acids (propionate, butyrate, isobutyrate, valerate, and isovalerate), which induce coma in animals and may be important in the pathogenesis of hepatic coma in humans. An in-vitro fecal...

journal_title：Gastroenterology

authors： Mortensen PB,Holtug K,Bonnén H,Clausen MR

更新日期：1990-02-01 00:00:00

abstract：:Twenty-nine patients with esophageal symptoms and contraction abnormalities of the esophageal body completed a 6-wk, double-blind, placebo-controlled trial of trazodone (100-150 mg/day). Measures of esophageal and psychologic symptoms were completed at entry and at each follow-up visit. Esophageal manometry was repeat...

journal_title：Gastroenterology

authors： Clouse RE,Lustman PJ,Eckert TC,Ferney DM,Griffith LS

更新日期：1987-04-01 00:00:00

abstract：:The pathogenesis of gastroesophageal reflux disease (GERD) is complex and involves changes in reflux exposure, epithelial resistance, and visceral sensitivity. The gastric refluxate is a noxious material that injures the esophagus and elicits symptoms. Esophageal exposure to gastric refluxate is the primary determinan...

journal_title：Gastroenterology

authors： Tack J,Pandolfino JE

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hypoxic inflammation (decreased oxygen tension at sites of inflammation) is a feature of inflammatory bowel disease (IBD). The hypoxia response is mediated by the transcription factors hypoxia-inducible factor (HIF) 1α and endothelial PAS domain protein 1 (EPAS1 or HIF2α), which are induced in intesti...

journal_title：Gastroenterology

authors： Xue X,Ramakrishnan S,Anderson E,Taylor M,Zimmermann EM,Spence JR,Huang S,Greenson JK,Shah YM

更新日期：2013-10-01 00:00:00

abstract：:Human intraepithelial lymphocytes (IEL) are CD8+ T cells located between intestinal epithelial cells, capable of only minimal proliferation to mitogens but brisk proliferation to mitogens combined with sheep red blood cells. This study examines this differential response of IEL. Both IEL and CD8+ T lymphocytes from th...

journal_title：Gastroenterology

authors： Ebert EC

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND & AIMS:Human tumors and liver cancer cell lines express the product of a fusion between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and the last 6 exons in the FER tyrosine kinase gene (FER), called MAN2A1-FER. We investigated whether MAN2A1-FER is expressed by human liver tumors ...

journal_title：Gastroenterology

authors： Chen ZH,Yu YP,Tao J,Liu S,Tseng G,Nalesnik M,Hamilton R,Bhargava R,Nelson JB,Pennathur A,Monga SP,Luketich JD,Michalopoulos GK,Luo JH

更新日期：2017-10-01 00:00:00

abstract：:Gastric mucosa of the rat generates both PGE2 and PGI2 activity in significantly higher concentrations in the antrum than in the fundus. Aspirin, given intravenously or intragastrically in doses producing gastric mucosal lesions, causes a dose-dependent decrease in the generation of mucosal PGE2 and PGI2, which is fur...

journal_title：Gastroenterology

authors： Konturek SJ,Piastucki I,Brzozowski T,Radecki T,Dembińska-Kieć A,Zmuda A,Gryglewski R

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND/AIMS:The role of cholecystokinin (CCK) in the regulation of gastric acid secretion is still controversial. This study examined the effect of the CCK-A receptor antagonist loxiglumide (lox) on gastrin- or CCK-induced gastric acid secretion and meal-stimulated plasma gastrin levels in a placebo-controlled stud...

journal_title：Gastroenterology

authors： Schmidt WE,Schenk S,Nustede R,Holst JJ,Fölsch UR,Creutzfeldt W

更新日期：1994-12-01 00:00:00

abstract：:Serial studies of plasma lipids and lipoproteins were performed in 4 patients with acute alcoholic liver disease characterized by a massive fatty liver and laboratory evidence of intrahepatic cholestasis. There were striking alterations in the plasma lipoprotein electrophoretic patterns characterized by the absence of...

journal_title：Gastroenterology

authors： Sabesin SM,Hawkins HL,Kuiken L,Ragland JB

更新日期：1977-03-01 00:00:00

abstract：:Colon motility and myoelectric slow wave activity were compared in 10 patients with progressive systemic sclerosis and 18 controls. Recordings were made in the rectosigmoid and rectum, 25-30 cm and 10-15 cm from the anal margin, respectively, during two 4-min baselines and in response to stepwise distention of the col...

journal_title：Gastroenterology

authors： Whitehead WE,Taitelbaum G,Wigley FM,Schuster MM

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND & AIMS:The anti-cancer effects of vegetables and fruit have been investigated extensively, but the association between vegetable and fruit consumption and risk of hepatocellular carcinoma (HCC) has not been quantified. We performed a meta-analysis of observational studies to clarify the association. METHODS...

journal_title：Gastroenterology

authors： Yang Y,Zhang D,Feng N,Chen G,Liu J,Chen G,Zhu Y

更新日期：2014-11-01 00:00:00

abstract：:The courses of 38 patients with severe, uncomplicated acute colitis (16 with Crohn's colitis and 22 with ulcerative colitis) were analyzed retrospectively. The patients were placed on total parenteral nutrition and treated concomitantly with corticosteroids, antibiotics (often metronidazole), sulfasalazine, and/or aza...

journal_title：Gastroenterology

authors： Sitzmann JV,Converse RL Jr,Bayless TM

更新日期：1990-12-01 00:00:00

abstract：:Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and pyroptosis, a form of phagocyte cell death induced by bacterial pathogens. Members of the Nod-like receptor family (including Nlrp1, Nlrp3, and...

journal_title：Gastroenterology

authors： Chen GY,Núñez G

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Celiac disease is a prevalent disorder characterized by a chronic intestinal inflammation driven by HLA-DQ2 or -DQ8-restricted T cells specific for ingested wheat gluten peptides. The dominant T-cell responses are to epitopes that cluster within a stable 33mer fragment formed by physiologic digestio...

journal_title：Gastroenterology

authors： Molberg O,Uhlen AK,Jensen T,Flaete NS,Fleckenstein B,Arentz-Hansen H,Raki M,Lundin KE,Sollid LM

更新日期：2005-02-01 00:00:00

abstract：:The effects of corticosteroid treatment on mucosal mast cells in rat jejunal mucosa were examined. Rats previously infected with Nippostrongylus brasiliensis received a single IP injection of 1 mg dexamethasone. Three hours later, one third of mucosal mast cells demonstrated minor granular changes (fusion or periphera...

journal_title：Gastroenterology

authors： Soda K,Kawabori S,Perdue MH,Bienenstock J

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND & AIMS:The peroxisome proliferator-activated receptor delta (PPARD) regulates cell metabolism, proliferation, and inflammation and has been associated with gastric and other cancers. Villin-positive epithelial cells are a small population of quiescent gastric progenitor cells. We expressed PPARD from a villi...

journal_title：Gastroenterology

authors： Zuo X,Deguchi Y,Xu W,Liu Y,Li HS,Wei D,Tian R,Chen W,Xu M,Yang Y,Gao S,Jaoude JC,Liu F,Chrieki SP,Moussalli MJ,Gagea M,Sebastian MM,Zheng X,Tan D,Broaddus R,Wang J,Ajami NJ,Swennes AG,Watowich SS,Shureiqi

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:This study was undertaken to prospectively compare the clinical outcomes of small bowel radiographs with the wireless capsule endoscopy. METHODS:Twenty-two patients were selected consecutively because of suspected small bowel disease. Two patients were excluded owing to ileal stenosis. Thus, the resu...

journal_title：Gastroenterology

authors： Costamagna G,Shah SK,Riccioni ME,Foschia F,Mutignani M,Perri V,Vecchioli A,Brizi MG,Picciocchi A,Marano P

更新日期：2002-10-01 00:00:00

abstract：:This literature review and the recommendations therein were prepared for the American Gastroenterological Association Clinical Practice and Practice Economics committee. The paper was approved by the committee on May 16, 1999, and by the AGA governing board on July 18, 1999. ...

journal_title：Gastroenterology

authors： Zuckerman GR,Prakash C,Askin MP,Lewis BS

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with previous stomach and terminal ileum resections are often treated with intramuscular vitamin B12 injections. Disadvantages are, on a worldwide scale, the frequent need for medical personnel to administer injections and the sometimes painful way of application. This study was designed to i...

journal_title：Gastroenterology

authors： Slot WB,Merkus FW,Van Deventer SJ,Tytgat GN

更新日期：1997-08-01 00:00:00

abstract：:The characteristics are described of an antibody (designated L6) which has virtually absolute specificity for heptadecapeptide gastrin. This antibody binds G17, but does not bind peptide fragments or molecular forms of gastrin comprising G17 with either amino acid deletions, or additions, at the carboxyl- and amino-te...

journal_title：Gastroenterology

authors： Dockray GJ,Taylor IL

更新日期：1976-12-01 00:00:00