PPARD and Interferon Gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice.

abstract：BACKGROUND & AIMS:Noninvasive methods are needed to identify clinically significant portal hypertension (CSPH) and esophageal varices (EVs) in patients with compensated cirrhosis. We looked for markers of the presence of CSPH and EVs in patients with cirrhosis. METHODS:We performed a cross-sectional study that include...

journal_title：Gastroenterology

authors： Berzigotti A,Seijo S,Arena U,Abraldes JG,Vizzutti F,García-Pagán JC,Pinzani M,Bosch J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND & AIMS:The mammalian small intestine is lined by a highly specialized epithelium that functions in the digestion and absorption of nutrients. The molecular mechanisms that direct intestinal epithelial cell morphogenesis and terminal differentiation are poorly understood. We have previously identified Elf3 (E...

journal_title：Gastroenterology

authors： Ng AY,Waring P,Ristevski S,Wang C,Wilson T,Pritchard M,Hertzog P,Kola I

更新日期：2002-05-01 00:00:00

abstract：:A 17-yr-old boy developed acute proctosigmoiditis after the institution of isotretinoin for the treatment of cystic acne vulgaris. Painless diarrhea, accompanied by mucus and eventually blood, began within days of commencing treatment and persisted while the drug was administered. At sigmoidoscopy patchy mucosal infla...

journal_title：Gastroenterology

authors： Martin P,Manley PN,Depew WT,Blakeman JM

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND & AIMS:Hereditary diffuse gastric cancer (HDGC) families carry CDH1 heterozygous germline mutations; their tumors acquire complete CDH1 inactivation through "2nd-hit" mechanisms. Most frequently, this occurs via promoter hypermethylation (epigenetic modification), and less frequently via CDH1 mutations and l...

journal_title：Gastroenterology

authors： Oliveira C,Sousa S,Pinheiro H,Karam R,Bordeira-Carriço R,Senz J,Kaurah P,Carvalho J,Pereira R,Gusmão L,Wen X,Cipriano MA,Yokota J,Carneiro F,Huntsman D,Seruca R

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND & AIMS:The long-term outcomes of patients treated for autoimmune hepatitis (AIH) are considered to be good. However, follow-up data beyond 10 years are limited and confined to tertiary referral centers. We assessed long-term outcomes and determinants of outcome in patients with AIH from a nontransplant cente...

journal_title：Gastroenterology

authors： Hoeroldt B,McFarlane E,Dube A,Basumani P,Karajeh M,Campbell MJ,Gleeson D

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:Ferroportin disease is characterized by iron overload. It has an autosomal-dominant pattern of inheritance and has been associated with mutations in the SLC40A1 gene, which encodes the cellular iron exporter ferroportin. Since the first description in 2001, about 30 mutations have been reported; the h...

journal_title：Gastroenterology

authors： Le Lan C,Mosser A,Ropert M,Detivaud L,Loustaud-Ratti V,Vital-Durand D,Roget L,Bardou-Jacquet E,Turlin B,David V,Loréal O,Deugnier Y,Brissot P,Jouanolle AM

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND & AIMS:p16(INK4a) is a cell cycle inhibitor and a major tumor-suppressor protein, but the regulation of p16(INK4a) is poorly understood and the physiologic settings in which it exerts its antiproliferative effects are unknown. A role for p16(INK4a) in intestinal neoplasia is suggested by the observation that...

journal_title：Gastroenterology

authors： Dai CY,Furth EE,Mick R,Koh J,Takayama T,Niitsu Y,Enders GH

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:No enzyme replacement therapy exists for patients with congenital sucrase-isomaltase deficiency (CSID). A by-product of the manufacture of baker's yeast is a liquid preparation containing high sucrase activity. The aim of the present study was to investigate the activity and stability of this preparation and...

journal_title：Gastroenterology

authors： Treem WR,Ahsan N,Sullivan B,Rossi T,Holmes R,Fitzgerald J,Proujansky R,Hyams J

更新日期：1993-10-01 00:00:00

abstract：:To determine the pattern of inheritance of lactase deficiency, we studied 104 American Indian and 2 white subjects in 19 families. Subjects were considered deficient in lactase if breath-hydrogen excretion exceeded 0.20 ml per min above fasting at 2 hr after a lactose load of 2 g per kg of body weight (maximum 50 g). ...

journal_title：Gastroenterology

authors： Newcomer AD,Gordon H,Thomas PJ,McGill DB

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND & AIMS:There are few validated biomarkers that can be used to predict outcomes for patients with colorectal cancer. Part of the challenge is the genetic and molecular heterogeneity of colorectal tumors not only among patients, but also within tumors. We have explored intratumor heterogeneity at the epigeneti...

journal_title：Gastroenterology

authors： Martínez-Cardús A,Moran S,Musulen E,Moutinho C,Manzano JL,Martinez-Balibrea E,Tierno M,Élez E,Landolfi S,Lorden P,Arribas C,Müller F,Bock C,Tabernero J,Esteller M

更新日期：2016-11-01 00:00:00

abstract：:Ileal Na+-dependent bile acid transport was quantified in vitro as the uptake of 3H-taurocholate into brush-border membrane vesicles. Vesicles were prepared from ileal biopsies of 158 patients placed in 10 diagnostic categories. Active bile acid transport (expressed as picomoles taurocholate uptake per milligram brush...

journal_title：Gastroenterology

authors： van Tilburg AJ,de Rooij FW,van Blankenstein M,van den Berg JW,Bosman-Jacobs EP

更新日期：1990-01-01 00:00:00

abstract：:To determine the frequency and significance of alpha-fetoprotein elevation in severe hepatitis B surface antigen-negative chronic active hepatitis, 558 serum samples obtained from 83 patients were tested by an immunoenzymometric assay. All patients received corticosteroids and sampling occurred at 6-12-mo intervals du...

journal_title：Gastroenterology

authors： Czaja AJ,Beaver SJ,Wood JR,Klee GG,Go VL

更新日期：1987-10-01 00:00:00

abstract：:The community of microorganisms within the human gut (or microbiota) is critical to health and functions with a level of complexity comparable to that of an organ system. Alterations of this ecology (or dysbiosis) have been implicated in a number of disease states, and the prototypical example is Clostridium difficile...

journal_title：Gastroenterology

authors： Kelly CR,Kahn S,Kashyap P,Laine L,Rubin D,Atreja A,Moore T,Wu G

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Somatostatin inhibits pancreatic exocrine secretion in intact animals but not in vitro, suggesting an indirect effect. The present study examined the influence of extrapancreatic nerves and intrapancreatic cholinergic activity on somatostatin-induced inhibition of pancreatic exocrine secretion in conscious d...

journal_title：Gastroenterology

authors： Kuvshinoff BW,Brodish RJ,James L,McFadden DW,Fink AS

更新日期：1993-08-01 00:00:00

abstract：:Antibodies to a membrane-bound antigen, localized to the canalicular structures of the parietal cell, are found in most sera of patients with chronic atrophic gastritis and pernicious anemia. In the present study immunoglobulins containing parietal cell antibodies were found to inhibit the activity of H+,K+-adenosine ...

journal_title：Gastroenterology

authors： Burman P,Mårdh S,Norberg L,Karlsson FA

更新日期：1989-06-01 00:00:00

abstract：:Plasma levels of gastrinlike, somatostatinlike, and cholecystokininlike immunoreactivity were determined by radioimmunoassay in peripheral blood from 11 beagles during pregnancy and in response to suckling during lactation. Cholecystokinin was determined in pooled and in individual plasma samples after separation of c...

journal_title：Gastroenterology

authors： Linden A,Eriksson M,Carlquist M,Uvnäs-Moberg K

更新日期：1987-03-01 00:00:00

abstract：:This literature review and the recommendations therein were prepared for the American Gastroenterological Association Clinical Practice and Practice Economics committee. The paper was approved by the committee on May 16, 1999, and by the AGA governing board on July 18, 1999. ...

journal_title：Gastroenterology

authors： Zuckerman GR,Prakash C,Askin MP,Lewis BS

更新日期：2000-01-01 00:00:00

abstract：:This study examines restitution of the gastric surface epithelium at luminal pH 1 after damage to the gastric mucosa by instillation of 2 M NaCl for 10 min. After mucosal damage, potential difference decreased to zero and H+ back-diffusion increased. Gastric blood flow increased after exposure to 2 M NaCl, irrespectiv...

journal_title：Gastroenterology

authors： Grönbech JE,Grong K,Varhaug JE,Lekven J,Svanes K

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Fiber and water-holding agents are used for the treatment of constipation. In what may appear to be a paradox, they are sometimes also used for the treatment of diarrhea; it has been proposed that they sequester water from liquid stools and/or increase the ratio of fecal solids to fecal water and thereby imp...

journal_title：Gastroenterology

authors： Eherer AJ,Santa Ana CA,Porter J,Fordtran JS

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Mutant hepatitis B virus is often associated with severe liver damage. The purpose of this study is to elucidate the relationship between mutations in hepatitis B precore/core gene and the severity of liver damage. METHODS:The hepatitis B precore/core gene from 20 patients with chronic hepatitis B virus inf...

journal_title：Gastroenterology

authors： Chuang WL,Omata M,Ehata T,Yokosuka O,Ito Y,Imazeki F,Lu SN,Chang WY,Ohto M

更新日期：1993-01-01 00:00:00

abstract：:The effects of pancreatic duct ligation on the digestion and absorption of a randomly 14C-labeled protein meal has been investigated in the rat. Although there was a significant reduction in luminal digestion and absorption of the protein meal in the pancreatic duct-ligated animals compared with controls, 37% of admin...

journal_title：Gastroenterology

authors： Curtis KJ,Gaines HD,Kim YS

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND/AIMS:Growth factors and their receptors play a role in healing ulcers of the rat. Somatostatin is a putative growth factor in the gastric mucosa with multiple functions mediated by specific receptors. Therefore, the distribution of somatostatin receptors was evaluated in the gastric mucosa of healing ulcers....

journal_title：Gastroenterology

authors： Reubi JC,Waser B,Schmassmann A,Halter F

更新日期：1994-08-01 00:00:00

abstract：:In rats, hypergastrinemia due to achlorhydria produced by antisecretory drugs or resection of the gastric fundus leads to enterochromaffinlike (ECL) cell hyperplasia and gastric carcinoids. In humans, achlorhydria due to pernicious anemia may also lead to ECL cell hyperplasia and multicentric gastric carcinoids in as ...

journal_title：Gastroenterology

authors： Hirschowitz BI,Griffith J,Pellegrin D,Cummings OW

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND & AIMS:The down-regulated in adenoma (DRA) protein, encoded by SLC26A3, a key intestinal chloride anion exchanger, has recently been identified as a novel susceptibility gene for inflammatory bowel disease (IBD). However, the mechanisms underlying the increased susceptibility to inflammation induced by the l...

journal_title：Gastroenterology

authors： Kumar A,Priyamvada S,Ge Y,Jayawardena D,Singhal M,Anbazhagan AN,Chatterjee I,Dayal A,Patel M,Zadeh K,Saksena S,Alrefai WA,Gill RK,Zadeh M,Zhao N,Mohamadzadeh M,Dudeja PK

更新日期：2020-11-13 00:00:00

abstract：:In a series of in vitro studies, both the soluble (plasmatic) coagulation system and the cellular (platelet-mediated) aspect of coagulation were shown to be extremely sensitive to relatively minor increases in hydrogen ion concentration. All studies became abnormal at pH 6.8. At pH 6.4, assays of the intrinsic and ext...

journal_title：Gastroenterology

authors： Green FW Jr,Kaplan MM,Curtis LE,Levine PH

更新日期：1978-01-01 00:00:00

abstract：:Basal and pentagastrin-stimulated gastric acid secretion, fasting serum gastrin concentrations, and the gastric output of prostaglandin E and its major metabolite 13,14-dihydro 15-keto prostaglandin E2 were measured in 9 normal subjects before and after 14-20 days of dietary supplementation with linoleic acid. Mean ma...

journal_title：Gastroenterology

authors： Grant HW,Palmer KR,Kelly RW,Wilson NH,Misiewicz JJ

更新日期：1988-04-01 00:00:00

abstract：:A recent study reports that patients with previous acute pancreatitis commonly have an abnormal clearance of serum triglycerides after an oral fat load. This observation supports the hypothesis that patients with previous acute pancreatitis and normal fasting serum triglyceride levels may have a preexistent abnormalit...

journal_title：Gastroenterology

authors： Rollán A,Guzmán S,Pimentel F,Nervi F

更新日期：1990-06-01 00:00:00

abstract：:A case of enterogenous cysts of the duodenum in a 44-yr-old man complicated by duodenal obstruction and relapsing pancreatitis is presented. The cystic duodenal lesions were visualized by endoscopic retrograde cholangiopancreatography and for the first time by computed tomography and abdominal sonography. Thus, the di...

journal_title：Gastroenterology

authors： Holstege A,Barner S,Brambs HJ,Wenz W,Gerok W,Farthmann EH

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND & AIMS:Although the cell of origin for pancreatic cancer remains unknown, prior studies have suggested that pancreatic neoplasia may be initiated in progenitor-like cells. To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of b...

journal_title：Gastroenterology

authors： Park SW,Davison JM,Rhee J,Hruban RH,Maitra A,Leach SD

更新日期：2008-06-01 00:00:00

abstract：:Non-major histocompatibility complex-restricted cytotoxicity triggered by antibodies to the CD3 component of the human T-cell receptor complex is thought to be an indirect measure of in vivo primed cytotoxic T-cell activity. We have used this technique to examine the lytic activity of freshly isolated T cells from non...

journal_title：Gastroenterology

authors： Shanahan F,Deem R,Nayersina R,Leman B,Targan S

更新日期：1988-04-01 00:00:00