Abstract:
:In rats, hypergastrinemia due to achlorhydria produced by antisecretory drugs or resection of the gastric fundus leads to enterochromaffinlike (ECL) cell hyperplasia and gastric carcinoids. In humans, achlorhydria due to pernicious anemia may also lead to ECL cell hyperplasia and multicentric gastric carcinoids in as many as 5% of cases. To examine the apparent gastrin dependence of gastric ECL carcinoids, three patients were studied (2 men aged 59 and 73 years; 1 woman aged 45 years) who had pernicious anemia, serum gastrin concentrations of greater than 1000 ng/L (greater than 1000 pg/mL), and multicentric gastric carcinoids. Antrectomy resulted in normalization of serum gastrin levels within 8 hours and disappearance of carcinoids in 6-16 weeks. In each of the three patients, a focus of microcarcinoid was found at 12-18 months. Further follow-up in each of the three patients 21-30 months after antrectomy again showed no carcinoids or ECL cell hyperplasia. It is concluded that multicentric ECL gastric carcinoids in patients with pernicious anemia and achlorhydria appear to be gastrin dependent and disappear after normalization of serum gastrin by antrectomy. Antrectomy rather than total gastrectomy may be the most appropriate treatment for this condition.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Hirschowitz BI,Griffith J,Pellegrin D,Cummings OWkeywords:
subject
Has Abstractpub_date
1992-04-01 00:00:00pages
1409-18issue
4 Pt 1eissn
0016-5085issn
1528-0012pii
0016-5085(92)70044-Cjournal_volume
102pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract::Chlorpromazine (CPZ) is a long recognized cause of jaundice, but the mechanism by which this agent produces icteric liver disease is not well defined. This study examined some effects of CPZ administration on bilirubin metabolism and biliary secretion in the rat. Acute CPZ treatment (25 mg per kg intravenously) produc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND & AIMS:Cystic fibrosis transmembrane regulator (CFTR) gene mutations are associated with pancreatic insufficiency and pancreatitis. Chronic pancreatitis, including cystic fibrosis-related disease, may exist as a continuum between acute and chronic disease and may manifest as recurrent pain. We hypothesized t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/j.gastro.2005.05.059
更新日期:2005-08-01 00:00:00
abstract::To explore the metabolic aspects of chronic liver disease, diurnal changes of arterial ketone body ratio (acetoacetate/3-hydroxybutyrate), reflecting hepatic mitochondrial redox potential, were investigated in normal subjects, patients with chronic liver disease (Child's class A or B), and patients with hepatic failur...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND & AIMS:Men have a higher incidence of hepatocellular carcinoma (HCC) than women, which is believed to partly be because of protective effects of estrogen. We sought to determine whether there were differences in levels of microRNA (miRNA) molecules between male and female HCC samples. METHODS:The expression...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.10.029
更新日期:2009-02-01 00:00:00
abstract::In recent years the hypothesis that the number of villus cells regulates crypt cell proliferation in the epithelium of the small intestine has been brought forward by a number of investigators. To test this hypothesis, the villus cell population was reduced by clamping the superior mesenteric artery and vein in rats f...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND & AIMS:Several studies have reported that low doses of interferon can delay the development of hepatocellular carcinoma (HCC) and progression of chronic hepatitis C. We investigated the incidence of clinical events among participants of the Evaluation of PegIntron in Control of Hepatitis C Cirrhosis (EPIC)3 ...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1053/j.gastro.2011.03.010
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND AIMS:The chemokines CCL19 and CCL21 bind CCR7, which is involved in the organization of secondary lymphoid tissue and is expressed during chronic tissue inflammation. We investigated the expression of CCL21 and CCR7 in chronic hepatitis C. The effects of CCL21 on hepatic stellate cells (HSCs) were also s...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)01194-6
更新日期:2003-10-01 00:00:00
abstract::The effect of thyroidectomy on the activity of liver alcohol dehydrogenase and on the rate of ethanol elimination was determined in the rat. Thyroidectomy resulted in a marked increase in liver alcohol dehydrogenase activity. Three isoenzymes of alcohol dehydrogenase activity were demonstrated in thyroidectomized anim...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND/AIMS:Several studies have shown that polymorphonuclear neutrophil leukocyte (PMN) margination is an early and critical event in the pathogenesis of gastric mucosal injury caused by nonsteroidal anti-inflammatory drugs. Tumor necrosis factor (TNF) alpha is a proinflammatory cytokine that causes PMN marginatio...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90065-9
更新日期:1995-02-01 00:00:00
abstract::We are delighted to introduce a new and simple format in the references section of the articles we publish in Gastroenterology that highlights joint first authors of citations. We believe this is an important step to acknowledging equal contribution to published work as research becomes increasingly team-oriented and ...
journal_title:Gastroenterology
pub_type: 社论
doi:10.1053/j.gastro.2012.08.009
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND/AIMS:Platelets show proinflammatory as well as prothrombotic properties. Patients with inflammatory bowel disease are at increased risk of systemic thromboembolism, and multifocal microvascular infarction has been proposed as a pathogenetic mechanism in Crohn's disease. The aim of this study was to determine...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90741-2
更新日期:1994-04-01 00:00:00
abstract::Spontaneous remission of gastric acid hypersecretion in the Zollinger-Ellison syndrome occurs rarely. This study shows the development of gastric secretory mucosal atrophy resulting in achlorhydria and loss of pepsin secretion in a 63-year-old woman with the Zollinger-Ellison syndrome. Reduced secretion began soon aft...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(91)90484-3
更新日期:1991-07-01 00:00:00
abstract::To determine the pattern of inheritance of lactase deficiency, we studied 104 American Indian and 2 white subjects in 19 families. Subjects were considered deficient in lactase if breath-hydrogen excretion exceeded 0.20 ml per min above fasting at 2 hr after a lactose load of 2 g per kg of body weight (maximum 50 g). ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract::Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2017.08.071
更新日期:2017-11-01 00:00:00
abstract::To clarify the intracellular distribution of myosin in normal rat hepatocytes and its alterations in phal-loidin-treated rat hepatocytes as a morphologic basis for the dysfunction of microfilaments, we performed indirect immunofluorescence using monospecific antibody raised against rat hepatocyte myosin. Cryostat rat ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)91507-2
更新日期:1989-10-01 00:00:00
abstract::Interstitial pneumonitis is an uncommon complication of low-dose methotrexate therapy in patients with psoriasis but occurs in 3%-5% of patients with rheumatoid arthritis. We found a higher incidence of interstitial pneumonitis in patients with primary biliary cirrhosis (14%) and describe its clinical manifestations, ...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1016/0016-5085(94)90085-x
更新日期:1994-07-01 00:00:00
abstract::Intestinal mucin and goblet cells were examined in streptozotocin-diabetic rats and age-matched controls. Mucin (tissue content and secretion) was measured using a highly specific enzyme-linked immunoassay. In contrast to the increased protein to deoxyribonucleic acid ratio, an absolute decrease was observed in the mu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)91417-0
更新日期:1989-07-01 00:00:00
abstract::Of 550 patients admitted with acute upper gastrointestinal hemorrhage, 143 with peptic ulcers containing stigmata of recent hemorrhage accessible to endoscopic therapy were included in a randomized comparison of neodymium yttrium aluminum garnet laser, heater probe, and no endoscopic therapy. The rebleeding rate in la...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0016-5085(90)90339-3
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND & AIMS:Changes in the properties of visceral sensory neurons contribute to the development of gastrointestinal pain. However, little is known about the molecules involved in mechanosensation from the gastrointestinal tract. We investigated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.01.031
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.8523
更新日期:2000-07-01 00:00:00
abstract::Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and pyroptosis, a form of phagocyte cell death induced by bacterial pathogens. Members of the Nod-like receptor family (including Nlrp1, Nlrp3, and...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2011.10.002
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND/AIMS:During liver fibrosis, there is a putative pacemaker role of fibronectin. Fibrinogen is closely linked to fibronectin during clotting processes. The aim of this study was to show fibrinogen gene expression during liver damage. METHODS:Fibrinogen/fibrin deposition in damaged livers was studied by immuno...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90211-2
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND & AIMS:The interactions among pre-S deletion, precore (PC) mutation, and basal core promoter (BCP) mutation in various stages of chronic hepatitis B virus (HBV) infection remain unclear and were thus investigated in this study. METHODS:The sequences of the pre-S region and the BCP (A1762T, G1764A) and PC (G...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.01.011
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND & AIMS:Infection with Helicobacter pylori is associated with reduced risk of esophageal adenocarcinoma (EAC), but it is not clear whether this reduction is modified by genotype, other host characteristics, or environmental factors. Furthermore, little is known about the association between H pylori and adeno...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.04.009
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND & AIMS:Sigmoidoscopy is an effective screening strategy for colorectal cancer that is not widely used by primary care providers. The aim of this study was to assess the impact of "academic detailing" in the form of an outreach educational seminar combined with implementation of on-site sigmoidoscopy services...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1053/gast.1999.0029900304
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND & AIMS:Immune-nonimmune cell interactions modulate mucosal immunity. We investigated the expression of adhesion molecules by intestinal fibroblasts, the effect of immune cell-derived factor on fibroblast binding of T cells, and the consequences of interfering with adhesion molecule expression on fibroblast-T...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(99)70447-6
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND & AIMS:Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair gene mutations that define this syndrome and result in microsatellite instability (MSI). The carcinogenic path...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1053/j.gastro.2010.01.035
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND & AIMS:Common germline genetic variation in the 3' region of myosin IXB (MYO9B) has been associated recently with susceptibility to celiac disease, with a hypothesis that MYO9B variants might influence intestinal permeability. These findings suggested the current study investigating a possible further role f...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1053/j.gastro.2006.09.011
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND & AIMS:The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a transmembrane glycoprotein with pleotropic functions, including clearance of hepatic insulin. We investigated the functions of the related protein CEACAM2, which has tissue-specific distribution (kidney, uterus, and crypt epi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.03.056
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The molecular basis of colorectal dysplasia and carcinoma arising in ulcerative colitis is poorly understood. Loss of heterozygosity involving the tumor suppressor gene p53 occurs frequently in neoplastic ulcerative colitis lesions. Point mutation affecting p53 is associated with loss of heterozygosity in ot...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90639-t
更新日期:1993-06-01 00:00:00