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Accumulation and cellular localization of fibrinogen/fibrin during short-term and long-term rat liver injury.

Abstract：

BACKGROUND/AIMS:During liver fibrosis, there is a putative pacemaker role of fibronectin. Fibrinogen is closely linked to fibronectin during clotting processes. The aim of this study was to show fibrinogen gene expression during liver damage. METHODS:Fibrinogen/fibrin deposition in damaged livers was studied by immunohistology. Fibrinogen gene expression was analyzed in vivo in a model of CCl4-induced rat liver damage and in vitro in isolated liver cells by means of Northern blot analysis and in situ hybridization. RESULTS:Immunohistology showed striking amounts of fibrinogen and fibrin deposits in pericentral necrotic areas (short-term damage) and within fibrotic septa (long-term damage). Total RNA extracted from short-term-damaged livers contained an increased fibrinogen messenger RNA level. By in situ hybridization, fibrinogen transcripts were localized in cells of the nonnecrotic areas (short-term damage) and outside fibrotic septa (long-term damage). In vitro studies showed fibrinogen de novo synthesis restricted to hepatocytes. CONCLUSIONS:The results show fibrinogen/fibrin deposition during short-term liver injury and liver fibrogenesis, which may suggest the involvement of a "clotting-like process" in short-term liver damage and liver fibrosis. The data might indicate that fibrin/fibronectin constitute a "provisional matrix," which affects the attraction and proliferation of inflammatory and matrix-producing cells.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Neubauer K,Knittel T,Armbrust T,Ramadori G

doi

10.1016/0016-5085(95)90211-2

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

1124-35

issue

4

eissn

0016-5085

issn

1528-0012

pii

0016-5085(95)90211-2

journal_volume

108

pub_type

杂志文章

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