Rats with gastritis have increased sensitivity to the gastrin stimulatory effects of luminal ammonia.


BACKGROUND & AIMS:Persons infected with Helicobacter pylori show an enhanced meal-stimulated gastrin release compared with uninfected controls. The aim of this study was to determine in animal models whether this gastrin release could be related to chronic gastric inflammation, elevated luminal ammonia level, or a combination of these factors. METHODS:Two rat models of mild gastric inflammation were studied. Rats given a long-term diet of 20 g/dL ammonium acetate (AmAc) in rat chow or 0.1% iodoacetamide in drinking water for 2-3 weeks underwent a short-term challenge with a normal or AmAc-supplemented meal. Serum gastrin and antral gastrin messenger RNA levels were measured. RESULTS:Compared with normal postprandial gastrin release, animals given the long-term AmAc feeding showed a normal response to rat chow but a greatly exaggerated response to rat chow plus 20 g/dL AmAc. Long-term feeding with iodoacetamide also resulted in enhanced gastrin release and antral gastrin messenger RNA in response to a meal supplemented with AmAc, but not to a normal meal or one supplemented with sodium acetate. CONCLUSIONS:Inflamed gastric mucosa is more sensitive to the effects of luminal ammonia and responds with an increase in both synthesis and release of gastrin. These animal models may provide insight into the pathogenesis of hypergastrinemia associated the H. pylori infection.






Dial EJ,Hall LR,Romero JJ,Lichtenberger LM




Has Abstract


1996-03-01 00:00:00














  • Fiberoptic endoscopy during laparotomy in the diagnosis of small intestinal bleeding.

    abstract::A patient with recurrent gastrointestinal bleeding caused by hereditary hemorrhagic telangiectasia localized to the small intestine is described. The diagnosis was made by combining two recognized investigational tools-fiberoptic endoscopy and laparotomy. ...


    pub_type: 杂志文章


    authors: Greenberg GR,Phillips MJ,Tovee EB,Jeejeebhoy KN

    更新日期:1976-07-01 00:00:00

  • Clinical features and prognosis of severe chronic active liver disease (CALD) after corticosteroid-induced remission.

    abstract::Disappearance of symptoms, resolution of most biochemical abnormalities, and histologic improvement to mild chronic inflammation were accomplished in 69 of 123 patients (56%) with severe chronic active liver disease treated with corticosteroids for up to 6.5 yr. Remission of at least 6 mo duration was possible in 35 o...


    pub_type: 杂志文章


    authors: Czaja AJ,Ammon HV,Summerskill WH

    更新日期:1980-03-01 00:00:00

  • Primary prophylaxis of variceal hemorrhage: a randomized controlled trial comparing band ligation, propranolol, and isosorbide mononitrate.

    abstract:BACKGROUND & AIMS:This randomized controlled trial compared variceal band ligation (VBL), propranolol (PPL), and isosorbide-5-mononitrate (ISMN) in the prevention of first esophageal variceal bleed. METHODS:Over a 6-year period, 172 patients with cirrhosis, grade II or III esophageal varices that had never bled, were ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lui HF,Stanley AJ,Forrest EH,Jalan R,Hislop WS,Mills PR,Finlayson ND,Macgilchrist AJ,Hayes PC

    更新日期:2002-09-01 00:00:00

  • Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis.

    abstract:BACKGROUND & AIMS:Interactions between genetic and environmental factors are believed to be involved in onset and initiation of inflammatory bowel disease. We analyzed the interaction between gastrointestinal mucosal microbiota and host genes in twin pairs discordant for ulcerative colitis (UC) to study the functional ...


    pub_type: 杂志文章,多中心研究


    authors: Lepage P,Häsler R,Spehlmann ME,Rehman A,Zvirbliene A,Begun A,Ott S,Kupcinskas L,Doré J,Raedler A,Schreiber S

    更新日期:2011-07-01 00:00:00

  • Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy.

    abstract:BACKGROUND & AIMS:Screening colonoscopy is an effective method to reduce the incidence of and mortality from colorectal cancer (CRC). There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with...


    pub_type: 杂志文章


    authors: Brenner H,Haug U,Arndt V,Stegmaier C,Altenhofen L,Hoffmeister M

    更新日期:2010-03-01 00:00:00

  • Role of Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease.

    abstract::Medical and recreational cannabis use has increased dramatically over the last decade, resulting from mainstream cultural acceptance and legalization in several countries worldwide. Cannabis and its derivatives affect many gastrointestinal processes via the endocannabinoid system (ECS). The ECS influences gastrointest...


    pub_type: 杂志文章,评审


    authors: Gotfried J,Naftali T,Schey R

    更新日期:2020-07-01 00:00:00

  • Measurement of fecal calprotectin improves monitoring and detection of recurrence of Crohn's disease after surgery.

    abstract:BACKGROUND & AIMS:Crohn's disease (CD) usually recurs after intestinal resection; postoperative endoscopic monitoring and tailored treatment can reduce the chance of recurrence. We investigated whether monitoring levels of fecal calprotectin (FC) can substitute for endoscopic analysis of the mucosa. METHODS:We analyze...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Wright EK,Kamm MA,De Cruz P,Hamilton AL,Ritchie KJ,Krejany EO,Leach S,Gorelik A,Liew D,Prideaux L,Lawrance IC,Andrews JM,Bampton PA,Jakobovits SL,Florin TH,Gibson PR,Debinski H,Macrae FA,Samuel D,Kronborg I,Radfor

    更新日期:2015-05-01 00:00:00

  • Expression of HLA-linked hemochromatosis in subjects homozygous or heterozygous for the C282Y mutation.

    abstract:BACKGROUND & AIMS:In the absence of a genetic test, diagnostic criteria for hereditary hemochromatosis have been imprecise. The identification of the HFE gene and the C282Y mutation allow definition of expression of this disease and reassessment of diagnostic criteria. The aim of this study was to analyze the concordan...


    pub_type: 杂志文章


    authors: Crawford DH,Jazwinska EC,Cullen LM,Powell LW

    更新日期:1998-05-01 00:00:00

  • Variable contribution of gastrin to gastric acid secretion after a meal in humans.

    abstract::The purpose of these experiments was to determine the contribution of gastrin to the acid secretory response to eating in healthy human subjects. To simulate the gastric and intestinal phases of eating, a meal was homogenized and then infused into the stomach through a nasogastric tube. At the same time, the cephalic ...


    pub_type: 杂志文章


    authors: Blair AJ 3rd,Richardson CT,Walsh JH,Feldman M

    更新日期:1987-04-01 00:00:00

  • Increased gastroduodenal concentrations of transforming growth factor alpha in adaptation to aspirin in monkeys and rats.

    abstract:BACKGROUND & AIMS:The mechanism by which gastric mucosa becomes more resistant to damage by repeated aspirin administration is not known. Transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) prevent drug-induced gastric injury. The aim of this study was to determine whether gastroduodenal tiss...


    pub_type: 杂志文章


    authors: Romano M,Lesch CA,Meise KS,Veljaca M,Sanchez B,Kraus ER,Boland CR,Guglietta A,Coffey RJ

    更新日期:1996-05-01 00:00:00

  • Favorable response to parenteral nutrition and medical therapy in Crohn's colitis. A report of 38 patients comparing severe Crohn's and ulcerative colitis.

    abstract::The courses of 38 patients with severe, uncomplicated acute colitis (16 with Crohn's colitis and 22 with ulcerative colitis) were analyzed retrospectively. The patients were placed on total parenteral nutrition and treated concomitantly with corticosteroids, antibiotics (often metronidazole), sulfasalazine, and/or aza...


    pub_type: 杂志文章


    authors: Sitzmann JV,Converse RL Jr,Bayless TM

    更新日期:1990-12-01 00:00:00

  • Effects of Eradicating Hepatitis C Virus Infection in Patients With Cirrhosis Differ With Stage of Portal Hypertension.

    abstract:BACKGROUND & AIMS:Clearance of hepatitis C virus (HCV) via antiviral treatment changes the course of liver disease. We evaluated the benefit of sustained virologic response (SVR) in patients with HCV and cirrhosis without (stage 1) and with (stage 2) esophageal varices (EV). METHODS:We performed a prospective cohort s...


    pub_type: 杂志文章


    authors: Di Marco V,Calvaruso V,Ferraro D,Bavetta MG,Cabibbo G,Conte E,Cammà C,Grimaudo S,Pipitone RM,Simone F,Peralta S,Arini A,Craxì A

    更新日期:2016-07-01 00:00:00

  • Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function.

    abstract:BACKGROUND & AIMS:Toll-like receptors (TLRs) represent a class of transmembrane pattern recognition receptors essential for microbial recognition and control of innate immune responses. Commensal bacteria play an important role in maintaining tolerance and active stability of the intestinal epithelial barrier by suppre...


    pub_type: 杂志文章


    authors: Cario E,Gerken G,Podolsky DK

    更新日期:2007-04-01 00:00:00

  • Regional esophageal distribution and clearance of refluxed gastric acid.

    abstract::Regional differences in the esophageal distribution and clearance of refluxed gastric acid was studied in seven asymptomatic volunteers and seven patients with reflux esophagitis. Intraluminal pH was recorded for 3 postprandial hours from the distal, middle, and proximal esophagus on two separate occasions (with subje...


    pub_type: 杂志文章


    authors: Shaker R,Dodds WJ,Helm JF,Kern MK,Hogan WJ

    更新日期:1991-08-01 00:00:00

  • Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics.

    abstract::Treatment options for inflammatory bowel disease (IBD) reflect a continuing shift from empiricism to strategies based on improved understanding of the pathophysiology of disease. In susceptible individuals, IBD appears to be the result of defective regulation of mucosal immune interactions with the enteric microflora....


    pub_type: 杂志文章,评审


    authors: Shanahan F

    更新日期:2001-02-01 00:00:00

  • Markers of fibrogenesis and basement membrane formation in alcoholic liver disease. Relation to severity, presence of hepatitis, and alcohol intake.

    abstract::This study investigated the relationships of the serum markers of fibrogenesis and basement membrane formation to the clinical and morphological severity of alcoholic liver disease and to the degree of alcohol abuse. The concentrations of the aminoterminal propeptide of type III collagen, type IV collagen, and laminin...


    pub_type: 杂志文章


    authors: Niemelä O,Risteli J,Blake JE,Risteli L,Compton KV,Orrego H

    更新日期:1990-06-01 00:00:00

  • Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: a case-control study.

    abstract:BACKGROUND & AIMS:Viral genotypes have been associated with different severity and outcome of hepatitis C virus (HCV)-related liver disease. The aim of this study was to determine whether HCV genotypes may influence the cirrhosis-related risk of the development of hepatocellular carcinoma (HCC). METHODS:Three groups o...


    pub_type: 杂志文章


    authors: Silini E,Bottelli R,Asti M,Bruno S,Candusso ME,Brambilla S,Bono F,Iamoni G,Tinelli C,Mondelli MU,Ideo G

    更新日期:1996-07-01 00:00:00

  • Increased risk of stomach and esophageal malignancies in people with AIDS.

    abstract:BACKGROUND & AIMS:People infected with human immunodeficiency virus (HIV) have an increased risk of some malignancies, but little is known about the effects of infection on risk of cancers of the upper gastrointestinal tract. We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hod...


    pub_type: 杂志文章,收录出版


    authors: Persson EC,Shiels MS,Dawsey SM,Bhatia K,Anderson LA,Engels EA

    更新日期:2012-10-01 00:00:00

  • Changes in hepatitis C virus antigen in liver with antiviral therapy.

    abstract:BACKGROUND:Although it has recently become possible to detect hepatitis C viral antigens in liver biopsy specimens, the frequency and clinical significance of this finding remains uncertain. Therefore, 49 liver biopsy specimens from 35 patients with hepatitis C were studied to make these assessments. METHODS:Hepatitis...


    pub_type: 杂志文章


    authors: Di Bisceglie AM,Hoofnagle JH,Krawczynski K

    更新日期:1993-09-01 00:00:00

  • STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen.

    abstract:BACKGROUND & AIMS:The signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors mediating acute-phase response (APR) of the human angiotensinogen (hAGT) gene in hepatocytes. The mechanisms of how STAT3 activates target genes are unknown. Here we analyzed the biochemistry of STAT3 ...


    pub_type: 杂志文章


    authors: Ray S,Boldogh I,Brasier AR

    更新日期:2005-11-01 00:00:00

  • Factors affecting the measurement of cholesterol nucleation in human gallbladder and duodenal bile.

    abstract::The study of cholesterol gallstone disease would be facilitated if the nucleation time of cholesterol crystals could be measured in duodenal bile and was correlated with nucleation occurring in vivo. Therefore, our aims were to determine (a) if nucleation time could be measured in duodenal bile, (b) the effect of bact...


    pub_type: 杂志文章


    authors: Marks JW,Broomfield P,Bonorris GG,Schoenfield LJ

    更新日期:1991-07-01 00:00:00

  • Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.

    abstract:BACKGROUND & AIMS:The cyclic adenosine monophosphate (cAMP) and Ca(2+) signaling pathways synergize to regulate many physiological functions. However, little is known about the mechanisms by which these pathways interact. We investigated the synergy between these signaling pathways in mouse pancreatic and salivary glan...


    pub_type: 杂志文章


    authors: Park S,Shcheynikov N,Hong JH,Zheng C,Suh SH,Kawaai K,Ando H,Mizutani A,Abe T,Kiyonari H,Seki G,Yule D,Mikoshiba K,Muallem S

    更新日期:2013-07-01 00:00:00

  • Communication via gap junctions modulates bile secretion in the isolated perfused rat liver.

    abstract:BACKGROUND & AIMS:Bile secretion is regulated in part by adenosine 3',5'-cyclic monophosphate (cAMP) and cytosolic Ca2+ (Ca2+i). Hormone receptors that link to these second messengers are not uniformly distributed across the hepatic lobule, but both cAMP and Ca2+i cross gap junctions, so we tested whether gap junctiona...


    pub_type: 杂志文章


    authors: Nathanson MH,Rios-Velez L,Burgstahler AD,Mennone A

    更新日期:1999-05-01 00:00:00

  • Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches.

    abstract::Intestinal microbiota are involved in the pathogenesis of Crohn's disease, ulcerative colitis, and pouchitis. We review the mechanisms by which these gut bacteria, fungi, and viruses mediate mucosal homeostasis via their composite genes (metagenome) and metabolic products (metabolome). We explain how alterations to th...


    pub_type: 杂志文章,评审


    authors: Sartor RB,Wu GD

    更新日期:2017-02-01 00:00:00

  • Combined functional and positional gene information for the identification of susceptibility variants in celiac disease.

    abstract:BACKGROUND & AIMS:Celiac disease is a complex, immune-mediated disorder of the intestinal mucosa with a strong genetic component. HLA-DQ2 is the major determinant of risk, but other minor genes, still to be identified, also are involved. METHODS:We designed a strategy that combines gene expression profiling of intesti...


    pub_type: 杂志文章


    authors: Castellanos-Rubio A,Martin-Pagola A,Santín I,Hualde I,Aransay AM,Castaño L,Vitoria JC,Bilbao JR

    更新日期:2008-03-01 00:00:00

  • Independent influences of body mass and gastric volumes on satiation in humans.

    abstract:BACKGROUND & AIMS:We assessed the association of body mass and gastric volumes (fasting and postprandial) with satiation and postprandial symptoms. METHODS:Healthy obese and nonobese subjects underwent measurement of caloric intake at maximum satiation; postprandial symptoms were measured with visual analogue scales 3...


    pub_type: 杂志文章


    authors: Delgado-Aros S,Cremonini F,Castillo JE,Chial HJ,Burton DD,Ferber I,Camilleri M

    更新日期:2004-02-01 00:00:00

  • Ornithine decarboxylase and diamine oxidase in human colon carcinoma cell line CaCo-2 in culture.

    abstract::The human colon carcinoma cell line CaCo-2, grown in vitro under standard culture conditions and in the absence of differentiation inducers, spontaneously exhibits structural and functional characteristics of mature small bowel enterocytes. Differentiation is complete at late confluency. High activities of ornithine d...


    pub_type: 杂志文章


    authors: D'Agostino L,Daniele B,Pignata S,Gentile R,Tagliaferri P,Contegiacomo A,Silvestro G,Polistina C,Bianco AR,Mazzacca G

    更新日期:1989-10-01 00:00:00

  • Hydrocortisone modulates cholera toxin endocytosis by regulating immature enterocyte plasma membrane phospholipids.

    abstract:BACKGROUND & AIMS:Diarrheal disease is a major cause of morbidity and mortality in infants and children worldwide. Evidence has indicated immature human enterocytes and their interaction with bacteria and enterotoxins may account for the noted increased susceptibility of neonates to diarrhea. Our aim was to characteriz...


    pub_type: 杂志文章


    authors: Lu L,Bao Y,Khan A,Goldstein AM,Newburg DS,Quaroni A,Brown D,Walker WA

    更新日期:2008-07-01 00:00:00

  • Consensus statements on the risk, prevention, and treatment of venous thromboembolism in inflammatory bowel disease: Canadian Association of Gastroenterology.

    abstract:BACKGROUND & AIMS:Guidelines for the management of venous thromboembolism (VTE) from the American College of Chest Physicians do not address patients with inflammatory bowel disease (IBD), a group with a high risk of both VTE and gastrointestinal bleeding. We present recommendations for the prevention and treatment of ...


    pub_type: 共识发展会议,杂志文章,评审


    authors: Nguyen GC,Bernstein CN,Bitton A,Chan AK,Griffiths AM,Leontiadis GI,Geerts W,Bressler B,Butzner JD,Carrier M,Chande N,Marshall JK,Williams C,Kearon C

    更新日期:2014-03-01 00:00:00

  • Plasma catecholamines and postoperative gastric emptying and small intestinal propulsion in the rat.

    abstract::The role of adrenal medullary discharge of catecholamines on inhibition of gastric emptying and small intestinal propulsion after laparotomy was examined in rats. The rate of movement of a 51Cr-labeled liquid test meal, which had been introduced by gastric intubation, out of the stomach and through the small intestine...


    pub_type: 杂志文章


    authors: Dubois A,Henry DP,Kopin IJ

    更新日期:1975-03-01 00:00:00