Rats with gastritis have increased sensitivity to the gastrin stimulatory effects of luminal ammonia.


BACKGROUND & AIMS:Persons infected with Helicobacter pylori show an enhanced meal-stimulated gastrin release compared with uninfected controls. The aim of this study was to determine in animal models whether this gastrin release could be related to chronic gastric inflammation, elevated luminal ammonia level, or a combination of these factors. METHODS:Two rat models of mild gastric inflammation were studied. Rats given a long-term diet of 20 g/dL ammonium acetate (AmAc) in rat chow or 0.1% iodoacetamide in drinking water for 2-3 weeks underwent a short-term challenge with a normal or AmAc-supplemented meal. Serum gastrin and antral gastrin messenger RNA levels were measured. RESULTS:Compared with normal postprandial gastrin release, animals given the long-term AmAc feeding showed a normal response to rat chow but a greatly exaggerated response to rat chow plus 20 g/dL AmAc. Long-term feeding with iodoacetamide also resulted in enhanced gastrin release and antral gastrin messenger RNA in response to a meal supplemented with AmAc, but not to a normal meal or one supplemented with sodium acetate. CONCLUSIONS:Inflamed gastric mucosa is more sensitive to the effects of luminal ammonia and responds with an increase in both synthesis and release of gastrin. These animal models may provide insight into the pathogenesis of hypergastrinemia associated the H. pylori infection.






Dial EJ,Hall LR,Romero JJ,Lichtenberger LM




Has Abstract


1996-03-01 00:00:00














  • Survival of liver transplant recipients with hemochromatosis in the United States.

    abstract:BACKGROUND AND AIMS:Earlier studies have suggested that patients with hemochromatosis have poor post-transplantation survival. We aimed to compare patients with hemochromatosis to those with other causes of liver disease with regard to post-transplantation survival. METHODS:We compared the post-transplant survival of ...


    pub_type: 杂志文章


    authors: Yu L,Ioannou GN

    更新日期:2007-08-01 00:00:00

  • Long-term extensive expansion of mouse hepatic stem/progenitor cells in a novel serum-free culture system.

    abstract:BACKGROUND & AIMS:The liver has high regenerative potential. We attempted to establish a novel culture system for extensive expansion of fetal mouse hepatic stem/progenitor cells and to characterize cultured cells. METHODS:Hepatic spheroids collected from 6-day floating cultures were cultured on collagen-coated dishes...


    pub_type: 杂志文章


    authors: Tsuchiya A,Heike T,Fujino H,Shiota M,Umeda K,Yoshimoto M,Matsuda Y,Ichida T,Aoyagi Y,Nakahata T

    更新日期:2005-06-01 00:00:00

  • Erythropoietic protoporphyria: unusual skin and neurological problems after liver transplantation.

    abstract::The case of a woman with protoporphyria who developed liver failure and underwent liver transplantation is described. During the pretransplant episode of liver failure she developed quadriparesis that rapidly progressed after transplantation to a severe polyneuropathy. Following transplantation she also developed a se...


    pub_type: 杂志文章


    authors: Herbert A,Corbin D,Williams A,Thompson D,Buckels J,Elias E

    更新日期:1991-06-01 00:00:00

  • Impaired viscerosomatic reflexes and abdominal-wall dystony associated with bloating.

    abstract:BACKGROUND & AIMS:Abdominal bloating is a frequent complaint in irritable bowel syndrome (IBS), but its underlying mechanism remains uncertain. Our aim was to determine whether the abdominal wall, specifically its adaptation to intra-abdominal volumes, plays a role. METHODS:In 12 patients complaining of abdominal bloa...


    pub_type: 杂志文章


    authors: Tremolaterra F,Villoria A,Azpiroz F,Serra J,Aguadé S,Malagelada JR

    更新日期:2006-04-01 00:00:00

  • Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione.

    abstract:BACKGROUND & AIMS:Barrier functions across epithelia and endothelia are essential for homeostatic tissue regulation. Astroglia interact with cerebral endothelia to maintain the blood-brain barrier. Whether similar interactions between astrocyte-like enteric glia and epithelia regulate intestinal barrier function is not...


    pub_type: 杂志文章


    authors: Savidge TC,Newman P,Pothoulakis C,Ruhl A,Neunlist M,Bourreille A,Hurst R,Sofroniew MV

    更新日期:2007-04-01 00:00:00

  • Increased intake of vegetables, but not fruit, reduces risk for hepatocellular carcinoma: a meta-analysis.

    abstract:BACKGROUND & AIMS:The anti-cancer effects of vegetables and fruit have been investigated extensively, but the association between vegetable and fruit consumption and risk of hepatocellular carcinoma (HCC) has not been quantified. We performed a meta-analysis of observational studies to clarify the association. METHODS...


    pub_type: 杂志文章,meta分析,评审


    authors: Yang Y,Zhang D,Feng N,Chen G,Liu J,Chen G,Zhu Y

    更新日期:2014-11-01 00:00:00

  • Inflammatory bowel disease in all three members of one family.

    abstract::The occurrence of inflammatory bowel disease in all three members of one family is described. Studies of white blood cell chromosomes, histocompatibility antigens, and cellular and humoral immunity failed to explain this unusual phenomenon. However, the appearance of inflammatory bowel disease in an entire family reem...


    pub_type: 杂志文章


    authors: Rosenberg JL,Kraft SC,Kirsner JB

    更新日期:1976-05-01 00:00:00

  • Dopamine as a possible neurotransmitter in gastric relaxation.

    abstract::In dogs with gastric fistulas, intragastric pressure was measured with a flaccid ballon containing 500 ml of water. Graded doses of dopamine caused graded decreases in intragastric pressure. The effect was blocked by pimozide or by metoclopramide but was not significantly affected by phenoxybenzamine, propranolol, gua...


    pub_type: 杂志文章


    authors: Valenzuela JE

    更新日期:1976-12-01 00:00:00

  • Food, immunity, and the microbiome.

    abstract::There is increasing evidence that ingested diet-borne components are involved in the pathogenesis of disorders such as inflammatory bowel diseases, atherosclerosis, and type 2 diabetes. Nutrients can have short- and long-term effects in shaping the composition of the microbiota. Western diets (enriched in fat, phospha...


    pub_type: 杂志文章,评审


    authors: Tilg H,Moschen AR

    更新日期:2015-05-01 00:00:00

  • Does lower esophageal sphincter incompetency contribute to esophageal bleeding?

    abstract::The purpose of this study is to determine whether lower esophageal sphincter (LES) incompetency is a common occurrence in patients with liver cirrhosis and contributes to the development of variceal bleeding. Resting LES pressure (17.8 +/- 1.1 mm Hg) in 35 patients with cirrhosis was similar to that of our control pop...


    pub_type: 杂志文章


    authors: Eckardt VF,Grace ND,Kantrowitz PA

    更新日期:1976-08-01 00:00:00

  • The impact of interferon plus ribavirin on response to therapy in black patients with chronic hepatitis C. The International Hepatitis Interventional Therapy Group.

    abstract:BACKGROUND & AIMS:Black patients with chronic hepatitis C have lower response rates than white patients to interferon monotherapy. The factors responsible for these differences are unknown, as is the impact of combination antiviral therapy on responsiveness among ethnic groups. We evaluated the impact of race on respon...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: McHutchison JG,Poynard T,Pianko S,Gordon SC,Reid AE,Dienstag J,Morgan T,Yao R,Albrecht J

    更新日期:2000-11-01 00:00:00

  • Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl⁻ channels and luminal anion exchangers.

    abstract:BACKGROUND & AIMS:The effects of trypsin on pancreatic ductal epithelial cells (PDECs) vary among species and depend on the localization of proteinase-activated receptor 2 (PAR-2). We compared PAR-2 localization in human and guinea-pig PDECs, and used isolated guinea pig ducts to study the effects of trypsin and a PAR-...


    pub_type: 杂志文章


    authors: Pallagi P,Venglovecz V,Rakonczay Z Jr,Borka K,Korompay A,Ozsvári B,Judák L,Sahin-Tóth M,Geisz A,Schnúr A,Maléth J,Takács T,Gray MA,Argent BE,Mayerle J,Lerch MM,Wittmann T,Hegyi P

    更新日期:2011-12-01 00:00:00

  • Increased hepatocyte expression of hepatitis B virus transcription in patients with features of fibrosing cholestatic hepatitis.

    abstract:BACKGROUND:Recurrent hepatitis B after liver transplantation may be complicated by fibrosing cholestatic hepatitis. This syndrome is associated with rapid graft failure and is characterized by ballooning degeneration of hepatocytes and abundant viral antigen expression. METHODS:To study this disorder further, in situ ...


    pub_type: 杂志文章


    authors: Mason AL,Wick M,White HM,Benner KG,Lee RG,Regenstein F,Riely CA,Bain VG,Campbell C,Perrillo RP

    更新日期:1993-07-01 00:00:00

  • Biliary-shunt fistula following transjugular intrahepatic portosystemic shunt placement.

    abstract::Sepsis following the placement of a transjugular intrahepatic portosystemic shunt (TIPS) has been reported in up to 10% of cases. This report describes an unusual case of polymicrobial gram-negative sepsis after placement of TIPS associated with a cholangiographically documented fistulous connection between the biliar...


    pub_type: 杂志文章


    authors: Mallery S,Freeman ML,Peine CJ,Miller RP,Stanchfield WR

    更新日期:1996-11-01 00:00:00

  • Duodenal volume and osmoreceptors in the stimulation of human pancreatic secretion.

    abstract::It is generally accepted that the intestinal phase of pancreatic secretion is initiated by the stimulation of chemoreceptors sensitive to fat and protein degradation products and hydrogen ions. The effect of the volume and osmolality of food emptied by the stomach into the duodenum has received less attention. We inve...


    pub_type: 杂志文章


    authors: Dooley CP,Valenzuela JE

    更新日期:1984-01-01 00:00:00

  • In vivo hepatic 31P magnetic resonance spectroscopy in chronic alcohol abusers.

    abstract:BACKGROUND/AIMS:In vivo hepatic 31P magnetic resonance spectroscopy (MRS) can provide information on hepatic energy metabolism, phospholipid substrates, and hepatocyte lipid bilayers. The aim of this study was to ascertain the effects of alcohol ingestion on hepatic 31P spectral variables. METHODS:Twenty-six chronic a...


    pub_type: 杂志文章


    authors: Menon DK,Harris M,Sargentoni J,Taylor-Robinson SD,Cox IJ,Morgan MY

    更新日期:1995-03-01 00:00:00

  • Effect of bethanechol or vagal nerve stimulation on ileocecal sphincter pressure in the cat.

    abstract::Ileocecal sphincter pressure was studied in the cat, using an open-tipped perfused catheter system. Ileocecal sphincter pressure was measured under basal conditions and in response to bethanechol or direct vagal nerve electrical stimulation. The pressure was 26.1 +/- 5.0 mmHg basally, and was unaltered by section of e...


    pub_type: 杂志文章


    authors: Rubin MR,Cardwell BA,Ouyang A,Snape WJ Jr,Cohen S

    更新日期:1981-05-01 00:00:00

  • Inward growth of colonic adenomatous polyps.

    abstract:BACKGROUND & AIMS:Most colon cancers arise from polypoid adenomas, but how these benign lesions develop into malignant neoplasms is not understood. This study examined the migration of epithelial cells within human adenomatous polyps by determining the distribution of proliferating and apoptotic cells and immunoreactiv...


    pub_type: 杂志文章


    authors: Moss SF,Liu TC,Petrotos A,Hsu TM,Gold LI,Holt PR

    更新日期:1996-12-01 00:00:00

  • Mast cells are closely apposed to nerves in the human gastrointestinal mucosa.

    abstract::Mast cell/nerve associations have been recorded in several publications; however, the human gastrointestinal tract has received little attention. Accordingly, mucosal samples from small bowel, appendix, and large bowel were studied. Combined histochemical/immunocytochemical techniques revealed that the proportion of m...


    pub_type: 杂志文章


    authors: Stead RH,Dixon MF,Bramwell NH,Riddell RH,Bienenstock J

    更新日期:1989-09-01 00:00:00

  • A small animal model of human Helicobacter pylori active chronic gastritis.

    abstract::Isolation of a spiral-shaped bacterium closely related to Helicobacter pylori from the cat stomach made it possible to investigate new small animal models of gastric infection. Pure cultures of this bacterium, provisionally named "Helicobacter felis," were fed to germ-free mice. The organism colonized the stomach in l...


    pub_type: 杂志文章


    authors: Lee A,Fox JG,Otto G,Murphy J

    更新日期:1990-11-01 00:00:00

  • Cryptosporidium: cellular localization, structural analysis of absorptive cell-parasite membrane-membrane interactions in guinea pigs, and suggestion of protozoan transport by M cells.

    abstract::In ilea of spontaneously infested guinea pigs, we examined the interface between the plasma membranes of cryptosporidia and absorptive cells using thin section and freeze fracture techniques. Initially, cryptosporidia invaginate microvilli, and the resulting redundant folds of membrane envelop the protozoan, thereby i...


    pub_type: 杂志文章


    authors: Marcial MA,Madara JL

    更新日期:1986-03-01 00:00:00

  • Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy.

    abstract::Because the esophagus is easily accessible with endoscopy, early diagnosis and curative treatment of esophageal cancer is possible. However, diagnosis is often delayed because symptoms are not specific during early stages of tumor development. The onset of dysphagia is associated with advanced disease, which has a sur...


    pub_type: 杂志文章,评审


    authors: di Pietro M,Canto MI,Fitzgerald RC

    更新日期:2018-01-01 00:00:00

  • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.

    abstract:BACKGROUND & AIMS:The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS:Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structu...


    pub_type: 杂志文章


    authors: Lerat H,Honda M,Beard MR,Loesch K,Sun J,Yang Y,Okuda M,Gosert R,Xiao SY,Weinman SA,Lemon SM

    更新日期:2002-02-01 00:00:00

  • Protease inhibitor-resistant hepatitis C virus mutants with reduced fitness from impaired production of infectious virus.

    abstract:BACKGROUND & AIMS:Several small molecule inhibitors of the hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease have advanced successfully to clinical trials. However, the selection of drug-resistant mutants is a significant issue with protease inhibitors (PIs). A variety of amino acid substitutions in the ...


    pub_type: 杂志文章


    authors: Shimakami T,Welsch C,Yamane D,McGivern DR,Yi M,Zeuzem S,Lemon SM

    更新日期:2011-02-01 00:00:00

  • Neuron specific enolase: a common marker for the endocrine cells and innervation of the gut and pancreas.

    abstract::Neuron specific enolase, the most acidic isoenzyme of the glycolytic enzyme enolase, was first believed to be present exclusively in central neurons. More recently, it has been found in peripheral autonomic nerves and in a number of endocrine cells. An immunocytochemical study was carried out concerning the distributi...


    pub_type: 杂志文章


    authors: Bishop AE,Polak JM,Facer P,Ferri GL,Marangos PJ,Pearse AG

    更新日期:1982-10-01 00:00:00

  • Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome.

    abstract:BACKGROUND & AIMS:To investigate the peripheral sensory effects of repeated stress in patients with postinfectious irritable bowel syndrome (IBS), we tested whether stress following self-limiting bacterial colitis increases colonic dorsal root ganglia (DRG) nociceptive signaling. METHODS:C57BL/6 mice were infected wit...


    pub_type: 杂志文章


    authors: Ibeakanma C,Ochoa-Cortes F,Miranda-Morales M,McDonald T,Spreadbury I,Cenac N,Cattaruzza F,Hurlbut D,Vanner S,Bunnett N,Vergnolle N,Vanner S

    更新日期:2011-12-01 00:00:00

  • Qualitative and quantitative analysis of muscarinic acetylcholine receptors in the piebald lethal mouse model of Hirschsprung's disease.

    abstract::Cholinergic innervation in the aganglionic bowel of the piebald lethal mouse model of Hirschsprung's disease was investigated by analysis of muscarinic acetylcholine receptors before and after administration of hexamethonium. After hexamethonium administration in the normal rectum, the maximum specific binding (Bmax) ...


    pub_type: 杂志文章


    authors: Ueki S,Okamoto E,Kuwata K,Toyosaka A,Nagai K

    更新日期:1985-06-01 00:00:00

  • Role of acquired and hereditary thrombotic risk factors in colon ischemia of ambulatory patients.

    abstract:BACKGROUND & AIMS:Hypercoagulable states may play an important role in the pathogenesis of colon ischemia. Aim of this study was to assess this hypothesis investigating the role of acquired and hereditary thrombotic risk factors in patients with definite diagnosis of colon ischemia. METHODS:We compared the frequency o...


    pub_type: 杂志文章


    authors: Koutroubakis IE,Sfiridaki A,Theodoropoulou A,Kouroumalis EA

    更新日期:2001-09-01 00:00:00

  • alpha-1-antitrypsin deficiency in liver disease: the extent of the problem.

    abstract::A prospective screening program was undertaken at the Royal Free Hospital, London, to ascertain the incidence of alpha-1-antitrypsin (AAT) deficiency in patients with liver disease. Quantitative determinations of serum alpha-1-antitrypsin were performed on 469 patients with hepatobiliary disease and 98 subjects with n...


    pub_type: 杂志文章


    authors: Fisher RL,Taylor L,Sherlock S

    更新日期:1976-10-01 00:00:00

  • Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C.

    abstract:BACKGROUND & AIMS:Iron overload may cause or contribute to hepatic injury and fibrosis. Mutations in the HFE gene may influence development or progression of chronic liver disease by increasing iron stores or modulating immune responses. The aim of this work was to assess the influence of HFE mutations and serum and he...


    pub_type: 临床试验,杂志文章


    authors: Bonkovsky HL,Naishadham D,Lambrecht RW,Chung RT,Hoefs JC,Nash SR,Rogers TE,Banner BF,Sterling RK,Donovan JA,Fontana RJ,Di Bisceglie AM,Ghany MG,Morishima C,HALT-C Trial Group.

    更新日期:2006-11-01 00:00:00