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Ventromedial hypothalamic lesions increase gastrointestinal DNA synthesis through vagus nerve in rats.

Abstract：

BACKGROUND:It was recently reported that ventromedial hypothalamic (VMH) lesions produced an increase in gastrointestinal DNA content in rats. In the present study, the mechanism of this alteration was examined. METHODS:The DNA content and synthesis after VMH lesioning in rat gastrointestinal tracts were determined. RESULTS:Total content of DNA in stomach and small intestine began to increase at 3 days and continued to increase for 7 days, whereas DNA content in the large intestine began to increase at 3 days and maintained the same level until 7 days after VMH lesioning. DNA synthesis of these organs increased and reached maximum at 3 days and then decreased to the initial level 7 days following the lesions. This increase in DNA content and synthesis in these organs was largely inhibited by bilateral subdiaphragmatic vagotomy or the administration of atropine, a cholinergic blocker, but not by the administration of anti-insulin antibody. CONCLUSIONS:VMH lesions induce cell proliferation in the rat gastrointestinal tract by the firing of vagus nerve activity mainly through the cholinergic receptor mechanism.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Kiba T,Tanaka K,Endo O,Inoue S

doi

10.1016/0016-5085(93)90416-a

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

475-84

issue

2

eissn

0016-5085

issn

1528-0012

pii

0016-5085(93)90416-A

journal_volume

104

pub_type

杂志文章

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