Abstract:
:Some of the most common symptoms of the inflammatory bowel diseases (IBD, which include ulcerative colitis and Crohn's disease) are abdominal pain, diarrhea, and weight loss. It is therefore not surprising that clinicians and patients have wondered whether dietary patterns influence the onset or course of IBD. The question of what to eat is among the most commonly asked by patients, and among the most difficult to answer for clinicians. There are substantial variations in dietary behaviors of patients and recommendations for them, although clinicians do not routinely endorse specific diets for patients with IBD. Dietary clinical trials have been limited by their inability to include a placebo control, contamination of study groups, and inclusion of patients receiving medical therapies. Additional challenges include accuracy of information on dietary intake, complex interactions between foods consumed, and differences in food metabolism among individuals. We review the roles of diet in the etiology and management of IBD based on plausible mechanisms and clinical evidence. Researchers have learned much about the effects of diet on the mucosal immune system, epithelial function, and the intestinal microbiome; these findings could have significant practical implications. Controlled studies of patients receiving enteral nutrition and observations made from patients on exclusion diets have shown that components of whole foods can have deleterious effects for patients with IBD. Additionally, studies in animal models suggested that certain nutrients can reduce intestinal inflammation. In the future, engineered diets that restrict deleterious components but supplement beneficial nutrients could be used to modify the luminal intestinal environment of patients with IBD; these might be used alone or in combination with immunosuppressive agents, or as salvage therapy for patients who do not respond or lose responsiveness to medical therapies. Stricter diets might be required to induce remission, and more sustainable exclusion diets could be used to maintain long-term remission.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Lee D,Albenberg L,Compher C,Baldassano R,Piccoli D,Lewis JD,Wu GDdoi
10.1053/j.gastro.2015.01.007subject
Has Abstractpub_date
2015-05-01 00:00:00pages
1087-106issue
6eissn
0016-5085issn
1528-0012pii
S0016-5085(15)00069-4journal_volume
148pub_type
杂志文章,评审相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND & AIMS:Methylation of specific microRNAs (miRNAs) often occurs in an age-dependent manner, as a field defect in some instances, and may be an early event in colitis-associated carcinogenesis. We aimed to determine whether specific mRNA signature patterns (MIR1, MIR9, MIR124, MIR137, MIR34B/C) could be used t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.08.037
更新日期:2017-12-01 00:00:00
abstract::Endoscopic screening in 123 patients with pernicious anemia (PA) yielded 4 patients with solitary and 1 patient with multiple gastric carcinoid tumors. Quantitative histologic studies of multiple standardized biopsy specimens showed a significantly increased number of fundic mucosal argyrophil endocrine cells in 40 pa...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90131-3
更新日期:1985-03-01 00:00:00
abstract::There are conflicting reports on the influence of cigarette smoking on healing in patients with duodenal ulcer; some studies show an adverse effect on healing rate and others no effect. This study reports the influence of smoking on short-term healing and relapse rate in 135 patients with duodenal ulcer who were treat...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::The goal of this study was to identify the structural and compositional features of human gallstones that influence in vitro gallstone dissolution in the cholesterol solvent monooctanoin. Gallstones were obtained from 86 consecutive patients who had at least three morphologically similar stones. One stone from each pa...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90320-9
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND & AIMS:Nuclear factor of activated T cells transcription factors plays a central role in immunity by regulating the expression of multiple cytokines and other regulatory molecules, many of which have been heavily implicated in the pathogenesis of inflammatory bowel disease. However, few studies have directly...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2004.01.013
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND & AIMS:A 3-dimensional (3D) culture system for immortalized human hepatocytes (HuS-E/2 cells) recently was shown to support the lifecycle of blood-borne hepatitis C virus (HCV). We used this system to identify proteins that are active during the HCV lifecycle under 3D culture conditions. METHODS:We compared...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.05.014
更新日期:2013-09-01 00:00:00
abstract::Increased type III collagen deposition in all layers of the intestinal tract, including the lamina propria, is a common feature of strictures in Crohn's disease. In the present study, it was found that in comparison with fibroblasts from normal or nonstrictured but inflamed intestinal lamina propria, the fibroblasts i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)90314-o
更新日期:1992-06-01 00:00:00
abstract::Many women report that bowel symptoms are associated with menstruation, but neither the prevalence of these complaints nor their physiological basis is known. This study aimed to estimate prevalence, to determine whether patients with irritable bowel syndrome are more likely to make such complaints, and to determine w...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)91079-l
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND & AIMS:Gain-of-function mutations in the KIT receptor tyrosine kinase gene and rare mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene are important events in gastrointestinal stromal tumor (GIST) development. Different mutations are reportedly associated with distinctive phenotypes...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.01.043
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND & AIMS:Early embryogenesis involves cell fate decisions that define the body axes and establish pools of progenitor cells. Development does not stop once lineages are specified; cells continue to undergo specific maturation events, and changes in gene expression patterns lead to their unique physiological fu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.04.011
更新日期:2012-08-01 00:00:00
abstract::Sweden has one of the highest incidences of gallstone disease in the Western world. It is therefore important to characterize the mechanisms responsible for the formation of cholesterol gallstones in this population. In the present study, we have determined the kinetics of the two primary bile acids, cholic acid and c...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90328-2
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND & AIMS:Nitrate ingestion leads to high luminal concentrations of nitric oxide being generated where saliva meets gastric acid. Nitric oxide generates N-nitrosative stress on reacting with oxygen at neutral pH. We aimed to ascertain if luminal nitric oxide exerts nitrosative stress in the human upper gastroin...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1053/j.gastro.2007.04.047
更新日期:2007-07-01 00:00:00
abstract::Liver copper concentration was studied in four groups of age-matched patients and in 9 patients with Wilson's disease of comparable age. Neutron activation analysis of hepatic copper concentration revealed markedly elevated hepatic copper levels, comparable with those in Wilson's disease, in 13 of 15 patients (P less ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract::We have recently demonstrated that release of oxygen-derived free radicals by activated hepatic macrophages may be involved in the pathogenesis of a rat model of liver injury induced by Corynebacterium parvum and endotoxin. In the present study we have compared the respiratory burst activity of isolated normal rat Kup...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90455-5
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND & AIMS:De novo hepatitis B virus (HBV)-related hepatitis after chemotherapy results in high morbidity and mortality. We evaluate the clinical course of de novo HBV-related hepatitis after chemotherapy. METHODS:Two hundred forty-four consecutive hepatitis B surface antigen (HBsAg)-negative lymphoma patients ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.04.015
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND & AIMS:Cancer progression/metastases and embryonic development share many properties including cellular plasticity, dynamic cell motility, and integral interaction with the microenvironment. We hypothesized that the heterogeneous nature of hepatocellular carcinoma (HCC), in part, may be owing to the presence...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.12.004
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND & AIMS:Lifestyle factors have been shown to influence prognosis in Crohn's disease. The purpose of this study was to prospectively assess the effects of smoking and oral contraceptive use on clinical relapse rates. METHODS:Placebo-treated patients formed a prospective cohort, followed up for 48 weeks or unt...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0016-5085(98)70419-6
更新日期:1998-06-01 00:00:00
abstract::Electromyogram of the submental muscles, esophageal manometry, and pH studies were simultaneously performed in an unselected group of 12 patients with subjective and objective evidence of gastroesophageal reflux (GER) disease to determine the frequency of transient relaxation of the lower esophageal sphincter (LES) an...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(88)80003-9
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND & AIMS:Fecal incontinence (FI) is characterized by uncontrolled passage of solid or liquid stool. We aimed to determine the prevalence and severity of FI in a large sample of US residents. METHODS:We recruited a representative sample of patients in October 2015 to complete the National Gastrointestinal (GI)...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2018.01.062
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND & AIMS:Some patients with irritable bowel syndrome with diarrhea (IBS-D) have intestinal hyperpermeability, which contributes to their diarrhea and abdominal pain. MicroRNA 29 (MIR29) regulates intestinal permeability in patients with IBS-D. We investigated and searched for targets of MIR29 and investigated ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2014.09.037
更新日期:2015-01-01 00:00:00
abstract::We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for d...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2015.12.042
更新日期:2016-05-01 00:00:00
abstract::S-Adenosylmethionine (800 mg i.v. per day) was used to treat two brothers and a brother and sister from each of two kindreds with benign recurrent intrahepatic cholestasis. Symptoms, routine tests of liver function, concentrations of total bile acids, and the oral clearances of [11,12-2H]chenodeoxycholic acid and [24-...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(89)80024-1
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND & AIMS:We followed patients with ongoing hepatitis C virus (HCV) exposure following control of an initial HCV infection to determine whether primary control conferred protection against future persistent infections. METHODS:Twenty-two active injection drug users (IDU) who had cleared a primary hepatitis C v...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.09.017
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Recurrent hepatitis B after liver transplantation may be complicated by fibrosing cholestatic hepatitis. This syndrome is associated with rapid graft failure and is characterized by ballooning degeneration of hepatocytes and abundant viral antigen expression. METHODS:To study this disorder further, in situ ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90032-8
更新日期:1993-07-01 00:00:00
abstract::A randomized, controlled trial was conducted to investigate the ability of indomethacin and chloroquine to reduce intestinal secretion in 29 adult patients with severe cholera. All patients received intravenous infusion to restore fluid balance, but no antibiotics were given. Patients treated with oral indomethacin (t...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0016-5085(85)90205-7
更新日期:1985-11-01 00:00:00
abstract::The onset, course, and regression of the biochemical and structural alterations associated with pancreatitis induced by various doses of caerulein were studied in the mouse. In addition, the protective effect of secretin was compared with that of the cholecystokinin-receptor antagonists proglumide and benzotript. Subc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(85)80079-2
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND/AIMS:Familial adenomatous polyposis is caused by germline mutation of the adenomatous polyposis coli (APC) gene. Affected individuals develop hundreds of colorectal adenomas at young age and can have extracolonic lesions. METHODS:This study evaluated the phenotype of 74 patients with familial adenomatous po...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90408-1
更新日期:1994-06-01 00:00:00
abstract::A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and user-friendliness. These approaches are based on the sensitive assay of molecular markers in stool, blood, and urine samples. New methods, especially next generation stool-bas...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2010.01.055
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND & AIMS:Abdominal bloating is a frequent complaint in irritable bowel syndrome (IBS), but its underlying mechanism remains uncertain. Our aim was to determine whether the abdominal wall, specifically its adaptation to intra-abdominal volumes, plays a role. METHODS:In 12 patients complaining of abdominal bloa...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.12.036
更新日期:2006-04-01 00:00:00
abstract::A patient is reported with eosinophilic enteritis of the jejunum with fatal evolution. Surgical resection was considered impossible and medical treatment with corticosteroids, elemental diet, parenteral nutrition, and antimicrobials to combat the intestinal bacterial overgrowth failed to control the disease. The destr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-09-01 00:00:00