Oral contraceptive use and smoking are risk factors for relapse in Crohn's disease. The Canadian Mesalamine for Remission of Crohn's Disease Study Group.

Abstract:

BACKGROUND & AIMS:Lifestyle factors have been shown to influence prognosis in Crohn's disease. The purpose of this study was to prospectively assess the effects of smoking and oral contraceptive use on clinical relapse rates. METHODS:Placebo-treated patients formed a prospective cohort, followed up for 48 weeks or until relapse. The influence of smoking and the use of oral contraceptives on relapse risk was examined by life-table analysis (log rank tests) and Cox proportional hazards modeling, taking into account demographic and disease characteristics. RESULTS:Of 152 patients, 61 (40%) had a relapse. Univariate analysis showed unfavorable outcomes for women (P = 0.05), current smokers (P = 0.005), and use of oral contraceptives (P = 0.001). Recent surgery was associated with a decreased risk of relapse (P = 0.02). The Cox model retained current smoking vs. never smoking (hazard ratio, 2.1; 95% confidence interval, 1.1-4.2), oral contraceptive use (hazard ratio, 3.0; 95% confidence interval, 1.5-5.9), and medical compared with surgical induction of remission (hazard ratio, 2.1; 95% confidence interval, 1.0-4.2) as predictors of relapse. Ex-smokers did not have an increased risk. Finally, sex, age, time in remission, disease location, and disease duration were not significant predictors. CONCLUSIONS:Oral contraceptive use and smoking are associated with an increased risk of relapse in patients with Crohn's disease.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Timmer A,Sutherland LR,Martin F

doi

10.1016/s0016-5085(98)70419-6

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

1143-50

issue

6

eissn

0016-5085

issn

1528-0012

pii

S0016508598005368

journal_volume

114

pub_type

临床试验,杂志文章,随机对照试验
  • Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver.

    abstract:BACKGROUND & AIMS:Drug-induced cholestasis is a frequent form of acquired liver disease. To elucidate the molecular pathogenesis of drug-induced cholestasis, we investigated the effects of prototypic cholestatic drugs on the canalicular bile salt export pump (Bsep) of rat liver. METHODS:Vesicles were isolated from Bse...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(00)70224-1

    authors: Stieger B,Fattinger K,Madon J,Kullak-Ublick GA,Meier PJ

    更新日期:2000-02-01 00:00:00

  • Bile acid is a host factor that regulates the composition of the cecal microbiota in rats.

    abstract:BACKGROUND & AIMS:Alterations in the gastrointestinal microbiota have been associated with metabolic diseases. However, little is known about host factors that induce changes in gastrointestinal bacterial populations. We investigated the role of bile acids in this process because of their strong antimicrobial activitie...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2011.07.046

    authors: Islam KB,Fukiya S,Hagio M,Fujii N,Ishizuka S,Ooka T,Ogura Y,Hayashi T,Yokota A

    更新日期:2011-11-01 00:00:00

  • Bismuth subsalicylate markedly decreases hydrogen sulfide release in the human colon.

    abstract:BACKGROUND & AIMS:Hydrogen sulfide is one of the main malodorous compounds in human flatus. This toxic gas also has been implicated in the pathogenesis of ulcerative colitis. Therefore, a treatment that reduces colonic H2S levels could be clinically useful in the treatment of flatus odor and of ulcerative colitis. In t...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(98)70311-7

    authors: Suarez FL,Furne JK,Springfield J,Levitt MD

    更新日期:1998-05-01 00:00:00

  • Biliary symptoms and complications more than 8 years after endoscopic sphincterotomy for choledocholithiasis.

    abstract:BACKGROUND & AIMS:Although long-term results of endoscopic sphincterotomy (ES) have been poorly estimated, extended indications of ES have been proposed, especially in young patients. The aim of this study was to assess late biliary complications of ES. METHODS:Between 1981 and 1986, 169 patients younger than age 70 (...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.1996.v110.pm8608900

    authors: Prat F,Malak NA,Pelletier G,Buffet C,Fritsch J,Choury AD,Altman C,Liguory C,Etienne JP

    更新日期:1996-03-01 00:00:00

  • Studies on lymphocyte hyporesponsiveness in cirrhosis: the role of increased monocyte suppressor cell activity.

    abstract::We investigated the possibility that monocyte suppressor cells play a role in the peripheral lymphocyte hyporesponsiveness of chronic liver disease by utilizing assays of monocyte-mediated suppressor activity in 46 patients with chronic liver disease and 46 controls. The percent change achieved by the addition of indo...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Holdstock G,Chastenay BF,Krawitt EL

    更新日期:1982-02-01 00:00:00

  • Prospective evaluation of early morphological changes in pelvic ileal pouches.

    abstract:BACKGROUND/AIMS:Little is known about the evolution of morphological changes in pelvic ileal-pouch mucosa. This study evaluates prospectively the sequence of early morphological, histochemical, and phenotypic features in pouch mucosal biopsy specimens. METHODS:Twenty-two patients with pelvic ileal pouches constructed ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(94)90169-4

    authors: Apel R,Cohen Z,Andrews CW Jr,McLeod R,Steinhart H,Odze RD

    更新日期:1994-08-01 00:00:00

  • Extracellular matrix composition influences insulinlike growth factor I receptor expression in rat IEC-18 cells.

    abstract:BACKGROUND:The composition of the extracellular matrix (ECM) as well as insulinlike growth factor I (IGF-I) receptor density vary along the crypt-villus axis. We determined whether components of the ECM influence IGF-I receptor expression in IEC-18 rat small intestine crypt cells. METHODS:IEC-18 cells were cultured on...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(93)90649-w

    authors: Benya RV,Duncan MD,Mishra L,Bass BL,Voyles NR,Korman LY

    更新日期:1993-06-01 00:00:00

  • American gastroenterological association institute medical position statement on the use of gastrointestinal medications in pregnancy.

    abstract::This document presents the official recommendations of the American Gastroenterological Association (AGA) Institute on "Use of Gastrointestinal Medications in Pregnancy." It was approved by the Clinical Practice and Economics Committee on February 22, 2006, and by the AGA Institute Governing Board on April 20, 2006. ...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2006.04.048

    authors: Mahadevan U,Kane S

    更新日期:2006-07-01 00:00:00

  • Prospective study reveals associations between colorectal cancer and type 2 diabetes mellitus or insulin use in men.

    abstract:BACKGROUND & AIMS:Type 2 diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC); it is not clear if this association varies by sex or other factors. Insulin use might also be associated with CRC risk. We investigated associations of type 2 DM and insulin use with CRC risk. METHODS:The C...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2010.06.072

    authors: Campbell PT,Deka A,Jacobs EJ,Newton CC,Hildebrand JS,McCullough ML,Limburg PJ,Gapstur SM

    更新日期:2010-10-01 00:00:00

  • Local gangrene: a complication of peripheral Pitressin therapy for bleeding esophageal varices.

    abstract::Two patients developed local gangrene after subcutaneous infiltration of vasopressin (Pitressin, Parke, Davis & Company, Detroit, Mich.) utilized for the control of bleeding from esophageal varices. In the 1st patient, ischemic gangrene resulted in transmetatarsal amputation and also necessitated skin grafts on the fo...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Greenwald RA,Rheingold OJ,Chiprut RO,Rogers AI

    更新日期:1978-04-01 00:00:00

  • Lack of cholinergic control in feedback regulation of pancreatic secretion in the rat.

    abstract::The effect of atropine (100 micrograms/kg/h, i.v.) on plasma cholecystokinin and pancreatic secretion during diversion of bile and pancreatic juice from the intestine was studied in 8 conscious rats equipped with jugular vein, pancreatic, biliary, and duodenal cannulas, and with pyloric ligation and gastric drainage. ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(90)90836-p

    authors: Guan D,Ohta H,Tawil T,Spannagel AW,Liddle RA,Green GM

    更新日期:1990-02-01 00:00:00

  • Brain-gut interactions in inflammatory bowel disease.

    abstract::Psycho-neuro-endocrine-immune modulation through the brain-gut axis likely has a key role in the pathogenesis of inflammatory bowel disease (IBD). The brain-gut axis involves interactions among the neural components, including (1) the autonomic nervous system, (2) the central nervous system, (3) the stress system (hyp...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2012.10.003

    authors: Bonaz BL,Bernstein CN

    更新日期:2013-01-01 00:00:00

  • Up-regulation of insulinlike growth factor I binding sites in experimental colitis in rats.

    abstract:BACKGROUND/AIMS:The gastrointestinal tract is a major target of insulinlike growth factor (IGF) I. IGF-I binds to two different receptors and to binding proteins (IGFBPs), which act as carriers and mediators. This study investigated the regulation of IGF-I binding sites in rat colitis. METHODS:Colitis was induced by c...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(95)90435-2

    authors: Zeeh JM,Hoffmann P,Sottili M,Eysselein VE,McRoberts JA

    更新日期:1995-03-01 00:00:00

  • The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis.

    abstract:BACKGROUND & AIMS:The mechanism by which sulindac causes regression of adenomas in patients with familial adenomatous polyposis (FAP) is unclear. Conflicting data on the drug's effects on colorectal epithelial proliferation have been reported. An alternative mechanism, and one not previously studied, is via induction o...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0016-5085(95)90411-5

    authors: Pasricha PJ,Bedi A,O'Connor K,Rashid A,Akhtar AJ,Zahurak ML,Piantadosi S,Hamilton SR,Giardiello FM

    更新日期:1995-09-01 00:00:00

  • Binding of secretin to plastic surfaces.

    abstract::Five carboxyl-terminal fragments of secretin ranging in size from 6 to 21 amino acid residues were tested for pancreatic secretory activity in the rat. None of the fragments displayed activity when given alone but each displayed significant activity when given after secretin. This apparent activity was shown to be the...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Bitar KN,Zfass AM,Makhlouf GM

    更新日期:1978-12-01 00:00:00

  • Angiostrongyliasis in a European patient: a rare cause of gangrenous ischemic enterocolitis.

    abstract::Angiostrongylus costaricensis causes a clinicopathologic disease first observed in Costa Rica, mainly in children characterized by highly symptomatic eosinophilic gastroenteritis involving the terminal ileum, cecum, appendix, and ascending colon. A case of angiostrongyliasis in an adult Spaniard infected during a brie...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(93)90163-7

    authors: Vázquez JJ,Boils PL,Sola JJ,Carbonell F,de Juan Burgueño M,Giner V,Berenguer-Lapuerta J

    更新日期:1993-11-01 00:00:00

  • Estrogen rapidly modulates 5-hydroxytrytophan-induced visceral hypersensitivity via GPR30 in rats.

    abstract:BACKGROUND & AIMS:Sex hormones have been reported to modulate visceral hypersensitivity (VH). Estrogen regulates neurons not only by binding to estrogen receptors (ERalpha and ERbeta) to initiate transcription but also via the G-protein coupled receptor GPR30, which binds and rapidly mediates actions of estrogen. We ex...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2009.03.047

    authors: Lu CL,Hsieh JC,Dun NJ,Oprea TI,Wang PS,Luo JC,Lin HC,Chang FY,Lee SD

    更新日期:2009-09-01 00:00:00

  • Stimulation of pancreatic secretion of water and electrolytes by furosemide.

    abstract::The effect of furosemide on secretin-stimulated pancreatic secretion was examined in 12 normal subjects using a perfusion method to quantitate pancreatic output. During continuous secretin infusion (0.9 U per kg per hr), secretory volume rose to a steady state level of 32.5 +/- 10.2 ml per min. When a bolus injection ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Thomas FB,Sinar D,Caldwell JH,Mekhjian HS,Falko JM

    更新日期:1977-08-01 00:00:00

  • Sex steroid metabolism and receptor status in hepatic hyperplasia and cancer in rats.

    abstract:BACKGROUND & AIMS:Both androgenic and estrogenic steroids have been implicated in the development and course of several liver diseases, including hepatocellular carcinoma. The aim of this study was to investigate temporal changes in hepatic estrogen and androgen receptors and hormone metabolism in a rat model of liver ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.1996.v110.pm8613010

    authors: Eagon PK,Elm MS,Epley MJ,Shinozuka H,Rao KN

    更新日期:1996-04-01 00:00:00

  • Acute cytomegalovirus infection in a child with Ménétrier's disease.

    abstract::The cause of Ménétrier's disease is unknown, although allergic, autoimmune, and infectious, particularly viral, causes have been postulated. This case report describes a 3-year-old child with Ménétrier's disease in whom evidence of acute cytomegalovirus (CMV) infection was found. To our knowledge, this is the first ca...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(95)90349-6

    authors: Eisenstat DD,Griffiths AM,Cutz E,Petric M,Drumm B

    更新日期:1995-08-01 00:00:00

  • High-resolution manometry and impedance-pH/manometry: valuable tools in clinical and investigational esophagology.

    abstract::Both high-resolution manometry (HRM) and impedance-pH/manometry monitoring have established themselves as research tools and both are now emerging in the clinical arena. Solid-state HRM capable of simultaneously monitoring the entire pressure profile from the pharynx to the stomach along with pressure topography plott...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2008.05.048

    authors: Kahrilas PJ,Sifrim D

    更新日期:2008-09-01 00:00:00

  • Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium.

    abstract:BACKGROUND & AIMS:Macrophage migration inhibitory factor (MIF) inhibits macrophage migration and has pleiotropic activities on immune and inflammatory responses, cell growth, and glucose metabolism. MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators imp...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2002.31891

    authors: Maaser C,Eckmann L,Paesold G,Kim HS,Kagnoff MF

    更新日期:2002-03-01 00:00:00

  • Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon.

    abstract:BACKGROUND & AIMS:A variety of gastrointestinal motility disorders have been attributed to alterations of interstitial cells of Cajal and malformations of the enteric nervous system. This study evaluates both the distribution of interstitial cells of Cajal and the pathohistology of the enteric nervous system in 2 sever...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2002.36600

    authors: Wedel T,Spiegler J,Soellner S,Roblick UJ,Schiedeck TH,Bruch HP,Krammer HJ

    更新日期:2002-11-01 00:00:00

  • Effect of FOY-305 (camostate) on severe acute pancreatitis in two experimental animal models.

    abstract::Two models of severe acute pancreatitis were chosen and pancreatitis induced by sodium taurocholate and by a choline-deficient ethionine-supplemented diet, to evaluate the effectiveness of FOY-305 (camostate), a new synthetic trypsin inhibitor. Prophylactic administration of FOY-305 had a significantly favorable effec...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(89)90780-4

    authors: Lankisch PG,Pohl U,Göke B,Otto J,Wereszczynska-Siemiatkowska U,Gröne HJ,Rahlf G

    更新日期:1989-01-01 00:00:00

  • Rat intestinal M cells contain acidic endosomal-lysosomal compartments and express class II major histocompatibility complex determinants.

    abstract:BACKGROUND:It is generally believed that M cells do not modify the antigens they transport from the intestinal lumen to underlying immunocompetent cells because it has been reported that M cells contain few elements of the lysosomal system. METHODS:We used specific cytochemical and immunocytochemical probes to examine...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(93)91004-2

    authors: Allan CH,Mendrick DL,Trier JS

    更新日期:1993-03-01 00:00:00

  • H+ disposal by rabbit gastric mucosal surface cells.

    abstract::Exposure of isolated gastric mucosal surface cells to NH4+ results in acidification of cells as determined by a fluorescent dye technique using acridine orange. The resulting intracellular pH gradient is maintained when cells are suspended in either buffered HCO3- -free Ringer's or choline chloride solution. Cells sus...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Olender EJ,Fromm D,Furukawa T,Kolis M

    更新日期:1984-04-01 00:00:00

  • Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease.

    abstract::Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2013.12.034

    authors: Costea I,Mack DR,Lemaitre RN,Israel D,Marcil V,Ahmad A,Amre DK

    更新日期:2014-04-01 00:00:00

  • Multigenic control of hepatic iron loading in a murine model of hemochromatosis.

    abstract:BACKGROUND & AIMS:Hereditary hemochromatosis is a common disorder of iron homeostasis characterized by increased dietary iron absorption and progressive iron accumulation, mainly in the liver. Most patients are homozygous for the C282Y mutation in the HFE gene. However, not all individuals carrying the hemochromatosis-...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2004.01.021

    authors: Bensaid M,Fruchon S,Mazères C,Bahram S,Roth MP,Coppin H

    更新日期:2004-05-01 00:00:00

  • Rats with gastritis have increased sensitivity to the gastrin stimulatory effects of luminal ammonia.

    abstract:BACKGROUND & AIMS:Persons infected with Helicobacter pylori show an enhanced meal-stimulated gastrin release compared with uninfected controls. The aim of this study was to determine in animal models whether this gastrin release could be related to chronic gastric inflammation, elevated luminal ammonia level, or a comb...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.1996.v110.pm8608890

    authors: Dial EJ,Hall LR,Romero JJ,Lichtenberger LM

    更新日期:1996-03-01 00:00:00

  • Human mucosal T-cell cytotoxicity.

    abstract::Non-major histocompatibility complex-restricted cytotoxicity triggered by antibodies to the CD3 component of the human T-cell receptor complex is thought to be an indirect measure of in vivo primed cytotoxic T-cell activity. We have used this technique to examine the lytic activity of freshly isolated T cells from non...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(88)90554-9

    authors: Shanahan F,Deem R,Nayersina R,Leman B,Targan S

    更新日期:1988-04-01 00:00:00