Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia.

abstract：:Gastric mucosa of the rat generates both PGE2 and PGI2 activity in significantly higher concentrations in the antrum than in the fundus. Aspirin, given intravenously or intragastrically in doses producing gastric mucosal lesions, causes a dose-dependent decrease in the generation of mucosal PGE2 and PGI2, which is fur...

journal_title：Gastroenterology

authors： Konturek SJ,Piastucki I,Brzozowski T,Radecki T,Dembińska-Kieć A,Zmuda A,Gryglewski R

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND & AIMS:Oral bile acid replacement has been shown to be an effective therapy in primary bile acid synthesis defects, but to date there have been no reports of the long-term effects of this therapy. The aim of the study was to evaluate the long-term effectiveness and safety of cholic acid (CA) therapy. METHOD...

journal_title：Gastroenterology

authors： Gonzales E,Gerhardt MF,Fabre M,Setchell KD,Davit-Spraul A,Vincent I,Heubi JE,Bernard O,Jacquemin E

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND & AIMS:We aimed to identify long noncoding RNAs (lncRNAs) that are up-regulated in gastric cancer tissues from patients and study their function in gastric tumor metastasis. METHODS:We collected gastric tumor and nontumor tissues from patients in China and analyzed levels of lncRNAs by microarray analysis, ...

journal_title：Gastroenterology

authors： Zhuo W,Liu Y,Li S,Guo D,Sun Q,Jin J,Rao X,Li M,Sun M,Jiang M,Xu Y,Teng L,Jin Y,Si J,Liu W,Kang Y,Zhou T

更新日期：2019-02-01 00:00:00

abstract：:The effect of changes in the rate of infusion versus glucose concentration on glucose, water, and sodium absorption was studied in 20 infant miniature pigs using the single-pass small intestinal perfusion technique. During infusions of glucose loads of up to 75.0 mumol/min, glucose absorption increased similarly wheth...

journal_title：Gastroenterology

authors： Shulman RJ,Lifschitz CH

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND & AIMS:We investigated the expression of estrogen receptor (ER) alpha and beta subtypes in cholangiocytes of normal and bile duct-ligated (BDL) rats and evaluated the role and mechanisms of estrogens in the modulation of cholangiocyte proliferation. METHODS:ER-alpha and ER-beta were analyzed by immunohistoc...

journal_title：Gastroenterology

authors： Alvaro D,Alpini G,Onori P,Perego L,Svegliata Baroni G,Franchitto A,Baiocchi L,Glaser SS,Le Sage G,Folli F,Gaudio E

更新日期：2000-12-01 00:00:00

abstract：:Erythromycin has been shown to act as a motilin agonist by binding to motilin receptors on gastrointestinal smooth muscle and to improve the severely impaired gastric emptying in patients with diabetic gastroparesis. To elucidate the motor pattern that accounts for this accelerated emptying, the effect of 200 mg eryth...

journal_title：Gastroenterology

authors： Annese V,Janssens J,Vantrappen G,Tack J,Peeters TL,Willemse P,Van Cutsem E

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND & AIMS:Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regula...

journal_title：Gastroenterology

authors： Garuti C,Tian Y,Montosi G,Sabelli M,Corradini E,Graf R,Ventura P,Vegetti A,Clavien PA,Pietrangelo A

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:Monocytes/macrophages infiltrate into injured livers. We tried to clarify their roles in inflammation and subsequent fibrogenesis by inhibiting their infiltration with a mutated form (7ND; 7 amino acids at the N-terminal were deleted) of monocyte chemoattractant protein 1, which may function as a domi...

journal_title：Gastroenterology

authors： Imamura M,Ogawa T,Sasaguri Y,Chayama K,Ueno H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND & AIMS:Dkk1 is a secreted antagonist of the Wnt/β-catenin signaling pathway. It is induced by inflammatory cytokines during colitis and exacerbates tissue damage by promoting apoptosis of epithelial cells. However, little is known about the physiologic role of Dkk1 in normal intestinal homeostasis and during...

journal_title：Gastroenterology

authors： Koch S,Nava P,Addis C,Kim W,Denning TL,Li L,Parkos CA,Nusrat A

更新日期：2011-07-01 00:00:00

abstract：:Helicobacter pylori has recently been implicated as an etiologic agent of gastroduodenal disorders. Comparing the antibody to H. pylori in the sera of patients with that of normal controls by Western blot analysis, a unique antibody was detected in the sera of patients, which reacted with the 25-kilodalton antigen of ...

journal_title：Gastroenterology

authors： Sugiyama T,Imai K,Yoshida H,Takayama Y,Yabana T,Yokota K,Oguma K,Yachi A

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:Increased levels of galectin 3 have been associated with nonalcoholic steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice. GR-MD-02 (belapectin) is an inhibitor of galectin 3 that reduces liver fibrosis and portal hypertension in rats and was safe and well tolerated in phase ...

journal_title：Gastroenterology

authors： Chalasani N,Abdelmalek MF,Garcia-Tsao G,Vuppalanchi R,Alkhouri N,Rinella M,Noureddin M,Pyko M,Shiffman M,Sanyal A,Allgood A,Shlevin H,Horton R,Zomer E,Irish W,Goodman Z,Harrison SA,Traber PG,Belapectin (GR-MD-02) Stud

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND & AIMS:Capillarization of the sinusoids in cirrhosis is proposed to reduce oxygen availability to the hepatocyte, resulting in the patterns of altered drug metabolism observed in cirrhosis. If this were true, drug metabolism in cirrhotic livers would be expected to be more sensitive to reduced oxygen deliver...

journal_title：Gastroenterology

authors： Hickey PL,McLean AJ,Angus PW,Choo EF,Morgan DJ

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND & AIMS:Two percent to 4% of all cases of colorectal cancer (CRC) are associated with Lynch syndrome. Dominant clustering of CRC (non-Lynch syndrome) accounts for 1%-3% of the cases. Because carcinogenesis is accelerated in Lynch syndrome, an intensive colonoscopic surveillance program has been recommended si...

journal_title：Gastroenterology

authors： Vasen HF,Abdirahman M,Brohet R,Langers AM,Kleibeuker JH,van Kouwen M,Koornstra JJ,Boot H,Cats A,Dekker E,Sanduleanu S,Poley JW,Hardwick JC,de Vos Tot Nederveen Cappel WH,van der Meulen-de Jong AE,Tan TG,Jacobs MA,Mohame

更新日期：2010-06-01 00:00:00

abstract：:We studied the effect of chronic aspirin ingestion on gastroduodenal epithelial proliferation by feeding rats aspirin in the drinking water. A control group of rats received plain water. At the end of 4 wk, [3H]-thymidine was given intravenously to label proliferating cells, and the rats were killed 1 h later. Section...

journal_title：Gastroenterology

authors： Eastwood GL,Quimby GF

更新日期：1982-05-01 00:00:00

abstract：:Intragastric titration, introduced in 1973, has become more popular than in the past and is being applied to the study of gastric secretion under a variety of conditions using NaHCO3 and NaOH as titrant. Physical chemical and technical considerations point to limitations on the conditions under which quantitative resu...

journal_title：Gastroenterology

authors： Spenney JG

更新日期：1979-05-01 00:00:00

abstract：:In vivo and in vitro ultrasonic characteristics of gallstones were compared with stone size and composition with the aim of understanding the basis for these features. In vivo and in vitro ultrasonic features of the same stone were identical. Acoustic shadowing was not due to stone type, radiodensity, or calcium conte...

journal_title：Gastroenterology

authors： Good LI,Edell SL,Soloway RD,Trotman BW,Mulhern C,Arger PA

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND & AIMS:Helicobacter pylori is believed to predispose to gastric cancer by inducing gastric atrophy and hypochlorhydria. First-degree relatives of patients with gastric cancer have an increased risk of developing gastric cancer. The aim of this study was to determine the prevalence of atrophy and hypochlorhyd...

journal_title：Gastroenterology

authors： El-Omar EM,Oien K,Murray LS,El-Nujumi A,Wirz A,Gillen D,Williams C,Fullarton G,McColl KE

更新日期：2000-01-01 00:00:00

abstract：:Endoscopic submucosal dissection was developed in Japan, early in this century, to provide a minimally invasive yet curative treatment for the large numbers of patients with early gastric cancer identified by the national screening program. Previously, the majority of these patients were treated surgically at substant...

journal_title：Gastroenterology

authors： Bourke MJ,Neuhaus H,Bergman JJ

更新日期：2018-05-01 00:00:00

abstract：:An increased risk of esophageal carcinoma has been reported in systemic sclerosis (scleroderma). Periodic endoscopic or radiologic surveillance, or both, of systemic sclerosis patients with gastroesophageal reflux symptoms has been recommended for early detection of Barrett's mucosa and esophageal adenocarcinoma. A re...

journal_title：Gastroenterology

authors： Segel MC,Campbell WL,Medsger TA Jr,Roumm AD

更新日期：1985-09-01 00:00:00

abstract：:A case of a 29-year-old woman who has had two episodes both clinically and biochemically consistent with acute fatty liver of pregnancy is described. These episodes occurred in two successive pregnancies, and liver biopsy confirmed the diagnosis in the second pregnancy. Both pregnancies were managed by prompt fetal de...

journal_title：Gastroenterology

authors： Schoeman MN,Batey RG,Wilcken B

更新日期：1991-02-01 00:00:00

abstract：:It has been suggested that the lower esophageal sphincter (LES) plays an important role in preventing gastroesophageal reflux. This study was designed to determine if abolition of the LES alone is sufficient to induce gastroesophageal reflux and esophagitis. Studies were performed in the Australian brush-tailed possum...

journal_title：Gastroenterology

authors： De Carle DJ

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The role of selectins in experimental colitis remains unknown. The aims of this study were to characterize the time-course expression of selectins in trinitrobenzene sulfonic acid (TNBS)-induced colitis, the functional role of selectins in colonic leukocyte-endothelial cell interactions, and the the...

journal_title：Gastroenterology

authors： Sans M,Salas A,Soriano A,Prats N,Gironella M,Pizcueta P,Elena M,Anderson DC,Piqué JM,Panés J

更新日期：2001-04-01 00:00:00

abstract：:Congenital esophageal stenosis (CES) is a rare disorder with narrowed esophageal lumen that presents as dysphagia from childhood and that is often associated with tracheobronchial remnants or webs. The pathogenesis of CES is unknown. The aim of this study was to examine the histological and immunohistochemical feature...

journal_title：Gastroenterology

authors： Singaram C,Sweet MA,Gaumnitz EA,Cameron AJ,Camilleri M

更新日期：1995-07-01 00:00:00

abstract：:Treatment options for inflammatory bowel disease (IBD) reflect a continuing shift from empiricism to strategies based on improved understanding of the pathophysiology of disease. In susceptible individuals, IBD appears to be the result of defective regulation of mucosal immune interactions with the enteric microflora....

journal_title：Gastroenterology

authors： Shanahan F

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND & AIMS:We investigated the transcriptome of esophageal squamous cell carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and the effects of blocking epigenetic regulatory proteins. METHODS:We performed chromatin immunoprecipitation sequencing with antibodies against H3K4me1,...

journal_title：Gastroenterology

authors： Jiang YY,Jiang Y,Li CQ,Zhang Y,Dakle P,Kaur H,Deng JW,Lin RY,Han L,Xie JJ,Yan Y,Doan N,Zheng Y,Mayakonda A,Hazawa M,Xu L,Li Y,Aswad L,Jeitany M,Kanojia D,Guan XY,Said JW,Yang W,Fullwood MJ,Lin DC,Koeffle

更新日期：2020-10-01 00:00:00

abstract：:The results of a clinical trial comparing slow-release 5-aminosalicylic acid tablets (Pentasa) and enteric-coated sulfasalazine tablets (Salazopyrin) with regard to the efficacy of maintaining ulcerative colitis patients in remission for 12 mo and with regard to safety of treatment are reported. Seventy-five patients ...

journal_title：Gastroenterology

authors： Mulder CJ,Tytgat GN,Weterman IT,Dekker W,Blok P,Schrijver M,van der Heide H

更新日期：1988-12-01 00:00:00

abstract：:It has recently been shown that repeated large-volume paracentesis associated with intravenous albumin infusion is a rapid, effective, and safe therapy of ascites in cirrhosis. To investigate whether intravenous albumin infusion is necessary in the treatment of cirrhotics with large-volume paracentesis, 105 patients w...

journal_title：Gastroenterology

authors： Ginès P,Titó L,Arroyo V,Planas R,Panés J,Viver J,Torres M,Humbert P,Rimola A,Llach J

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanisms by which mutations in the familial intrahepatic cholestasis-1 gene cause Byler's disease (progressive familial intrahepatic cholestasis type 1) are unknown. METHODS:Interactions among the apical sodium-dependent bile acid transporter, the farnesoid X receptor (FXR), and familial intrah...

journal_title：Gastroenterology

authors： Chen F,Ananthanarayanan M,Emre S,Neimark E,Bull LN,Knisely AS,Strautnieks SS,Thompson RJ,Magid MS,Gordon R,Balasubramanian N,Suchy FJ,Shneider BL

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND & AIMS:Because alterations of integrin expression in cancers contribute to cancer cell biology, we analyzed the association between the potential for peritoneal dissemination and integrin expression. METHODS:The dissemination potential of 10 human gastric cancer cell lines in mice with severe combined immun...

journal_title：Gastroenterology

authors： Ishii Y,Ochiai A,Yamada T,Akimoto S,Yanagihara K,Kitajima M,Hirohashi S

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND/AIMS:Staphylococcal enterotoxin B (SEB) acts as a superantigen binding to class II major histocompatibility complex proteins, and this complex stimulates T cells. The aim of this study was to investigate the pathogenic effects of SEB on hepatic injury and lethal shock in mice. METHODS:SEB was administered t...

journal_title：Gastroenterology

authors： Nagaki M,Muto Y,Ohnishi H,Yasuda S,Sano K,Naito T,Maeda T,Yamada T,Moriwaki H

更新日期：1994-02-01 00:00:00