Abstract：
:Gastric mucosa of the rat generates both PGE2 and PGI2 activity in significantly higher concentrations in the antrum than in the fundus. Aspirin, given intravenously or intragastrically in doses producing gastric mucosal lesions, causes a dose-dependent decrease in the generation of mucosal PGE2 and PGI2, which is further enhanced by gastric perfusion of HCl. Exogenous PGE2 and PGI2 administered intravenously in doses not affecting gastric secretion almost completely prevented the formation of aspirin-induced ulcers. This study indicates that gastric mucosa is capable of generating PGE2 and PGI2 which may be responsible for its protection against chemical injury.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Konturek SJ,Piastucki I,Brzozowski T,Radecki T,Dembińska-Kieć A,Zmuda A,Gryglewski Rsubject
Has Abstractpub_date
1981-01-01 00:00:00pages
4-9issue
1eissn
0016-5085issn
1528-0012pii
S0016508581000279journal_volume
80pub_type
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