当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Effect of rabbit anti-pancreatic polypeptide serum on postprandial pancreatic exocrine secretion in dogs.

Effect of rabbit anti-pancreatic polypeptide serum on postprandial pancreatic exocrine secretion in dogs.

Abstract：

:To determine whether pancreatic polypeptide (PP) is a physiologic inhibitor of pancreatic secretion, we have studied the effects of normal rabbit serum and anti-PP serum on pancreatic secretion during infusion of a physiologic dose of PP or intragastric food instillation in dogs. Infusion of 180 pmol/kg X h of PP, previously incubated with normal rabbit serum, induced increases in plasma PP (220 +/- 21 pmol/L) similar to those after the meal (213 +/- 51 pmol/L) and was accompanied by significant inhibition of pancreatic flow rate, bicarbonate output, and protein output (p less than 0.05) stimulated by secretin and cholecystokinin (n = 6). However, when the effect of exogenous PP was studied after in vivo administration of anti-PP serum or after previous in vitro incubation with anti-PP serum, no inhibition of pancreatic secretion was found, indicating that immunoneutralization of PP blocks the biologic activity of the hormone. Intragastric instillation of 400 ml of liver extract resulted in significant increases in pancreatic flow rate and outputs of protein and bicarbonate (p less than 0.01; n = 8), both during administration of normal rabbit serum and anti-PP serum. The postprandial increase in pancreatic secretion during administration of anti-PP serum was not significantly different from that during administration of normal rabbit serum. We, therefore, conclude that PP is not a physiologic inhibitor of postprandial pancreatic secretion.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

de Jong AJ,Singer MV,Lamers CB

doi

10.1016/0016-5085(86)90263-5

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

1926-31

issue

6

eissn

0016-5085

issn

1528-0012

pii

0016-5085(86)90263-5

journal_volume

90

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Peptide-containing neurons in different regions of the submucous plexus of human sigmoid colon.

    abstract：:Specimens of the sigmoid colon were obtained from male and female patients (n = 11) with carcinoma of the colon or rectum and studied immunohistochemically for vasoactive intestinal polypeptide-, somatostatin-, substance P-, neuropeptide Y-, calcitonin gene-related peptide-, met- and leu-enkephalin-, 5-hydroxytryptami...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(92)90091-c

    authors： Crowe R,Kamm MA,Burnstock G,Lennard-Jones JE

    更新日期：1992-02-01 00:00:00

  • Abnormalities in the distribution of laminin and collagen type IV in Hirschsprung's disease.

    abstract：:In vitro neurite outgrowth and neuronal survival are promoted by laminin, and neuronal migration is promoted by collagen type IV. This led to the hypothesis that Hirschsprung's disease (HD) could be the result of an abnormal extracellular matrix microenvironment in the affected bowel during embryogenesis. Using indire...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Parikh DH,Tam PK,Van Velzen D,Edgar D

    更新日期：1992-04-01 00:00:00

  • Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse.

    abstract：BACKGROUND & AIMS:Because current therapies for chronic hepatitis C virus (HCV) infections are suboptimal and associated with severe side effects, novel treatment options are needed. A small animal model has recently been developed to study HCV infections. To examine the usefulness of this human liver-urokinase-type pl...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2007.07.007

    authors： Vanwolleghem T,Meuleman P,Libbrecht L,Roskams T,De Vos R,Leroux-Roels G

    更新日期：2007-10-01 00:00:00

  • Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat.

    abstract：BACKGROUND:Capsaicin-sensitive neurons contain various peptides including calcitonin gene-related peptide. This study examines (1) whether calcitonin gene-related peptide is involved in capsaicin-induced gastroprotection and (2) whether nitric oxide and prostaglandin are required for calcitonin gene-related peptide to ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)90345-d

    authors： Lambrecht N,Burchert M,Respondek M,Müller KM,Peskar BM

    更新日期：1993-05-01 00:00:00

  • Spontaneous rupture of nonparasitic cyst of the liver.

    abstract：:A case of spontaneous rupture of a nonparasitic liver cyst, documented by serial computed tomography scans, is reported. The patient was closely followed clinically after the rupture of the cyst and was treated conservatively, without surgical intervention. No peritonitis developed. This unusual complication of nonpar...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)91438-8

    authors： Akriviadis EA,Steindel H,Ralls P,Redeker AG

    更新日期：1989-07-01 00:00:00

  • Ursodeoxycholic acid and cholesterol induce enterohepatic cycling of bilirubin in rodents.

    abstract：BACKGROUND & AIMS:Oral administration of ursodeoxycholic acid (UDCA) and cholesterol causes bile salt malabsorption; the former by competition for and the latter by down-regulation of ileal bile acid transporters. Because ileectomy in rats induces enterohepatic cycling of bilirubin, the hypothesis that dietary steroids...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(98)70152-0

    authors： Méndez-Sánchez N,Brink MA,Paigen B,Carey MC

    更新日期：1998-09-01 00:00:00

  • Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:De novo lipogenesis is believed to be involved in oncogenesis. We investigated the role of aberrant lipid biosynthesis in the pathogenesis of human hepatocellular carcinoma (HCC). METHODS:We evaluated expression of enzymes that regulate lipogenesis in human normal liver tissues and HCC and surroundin...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.12.006

    authors： Calvisi DF,Wang C,Ho C,Ladu S,Lee SA,Mattu S,Destefanis G,Delogu S,Zimmermann A,Ericsson J,Brozzetti S,Staniscia T,Chen X,Dombrowski F,Evert M

    更新日期：2011-03-01 00:00:00

  • A study on the nature of macroamylase complex. Dissociation of macroamylase by substrates.

    abstract：:Characteristics of a macroamylase that was considered not to be formed by the binding of normal amylase to immunoglobulins were studied. The macroamylase was reversibly dissociated into apparently normal amylase by treating the macroamylasemic serum with guanidine hydrochloride. Concanavalin A precipitated a large por...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Kitamura T,Yoshioka K,Ehara M,Akedo H

    更新日期：1977-07-01 00:00:00

  • Effect of a catheter in the pharynx on the frequency of transient lower esophageal sphincter relaxations.

    abstract：:Transient relaxation of the lower esophageal sphincter (LES) is observed fairly frequently during prolonged continuous monitoring of the LES. The aim of this study was to test whether the presence of a catheter in the pharynx through the stimulation of mechanoreceptors may induce transient LES relaxation. LES and esop...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(92)91509-3

    authors： Mittal RK,Stewart WR,Schirmer BD

    更新日期：1992-10-01 00:00:00

  • Hepatocyte tight-junctional permeability is increased in rat experimental colitis.

    abstract：BACKGROUND & AIMS:Hepatobiliary complications occur in inflammatory bowel disease and may be caused by the translocation of intestinal toxins from portal blood into bile through leaky hepatocyte tight junctions. The role of tight junctions in the pathogenesis of hepatobiliary complications in experimental inflammatory ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v113.pm9322530

    authors： Lora L,Mazzon E,Martines D,Fries W,Muraca M,Martin A,d'Odorico A,Naccarato R,Citi S

    更新日期：1997-10-01 00:00:00

  • A prospective randomized study comparing forceful dilatation and esophagomyotomy in patients with achalasia of the esophagus.

    abstract：:A prospective and randomized study was performed comparing pneumatic forceful dilatation and surgical esophagomyotomy as primary treatment of patients with achalasia of the esophagus. Eighteen dilated and 20 operated patients were studied before and after treatment with 1 patient lost. Clinical, radiologic, and manome...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Csendes A,Velasco N,Braghetto I,Henriquez A

    更新日期：1981-04-01 00:00:00

  • Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis.

    abstract：BACKGROUND & AIMS:Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2014.08.028

    authors： Schoepfer AM,Straumann A,Panczak R,Coslovsky M,Kuehni CE,Maurer E,Haas NA,Romero Y,Hirano I,Alexander JA,Gonsalves N,Furuta GT,Dellon ES,Leung J,Collins MH,Bussmann C,Netzer P,Gupta SK,Aceves SS,Chehade M,Moawad F

    更新日期：2014-12-01 00:00:00

  • Accumulation and cellular localization of fibrinogen/fibrin during short-term and long-term rat liver injury.

    abstract：BACKGROUND/AIMS:During liver fibrosis, there is a putative pacemaker role of fibronectin. Fibrinogen is closely linked to fibronectin during clotting processes. The aim of this study was to show fibrinogen gene expression during liver damage. METHODS:Fibrinogen/fibrin deposition in damaged livers was studied by immuno...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90211-2

    authors： Neubauer K,Knittel T,Armbrust T,Ramadori G

    更新日期：1995-04-01 00:00:00

  • Severe cholestatic jaundice associated with piroxicam.

    abstract：:A 62-year-old man with rheumatoid arthritis developed jaundice while taking piroxicam. A full evaluation including ultrasound, computerized tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic cholestasis. The patient's jaundice and all other liver function abnormalities nor...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1016/0016-5085(91)90417-j

    authors： Hepps KS,Maliha GM,Estrada R,Goodgame RW

    更新日期：1991-12-01 00:00:00

  • Colostomy closure promotes cell proliferation and dimethylhydrazine-induced carcinogenesis in rat distal colon.

    abstract：:The influence of adaptive cell proliferation on colonic carcinogenesis was studied in male Fischer rats with a defunctioning transverse colostomy that was closed 4 wk later. Control observations were made in other rats after colonic transection, repeated at 4 wk, after laparotomy alone, or after permanent colostomy. T...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Terpstra OT,Dahl EP,Williamson RC,Ross JS,Malt RA

    更新日期：1981-09-01 00:00:00

  • Lipoxygenase metabolites in the rat gastric microvascular response to intragastric ethanol.

    abstract：:The role of lipoxygenase metabolites in ethanol-induced gastric mucosal injury and submucosal microvascular change in the rat was studied by in vivo microscopy. Intragastric ethanol-instillation caused marked submucosal venular constriction, dilatation of small arterioles, and corpus mucosal gross lesion formation. Th...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)90065-6

    authors： Yonei Y,Guth PH

    更新日期：1989-08-01 00:00:00

  • Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus.

    abstract：BACKGROUND & AIMS:Carcinogenesis in Barrett's esophagus (BE) is associated with an increased expression of cyclooxygenase (COX) 2. However, there has been no direct evidence that inhibition of COX-2 prevents cancer in BE. We studied the effect of MF-Tricyclic, a selective COX-2 inhibitor, on the development of BE and a...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2002.32371

    authors： Buttar NS,Wang KK,Leontovich O,Westcott JY,Pacifico RJ,Anderson MA,Krishnadath KK,Lutzke LS,Burgart LJ

    更新日期：2002-04-01 00:00:00

  • Early detection of protein depletion in alcoholic cirrhosis: role of body composition analysis.

    abstract：BACKGROUND:Malnutrition is common in alcoholic cirrhosis. Bedside nutritional assessment techniques may be unreliable in patients with chronic liver disease. The aim of this study was to quantify changes in body composition and compare methods for measuring body composition in alcoholic cirrhosis. METHODS:Thirty-eight...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)91083-t

    authors： Prijatmoko D,Strauss BJ,Lambert JR,Sievert W,Stroud DB,Wahlqvist ML,Katz B,Colman J,Jones P,Korman MG

    更新日期：1993-12-01 00:00:00

  • Identification of EpCAM as the gene for congenital tufting enteropathy.

    abstract：BACKGROUND & AIMS:Congenital tufting enteropathy (CTE) is a rare autosomal recessive diarrheal disorder presenting in the neonatal period. CTE is characterized by intestinal epithelial cell dysplasia leading to severe malabsorption and significant morbidity and mortality. The pathogenesis and genetics of this disorder ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2008.05.036

    authors： Sivagnanam M,Mueller JL,Lee H,Chen Z,Nelson SF,Turner D,Zlotkin SH,Pencharz PB,Ngan BY,Libiger O,Schork NJ,Lavine JE,Taylor S,Newbury RO,Kolodner RD,Hoffman HM

    更新日期：2008-08-01 00:00:00

  • Asymptomatic pancreatic cystic neoplasms: maximizing survival and quality of life using Markov-based clinical nomograms.

    abstract：BACKGROUND & AIMS:The natural history and management of pancreatic cysts, especially for branch duct intraductal papillary mucinous neoplasms (BD-IPMNs), remain uncertain. We developed evidence-based nomograms to assist with clinical decision making. METHODS:We used decision analysis with Markov modeling to compare co...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2009.10.001

    authors： Weinberg BM,Spiegel BM,Tomlinson JS,Farrell JJ

    更新日期：2010-02-01 00:00:00

  • Aerobilia and hypomotility of the sphincter of Oddi in a patient with chronic intestinal pseudo-obstruction.

    abstract：:A 50-year-old woman with a typical history of chronic idiopathic intestinal pseudo-obstruction was admitted to hospital because of an acute episode of abdominal cramps, nausea, and vomiting. The diagnosis of chronic idiopathic intestinal pseudo-obstruction had been established in this patient who had malnutrition and ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(92)91744-o

    authors： Allescher HD,Safrany L,Neuhaus H,Feussner H,Classen M

    更新日期：1992-05-01 00:00:00

  • Colonoscopic polypectomy in chronic colitis: conservative management after endoscopic resection of dysplastic polyps.

    abstract：BACKGROUND & AIMS:Adenomatous polyps are by definition dysplastic and pathologically indistinguishable from the dysplasia-associated lesion or mass (DALM) described in 1981. Yet, adenomatous polyps in noncolitic colons are usually removed definitively endoscopically, whereas DALMs are regarded as harbingers of colon ca...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(99)70279-9

    authors： Rubin PH,Friedman S,Harpaz N,Goldstein E,Weiser J,Schiller J,Waye JD,Present DH

    更新日期：1999-12-01 00:00:00

  • Role of Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease.

    abstract：:Medical and recreational cannabis use has increased dramatically over the last decade, resulting from mainstream cultural acceptance and legalization in several countries worldwide. Cannabis and its derivatives affect many gastrointestinal processes via the endocannabinoid system (ECS). The ECS influences gastrointest...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2020.03.087

    authors： Gotfried J,Naftali T,Schey R

    更新日期：2020-07-01 00:00:00

  • An 125I radioimmunoassay for primary conjugated bile salts.

    abstract：:Cholylglycylhistamine, a derivative of cholic acid, has been synthesized and characterized. This derivative has been iodinated using Na125I and chloramine-T and purified free from unlabeled cholylglycylhistamine. Application of this iodinated bile salt derivative to radioimmunoassay of bile salts in human serum is rep...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Spenney JG,Johnson BJ,Hirschowitz BI,Mihas AA,Gibson R

    更新日期：1977-02-01 00:00:00

  • Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene.

    abstract：:We describe 2 siblings with multiple gastrointestinal stromal tumors (GISTs) and cutaneous hyperpigmentation. Both had a point mutation of the c-kit gene. The patients were sisters who had exhibited cutaneous hyperpigmentation since their late teens, but the diagnosis of multiple gastrointestinal submucosal tumors was...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.20880

    authors： Maeyama H,Hidaka E,Ota H,Minami S,Kajiyama M,Kuraishi A,Mori H,Matsuda Y,Wada S,Sodeyama H,Nakata S,Kawamura N,Hata S,Watanabe M,Iijima Y,Katsuyama T

    更新日期：2001-01-01 00:00:00

  • NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis.

    abstract：BACKGROUND & AIMS:Pancreatitis starts with primarily sterile local inflammation that induces systemic inflammatory response syndrome, followed by compensatory anti-inflammatory response syndrome (CARS). We investigated the mechanisms of these processes in mice and human serum. METHODS:We induced severe acute pancreati...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2019.09.040

    authors： Sendler M,van den Brandt C,Glaubitz J,Wilden A,Golchert J,Weiss FU,Homuth G,De Freitas Chama LL,Mishra N,Mahajan UM,Bossaller L,Völker U,Bröker BM,Mayerle J,Lerch MM

    更新日期：2020-01-01 00:00:00

  • CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions.

    abstract：BACKGROUND & AIMS:Crohn's disease (CD) is an inflammatory bowel disease characterized by uncontrolled immune responses to bacterial flora, with excessive activation of T lymphocytes. MICA is a stress-induced major histocompatibility complex-related molecule expressed on normal intestinal epithelial cells (IECs) and rec...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2007.03.025

    authors： Allez M,Tieng V,Nakazawa A,Treton X,Pacault V,Dulphy N,Caillat-Zucman S,Paul P,Gornet JM,Douay C,Ravet S,Tamouza R,Charron D,Lémann M,Mayer L,Toubert A

    更新日期：2007-06-01 00:00:00

  • Krüppel-like factor 5 protects against dextran sulfate sodium-induced colonic injury in mice by promoting epithelial repair.

    abstract：BACKGROUND & AIMS:Krüppel-like factor 5 (KLF5) is a transcription factor that promotes proliferation, is highly expressed in dividing crypt cells of the gastrointestinal epithelium, and is induced by various stress stimuli. We sought to determine the role of KLF5 in colonic inflammation and recovery by studying mice wi...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.10.061

    authors： McConnell BB,Kim SS,Bialkowska AB,Yu K,Sitaraman SV,Yang VW

    更新日期：2011-02-01 00:00:00

  • Genetic variants in cyclooxygenase-2: Expression and risk of gastric cancer and its precursors in a Chinese population.

    abstract：BACKGROUND & AIMS:To screen the genetic variants in cyclooxygenase-2 (COX-2), and evaluate their effects on COX-2 expression and risk of gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, Shangdong Province, an area of China, a high-risk area of GC. METHODS:Genotypes were d...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2006.03.021

    authors： Liu F,Pan K,Zhang X,Zhang Y,Zhang L,Ma J,Dong C,Shen L,Li J,Deng D,Lin D,You W

    更新日期：2006-06-01 00:00:00

  • Removal of gastrin by various organs in dogs.

    abstract：:In 6 anesthetized dogs receiving 400 pmoles kg-1 hr-1 of natural human little gastrin intravenously, blood samples for radioimmunoassay of gastrin were taken repeatedly from a carotid artery, jugular vein, femoral vein, renal vein, and mesenteric vein. The calculated removal of gastrin in a single passage through thes...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Strunz UT,Walsh JH,Grossman MI

    更新日期：1978-01-01 00:00:00