Abstract:
BACKGROUND & AIMS:Oral administration of ursodeoxycholic acid (UDCA) and cholesterol causes bile salt malabsorption; the former by competition for and the latter by down-regulation of ileal bile acid transporters. Because ileectomy in rats induces enterohepatic cycling of bilirubin, the hypothesis that dietary steroids might have the same effect was tested. METHODS:Male inbred C57L/J mice and Sprague-Dawley rats were fed low doses of UDCA, chenodeoxycholic acid (CDCA), or cholesterol added to laboratory chow with simultaneous chow-fed controls. After 1 week (mice) or 2 weeks (rats), indices of bile salt malabsorption and enterohepatic cycling of bilirubin were measured, including bilirubin secretion rates into bile, serum and intestinal bilirubin and bile salt levels, and urobilinogen levels in cecum, large intestine, and feces. RESULTS:Dietary UDCA and cholesterol, but not CDCA, significantly increased bilirubin secretion rates into bile. In UDCA-fed mice, gallbladder biles contained increased levels of bilirubin conjugates and unconjugated bilirubin, and in 60%, granules of amorphous calcium bilirubinate precipitated. Dietary cholesterol and bile acids, particularly UDCA, increased cecal bile salt levels, unconjugated bilirubin and urobilinogen concentrations, and decreased fecal bilirubin outputs, consistent with colonic absorption. CONCLUSIONS:By causing bile salt malabsorption, dietary UDCA and cholesterol induce enterohepatic cycling of bilirubin.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Méndez-Sánchez N,Brink MA,Paigen B,Carey MCdoi
10.1016/s0016-5085(98)70152-0subject
Has Abstractpub_date
1998-09-01 00:00:00pages
722-32issue
3eissn
0016-5085issn
1528-0012pii
S0016508598002820journal_volume
115pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract::Three structurally related peptides, ovine corticotropin-releasing factor, sauvagine, and urotensin I are selective mesenteric vasodilators in dogs. To assess the possible benefit of these peptides in nonocclusive mesenteric ischemia, they were compared with a nonselective vasodilator, sodium nitroprusside, in the ane...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)91122-4
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND & AIMS:People infected with human immunodeficiency virus (HIV) have an increased risk of some malignancies, but little is known about the effects of infection on risk of cancers of the upper gastrointestinal tract. We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hod...
journal_title:Gastroenterology
pub_type: 杂志文章,收录出版
doi:10.1053/j.gastro.2012.07.013
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND & AIMS:Biliary epithelial cells are the target of numerous immune-mediated liver diseases, yet their role in pathogenesis remains unclear because of difficulties in obtaining pure preparations. The aim of this study was to establish pure clones of immortalized murine intrahepatic biliary epithelial cells. M...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90593-6
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND & AIMS:De novo lipogenesis is believed to be involved in oncogenesis. We investigated the role of aberrant lipid biosynthesis in the pathogenesis of human hepatocellular carcinoma (HCC). METHODS:We evaluated expression of enzymes that regulate lipogenesis in human normal liver tissues and HCC and surroundin...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.12.006
更新日期:2011-03-01 00:00:00
abstract::The mortality experienced by a cohort of 653 patients with celiac disease in Edinburgh and the Lothian region has been analyzed. Mortality overall was 1.9-fold (95% confidence limits, 1.5-2.2) that of the general population (115 deaths observed, 61.8 expected; p less than 0.0001). The increased mortality was greatest ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)90060-7
更新日期:1989-08-01 00:00:00
abstract:DESCRIPTION:The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update is to review the available evidence and best practice advice statements regarding the use of endoscopic therapies in treating patients with non-variceal upper gastrointestinal bleeding. METHODS:This expert...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2020.05.095
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatic steatosis is frequent in chronic hepatitis C. Several mechanisms might be implicated, including metabolic cofactors and direct viral effects on intracellular lipid pathways. In a transgenic mouse model, hepatitis C virus (HCV) was shown to inhibit microsomal triglyceride transfer protein (MTP)...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.02.035
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is often associated with hepatitis B virus (HBV) infection. Cells of most HBV-related HCCs contain HBV-DNA fragments that do not encode entire HBV antigens. We investigated whether these integrated HBV-DNA fragments encode epitopes that are recognized by T cells and whet...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2019.01.251
更新日期:2019-05-01 00:00:00
abstract::Four patients who underwent transplantation for hepatitis B virus-related liver disease developed rapidly progressive liver failure attributable to recurrent hepatitis B disease typified by hyperbilirubinemia and distinctive hepatocyte ballooning and progressive fibrosis consistent with recently reported fibrosing cho...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)91521-5
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND & AIMS:Current therapy for primary sclerosing cholangitis is of limited efficacy. Multidrug resistance gene 2 knockout mice (Mdr2(-/-)) represent a well-characterized model for sclerosing cholangitis. Experiments were performed to test in such mice the therapeutic effects of 24-norUrsodeoxycholic acid, a C(2...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.10.018
更新日期:2006-02-01 00:00:00
abstract::To find a possible explanation for the selective hepatic conjugation of bile acids with glycine or taurine, the N-acyl amidates of cholic acid and a number of amino acids and amino acid analogues were synthesized, and their susceptibility to hydrolysis by pancreatic juice, gastric juice, serum, or small intestinal muc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90925-x
更新日期:1986-02-01 00:00:00
abstract::A patient with recurrent gastrointestinal bleeding caused by hereditary hemorrhagic telangiectasia localized to the small intestine is described. The diagnosis was made by combining two recognized investigational tools-fiberoptic endoscopy and laparotomy. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatic encephalopathy (HE) is associated with typical changes of cerebral metabolite pattern observed by proton magnetic resonance (MR) spectroscopy consisting of a depletion of myo-inositol and an increase of glutamine. The aim of this study was to determine whether abnormalities in brain metabolism...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70043-x
更新日期:1997-05-01 00:00:00
abstract::Spontaneous remission of gastric acid hypersecretion in the Zollinger-Ellison syndrome occurs rarely. This study shows the development of gastric secretory mucosal atrophy resulting in achlorhydria and loss of pepsin secretion in a 63-year-old woman with the Zollinger-Ellison syndrome. Reduced secretion began soon aft...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(91)90484-3
更新日期:1991-07-01 00:00:00
abstract::Autophagy is a lysosomal pathway that degrades and recycles intracellular organelles and proteins to maintain energy homeostasis during times of nutrient deprivation and to remove damaged cell components. Recent studies have identified new functions for autophagy under basal and stressed conditions. In the liver and p...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2011.04.038
更新日期:2011-06-01 00:00:00
abstract::The effects of chronic mild restraint on the susceptibility of the rat gastric mucosa to ethanol or cold-restraint injury were studied. Gastric mucosas of animals subjected to chronic mild restraint exhibited less damage when bathed with 40% ethanol than those of control animals. This reduced damage was observed with ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND & AIMS:Mechanisms of diarrhea in ulcerative colitis (UC) are still unknown. Functional and structural characterization of epithelial barrier and transport properties in ulcerative colitis (UC) was performed. METHODS:Inflamed sigmoid colon epithelium from UC patients was studied by alternating current impeda...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(99)70126-5
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND & AIMS:Current stool DNA tests identify about half of individuals with colorectal cancers and miss most individuals with advanced adenomas. We developed a digital melt curve (DMC) assay to quantify low-abundance mutations in stool samples for detection of colorectal neoplasms and compared this test with othe...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.10.023
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND & AIMS:Biliary epithelial cells (BECs) are considered to be a source of regenerating hepatocytes when hepatocyte proliferation is compromised. However, there is still controversy about the extent to which BECs can contribute to the regenerating hepatocyte population, and thereby to liver recovery. To investi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.10.019
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND & AIMS:Liver disease has been associated with cardiovascular disorders, but little is known about the relationship between serum levels of alanine aminotransferase (ALT) and markers of atherogenesis. We investigated the relationship between low-normal and high-normal levels of ALT and an extended panel of ca...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.08.036
更新日期:2013-12-01 00:00:00
abstract::Ileocecal sphincter pressure was studied in the cat, using an open-tipped perfused catheter system. Ileocecal sphincter pressure was measured under basal conditions and in response to bethanechol or direct vagal nerve electrical stimulation. The pressure was 26.1 +/- 5.0 mmHg basally, and was unaltered by section of e...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1981-05-01 00:00:00
abstract::A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursor-product relationship betwe...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-12-01 00:00:00
abstract:BACKGROUND & AIMS:Calcitonin gene-related peptide (CGRP) protects the gastric mucosa against injurious stimuli in various experimental models. The underlying mechanism could be the increase in gastric mucosal blood flow (GMBF). A number of endogenous vasodilators exert their effects through the activation of adenosine ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(98)70634-1
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND/AIMS:Butyrate and factor XIII may improve ulcerative colitis; they also affect tissue and serum transglutaminase levels. We investigated the therapeutic potential of sodium butyrate and factor XIII and the role of transglutaminase during mucosal repair in experimental colitis. METHODS:Rats with induced coli...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90598-3
更新日期:1994-02-01 00:00:00
abstract::There are apparent similarities in the mechanisms of the intestinal phase of exocrine and pancreatic polypeptide (PP) secretion by the pancreas. To characterize this relationship, we measured incremental responses of protein, bicarbonate, and PP to graded doses of intravenous secretin, caerulein, CCK8, CCK33, bethanec...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND & AIMS:Infection with Helicobacter pylori is associated with reduced risk of esophageal adenocarcinoma (EAC), but it is not clear whether this reduction is modified by genotype, other host characteristics, or environmental factors. Furthermore, little is known about the association between H pylori and adeno...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.04.009
更新日期:2010-07-01 00:00:00
abstract::To estimate vascular changes in chronic liver disease, we quantitated intrahepatic arteriovenous and portal-systemic shunts in 12 patients with cirrhosis and arteriovenous shunts alone in 4 patients with cirrhosis. An index was obtained for intrahepatic arteriovenous shunts by instilling technetium 99m-macroaggregated...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90324-6
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND & AIMS:Protein kinase C (PKC) has been implicated as a mediator of growth control during colorectal carcinogenesis, but the mechanisms involved are still a matter of dispute. The aim of this study was to analyze PKC patterns and tissue distribution to gain further insight in PKC function during tumor develop...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v110.pm8964400
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND & AIMS:We have shown that intestinal manipulation leads to a significant inhibition of circular muscle contraction. We hypothesized that the inflammatory mediator inducible nitric oxide (NO) plays a role in surgically induced ileus. METHODS:Rats and inducible NO synthase (iNOS) knockout and wild-type mice u...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(00)70214-9
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Cholestasis is one of the principal manifestations of liver disease and often results from disorders involving bile duct epithelia rather than hepatocytes. A range of disorders affects biliary epithelia, and no unifying pathophysiologic event in these cells has been identified as the cause of choles...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)01201-0
更新日期:2003-10-01 00:00:00