Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease.

abstract：:In addition to the previously described molecular forms of gastrin, a new component has been found in high concentrations in the serum of 6 patients with Zollinger-Ellison syndrome. Serum was fractionated by gel filtration, and ion exchange chromatography, and the new component was identified in eluates by radioimmuno...

journal_title：Gastroenterology

authors： Dockray GJ,Walsh JH

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) and hepatitis C virus (HCV) can be transmitted during administration of intravenous anesthesia when medication vials are used for multiple patients using incorrect technique. We investigated an outbreak of acute HBV and HCV infections among patients who received anesthesia duri...

journal_title：Gastroenterology

authors： Gutelius B,Perz JF,Parker MM,Hallack R,Stricof R,Clement EJ,Lin Y,Xia GL,Punsalang A,Eramo A,Layton M,Balter S

更新日期：2010-07-01 00:00:00

abstract：:In rats fasted 4 days, immunoreactive gastrin concentrations decreased to one-third of the fed levels in antral tissue and to one-eight of the fed levels in serum. The number of antral cells that reacted with fluorescent antigastrin antiserum was also correspondingly decreased. After refeeding, serum gastrin returned ...

journal_title：Gastroenterology

authors： Lichtenberger LM,Lechago J,Johnson LR

更新日期：1975-06-01 00:00:00

abstract：:In dogs with Heidenhain pouches and gastric fistulas, we studied acid secretion in response to systemic or portal infusion of methionine-enkephalin (met-enkephalin), enkephalin-analog, or morphine. All these opiate compounds caused a dose-dependent increase in acid secretion under basal conditions and resulted in a si...

journal_title：Gastroenterology

authors： Konturek SJ,Tasler J,Cieszkowski M,Mikoś E,Coy DH,Schally AV

更新日期：1980-02-01 00:00:00

abstract：:A patient with post-traumatic seizure disorder developed lymphadenopathy, exfoliative dermatitis, and hepatic failure while on diphenylhydantoin therapy and died in hepatic coma. Autopsy disclosed massive hepatic necrosis. The clinical and pathological pictures are similar to the six previously reported cases of diphe...

journal_title：Gastroenterology

authors： Lee TJ,Carney CN,Lapis JL,Higgins T,Fallon HJ

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND/AIMS:Gastrointestinal peptides and biogenic monoamines participate in the regulation of gastrointestinal functions. The aim of this study was to examine the influence of the microflora on the distribution of endocrine cells and on the release of gastrointestinal peptides. METHODS:A quantitative morphologica...

journal_title：Gastroenterology

authors： Uribe A,Alam M,Johansson O,Midtvedt T,Theodorsson E

更新日期：1994-11-01 00:00:00

abstract：:Approximately 10% of persons 70 years old or older are now diagnosed with pancreatic cysts, but it is not clear which ones require additional analysis, interventions, or follow-up. Primary care doctors rely on gastroenterologists for direction because no one wants to miss a diagnosis of pancreatic cancer, but meanwhil...

journal_title：Gastroenterology

authors： Farrell JJ,Fernández-del Castillo C

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND & AIMS:Early growth response gene-1 (Egr-1) is an important inflammatory transcription factor. We hypothesize that leukocyte-derived Egr-1 plays a key inflammatory role in causing postoperative ileus. METHODS:Wild-type, Egr-1 knockout, and chimera mice (constructed by irradiation followed by injection with ...

journal_title：Gastroenterology

authors： Schmidt J,Stoffels B,Moore BA,Chanthaphavong RS,Mazie AR,Buchholz BM,Bauer AJ

更新日期：2008-09-01 00:00:00

abstract：:The effect of deoxycholate ingestion, 750 mg per day, on bile acid kinetics, biliary bile acid composition, and biliary lipid secretion was studied in 7 healthy volunteers. Bile acid kinetics were measured by isotope dilution, and hourly outputs of bile acid, cholesterol, and phospholipid were quantitated by a duodena...

journal_title：Gastroenterology

authors： LaRusso NF,Szczepanik PA,Hofmann AF

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND & AIMS:Inflammation is created by the movement of leukocytes toward soluble attractants (chemokines). The aim of this study was to identify the chemokines that attract intestinal lymphocytes. METHODS:Intraepithelial and lamina propria lymphocytes were isolated from human jejunal mucosa of healthy individual...

journal_title：Gastroenterology

authors： Ebert EC

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND & AIMS:Accurate biomarkers of disease activity and therapeutic response can be valuable for clinical trials. We performed a post hoc analysis of data from a phase 2 trial to assess the relationship between the concentration of fecal calprotectin (FCP) and clinical and endoscopic outcomes of patients with mod...

journal_title：Gastroenterology

authors： Sandborn WJ,Panés J,Zhang H,Yu D,Niezychowski W,Su C

更新日期：2016-01-01 00:00:00

abstract：:A 36-year-old man with brittle diabetes mellitus developed hepatic infarction immediately after an episode of ketoacidosis. The infarction was documented by angiogram 99mTc sulfur colloid scan, and biopsy. Except for the association with ketoacidosis, no other possible cause of hepatic infarction was found. ...

journal_title：Gastroenterology

authors： Ng RC,Sigmund CJ Jr,Lagos JA,Chernin M

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND & AIMS:Conflicting results have been published concerning the effects of different opioid-receptor agonists against visceral noxious stimulation. The introduction of colorectal distention facilitates research in this field. The aim of this study was to examine intrathecally administered opioid agonists again...

journal_title：Gastroenterology

authors： Borgbjerg FM,Frigast C,Madsen JB,Mikkelsen LF

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND & AIMS:The physiologic function of the efflux transporter Multidrug Resistance Protein 3 (MRP3) remains poorly defined. In vitro, MRP3 transports several glucuronidated compounds, but the compounds transported under physiologic conditions are unknown. Knowledge of the compounds transported by MRP3 in vivo wo...

journal_title：Gastroenterology

authors： van de Wetering K,Feddema W,Helms JB,Brouwers JF,Borst P

更新日期：2009-11-01 00:00:00

abstract：:Endogenous pancreatic prostaglandin production in control and obstructive jaundice was investigated using isolated and perfused dog pancreas. In both groups, spontaneous production of prostaglandin E2 and prostaglandin I2 was recorded, and the levels did not change in both groups. The production of both prostaglandins...

journal_title：Gastroenterology

authors： Kuroda T,Kajikawa S,Hanazaki K,Horigome N,Sodeyama H,Horiuchi A,Iwatsuki K,Chiba S,Homma T,Iida F

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND & AIMS:The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic activity of MIF has been described in several cancer models. Therefore, we investigated the expression and function of MIF during the early stages of intestinal ...

journal_title：Gastroenterology

authors： Wilson JM,Coletta PL,Cuthbert RJ,Scott N,MacLennan K,Hawcroft G,Leng L,Lubetsky JB,Jin KK,Lolis E,Medina F,Brieva JA,Poulsom R,Markham AF,Bucala R,Hull MA

更新日期：2005-11-01 00:00:00

abstract：:Severe cholestasis associated with long-term home parenteral nutrition is rare, and no treatment is known to be effective. This study shows a case of a patient who developed jaundice while receiving long-term home parenteral nutrition. Causes of jaundice, other than the patient's parenteral feedings, were excluded. Th...

journal_title：Gastroenterology

authors： Lindor KD,Burnes J

更新日期：1991-07-01 00:00:00

abstract：:A case of primary undifferentiated sarcoma of the liver in a 66-year-old woman is reported. The similarity of the presenting symptoms to those of a hepatic abscess is emphasized. The patient's response to palliative treatment by means of hepatic artery ligation and chemotherapy was excellent. We believe that this is t...

journal_title：Gastroenterology

authors： Tanner AR,Bolton PM,Powell LW

更新日期：1978-01-01 00:00:00

abstract：:Increased type III collagen deposition in all layers of the intestinal tract, including the lamina propria, is a common feature of strictures in Crohn's disease. In the present study, it was found that in comparison with fibroblasts from normal or nonstrictured but inflamed intestinal lamina propria, the fibroblasts i...

journal_title：Gastroenterology

authors： Stallmach A,Schuppan D,Riese HH,Matthes H,Riecken EO

更新日期：1992-06-01 00:00:00

abstract：:Two models of severe acute pancreatitis were chosen and pancreatitis induced by sodium taurocholate and by a choline-deficient ethionine-supplemented diet, to evaluate the effectiveness of FOY-305 (camostate), a new synthetic trypsin inhibitor. Prophylactic administration of FOY-305 had a significantly favorable effec...

journal_title：Gastroenterology

authors： Lankisch PG,Pohl U,Göke B,Otto J,Wereszczynska-Siemiatkowska U,Gröne HJ,Rahlf G

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND & AIMS:The effects of short-term antigenic activation of mast cells on the gastrointestinal tract have been well characterized, but little is known about the effects of long-term exposure to antigen on mucosal mast cell reactivity. The aim of this study was to determine the effects of long-term antigen expos...

journal_title：Gastroenterology

authors： Rioux KP,Wallace JL

更新日期：1996-12-01 00:00:00

abstract：:In seven healthy volunteers pure pancreatic juice was obtained by endoscopic cannulation of the papilla of Vater. Synthetic secretin was intravenously infused in doses doubled every 20 min. The volume of pancreatic juice was proportional to the log of the secretin dose. A significant rise (P less than 0.05) in pancrea...

journal_title：Gastroenterology

authors： Domschke S,Domschke W,Rösch W,Konturek SJ,Wünsch E,Demling L

更新日期：1976-04-01 00:00:00

abstract：:Hyperplasia of the oxyntic enterochromaffinlike cells in response to long-lasting blockade of acid secretion is closely related to hypergastrinemia. In the present study, the effect of a specific gastrin receptor antagonist on proton pump inhibitor-induced changes on serum gastrin levels, mucosal height, as well as ga...

journal_title：Gastroenterology

authors： Eissele R,Patberg H,Koop H,Krack W,Lorenz W,McKnight AT,Arnold R

更新日期：1992-11-01 00:00:00

abstract：:Antigliadin antibodies have been widely used in the screening of celiac disease. Using this test, candidates for jejunal biopsy were selected from 328 first-degree relatives of 128 adult celiac patients. All relatives geographically available were willing to participate in the study. Twenty-one turned out to be positi...

journal_title：Gastroenterology

authors： Corazza G,Valentini RA,Frisoni M,Volta U,Corrao G,Bianchi FB,Gasbarrini G

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND & AIMS:We have few population-level data on the performance of endoscopic retrograde cholangiopancreatography (ERCP) in the United States. We investigated the numbers of unplanned hospital encounters (UHEs), patient and facility factors associated with UHEs, and variation in quality and outcomes in the perfo...

journal_title：Gastroenterology

authors： Huang RJ,Barakat MT,Girotra M,Lee JS,Banerjee S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND & AIMS:Cystic fibrosis transmembrane regulator (CFTR) gene mutations are associated with pancreatic insufficiency and pancreatitis. Chronic pancreatitis, including cystic fibrosis-related disease, may exist as a continuum between acute and chronic disease and may manifest as recurrent pain. We hypothesized t...

journal_title：Gastroenterology

authors： Dimagno MJ,Lee SH,Hao Y,Zhou SY,McKenna BJ,Owyang C

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND & AIMS:Keratins 8 and 18 (K8/K18) provide anti-apoptotic functions upon liver injury. The cytoprotective function of keratins explains the overrepresentation of K8/K18 variants in patients with cirrhosis. However, K8/K18 variant-associated susceptibility to acute liver injury, which is well-described in anim...

journal_title：Gastroenterology

authors： Strnad P,Zhou Q,Hanada S,Lazzeroni LC,Zhong BH,So P,Davern TJ,Lee WM,Acute Liver Failure Study Group.,Omary MB

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIMS:Staphylococcal enterotoxin B (SEB) acts as a superantigen binding to class II major histocompatibility complex proteins, and this complex stimulates T cells. The aim of this study was to investigate the pathogenic effects of SEB on hepatic injury and lethal shock in mice. METHODS:SEB was administered t...

journal_title：Gastroenterology

authors： Nagaki M,Muto Y,Ohnishi H,Yasuda S,Sano K,Naito T,Maeda T,Yamada T,Moriwaki H

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND & AIMS:Chemoembolization is one of several standards of care treatment for hepatocellular carcinoma (HCC). Radioembolization with Yttrium-90 microspheres is a novel, transarterial approach to radiation therapy. We performed a comparative effectiveness analysis of these therapies in patients with HCC. METHOD...

journal_title：Gastroenterology

authors： Salem R,Lewandowski RJ,Kulik L,Wang E,Riaz A,Ryu RK,Sato KT,Gupta R,Nikolaidis P,Miller FH,Yaghmai V,Ibrahim SM,Senthilnathan S,Baker T,Gates VL,Atassi B,Newman S,Memon K,Chen R,Vogelzang RL,Nemcek AA,Resnick SA

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND & AIMS:Small intestinal carcinomas are rare but occur with increased incidence in Crohn's disease. The aim of this study was to elucidate the genetic alterations. METHODS:Mutations and deletions involved in colorectal carcinoma were studied in sporadic and Crohn's-associated intestinal carcinomas and precur...

journal_title：Gastroenterology

authors： Rashid A,Hamilton SR

更新日期：1997-07-01 00:00:00