Abstract:
:A patient with post-traumatic seizure disorder developed lymphadenopathy, exfoliative dermatitis, and hepatic failure while on diphenylhydantoin therapy and died in hepatic coma. Autopsy disclosed massive hepatic necrosis. The clinical and pathological pictures are similar to the six previously reported cases of diphenylhydantoin-induced hepatic necrosis, with the exception of the time of onset of hepatic failure, which is explained. The cause of such hepatotoxicity is unknown, although hypersensitivity is postulated. It appears that studies of liver function in patients receiving diphenylhydantion are indicated to assess the true indicence of hepatocellular injury.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Lee TJ,Carney CN,Lapis JL,Higgins T,Fallon HJsubject
Has Abstractpub_date
1976-03-01 00:00:00pages
422-4issue
3eissn
0016-5085issn
1528-0012pii
S0016508576000693journal_volume
70pub_type
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