Abstract：
BACKGROUND & AIMS:Animal studies have shown that more than half of the dietary protein intake is used by the gut and that a large proportion of this utilization is devoted to (glyco-)protein synthesis. Recycling of these secretions may play a critical role in the regulation of overall dietary amino acid bioavailability. METHODS:Four piglets (age 32 days, 8-10 kg) bearing portal, arterial, and duodenal catheters and a portal flow probe were infused with a complete diet via the duodenum for 12 hours, followed by 12 hours of fasting. The portal balance of glucose and amino acids was measured throughout the 24-hour period. The animals also received duodenal and intravenous infusions of different lysine and threonine tracers. Measurements of intestinal tracer utilization and reappearance in the portal blood were used to calculate intestinal amino acid utilization and recycling. RESULTS:From 0 to 6 hours, one third of the protein intake appeared in the portal blood. As feeding continued, the portal glucose balance (60% of intake) was constant, but the net amino acid portal balance became progressively more positive. Significant net amino acid absorption continued for at least 6 hours after the cessation of feeding. Over 24 hours, 52% of the dietary protein intake appeared in the circulation and one third of this derived from recycled intestinal secretions. CONCLUSIONS:Intestinal recycling of amino acids contributes significantly to their systemic availability and may be a critical factor in amino acid nutrition.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Van Der Schoor SR,Reeds PJ,Stoll B,Henry JF,Rosenberger JR,Burrin DG,Van Goudoever JBdoi
10.1053/gast.2002.37062keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
1931-40issue
6eissn
0016-5085issn
1528-0012pii
S0016508502004651journal_volume
123pub_type
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