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Long-term antigen challenge results in progressively diminished mucosal mast cell degranulation in rats.

Abstract：

BACKGROUND & AIMS:The effects of short-term antigenic activation of mast cells on the gastrointestinal tract have been well characterized, but little is known about the effects of long-term exposure to antigen on mucosal mast cell reactivity. The aim of this study was to determine the effects of long-term antigen exposure on mucosal mast cell reactivity in the gastrointestinal mucosa. METHODS:Rats sensitized to chicken ovalbumin were orally challenged (short-term or long-term) with antigen. Rat mast cell protease II (RMCP-II) content was measured in serum as an index of mucosal mast cell degranulation. RESULTS:Short-term oral antigen challenge caused a 30-fold increase in serum RMCP-II levels. RMCP-II release was markedly diminished in long term-challenged rats (P < 0.001), despite increased tissue RMCP-II levels in stomach and jejunum. Although short-term antigen challenge significantly increased gastric acid secretion, no such response was observed after the long-term antigen challenge. In rats undergoing long-term challenge, a significant release of RMCP-II in response to intravenous antigen was not observed; however, mucosal mast cells remained responsive to intravenous anti-immunoglobulin E. CONCLUSIONS:Repeated activation of mucosal mast cells results in a progressive diminution of RMCP-II release not attributable to depletion of this mediator. This may represent an adaptive response aimed at minimizing the potentially deleterious effects of repeated exposure to an antigen.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Rioux KP,Wallace JL

doi

10.1016/s0016-5085(96)70013-6

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

1516-23

issue

6

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(96)70013-6

journal_volume

111

pub_type

杂志文章

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