Vasodilation, fibrinolysis, and thrombolysis with intraarterial infusion of urokinase in the canine superior mesenteric artery.

abstract：BACKGROUND & AIMS:Screening colonoscopy is an effective method to reduce the incidence of and mortality from colorectal cancer (CRC). There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with...

journal_title：Gastroenterology

authors： Brenner H,Haug U,Arndt V,Stegmaier C,Altenhofen L,Hoffmeister M

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND & AIMS:Numerous studies have linked the proliferation of liver progenitor cells (LPCs) during chronic liver disease to the risk for development of hepatocellular carcinoma. Thus, selective inhibition of LPC growth during preneoplastic injury may prevent or delay the onset of liver cancer. Rats carrying a ger...

journal_title：Gastroenterology

authors： Knight B,Tirnitz-Parker JE,Olynyk JK

更新日期：2008-09-01 00:00:00

abstract：:Female monozygotic triplets all developed Crohn's disease within a period of 11 mo. The monozygosity was demonstrated by analysis of 24 genetic markers of different chromosomal localization. Crohn's disease was diagnosed using clinical, radiologic, and endoscopic findings. Histologic evaluation of bowel tissue was con...

journal_title：Gastroenterology

authors： Purrmann J,Bertrams J,Borchard F,Miller B,Cleveland S,Stolze T,Strohmeyer G

更新日期：1986-12-01 00:00:00

abstract：:Because approximately 80% of reported patients with somatostatinomas have gallstones, this study was performed to determine the effects of exogenous somatostatin on gallbladder emptying responses to liquid and solid meals, direct cholinergic stimulation by bethanechol, indirect cholinergic stimulation by sham feeding,...

journal_title：Gastroenterology

authors： Fisher RS,Rock E,Levin G,Malmud L

更新日期：1987-04-01 00:00:00

abstract：:Phospholipases are enzymes that hydrolyze specific portions of phospholipid molecules. Their role in the digestion of exogenous phospholipids and as the active principle in snake and bee venoms has long been appreciated. Interest has increased in phospholipases recently because of new data implicating them in the infl...

journal_title：Gastroenterology

authors： Mansbach CM 2nd

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND & AIMS:The liver has high regenerative potential. We attempted to establish a novel culture system for extensive expansion of fetal mouse hepatic stem/progenitor cells and to characterize cultured cells. METHODS:Hepatic spheroids collected from 6-day floating cultures were cultured on collagen-coated dishes...

journal_title：Gastroenterology

authors： Tsuchiya A,Heike T,Fujino H,Shiota M,Umeda K,Yoshimoto M,Matsuda Y,Ichida T,Aoyagi Y,Nakahata T

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND & AIMS:We previously isolated a monoclonal antibody against a Necturus gallbladder epitope that blocks native adenosine 3',5'-cyclic monophosphate (cAMP)-dependent chloride channels in intestine, gallbladder, urinary bladder, and airway epithelia in various animals. METHODS:Using this antibody, we purified ...

journal_title：Gastroenterology

authors： Finn AL,Kuzhikandathil EV,Oxford GS,Itoh-Lindstrom Y

更新日期：2001-01-01 00:00:00

abstract：:A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and user-friendliness. These approaches are based on the sensitive assay of molecular markers in stool, blood, and urine samples. New methods, especially next generation stool-bas...

journal_title：Gastroenterology

authors： Ahlquist DA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND/AIMS:Both hemorrhagic and cardiogenic shock are associated with hepatic shock gene expression at resuscitation. This study investigated the potential role of intravascular superoxide anion as a proximal trigger of heat shock protein gene expression. METHODS:Preanesthetized pigs were subjected to 120 m of to...

journal_title：Gastroenterology

authors： Schoeniger LO,Andreoni KA,Ott GR,Risby TH,Bulkley GB,Udelsman R,Burdick JF,Buchman TG

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND & AIMS:Platelet-activating factor (PAF) is increased during relapse of ulcerative colitis. In animal models of experimental colitis, specific inhibition of PAF has reduced inflammation. The aim of this study was to evaluate the efficacy and safety of the PAF antagonist SR27417A in moderately active UC. METH...

journal_title：Gastroenterology

authors： Stack WA,Jenkins D,Vivet P,Hawkey CJ

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND/AIMS:Capillarization of the hepatic sinusoid occurs in alcoholic liver disease. Because endothelial cell proliferation is relevant to capillarization, we used the intragastric feeding rat model to evaluate the relationship between pathological liver injury and endothelial cell proliferation. METHODS:Male Wi...

journal_title：Gastroenterology

authors： Nanji AA,Tahan SR,Wei Y,Sadrzadeh SM

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis G virus (HGV) has been recently identified as a new transfusion-transmissible agent. This study was performed to evaluate the role of HGV infection in patients with acute posttransfusion hepatitis in Taiwan. METHODS:Sera from 63 patients with acute posttransfusion hepatitis and 61 patients ...

journal_title：Gastroenterology

authors： Hwang SJ,Lu RH,Chan CY,Wang YJ,Wu JC,Lee SD

更新日期：1997-04-01 00:00:00

abstract：:The case of a 21-yr-old man, who died in cachexia after 2 yr of intermittent abdominal pain, bouts of diarrhea, and anorexia, is reported. Laboratory tests performed shortly before death disclosed signs of malabsorption. Radiologic examination of the gastrointestinal tract showed a coarse mucosal relief in the upper j...

journal_title：Gastroenterology

authors： Jacobs E,Ardichvili D,Perissino A,Gottignies P,Hanssens JF

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND & AIMS:The finding of bone morphogenetic protein (BMP) receptor 1a mutations in juvenile polyposis suggests that BMPs are important in colorectal cancer (CRC). We investigated the BMP pathway in sporadic CRC. METHODS:We investigated BMP receptor (BMPR) expression using immunoblotting and sequenced BMPR2 in ...

journal_title：Gastroenterology

authors： Kodach LL,Wiercinska E,de Miranda NF,Bleuming SA,Musler AR,Peppelenbosch MP,Dekker E,van den Brink GR,van Noesel CJ,Morreau H,Hommes DW,Ten Dijke P,Offerhaus GJ,Hardwick JC

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND & AIMS:SMAD4 frequently is lost from colorectal cancers (CRCs), which is associated with the development of metastases and a poor prognosis. SMAD4 loss is believed to alter transforming growth factor β signaling to promote tumor progression. However, SMAD4 is also a central component of the bone morphogeneti...

journal_title：Gastroenterology

authors： Voorneveld PW,Kodach LL,Jacobs RJ,Liv N,Zonnevylle AC,Hoogenboom JP,Biemond I,Verspaget HW,Hommes DW,de Rooij K,van Noesel CJ,Morreau H,van Wezel T,Offerhaus GJ,van den Brink GR,Peppelenbosch MP,Ten Dijke P,Hardwick JC

更新日期：2014-07-01 00:00:00

abstract：:The effect of continuous intraduodenal enteral nutrition on gastric pH was compared with the effects of fasting and of parenteral and standard nutrition control regimens containing equal amounts of carbohydrate, protein, and lipid. Eleven healthy volunteers underwent four 24-hour intragastric pH-metry studies; serum g...

journal_title：Gastroenterology

authors： Armstrong D,Castiglione F,Emde C,Cilluffo T,Duroux P,Koerfer J,Temler E,Lamers CB,Jansens JB,Blum AL

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND & AIMS:Body weight (BW) loss and reduction of blood ghrelin level are commonly observed after total gastrectomy (TG). A prospective study was designed to elucidate whether exogenous ghrelin administration prevents postoperative BW loss by improving appetite and oral food intake in patients with gastric cance...

journal_title：Gastroenterology

authors： Adachi S,Takiguchi S,Okada K,Yamamoto K,Yamasaki M,Miyata H,Nakajima K,Fujiwara Y,Hosoda H,Kangawa K,Mori M,Doki Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND & AIMS:Induction of colitis in mice by administration of oxazolone is mediated by T-helper (Th) 2 cells and has features of human ulcerative colitis. We investigated whether activation of interleukin (IL)-4Rα on T and B cells determines their effector functions and mediates oxazolone-induced colitis. METHOD...

journal_title：Gastroenterology

authors： Hoving JC,Kirstein F,Nieuwenhuizen NE,Fick LC,Hobeika E,Reth M,Brombacher F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND & AIMS:The molecular basis underlying visceral hypersensitivity in functional irritable bowel syndrome remains elusive, resulting in poor treatment effectiveness. Because alterations in spinal non-neuronal (astrocytic) glutamate reuptake are suspected to participate in chronic pain, we asked whether such pro...

journal_title：Gastroenterology

authors： Gosselin RD,O'Connor RM,Tramullas M,Julio-Pieper M,Dinan TG,Cryan JF

更新日期：2010-06-01 00:00:00

abstract：:In these studies we compared jejunal permeability to two probes--chromium 51-labeled ethylenediaminetetraacetic acid (51Cr-EDTA) (mol wt, 360) and ovalbumin (mol wt, 45,000)--under control conditions, during acute intestinal inflammation, and in response to systemic anaphylaxis. Acute inflammation was produced after i...

journal_title：Gastroenterology

authors： Ramage JK,Stanisz A,Scicchitano R,Hunt RH,Perdue MH

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND & AIMS:Prior thermal stress induces heat shock protein 70 (HSP70) expression in the pancreas and protects against secretagogue-induced pancreatitis, but it is not clear that this thermal stress-induced protection is actually mediated by HSP70 since thermal stress may have other, non-HSP related, effects. ME...

journal_title：Gastroenterology

authors： Bhagat L,Singh VP,Song AM,van Acker GJ,Agrawal S,Steer ML,Saluja AK

更新日期：2002-01-01 00:00:00

abstract：:The influence of endogenous prostaglandins on secretin-mediated inhibition of gastric acid secretion was examined in 6 mongrel dogs with Thomas gastric and Herrera pancreatic cannulas. The dogs were given intravenous pentagastrin (1 microgram/kg.h) during the 180-min experiment, and graded doses of secretin (0.3-1.5 m...

journal_title：Gastroenterology

authors： MacLellan DG,Upp JR Jr,Thompson JC

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Calretinin and calbindin-D28k are similar Ca(2+)-binding proteins previously described in specific central neurons and other cells. METHODS:The immunocytochemical distribution of these two proteins was studied in the human gastrointestinal tract. RESULTS:In gastric and small intestinal endocrine cells, cal...

journal_title：Gastroenterology

authors： Walters JR,Bishop AE,Facer P,Lawson EM,Rogers JH,Polak JM

更新日期：1993-05-01 00:00:00

abstract：:A 17-yr-old boy developed acute proctosigmoiditis after the institution of isotretinoin for the treatment of cystic acne vulgaris. Painless diarrhea, accompanied by mucus and eventually blood, began within days of commencing treatment and persisted while the drug was administered. At sigmoidoscopy patchy mucosal infla...

journal_title：Gastroenterology

authors： Martin P,Manley PN,Depew WT,Blakeman JM

更新日期：1987-09-01 00:00:00

abstract：:A prospective and randomized study was performed comparing pneumatic forceful dilatation and surgical esophagomyotomy as primary treatment of patients with achalasia of the esophagus. Eighteen dilated and 20 operated patients were studied before and after treatment with 1 patient lost. Clinical, radiologic, and manome...

journal_title：Gastroenterology

authors： Csendes A,Velasco N,Braghetto I,Henriquez A

更新日期：1981-04-01 00:00:00

abstract：:We analyzed the clinical, radiographic, esophageal manometric, and pathologic features of 26 women with severe, idiopathic constipation. Twenty-four patients were between 19 and 39 yr of age. Stool frequency was once every 5-28 days. On barium enema examination, 9 of 24 patients had colons of increased length and 4 of...

journal_title：Gastroenterology

authors： Krishnamurthy S,Schuffler MD,Rohrmann CA,Pope CE 2nd

更新日期：1985-01-01 00:00:00

abstract：:We studied the effect of chronic aspirin ingestion on gastroduodenal epithelial proliferation by feeding rats aspirin in the drinking water. A control group of rats received plain water. At the end of 4 wk, [3H]-thymidine was given intravenously to label proliferating cells, and the rats were killed 1 h later. Section...

journal_title：Gastroenterology

authors： Eastwood GL,Quimby GF

更新日期：1982-05-01 00:00:00

abstract：:The role of the endothelium-derived vasodilator, nitric oxide, as a mediator of the increase in gastric mucosal blood flow and as a modulator of the acid secretory response induced by pentagastrin was investigated in the anesthetised rat. Intravenous administration of the selective inhibitor of endogenous nitric oxide...

journal_title：Gastroenterology

authors： Pique JM,Esplugues JV,Whittle BJ

更新日期：1992-01-01 00:00:00

abstract：:The clinical case is presented of a 16-yr-old patient with thoracoabdominal duplication that communicated with the main pancreatic duct and the right pleural cavity and resulted in pancreaticopleural fistula. Although abdominal duplications communicating with the pancreas have been described before, to our knowledge, ...

journal_title：Gastroenterology

authors： Fitzgibbons RJ Jr,Nugent FW,Ellis FH Jr,Braasch JW,Scholz FJ

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND & AIMS:Hereditary hemochromatosis is a common disorder of iron homeostasis characterized by increased dietary iron absorption and progressive iron accumulation, mainly in the liver. Most patients are homozygous for the C282Y mutation in the HFE gene. However, not all individuals carrying the hemochromatosis-...

journal_title：Gastroenterology

authors： Bensaid M,Fruchon S,Mazères C,Bahram S,Roth MP,Coppin H

更新日期：2004-05-01 00:00:00