Relapsing ulcerative colitis associated with spinal cord stimulation.

abstract：BACKGROUND & AIMS:Induction of colitis in mice by administration of oxazolone is mediated by T-helper (Th) 2 cells and has features of human ulcerative colitis. We investigated whether activation of interleukin (IL)-4Rα on T and B cells determines their effector functions and mediates oxazolone-induced colitis. METHOD...

journal_title：Gastroenterology

authors： Hoving JC,Kirstein F,Nieuwenhuizen NE,Fick LC,Hobeika E,Reth M,Brombacher F

更新日期：2012-01-01 00:00:00

abstract：:The possible involvement of tumor necrosis factor-alpha in the pathogenesis of an experimentally induced hepatitis was investigated. Balb/c mice were primed with Propionibacterium acnes to induce the infiltration of mononuclear cells into the liver. Immunohistochemical study showed that most of the accumulated mononuc...

journal_title：Gastroenterology

authors： Nagakawa J,Hishinuma I,Hirota K,Miyamoto K,Yamanaka T,Tsukidate K,Katayama K,Yamatsu I

更新日期：1990-09-01 00:00:00

abstract：:To clarify the role of fat maldigestion in the pathogenesis of steatorrhea in patients with ileal resection the total and aqueous phase concentrations of bile acid and fatty acid were characterized in 8 such patients (5 patients with small ileal resection, bile acid diarrhea, and steatorrhea less than 20 g per day; 3 ...

journal_title：Gastroenterology

authors： Poley JR,Hofmann AF

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND & AIMS:The signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors mediating acute-phase response (APR) of the human angiotensinogen (hAGT) gene in hepatocytes. The mechanisms of how STAT3 activates target genes are unknown. Here we analyzed the biochemistry of STAT3 ...

journal_title：Gastroenterology

authors： Ray S,Boldogh I,Brasier AR

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND & AIMS:Dilutional hyponatremia is a frequent complication of cirrhosis partly because of nonosmotic vasopressin release. No effective therapy exists for this complication. Therefore, we investigated the effects of VPA-985, an orally active vasopressin V2 receptor antagonist, in patients with cirrhosis and di...

journal_title：Gastroenterology

authors： Gerbes AL,Gülberg V,Ginès P,Decaux G,Gross P,Gandjini H,Djian J,VPA Study Group.

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND & AIMS:Methylation of specific microRNAs (miRNAs) often occurs in an age-dependent manner, as a field defect in some instances, and may be an early event in colitis-associated carcinogenesis. We aimed to determine whether specific mRNA signature patterns (MIR1, MIR9, MIR124, MIR137, MIR34B/C) could be used t...

journal_title：Gastroenterology

authors： Toiyama Y,Okugawa Y,Tanaka K,Araki T,Uchida K,Hishida A,Uchino M,Ikeuchi H,Hirota S,Kusunoki M,Boland CR,Goel A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND & AIMS:There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to compare de novo lipogenesis and fatty acid flux between subjects with NAFLD and those without, matched for metabolic factors (controls). METHODS:W...

journal_title：Gastroenterology

authors： Lambert JE,Ramos-Roman MA,Browning JD,Parks EJ

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanism by which antimicrobial therapy against Helicobacter pylori is enhanced by acid suppression is unknown. The aim of this study was to investigate the effect of omeprazole on gastric juice, plasma, and saliva concentrations of metronidazole, amoxicillin, and clarithromycin. METHODS:Single ...

journal_title：Gastroenterology

authors： Goddard AF,Jessa MJ,Barrett DA,Shaw PN,Idström JP,Cederberg C,Spiller RC

更新日期：1996-08-01 00:00:00

abstract：:With a worldwide prevalence of 15%, chronic constipation is one of the most frequent gastrointestinal diagnoses made in ambulatory medicine clinics, and is a common source cause for referrals to gastroenterologists and colorectal surgeons in the United States. Symptoms vary among patients; straining, incomplete evacua...

journal_title：Gastroenterology

authors： Bharucha AE,Lacy BE

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND & AIMS:A Th1 clone, II-6, established from an autoimmune gastritis BALB/c mouse that underwent thymectomy 3 days after birth, recognized a 15 mer peptide constructing the alpha subunit of H+, K(+)-adenosine triphosphatase as antigen and induced gastritis in nu/nu mice by adoptive transfer. The aim of this st...

journal_title：Gastroenterology

authors： Nishio A,Katakai T,Oshima C,Kasakura S,Sakai M,Yonehara S,Suda T,Nagata S,Masuda T

更新日期：1996-10-01 00:00:00

abstract：:Chronic graft-vs.-host disease occurs in 30%-50% of long-term survivors of allogeneic bone marrow grafts, and may eventuate in cirrhosis. In this study, a young woman, originally diagnosed as having acute myelogenous leukemia, underwent successful bone marrow transplantation but later developed graft-vs.-host disease-...

journal_title：Gastroenterology

authors： Rhodes DF,Lee WM,Wingard JR,Pavy MD,Santos GW,Shaw BW,Wood RP,Sorrell MF,Markin RS

更新日期：1990-08-01 00:00:00

abstract：:The genes associated with each of the inherited syndromes of colon cancer have now been identified, and genetic testing is available for diagnosis. These syndromes include familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer, Peutz-Jeghers syndrome, juvenile polyposis syndrome, and, possibly, Cowd...

journal_title：Gastroenterology

authors： Burt R,Neklason DW

更新日期：2005-05-01 00:00:00

abstract：:Individuals who deny alcohol consumption may develop liver injury that histologically resembles the liver injury found in alcoholic patients. To determine whether any clinical or histologic features distinguish alcoholic and nonalcoholic subjects with "alcohollike" liver injury, the clinical records and liver biopsy s...

journal_title：Gastroenterology

authors： Diehl AM,Goodman Z,Ishak KG

更新日期：1988-10-01 00:00:00

abstract：:Ketoconazole has only recently been recognized as a cause of hepatic injury, with most reports coming from outside the United States. In order to characterize more fully the U.S. experience, we undertook an analysis of 54 reports of alleged ketoconazole-induced liver injury submitted to the Food and Drug Administratio...

journal_title：Gastroenterology

authors： Lewis JH,Zimmerman HJ,Benson GD,Ishak KG

更新日期：1984-03-01 00:00:00

abstract：:The diagnosis of inflammatory bowel disease (IBD) with its 2 main subforms, Crohn's disease and ulcerative colitis, is based on clinical, endoscopic, radiologic, and histologic criteria. This paradigm remains unchanged despite the advent of new molecular technologies for the examination of serum proteins and genetic s...

journal_title：Gastroenterology

authors： Nikolaus S,Schreiber S

更新日期：2007-11-01 00:00:00

abstract：:Disseminated cytomegalovirus infection occurs predominantly in immunocompromised hosts. Involvement of the gastrointestinal tract in the acquired immunodeficiency syndrome is frequent, but to our knowledge there is only one report of involvement of the appendix. In this study, a patient with a history of the acquired ...

journal_title：Gastroenterology

authors： Valerdiz-Casasola S,Pardo-Mindan FJ

更新日期：1991-07-01 00:00:00

abstract：:We constructed ileocolonic loops of distal ileum, ileocolonic sphincter, and proximal colon in 5 dogs; neuromuscular continuity was maintained between loop and intact bowel by a bridge of tunica muscularis. To study ileocolonic sphincter function, we recorded myoelectric activity from subserosal electrodes and intralu...

journal_title：Gastroenterology

authors： Quigley EM,Phillips SF,Dent J,Taylor BM

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND & AIMS:Induction of heat-shock protein 72 is associated with enhanced tolerance to subsequent nonthermal stresses. This study evaluated whether induction of heat-shock protein 72 protects against intestinal ischemia/reperfusion injury. METHODS:Groups of nonheated and heated rats underwent sham operation, 30...

journal_title：Gastroenterology

authors： Stojadinovic A,Kiang J,Smallridge R,Galloway R,Shea-Donohue T

更新日期：1995-08-01 00:00:00

abstract：:Intragastric titration, introduced in 1973, has become more popular than in the past and is being applied to the study of gastric secretion under a variety of conditions using NaHCO3 and NaOH as titrant. Physical chemical and technical considerations point to limitations on the conditions under which quantitative resu...

journal_title：Gastroenterology

authors： Spenney JG

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND & AIMS:Studies on the early steps in the life cycle of hepatitis B virus have been hampered by the lack of readily available target cells. In this study, we mapped a defined virus attachment site to primary hepatocytes that is essential for infection. METHODS:We used purified virus particles from human carr...

journal_title：Gastroenterology

authors： Glebe D,Urban S,Knoop EV,Cag N,Krass P,Grün S,Bulavaite A,Sasnauskas K,Gerlich WH

更新日期：2005-07-01 00:00:00

abstract：:The histological and immunohistochemical characteristics of the liver in 44 children (28 boys, 16 girls) with extrahepatic biliary atresia at different stages of the clinical course were studied. Thirty-four wedge liver biopsy specimens taken during Kasai operations (25 specimens) and relaparotomy (9 specimens) and 20...

journal_title：Gastroenterology

authors： Nietgen GW,Vacanti JP,Perez-Atayde AR

更新日期：1992-06-01 00:00:00

abstract：:The acid secretory effect of combined stimulation with balloon distention of the fundus and body of the stomach and intravenous infusion of pentagastrin has been studied in patients with duodenal ulcer (DU) and in healthy subjects. In 8 nonoperated DU subjects and in 5 DU patients subjected to proximal gastric vagotom...

journal_title：Gastroenterology

authors： Grötzinger U,Bergegårdh S,Olbe L

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease (CD) and ulcerative colitis (UC) are associated with chronic tissue damage and continuous tissue repair. A central, but not well-characterized, event during this process is the migration of activated fibroblasts to the wound. METHODS:Human colonic lamina propria fibroblasts (CLPF) wer...

journal_title：Gastroenterology

authors： Leeb SN,Vogl D,Gunckel M,Kiessling S,Falk W,Göke M,Schölmerich J,Gelbmann CM,Rogler G

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND & AIMS:It has been proposed that activation of the sympathetic nervous system causes a rightward shift in the renal autoregulatory curve such that renal blood flow is critically dependent on renal perfusion pressure and that this contributes to the development of the hepatorenal syndrome. The aims of the stu...

journal_title：Gastroenterology

authors： Stadlbauer V,Wright GA,Banaji M,Mukhopadhya A,Mookerjee RP,Moore K,Jalan R

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND & AIMS:The metabolic and urease responses of Helicobacter pylori to variations in gastric acidity are unknown. The aim of this study was to determine effects of changes of environmental pH on metabolism, urease activity, and survival of H. pylori in an unbuffered environment. METHODS:Bacterial metabolism an...

journal_title：Gastroenterology

authors： Rektorschek M,Weeks D,Sachs G,Melchers K

更新日期：1998-09-01 00:00:00

abstract：:Severe cholestasis associated with long-term home parenteral nutrition is rare, and no treatment is known to be effective. This study shows a case of a patient who developed jaundice while receiving long-term home parenteral nutrition. Causes of jaundice, other than the patient's parenteral feedings, were excluded. Th...

journal_title：Gastroenterology

authors： Lindor KD,Burnes J

更新日期：1991-07-01 00:00:00

abstract：:A patient is reported with eosinophilic enteritis of the jejunum with fatal evolution. Surgical resection was considered impossible and medical treatment with corticosteroids, elemental diet, parenteral nutrition, and antimicrobials to combat the intestinal bacterial overgrowth failed to control the disease. The destr...

journal_title：Gastroenterology

authors： Tytgat GN,Grijm R,Dekker W,Den Hartog NA

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND & AIMS:Dkk1 is a secreted antagonist of the Wnt/β-catenin signaling pathway. It is induced by inflammatory cytokines during colitis and exacerbates tissue damage by promoting apoptosis of epithelial cells. However, little is known about the physiologic role of Dkk1 in normal intestinal homeostasis and during...

journal_title：Gastroenterology

authors： Koch S,Nava P,Addis C,Kim W,Denning TL,Li L,Parkos CA,Nusrat A

更新日期：2011-07-01 00:00:00

abstract：:Lamins have important roles in nuclear structure and cell signaling. Several diseases are associated with mutations in the lamin A/C gene (LMNA in humans). Patients with familial partial lipodystrophy caused by LMNA mutations develop pancreatitis, but lamin function in the pancreas and how these mutations affect pancr...

journal_title：Gastroenterology

authors： Elenbaas JS,Bragazzi Cunha J,Azuero-Dajud R,Nelson B,Oral EA,Williams JA,Stewart CL,Omary MB

更新日期：2018-05-01 00:00:00

abstract：:Much of what is currently accepted on the natural history of Helicobacter pylori-induced gastritis and its relationship with gastric adenocarcinoma rests on the assumption that atrophic gastritis can be correctly identified and reproducibly recognized. Recently, several studies have indicated that pathologists have a ...

journal_title：Gastroenterology

authors： Genta RM

更新日期：1997-12-01 00:00:00