Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice.

abstract：BACKGROUND & AIMS:Regenerating (Reg) gene IV is predominantly expressed in gastrointestinal cells and highly up-regulated in many gastrointestinal malignancies, including colorectal cancer (CRC). Human CRC cells expressing higher levels of Reg IV gene and its protein product (Reg IV) are resistant to conventional thera...

journal_title：Gastroenterology

authors： Bishnupuri KS,Luo Q,Sainathan SK,Kikuchi K,Sureban SM,Sabarinathan M,Gross JH,Aden K,May R,Houchen CW,Anant S,Dieckgraefe BK

更新日期：2010-02-01 00:00:00

abstract：:An adult patient with chronic idiopathic intestinal pseudo-obstruction maintained on home parenteral nutrition for 6 consecutive years died from cardiomyopathy and ventricular fibrillation. Postmortem examination of the heart revealed widespread myocytolysis and replacement fibrosis similar to that seen in the seleniu...

journal_title：Gastroenterology

authors： Fleming CR,Lie JT,McCall JT,O'Brien JF,Baillie EE,Thistle JL

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND & AIMS:Nuclear factor of activated T cells transcription factors plays a central role in immunity by regulating the expression of multiple cytokines and other regulatory molecules, many of which have been heavily implicated in the pathogenesis of inflammatory bowel disease. However, few studies have directly...

journal_title：Gastroenterology

authors： Gerth AJ,Lin L,Neurath MF,Glimcher LH,Peng SL

更新日期：2004-04-01 00:00:00

abstract：:Hepatocellular carcinoma often affects blacks at an early age. The purpose of this study was to ascertain if the association between chronic hepatitis B virus infection and hepatocellular carcinoma is the same in young and older black patients. Serum markers of hepatitis B infection were measured by radioimmunoassay i...

journal_title：Gastroenterology

authors： Kew MC,Macerollo P

更新日期：1988-02-01 00:00:00

abstract：:The effects of cisapride on jejunal interdigestive motor activity were studied in 12 healthy men participating in three experiments each. Five minutes after an activity front (phase III) they received, in random double-blind fashion, 10 mg of cisapride, 4 mg of cisapride, or saline placebo by intravenous injection. Mo...

journal_title：Gastroenterology

authors： Stacher G,Steinringer H,Schneider C,Winklehner S,Mittelbach G,Gaupmann G

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND & AIMS:Intercellular communication through gap junctions has been proposed to be an important mechanism for the maintenance of tissue homeostasis. However, few studies have considered the role of gap junctions in gastric mucosa. The purpose of this study was to evaluate the distribution of gap junction-speci...

journal_title：Gastroenterology

authors： Uchida Y,Matsuda K,Sasahara K,Kawabata H,Nishioka M

更新日期：1995-11-01 00:00:00

abstract：:The long term administration of chenodeoxycholic acid in man has to be regarded with caution because chenodeoxycholic acid has caused liver damage in various species of animals, including primates. To study the effect of three doses of chenodeoxycholic acid (10, 40, and 100 mg per kg per day) on hepatic function and m...

journal_title：Gastroenterology

authors： Dyrszka H,Salen G,Zaki FG,Chen T,Mosbach EH

更新日期：1976-01-01 00:00:00

abstract：:In Japan, approximately 30,000 patients died of hepatocellular carcinoma (HCC) in 2003. Ten percent had hepatitis B virus infection and 80% had hepatitis C virus (HCV) infection, indicating that viral hepatitis accounted for >90% of cases of HCC. In comparison, only 3% (1.5%, hepatitis B virus; 1.5%, HCV) of the gener...

journal_title：Gastroenterology

authors： Omata M,Tateishi R,Yoshida H,Shiina S

更新日期：2004-11-01 00:00:00

abstract：:In seven healthy volunteers pure pancreatic juice was obtained by endoscopic cannulation of the papilla of Vater. Synthetic secretin was intravenously infused in doses doubled every 20 min. The volume of pancreatic juice was proportional to the log of the secretin dose. A significant rise (P less than 0.05) in pancrea...

journal_title：Gastroenterology

authors： Domschke S,Domschke W,Rösch W,Konturek SJ,Wünsch E,Demling L

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND & AIMS:An increased duodenal expression of the iron transporters, divalent-metal-transporter-1, and ferroportin is observed in patients with iron deficiency or hereditary hemochromatosis. Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transpor...

journal_title：Gastroenterology

authors： Zoller H,Theurl I,Koch RO,McKie AT,Vogel W,Weiss G

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND & AIMS:There is no clear and point for the response to treatment of gastrointestinal human cytomegalovirus (HCMV) disease. HCMV-DNA quantitation on gastrointestinal biopsy specimens has proven its value for the diagnosis of gastrointestinal HCMV disease in patients with acquired immunodeficiency syndrome (AI...

journal_title：Gastroenterology

authors： Cotte L,Drouet E,Bailly F,Vitozzi S,Denoyel G,Trepo C

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND & AIMS:Apart from its importance as an acid secretogogue, the role of histamine as a downstream target of gastrin has not been fully explored. Previous studies have shown that the combination of hypergastrinemia and Helicobacter infection resulted in accelerated gastric cancer in mice. We used this model to ...

journal_title：Gastroenterology

authors： Takaishi S,Cui G,Frederick DM,Carlson JE,Houghton J,Varro A,Dockray GJ,Ge Z,Whary MT,Rogers AB,Fox JG,Wang TC

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND & AIMS:Immune responses to innocuous intestinal antigens appear tightly controlled by regulatory T lymphocytes. While CD4+ T lymphocytes have recently attracted the most attention, CD8+ regulatory T-cell populations are also believed to play an important role in control of mucosal immunity. However, CD8+ reg...

journal_title：Gastroenterology

authors： Ménager-Marcq I,Pomié C,Romagnoli P,van Meerwijk JP

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND & AIMS:Inflammation is created by the movement of leukocytes toward soluble attractants (chemokines). The aim of this study was to identify the chemokines that attract intestinal lymphocytes. METHODS:Intraepithelial and lamina propria lymphocytes were isolated from human jejunal mucosa of healthy individual...

journal_title：Gastroenterology

authors： Ebert EC

更新日期：1995-10-01 00:00:00

abstract：:Hepatic morphology and immunocytology were evaluated in 4 children with clinical and immunologic characteristics of the acquired immune deficiency syndrome or acquired immune deficiency syndrome related complex. All 4 children had hepatomegaly and increased serum alanine and aspartate aminotransferase activity. Both l...

journal_title：Gastroenterology

authors： Duffy LF,Daum F,Kahn E,Teichberg S,Pahwa R,Fagin J,Kenigsberg K,Kaplan M,Fisher SE,Pahwa S

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:Nitric oxide is a major inhibitory neurotransmitter in the enteric nervous system. Loss or dysfunction of nitrinergic neurons is associated with serious disruptions of motility, intractable symptoms, and long-term suffering. The aim of this study was to evaluate the effect of intrapyloric transplantat...

journal_title：Gastroenterology

authors： Micci MA,Kahrig KM,Simmons RS,Sarna SK,Espejo-Navarro MR,Pasricha PJ

更新日期：2005-12-01 00:00:00

abstract：:Peptic digestion of gluten results in the production of substances having opiatelike activity in bio- and receptor assays. These substances have been termed exorphins. In this study, we determined the effect of gluten, hydrolyzed gluten, and hydrolyzed gluten plus the opiate blocker naloxone on a variety of hormonal p...

journal_title：Gastroenterology

authors： Morley JE,Levine AS,Yamada T,Gebhard RL,Prigge WF,Shafer RB,Goetz FC,Silvis SE

更新日期：1983-06-01 00:00:00

abstract：:The purposes of this study were to determine the association, in 10 pedigrees, between adenomatous polyposis coli, hereditary nonpolyposis colorectal cancer, and occult radiopaque jaw lesions, and to assess whether these radiodensities are predictors for adenomatous polyposis. In seven kindreds with adenomatous polypo...

journal_title：Gastroenterology

authors： Offerhaus GJ,Levin LS,Giardiello FM,Krush AJ,Welsh SB,Booker SV,Hasler JF,McKusick VA,Yardley JH,Hamilton SR

更新日期：1987-09-01 00:00:00

abstract：:Helicobacter pylori has recently been implicated as an etiologic agent of gastroduodenal disorders. Comparing the antibody to H. pylori in the sera of patients with that of normal controls by Western blot analysis, a unique antibody was detected in the sera of patients, which reacted with the 25-kilodalton antigen of ...

journal_title：Gastroenterology

authors： Sugiyama T,Imai K,Yoshida H,Takayama Y,Yabana T,Yokota K,Oguma K,Yachi A

更新日期：1991-07-01 00:00:00

abstract：:Colchicine can induce the malabsorption of vitamin B12 and other nutrients. Previous investigations have suggested but not proved that this malabsorption was due to a lesion in the ileal mucosa. Employing the receptor assay of M. Katz and B. A. Cooper (J Clin Invest 54:733-739, 1974), the authors have observed a dose-...

journal_title：Gastroenterology

authors： Stopa EG,O'Brien R,Katz M

更新日期：1979-02-01 00:00:00

abstract：:A monoclonal antibody to bromodeoxyuridine was used in tissue specimens previously incubated with bromodeoxyuridine to show S-phase cells by immunohistochemical technique. Biopsy specimens of normal mucosa (n = 10), hyperplastic polyps (n = 10), adenomas with low-grade dysplasia (n = 20), adenomas with high-grade dysp...

journal_title：Gastroenterology

authors： Risio M,Coverlizza S,Ferrari A,Candelaresi GL,Rossini FP

更新日期：1988-04-01 00:00:00

abstract：:We studied the procoagulant activity of peripheral blood monocytes in 41 patients with severe obstructive jaundice and in 27 nonjaundiced control patients using a one-stage clotting assay. Mononuclear cells from jaundiced patients, tested immediately after isolation, expressed low levels of procoagulant activity, whic...

journal_title：Gastroenterology

authors： Semeraro N,Montemurro P,Chetta G,Altomare DF,Giordano D,Colucci M

更新日期：1989-03-01 00:00:00

abstract：:Intestinal handling of water and electrolytes was monitored in 5 conscious dogs with chronic 25-cm Thiry-Vella loops of proximal jejunum using a neutral isosmotic perfusate containing [14C]polyethylene glycol as a recovery marker. Under basal conditions the animals absorbed water, Na+, and Cl-, and there was minimal n...

journal_title：Gastroenterology

authors： Zinner MJ,McFadden D,Sherlock D,Jaffe BM

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND & AIMS:Although dextran sodium sulfate (DSS)-induced colitis is a commonly used model of colonic injury, the mechanism of this model is not understood. The aim of this study was to determine the contribution of prostaglandins to the mechanism of DSS-induced epithelial injury. METHODS:Mice were treated with ...

journal_title：Gastroenterology

authors： Tessner TG,Cohn SM,Schloemann S,Stenson WF

更新日期：1998-10-01 00:00:00

abstract：:Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease...

journal_title：Gastroenterology

authors： Gukovskaya AS,Gukovsky I,Algül H,Habtezion A

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND & AIMS:Studies in gastrin-deficient mice have demonstrated critical roles for gastrin peptides in the regulation of gastric acid secretion, but the relative contributions of amidated (G-17) and glycine-extended (G17-Gly) gastrin remain unclear. We examined the effects of these 2 forms of gastrin on acid secr...

journal_title：Gastroenterology

authors： Chen D,Zhao CM,Dockray GJ,Varro A,Van Hoek A,Sinclair NF,Wang TC,Koh TJ

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with sphincter of Oddi dysfunction are at high risk of developing pancreatitis after endoscopic biliary sphincterotomy. Impaired pancreatic drainage caused by pancreatic sphincter hypertension is the likely explanation for this increased risk. A prospective, randomized controlled trial was co...

journal_title：Gastroenterology

authors： Tarnasky PR,Palesch YY,Cunningham JT,Mauldin PD,Cotton PB,Hawes RH

更新日期：1998-12-01 00:00:00

abstract：:Circulating precursors of mucosal immunoglobulin A plasma cells and T-cell immunoblasts migrate selectively into mucosal sites from the blood, but the mechanisms controlling this selective trafficking have not been determined. One possibility is that the site-specific extravasation of circulating effector cell populat...

journal_title：Gastroenterology

authors： Schmitz M,Nunez D,Butcher EC

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have shown that psychological factors play a role in symptom perception among patients with gastroesophageal reflux disease. This report describes the first controlled study showing the effects of relaxation training on symptom reports and esophageal acid exposure in patients with reflu...

journal_title：Gastroenterology

authors： McDonald-Haile J,Bradley LA,Bailey MA,Schan CA,Richter JE

更新日期：1994-07-01 00:00:00

abstract：:A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and user-friendliness. These approaches are based on the sensitive assay of molecular markers in stool, blood, and urine samples. New methods, especially next generation stool-bas...

journal_title：Gastroenterology

authors： Ahlquist DA

更新日期：2010-06-01 00:00:00