Abstract：
:Lamins have important roles in nuclear structure and cell signaling. Several diseases are associated with mutations in the lamin A/C gene (LMNA in humans). Patients with familial partial lipodystrophy caused by LMNA mutations develop pancreatitis, but lamin function in the pancreas and how these mutations affect pancreatic regulation are unknown. We generated mice with inducible exocrine pancreas-specific disruption of Lmna and showed that LMNA is lost from most exocrine pancreas cells. LMNA-knockout pancreata develop endoplasmic reticulum stress with loss of acinar cell markers, increased autophagy, apoptosis, and cell proliferation, compared to CreERT2- mice (littermate controls). Disruption of Lmna led to a phenotype that resembled chronic pancreatitis, with increased Sirius Red staining and α-smooth muscle actin in male LMNA-knockout mice compared to littermate males, but not in female mice. LMNA-knockout pancreata have reduced levels of RB and activation of E2F, based on increased expression of E2F target genes. Therefore, lamins maintain pancreatic homeostasis by regulating RB stability and E2F activity.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Elenbaas JS,Bragazzi Cunha J,Azuero-Dajud R,Nelson B,Oral EA,Williams JA,Stewart CL,Omary MBdoi
10.1053/j.gastro.2018.01.024subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1625-1629.e8issue
6eissn
0016-5085issn
1528-0012pii
S0016-5085(18)30064-7journal_volume
154pub_type
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