Abstract:
:The effect of local intraarterial infusion of arginine vasopressin was studied in a vascularly perfused segment of cat ileum. Systemic arterial pressure (Pa), superior mesenteric arterial pressure (Pma), superior mesenteric venous pressure (Pv), blood flow (QB) and intestinal volume (V) were continuously monitored. Intestinal lymph flow (QL), lymphatic protein clearance (LPC), isovolumetric capillary pressure (PC), capillary filtration coefficient (KF,C) and vascular resistances were also determined. A dose-response relationship was obtained for several parameters and a dosage of 17.5 mU per kg per min was chosen for more extensive study. At this level vasopressin was found to increase both systemic (Pa) and local (Pma) arterial pressures while decreasing superior mesenteric venous pressure (Pv), capillary pressure (PC) and blood flow (QB). Precapillary (Ra), postcapillary (Rv), and total (Rt) vascular resistance were all increased during the vasopressin infusion; however, a greater effect was demonstrated on the precapillary vessels as indicated by an increased pre- to postcapillary resistance ratio (Ra/Rv). Vasopressin infusion also reduced the capillary filtration coefficient(KF,C), intestinal volume (VT), lymph flow (QL) and lymphatic protein clearance (LPC). The results of this study clearly establish an effect of vasopressin on transcapillary and lymphatic volume flows in the small intestine.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Quillen EW,Granger DN,Taylor AEsubject
Has Abstractpub_date
1977-12-01 00:00:00pages
1290-5issue
6eissn
0016-5085issn
1528-0012pii
S0016508577003382journal_volume
73pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract::The noninvasive assessment of intestinal permeability in humans has a 20-year history. Because the tests are increasingly used in clinical practice and research and because there is much controversy, we reviewed the literature and outlined the potential and possible shortcomings of these procedures. Data was obtained ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1016/0016-5085(95)90708-4
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND & AIMS:The aim of this study was to evaluate the role of known colorectal adenoma and carcinoma susceptibility genes and to locate a novel susceptibility gene in an Ashkenazi family (SM1311) with dominantly inherited predisposition to colorectal adenomas and carcinomas. METHODS:Clinicopathologic and family ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(99)70061-2
更新日期:1999-04-01 00:00:00
abstract::We constructed ileocolonic loops of distal ileum, ileocolonic sphincter, and proximal colon in 5 dogs; neuromuscular continuity was maintained between loop and intact bowel by a bridge of tunica muscularis. To study ileocolonic sphincter function, we recorded myoelectric activity from subserosal electrodes and intralu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract::Eight homosexual men presented with odynophagia. Five had a maculopapular rash and 2 had oral ulcers. Upper panendoscopy revealed the presence of multiple discrete ulcers measuring 3 mm-1.5 cm in diameter in the esophagus of each patient. The intervening mucosa appeared normal. Endoscopic brushings and biopsy specimen...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90257-x
更新日期:1986-06-01 00:00:00
abstract::To understand the disorders of bowel motility, it is important to know the range of bowel patterns in the general population. We have devised a brief self-administered questionnaire which, when used among a group of 789 students and hospital employees, disclosed that 94.2% had stool frequencies between three per day a...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND & AIMS:Men have a higher incidence of hepatocellular carcinoma (HCC) than women, which is believed to partly be because of protective effects of estrogen. We sought to determine whether there were differences in levels of microRNA (miRNA) molecules between male and female HCC samples. METHODS:The expression...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.10.029
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND & AIMS:Recombinant human interleukin 11 (rhIL-11) is a cytokine with thrombocytopoietic activity and anti-inflammatory and mucosal protective effects. The objectives of this study were to investigate the safety and tolerability of rhIL-11 in patients with Crohn's disease and to explore the effects of dose an...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0016-5085(99)70550-0
更新日期:1999-07-01 00:00:00
abstract::We studied 375 chronic hemodialysis patients for evidence of hepatitis B virus infection using first- and second-generation monoclonal radioimmunoassays. These assays employ high-affinity monoclonal antibodies produced against antigenic determinants that reside on hepatitis B surface antigen. Such assays have a lower ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90187-3
更新日期:1986-12-01 00:00:00
abstract::Eosinophilic esophagitis (EoE) was historically distinguished from gastroesophageal reflux disease on the basis of histology and lack of responsiveness to acid suppressive therapy, but it is now appreciated that esophageal eosinophilia can respond to proton pump inhibitors. Genetic and environmental factors contribute...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2015.02.002
更新日期:2015-05-01 00:00:00
abstract::A 36-year-old woman was admitted to hospital with a first attack of acute intermittent porphyria. At the same time increased serum levels of amylase and lipase as well as an increased amylase clearance to creatinine clearance ratio were observed, permitting the diagnosis of acute pancreatitis. The etiology of the latt...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-09-01 00:00:00
abstract::In addition to the previously described molecular forms of gastrin, a new component has been found in high concentrations in the serum of 6 patients with Zollinger-Ellison syndrome. Serum was fractionated by gel filtration, and ion exchange chromatography, and the new component was identified in eluates by radioimmuno...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-02-01 00:00:00
abstract:BACKGROUND & AIMS:Spontaneous hepatitis B surface antigen (HBsAg) seroclearance is a rare event in patients with chronic hepatitis B virus infection. The aim of this study was to clarify the controversy on long-term prognosis following spontaneous HBsAg seroclearance using a large series of patients. METHODS:A total o...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.36026
更新日期:2002-10-01 00:00:00
abstract::Antimitochondrial antibodies, serological hallmarks of primary biliary cirrhosis, recently were found to be directed against the E2 subunits of mitochondrial dehydrogenase complexes (pyruvate, branched-chain ketoacid, and alpha-ketoglutarate dehydrogenases). The objectives of this study were to extend these findings a...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)91247-4
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND & AIMS:Integrity of the intestinal epithelium is required for nutrition absorption and defense against pathogens. Claudins are cell adhesion molecules that localize at tight junctions (TJs); many are expressed in the intestinal tract, but little is known about their functions. Claudin-7 is unique in that it ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.10.025
更新日期:2012-02-01 00:00:00
abstract::The effect of neuropeptide Y on the motor activity of the circular and longitudinal muscle of the guinea pig small intestine was investigated. Neuropeptide Y (0.3-30 nM) inhibited, in a concentration-dependent manner, the ascending enteric reflex contraction of the circular muscle; both the cholinergic and noncholiner...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90628-7
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND & AIMS:To elucidate the survival of the patients with unresectable hepatocellular carcinoma (HCC) who underwent transcatheter arterial lipiodol chemoembolization (TACE) and to analyze the factors affecting the survivals. METHODS:During the last 8 years, a nationwide prospective cohort study was performed in...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.05.021
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND & AIMS:In patients with achalasia esophagus, swallows induce simultaneous pressure waves known as esophageal pressurization. We studied the mechanism of esophageal pressurization and bolus flow patterns in patients with type 2 or type 3 achalasia. METHODS:We recorded high-resolution manometry with impedance...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2018.04.033
更新日期:2018-08-01 00:00:00
abstract::Antigliadin antibodies have been widely used in the screening of celiac disease. Using this test, candidates for jejunal biopsy were selected from 328 first-degree relatives of 128 adult celiac patients. All relatives geographically available were willing to participate in the study. Twenty-one turned out to be positi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)91172-z
更新日期:1992-11-01 00:00:00
abstract::The efficacy of cimetidine (1.6 g per day) was evaluated using a double blind placebo-controlled trial in 24 patients with moderate or severe peptic reflux esophagitis. The results show that cimetidine is superior to placebo when using endoscopic and histological criteria. Improved patient symptomatology and lower ant...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1978-05-01 00:00:00
abstract::Gastric mucosa of the rat generates both PGE2 and PGI2 activity in significantly higher concentrations in the antrum than in the fundus. Aspirin, given intravenously or intragastrically in doses producing gastric mucosal lesions, causes a dose-dependent decrease in the generation of mucosal PGE2 and PGI2, which is fur...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND & AIMS:Transplantation of wild-type (H-2k) bone marrow into tg epsilon26 mice (BM-->tg epsilon26) induces colitis, characterized by T-helper cell type 1 activation in the lamina propria. Here we determined whether pathogenic T-cell clones could be derived by serial adoptive transfers into healthy tg epsilon2...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.01.060
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND & AIMS:Although the cell of origin for pancreatic cancer remains unknown, prior studies have suggested that pancreatic neoplasia may be initiated in progenitor-like cells. To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of b...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.02.084
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND & AIMS:Therapies for perianal fistulas in patients with Crohn's disease are often ineffective in producing long-term healing. We performed a randomized placebo-controlled trial to determine the long-term efficacy and safety of a single local administration of allogeneic expanded adipose-derived stem cells (C...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1053/j.gastro.2017.12.020
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND & AIMS:Colonic crypt elongation occurs during both chronic colitis and in the recovery phase of acute colitis. The impact of these alterations on epithelial cell functions is not fully defined. METHODS:DNA microarray analysis of freshly isolated colonic epithelial cells (CECs) from acute and chronic colitis...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)00665-6
更新日期:2003-07-01 00:00:00
abstract::Antibody prevalence and titer to rotavirus and Norwalk virus were studied in Crohn's disease patients and in age-, sex-, and time-matched controls. There were no significant antibody differences between the groups studied. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1979-02-01 00:00:00
abstract::Helicobacter pylori infection has been associated with gastritis, duodenal ulcer, gastric ulcer, and the epidemic form of gastric carcinoma. Eradication of H. pylori infection has proven to be difficult. Recently, combinations of antimicrobial drugs have been shown to eradicate greater than 50% of infections; however,...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)90095-g
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND & AIMS:The early detection of colorectal cancer is desired because this cancer can be cured surgically if diagnosed early. The purpose of the present study was to determine the feasibility of a new methodology for isolating colonocytes from naturally evacuated feces, followed by cytology or molecular biology...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.10.007
更新日期:2005-12-01 00:00:00
abstract::The G-cell population in the pyloric antrum and proximal duodenum was studied quantitatively by immunofluorescence in specimens from 10 gastric and 12 duodenal ulcer patients. In both groups, G-cell density was highest in the pyloric antrum and much lower in the intermediate zone and proximal duodenum, and G-cell coun...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1980-03-01 00:00:00
abstract::Encephalopathy in liver disease may be unresponsive to protein restriction, lactulose, and neomycin. Zinc supplements have been reported to improve psychometric performance in liver cirrhosis, but the importance of zinc deficiency in overt hepatic encephalopathy has not yet been clearly established. A patient with sev...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(91)90290-2
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND & AIMS:Although long-term results of endoscopic sphincterotomy (ES) have been poorly estimated, extended indications of ES have been proposed, especially in young patients. The aim of this study was to assess late biliary complications of ES. METHODS:Between 1981 and 1986, 169 patients younger than age 70 (...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v110.pm8608900
更新日期:1996-03-01 00:00:00