alpha-1-antitrypsin deficiency in liver disease: the extent of the problem.

abstract：:In 48 patients with obstructive jaundice caused by unresectable lesions, a polyethylene tube was inserted into the biliary tract using a percutaneous transhepatic technique. This endoprosthesis provided permanent internal drainage without an external catheter. In 27 patients, bilirubin declined to anicteric or subicte...

journal_title：Gastroenterology

authors： Burcharth F,Jensen LI,Olesen K

更新日期：1979-07-01 00:00:00

abstract：:The purpose of the study was to determine (a) the frequency and cause of mortality in patients with chronic pancreatitis; (b) the cumulative survival rates corrected by comparison of patients with a matched French population; and (c) the factors associated with mortality by a unidimensional and multidimensional analys...

journal_title：Gastroenterology

authors： Levy P,Milan C,Pignon JP,Baetz A,Bernades P

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND & AIMS:Clearance of hepatitis C virus (HCV) via antiviral treatment changes the course of liver disease. We evaluated the benefit of sustained virologic response (SVR) in patients with HCV and cirrhosis without (stage 1) and with (stage 2) esophageal varices (EV). METHODS:We performed a prospective cohort s...

journal_title：Gastroenterology

authors： Di Marco V,Calvaruso V,Ferraro D,Bavetta MG,Cabibbo G,Conte E,Cammà C,Grimaudo S,Pipitone RM,Simone F,Peralta S,Arini A,Craxì A

更新日期：2016-07-01 00:00:00

abstract：:We have examined the T-cell functional capabilities of human intestinal mononuclear cells isolated from surgically obtained normal and inflammatory bowel disease intestinal specimens. Intestinal mononuclear cells have T cells present which respond to the mitogenic lectins E-PHA, Con A, and PWM and to foreign cell-surf...

journal_title：Gastroenterology

authors： MacDermott RP,Bragdon MJ,Jenkins KM,Franklin GO,Shedlofsky S,Kodner IJ

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND AND AIMS:CD4+CD25+Foxp3+ T-regulatory (Treg) cells control immune responses and maintain immune homeostasis. However, under inflammatory conditions, Treg cells produce cytokines that promote inflammation. We investigated production of tumor necrosis factor (TNF) by Treg cells in patients with acute hepatitis...

journal_title：Gastroenterology

authors： Choi YS,Jung MK,Lee J,Choi SJ,Choi SH,Lee HW,Lee JJ,Kim HJ,Ahn SH,Lee DH,Kim W,Park SH,Huh JR,Kim HP,Park JY,Shin EC

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND & AIMS:Early embryogenesis involves cell fate decisions that define the body axes and establish pools of progenitor cells. Development does not stop once lineages are specified; cells continue to undergo specific maturation events, and changes in gene expression patterns lead to their unique physiological fu...

journal_title：Gastroenterology

authors： Direnzo D,Hess DA,Damsz B,Hallett JE,Marshall B,Goswami C,Liu Y,Deering T,Macdonald RJ,Konieczny SF

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND & AIMS:The lipocalin superfamily, including the mouse and human homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin, show great functional diversity including roles in olfaction, transportation, and prostaglandin synthesis in mammals. Their potential role in maintaining gastrointestinal mucos...

journal_title：Gastroenterology

authors： Playford RJ,Belo A,Poulsom R,Fitzgerald AJ,Harris K,Pawluczyk I,Ryon J,Darby T,Nilsen-Hamilton M,Ghosh S,Marchbank T

更新日期：2006-09-01 00:00:00

abstract：:To test whether bile acids interact with mast cells, dilute, aqueous solutions of five pure unconjugated natural bile acids and their corresponding glycine or taurine conjugates were incubated with murine PT-18 cells (a mast cell line functionally and cytochemically similar to mucosal mast cells) or with freshly isola...

journal_title：Gastroenterology

authors： Quist RG,Ton-Nu HT,Lillienau J,Hofmann AF,Barrett KE

更新日期：1991-08-01 00:00:00

abstract：:We have examined the receptor binding of radio-iodinated murine epidermal growth factor and the effects of epidermal growth factor on both amylase release and incorporation of [3H]leucine into protein in isolated adult mouse pancreatic acini in primary culture. Binding of radioiodinated murine epidermal growth factor ...

journal_title：Gastroenterology

authors： Logsdon CD,Williams JA

更新日期：1983-08-01 00:00:00

abstract：:This study was undertaken to determine the pathogenesis of muscle atrophy that frequently accompanies liver disease. Hepatic injury was induced in rats by giving weekly intragastric doses of carbon tetrachloride (CCl4) in combination with phenobarbital in the drinking water. Muscle protein catabolism was assessed duri...

journal_title：Gastroenterology

authors： Weber FL Jr,Macechko PT,Kelson SR,Karajiannis E,Hassan MO

更新日期：1992-05-01 00:00:00

abstract：:Eight homosexual men presented with odynophagia. Five had a maculopapular rash and 2 had oral ulcers. Upper panendoscopy revealed the presence of multiple discrete ulcers measuring 3 mm-1.5 cm in diameter in the esophagus of each patient. The intervening mucosa appeared normal. Endoscopic brushings and biopsy specimen...

journal_title：Gastroenterology

authors： Rabeneck L,Boyko WJ,McLean DM,McLeod WA,Wong KK

更新日期：1986-06-01 00:00:00

abstract：:A patient with ulcerative ileojejunitis was studied by determination of HL-A phenotype, by measurement of jejunal IgA synthesis using a labeled amino acid incorporation technique, and by in vitro organ culture. The patient carried the HL-A8 phenotype in common with 87.5% of patients with gluten-sensitive enteropathy. ...

journal_title：Gastroenterology

authors： Klaeveman HL,Gebhard RL,Sessoms C,Strober W

更新日期：1975-03-01 00:00:00

abstract：BACKGROUND & AIMS:Helicobacter pylori infection causes inflammation, accumulation of reactive oxygen species, and oxidative DNA damage in the gastric mucosa. Apurinic/apyrimidinic endonuclease-1 (APE-1)/redox factor-1 (Ref-1) repairs damaged DNA and reductively activates transcription factors, including activator prote...

journal_title：Gastroenterology

authors： Ding SZ,O'Hara AM,Denning TL,Dirden-Kramer B,Mifflin RC,Reyes VE,Ryan KA,Elliott SN,Izumi T,Boldogh I,Mitra S,Ernst PB,Crowe SE

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND & AIMS:Practice guidelines recommend that endoscopists spend at least 7 minutes examining the colonic mucosa during colonoscopy withdrawal to optimize polyp yield. The aim of this study was to determine if the implementation of an institution-wide policy of colonoscopy withdrawal time > or = 7 minutes was as...

journal_title：Gastroenterology

authors： Sawhney MS,Cury MS,Neeman N,Ngo LH,Lewis JM,Chuttani R,Pleskow DK,Aronson MD

更新日期：2008-12-01 00:00:00

abstract：:Propulsion of colonic contents after eating in the whole colon was studied in 15 volunteers by scintigraphy with injection of 111In-diethylenetriamine-pentaacetic acid and 99mTc-sulfur colloid into the colon through a nasogastric tube. The radionuclide was injected into the cecoascending colon (n = 7), the hepatic fle...

journal_title：Gastroenterology

authors： Picon L,Lémann M,Flourié B,Rambaud JC,Rain JD,Jian R

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND & AIMS:Predictors of reactivation of hepatitis B following hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B have rarely been reported before and deserve further study. METHODS:A total of 133 HBeAg-positive asymptomatic carriers who have undergone HBeAg seroconversion were studied. Reactiv...

journal_title：Gastroenterology

authors： Chu CM,Liaw YF

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND & AIMS:An increased duodenal expression of the iron transporters, divalent-metal-transporter-1, and ferroportin is observed in patients with iron deficiency or hereditary hemochromatosis. Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transpor...

journal_title：Gastroenterology

authors： Zoller H,Theurl I,Koch RO,McKie AT,Vogel W,Weiss G

更新日期：2003-09-01 00:00:00

abstract：:Water and electrolyte transport were determined in rat ileum and colon using the single-pass perfusion technique. Intraperitoneal dopamine caused prompt stimulation of both ileal and colonic water absorption. The dopamine effect was mediated by both specific dopamine and alpha 2-adrenergic receptors. Haloperidol, a sp...

journal_title：Gastroenterology

authors： Donowitz M,Elta G,Battisti L,Fogel R,Label-Schwartz E

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND & AIMS:Approximately 10% of children on the liver transplant wait-list in the United States die every year. We examined deceased donor liver offer acceptance patterns and their contribution to pediatric wait-list mortality. METHODS:We performed a retrospective cohort study of children on the US liver transp...

journal_title：Gastroenterology

authors： Hsu EK,Shaffer ML,Gao L,Sonnenday C,Volk ML,Bucuvalas J,Lai JC

更新日期：2017-10-01 00:00:00

abstract：:Congenital esophageal stenosis (CES) is a rare disorder with narrowed esophageal lumen that presents as dysphagia from childhood and that is often associated with tracheobronchial remnants or webs. The pathogenesis of CES is unknown. The aim of this study was to examine the histological and immunohistochemical feature...

journal_title：Gastroenterology

authors： Singaram C,Sweet MA,Gaumnitz EA,Cameron AJ,Camilleri M

更新日期：1995-07-01 00:00:00

abstract：:In recent years the hypothesis that the number of villus cells regulates crypt cell proliferation in the epithelium of the small intestine has been brought forward by a number of investigators. To test this hypothesis, the villus cell population was reduced by clamping the superior mesenteric artery and vein in rats f...

journal_title：Gastroenterology

authors： Rijke RP,Hanson WR,Plaisier HM,Osborne JW

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND & AIMS:The I1307K allele of the APC gene has been shown to confer a modestly elevated risk of colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5-1.7). However, it is unclear whether the alteration predisposes to adenomas and whether the genetic information can be used in clinical practi...

journal_title：Gastroenterology

authors： Stern HS,Viertelhausen S,Hunter AG,O'Rourke K,Cappelli M,Perras H,Serfas K,Blumenthall A,Dewar D,Baumann E,Lagarde AE

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND & AIMS:Simeprevir (TMC435) is an oral NS3/4 protease inhibitor in phase III trials for chronic hepatitis C virus (HCV) infection. We performed a phase IIb, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of the combination of simeprevir, peginterferon-α2a (PegIFN), and ...

journal_title：Gastroenterology

authors： Zeuzem S,Berg T,Gane E,Ferenci P,Foster GR,Fried MW,Hezode C,Hirschfield GM,Jacobson I,Nikitin I,Pockros PJ,Poordad F,Scott J,Lenz O,Peeters M,Sekar V,De Smedt G,Sinha R,Beumont-Mauviel M

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND & AIMS:As life expectancy increases, there are greater numbers of patients with liver diseases who require surgery or transplantation. Livers of older patients have significantly less reparative capacity following ischemia and reperfusion (I/R) injury, which occurs during these operations. There are no strat...

journal_title：Gastroenterology

authors： Wang JH,Ahn IS,Fischer TD,Byeon JI,Dunn WA Jr,Behrns KE,Leeuwenburgh C,Kim JS

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hereditary hemochromatosis is a common disorder of iron homeostasis characterized by increased dietary iron absorption and progressive iron accumulation, mainly in the liver. Most patients are homozygous for the C282Y mutation in the HFE gene. However, not all individuals carrying the hemochromatosis-...

journal_title：Gastroenterology

authors： Bensaid M,Fruchon S,Mazères C,Bahram S,Roth MP,Coppin H

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Although cholesterol is the most abundant sterol in animal tissues, oxidized products of cholesterol (oxysterols) also occur in mammalian organs and blood and are cytotoxic, atherogenic, and carcinogenic. However, the presence of oxysterols in bile or gallstones has never been reported. METHODS:Fre...

journal_title：Gastroenterology

authors： Haigh WG,Lee SP

更新日期：2001-07-01 00:00:00

abstract：:Because approximately 80% of reported patients with somatostatinomas have gallstones, this study was performed to determine the effects of exogenous somatostatin on gallbladder emptying responses to liquid and solid meals, direct cholinergic stimulation by bethanechol, indirect cholinergic stimulation by sham feeding,...

journal_title：Gastroenterology

authors： Fisher RS,Rock E,Levin G,Malmud L

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND & AIMS:Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate into hepatocytes. Little is known about the mechanisms of LPC differentiation. We used zebrafish and mouse models of liver injury to study the ...

journal_title：Gastroenterology

authors： Ko S,Russell JO,Tian J,Gao C,Kobayashi M,Feng R,Yuan X,Shao C,Ding H,Poddar M,Singh S,Locker J,Weng HL,Monga SP,Shin D

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND & AIMS:The complications of diverticulosis cause considerable morbidity in the United States; health care expenditures for this disorder are estimated to be $2.5 billion per year. Many physicians and patients believe that a high-fiber diet and frequent bowel movements prevent the development of diverticulosi...

journal_title：Gastroenterology

authors： Peery AF,Barrett PR,Park D,Rogers AJ,Galanko JA,Martin CF,Sandler RS

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND & AIMS:Cytotoxic T cells have been suggested to be responsible for lysis of hepatitis B virus (HBV)-infected hepatocytes and control of virus infection. The frequency, kinetics, phenotype, and capacity for clonal expansion of circulating HBV-specific CD8 cells were analyzed directly in patients with acute HB...

journal_title：Gastroenterology

authors： Maini MK,Boni C,Ogg GS,King AS,Reignat S,Lee CK,Larrubia JR,Webster GJ,McMichael AJ,Ferrari C,Williams R,Vergani D,Bertoletti A

更新日期：1999-12-01 00:00:00