Abstract：
:Propulsion of colonic contents after eating in the whole colon was studied in 15 volunteers by scintigraphy with injection of 111In-diethylenetriamine-pentaacetic acid and 99mTc-sulfur colloid into the colon through a nasogastric tube. The radionuclide was injected into the cecoascending colon (n = 7), the hepatic flexure (n = 6), the splenic flexure (n = 9), and the descending colon (n = 4). Changes of activity in the regions distal from and proximal to the injection points were determined before and after a 1000-kcal meal. Isotopic movements were also analyzed when a simultaneous injection of the two markers in the right and left parts of the colon was achieved (n = 11). During fasting, no significant change of activity was seen. After eating, radioactivity injected into the cecoascending and the hepatic flexure was transferred distally (P less than 0.01 and P = 0.07); radioactivity injected into the splenic flexure was transferred both distally (P = 0.07) and proximally (P less than 0.02); and no significant change of activity was seen proximally from or distally to the descending colon. Both antegrade and retrograde isotopic movements increased after eating (P less than 0.01), but the number of antegrade movements was significantly greater (P less than 0.05). This study confirms the colonic propulsive effect of eating and shows that this response is different in the right and left parts of the colon.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Picon L,Lémann M,Flourié B,Rambaud JC,Rain JD,Jian Rdoi
10.1016/0016-5085(92)91098-okeywords:
subject
Has Abstractpub_date
1992-07-01 00:00:00pages
80-5issue
1eissn
0016-5085issn
1528-0012pii
0016-5085(92)91098-Ojournal_volume
103pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：BACKGROUND & AIMS:Serine proteases are postulated to influence gastrointestinal function by stimulating protease-activated receptors (PARs). This study identified the effects on myenteric neurons of activating PARs and investigated underlying mechanisms of action. METHODS:Intracellular electrophysiologic methods were ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2002.36581
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND & AIMS:Interactions between genetic and environmental factors are believed to be involved in onset and initiation of inflammatory bowel disease. We analyzed the interaction between gastrointestinal mucosal microbiota and host genes in twin pairs discordant for ulcerative colitis (UC) to study the functional ...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.1053/j.gastro.2011.04.011
更新日期：2011-07-01 00:00:00
abstract：:Three cases of Stevens-Johnson syndrome with intestinal involvement are described. Two patients had esophageal involvement, the severity of which paralleled skin lesions and, in 1 case, probably contributed to death. Dysphagia and bleeding were manifestations. The third patient was unique and had gastric, small and la...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(86)90585-8
更新日期：1986-08-01 00:00:00
abstract：BACKGROUND & AIMS:Black patients with chronic hepatitis C have lower response rates than white patients to interferon monotherapy. The factors responsible for these differences are unknown, as is the impact of combination antiviral therapy on responsiveness among ethnic groups. We evaluated the impact of race on respon...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/gast.2000.19289
更新日期：2000-11-01 00:00:00
abstract：:A patient with post-traumatic seizure disorder developed lymphadenopathy, exfoliative dermatitis, and hepatic failure while on diphenylhydantoin therapy and died in hepatic coma. Autopsy disclosed massive hepatic necrosis. The clinical and pathological pictures are similar to the six previously reported cases of diphe...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：
更新日期：1976-03-01 00:00:00
abstract：BACKGROUND & AIMS:Mutations in TP53, a tumor suppressor gene, are associated with prognosis of many cancers. However, the prognostic values of TP53 mutation sites are not known for patients with hepatocellular carcinoma (HCC) because of heterogeneity in their geographic and etiologic backgrounds. METHODS:TP53 mutation...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.11.034
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND & AIMS:The sarcomatoid change in cholangiocarcinoma (CC) contributes to more aggressive intrahepatic spread and widespread metastasis. Therefore, the aim of this study was to identify the molecular mechanisms of CC metastasis during tumor progression and sarcomatoid change. METHODS:Using the subtraction sup...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2009.04.015
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND & AIMS:Patients with Barrett's esophagus (BE) show increased risk of developing esophageal adenocarcinoma and are routinely examined using upper endoscopy with biopsy to detect neoplastic changes. Angle-resolved low coherence interferometry (a/LCI) uses in vivo depth-resolved nuclear morphology measurements ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.09.008
更新日期：2011-01-01 00:00:00
abstract：:Based on in vitro experiments measuring daily secretion rates in the culture media of rat hepatocytes and in vivo experiments using pulse labeling of intracellular precursors, the present study examines the ontogenic expression of the polymeric immunoglobulin receptor and secretory component by hepatocytes during grow...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)90181-w
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND/AIMS:Hepatic vein thrombosis is thought to be manifested by ascites, abdominal pain, and hepatomegaly, with a uniformly poor prognosis. However, new imaging techniques allow for the diagnosis of hepatic vein thrombosis in asymptomatic cases. The aim of our study was to re-evaluate symptoms and prognosis in p...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(94)90765-x
更新日期：1994-04-01 00:00:00
abstract：BACKGROUND & AIMS:Cirrhotic liver diseases are associated with abnormalities in cardiac geometry and function in adults (cirrhotic cardiomyopathy) but rarely explored in cirrhotic infants or children. We proposed that features of cirrhotic cardiomyopathy are present in infants with cirrhosis due to biliary atresia (BA)...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.06.082
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND & AIMS:Nitric oxide is a major inhibitory neurotransmitter in the enteric nervous system. Loss or dysfunction of nitrinergic neurons is associated with serious disruptions of motility, intractable symptoms, and long-term suffering. The aim of this study was to evaluate the effect of intrapyloric transplantat...
journal_title：Gastroenterology
pub_type： 评论,杂志文章
doi：10.1053/j.gastro.2005.08.055
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND & AIMS:Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive human disorder characterized by reduced activities of the brush border enzyme sucrase-isomaltase (SI). Here, we elucidate the pathogenesis of a new variant of CSID at the cellular and molecular level. METHODS:Assessment of the ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2003.09.022
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND/AIMS:Liver fat-storing cells (FSCs) actively proliferate and secrete extracellular matrix during liver injury. Platelet-derived growth factor (PDGF) is a potent mitogen for cultured FSCs. In the present study, we investigated the regulation of PDGF gene expression and production in cultured human liver FSCs....
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(94)90236-4
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND & AIMS:We assessed the influence of genetic variants in the hepatitis B virus (HBV) core, which is a principal immunologic target, on the progression to hepatocellular carcinoma (HCC) in a cohort of 4841 male HBV carriers followed up for 16 years. METHODS:First, baseline sera from 116 HCC cases and 154 cont...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2009.07.063
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND & AIMS:Apart from its importance as an acid secretogogue, the role of histamine as a downstream target of gastrin has not been fully explored. Previous studies have shown that the combination of hypergastrinemia and Helicobacter infection resulted in accelerated gastric cancer in mice. We used this model to ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2005.03.027
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND & AIMS:The mechanisms for tissue regeneration and renewal after acute pancreatitis are not well understood but may involve activation of Notch signaling. To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling i...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.11.003
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND & AIMS:We followed patients with ongoing hepatitis C virus (HCV) exposure following control of an initial HCV infection to determine whether primary control conferred protection against future persistent infections. METHODS:Twenty-two active injection drug users (IDU) who had cleared a primary hepatitis C v...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2009.09.017
更新日期：2010-01-01 00:00:00
abstract：:The type of cirrhosis was blindly evaluated in follow-up liver biopsies performed on 106 alcoholic men with micronodular cirrhosis. The median time interval from entry to follow-up liver biopsy was 31 mo (range, 3-44 mo). Patients were stratified into four groups according to their maximal registered ethanol consumpti...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(87)91011-0
更新日期：1987-08-01 00:00:00
abstract：:Much of what is currently accepted on the natural history of Helicobacter pylori-induced gastritis and its relationship with gastric adenocarcinoma rests on the assumption that atrophic gastritis can be correctly identified and reproducibly recognized. Recently, several studies have indicated that pathologists have a ...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1016/s0016-5085(97)80012-1
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND & AIMS:Long-term data on the risk of colorectal cancer according to dose, duration, and consistency of aspirin therapy are limited. METHODS:We conducted a prospective study of 47,363 male health professionals who were ages 40-75 years at enrollment in 1986. Biennially, we collected data on aspirin use, othe...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.09.035
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Antibodies directed against oligomannose sequences alpha-1,3 Man (alpha-1,2 Man alpha-1,2 Man)(n) (n = 1 or 2), termed anti-Saccharomyces cerevisiae antibodies (ASCAs) are markers of Crohn's disease (CD). S. cerevisiae mannan, which expresses these haptens, is used to detect ASCA, but the exact immu...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2006.02.009
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND & AIMS:The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a transmembrane glycoprotein with pleotropic functions, including clearance of hepatic insulin. We investigated the functions of the related protein CEACAM2, which has tissue-specific distribution (kidney, uterus, and crypt epi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.03.056
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND & AIMS:Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2013.02.005
更新日期：2013-06-01 00:00:00
abstract：:In humans and most other species, a decline in pH of gallbladder contents occurs during the concentration of bile. Recent in vitro studies in rabbit, guinea pig, and Necturus gallbladders have strongly suggested mucosal H+ secretion during sodium reabsorption, presumably representing a Na+/H+ exchange. The present in ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(87)90118-1
更新日期：1987-02-01 00:00:00
abstract：:Cellular protooncogenes such as c-myc and c-Ha-ras may play important roles in the control of regeneration of the stomach. In this study, in situ hybridization histochemistry and immunohistochemistry were used to determine how these protooncogenes and the corresponding oncoproteins are expressed at the cellular level ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(90)91085-k
更新日期：1990-06-01 00:00:00
abstract：:Previous studies suggested that the food-containing canine stomach retains large, nondigestible spheres until all food has emptied; but it is not known whether there is a threshold size or a gradation of sizes that will empty along with food. Further, nothing is known of the effects of such parameters as density, shap...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(85)90576-1
更新日期：1985-10-01 00:00:00
abstract：BACKGROUND/AIMS:Platelets show proinflammatory as well as prothrombotic properties. Patients with inflammatory bowel disease are at increased risk of systemic thromboembolism, and multifocal microvascular infarction has been proposed as a pathogenetic mechanism in Crohn's disease. The aim of this study was to determine...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(94)90741-2
更新日期：1994-04-01 00:00:00
abstract：:Data collected by nine population-based tumor registries participating in the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute were analyzed to characterize the epidemiology of noncarcinoid adenocarcinomas of the colon and rectum in young adults. Tumors diagnosed in persons under 40...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90279-t
更新日期：1991-04-01 00:00:00
abstract：:In the previous decade, comprehensive genomic analyses have yielded important insights about the genetic alterations that underlie pancreatic tumorigenesis. Whole-exome and whole-genome sequencing of pancreatic ductal adenocarcinomas have confirmed the critical driver genes altered in the majority of pancreatic cancer...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2018.12.039
更新日期：2019-05-01 00:00:00
