Abstract：
:To define a potential role for the angiotensin system in Crohn's colitis, the colonic mucosal levels of angiotensin I and II were measured in endoscopic biopsy samples from patients with active Crohn's colitis (n = 20), ulcerative colitis (n = 13), other forms of colitis (n = 3), and normal controls (n = 17). Colonic mucosal levels of angiotensin I and II were greater in patients with Crohn's colitis than in normal subjects (p less than 0.001 and p less than 0.001, respectively). Mucosal levels of angiotensin I and II were also higher in Crohn's colitis than in ulcerative colitis (p less than 0.001 and p less than 0.001, respectively), and levels of angiotensin II were higher in Crohn's than in other forms of colitis (p = 0.014). Mucosal levels of angiotensin I and II correlated well with the degree of macroscopic inflammation in Crohn's colitis (r = 0.86, p less than 0.001 and r = 0.68, p less than 0.001, respectively). Mucosal levels of angiotensin I correlated fairly well with the Crohn's Disease Activity Index (r = 0.46, p less than 0.05) while angiotensin II levels correlated poorly. These studies suggest that angiotensin I and II may have a role in the inflammation associated with Crohn's colitis.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Jaszewski R,Tolia V,Ehrinpreis MN,Bodzin JH,Peleman RR,Korlipara R,Weinstock JVdoi
10.1016/0016-5085(90)91088-nsubject
Has Abstractpub_date
1990-06-01 00:00:00pages
1543-8issue
6eissn
0016-5085issn
1528-0012pii
0016-5085(90)91088-Njournal_volume
98pub_type
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