Abstract：
:Cell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. Although the literature on cell death has grown enormously in size and complexity, a pattern has emerged that each of several distinct organelles (plasma membrane, mitochondrion, nucleus, endoplasmic reticulum, lysosome) gives rise to signals that induce cell death. Most often these signals converge on mitochondria to initiate a common pathway to either caspase-dependent apoptosis or ATP depletion-dependent necrosis. This brief overview emphasizes the multiple and often redundant pathways between different organelles that lead ultimately to a cell's demise.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Lemasters JJdoi
10.1053/j.gastro.2005.06.006keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
351-60issue
1eissn
0016-5085issn
1528-0012pii
S0016508505011042journal_volume
129pub_type
杂志文章,评审相关文献
GASTROENTEROLOGY文献大全abstract：:To characterize gastric mucosal perfusion in cirrhotic patients with portal hypertensive gastropathy, 34 cirrhotics with this lesion and 24 noncirrhotics were studied by reflectance spectrophotometry and laser-Doppler flowmetry during endoscopy. A significant correlation was observed between the hemoglobin content of ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)91447-c
更新日期：1992-12-01 00:00:00
abstract：:We have analyzed the frequency of chronicity and its distribution according to epidemiologic background following acute non-A, non-B hepatitis. Eighteen of 45 cases (40%) developed chronic liver disease. The incidence of chronicity was significantly higher following transfusion and among drug addicts (54% and 58%) tha...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1979-12-01 00:00:00
abstract：BACKGROUND & AIMS:The Paris pediatric modification of the Montreal classification defines very early onset inflammatory bowel disease (VEO-IBD) as a form of IBD distinct from that of older children. We compared the incidence and outcomes of VEO-IBD with those of IBD in older children. METHODS:We performed a population...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2014.06.023
更新日期：2014-10-01 00:00:00
abstract：:Intracellular microelectrodes were used to evaluate electrical properties of the cell membranes in Necturus antral mucosa during exposure to luminal acid alone (pH 4) or to 5 mmol/L aspirin [acetylsalicylic acid (ASA)] in the presence of luminal acid. When nutrient solutions were buffered by HCO3- (pH 7.3), ASA modera...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)91167-3
更新日期：1992-11-01 00:00:00
abstract：:Chloroquine and metronidazole were compared in a randomized trial for the treatment of amoebic liver abscess in 36 patients. An additional 30 patients were treated without randomization. Chloroquine was given according to the standard protocol at Los tangeles County-University of Southern California Medical Center, wh...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1975-07-01 00:00:00
abstract：:The influence of adaptive cell proliferation on colonic carcinogenesis was studied in male Fischer rats with a defunctioning transverse colostomy that was closed 4 wk later. Control observations were made in other rats after colonic transection, repeated at 4 wk, after laparotomy alone, or after permanent colostomy. T...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-09-01 00:00:00
abstract：BACKGROUND & AIMS:Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We inve...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2016.11.010
更新日期：2017-03-01 00:00:00
abstract：:The cause of Ménétrier's disease is unknown, although allergic, autoimmune, and infectious, particularly viral, causes have been postulated. This case report describes a 3-year-old child with Ménétrier's disease in whom evidence of acute cytomegalovirus (CMV) infection was found. To our knowledge, this is the first ca...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(95)90349-6
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND & AIMS:The effects of aging on pancreatic acinar cell proliferation have not been clearly defined. Phosphatidylinositol 3-kinase (PI3K)-mediated phosphorylation of Akt is a critical step for proliferation of various cell types and insulin secretion from pancreatic endocrine cells; however, its role in acinar...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2005.03.016
更新日期：2005-05-01 00:00:00
abstract：:In rats fasted 4 days, immunoreactive gastrin concentrations decreased to one-third of the fed levels in antral tissue and to one-eight of the fed levels in serum. The number of antral cells that reacted with fluorescent antigastrin antiserum was also correspondingly decreased. After refeeding, serum gastrin returned ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-06-01 00:00:00
abstract：:Recent reports suggest most solid food enters the duodenum as small particles. Our studies showed that small particles of liver were capable of binding hydrogen ions (H+), but there was slow equilibration of H+ between particulate and aqueous phases. We wondered whether titratable acid as H+ bound to meat particles co...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:The importance of cholecystectomy as a risk factor for colorectal cancer was analyzed in an historical cohort study covering 16,773 cases during 11-14 years completed after operation. The observed number of colorectal cancers (130) was lower than the expected 153.5 [relative risk (RR) = 0.85]. For cancer of the colon,...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:A case is presented of a 76-yr-old woman with primary biliary cirrhosis and adult polycystic liver disease who developed bone marrow toxicity associated with chronic low-dose colchicine therapy. Two months after starting colchicine therapy (0.6 mg b.i.d. p.o.), the patient developed hematologic toxicity as evidenced b...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(87)90249-6
更新日期：1987-12-01 00:00:00
abstract：BACKGROUND & AIMS:To investigate the efficacy and safety of certolizumab pegol (a polyethylene-glycolated Fab' fragment of anti-tumor necrosis factor, CDP870) in Crohn's disease. METHODS:In a placebo-controlled, phase II study, 292 patients with moderate to severe Crohn's disease received subcutaneous certolizumab 100...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1053/j.gastro.2005.06.064
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND & AIMS:Cyclosporin A specifically suppresses hepatitis C virus (HCV) replication in vitro at clinically achievable concentrations. In this study, we investigated the mechanisms of action of cyclosporin A against HCV replication. METHODS:The in vitro effects of cyclosporin A on HCV replication were analyzed ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2005.06.031
更新日期：2005-09-01 00:00:00
abstract：:In Japan, approximately 30,000 patients died of hepatocellular carcinoma (HCC) in 2003. Ten percent had hepatitis B virus infection and 80% had hepatitis C virus (HCV) infection, indicating that viral hepatitis accounted for >90% of cases of HCC. In comparison, only 3% (1.5%, hepatitis B virus; 1.5%, HCV) of the gener...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2004.09.030
更新日期：2004-11-01 00:00:00
abstract：:The goal of this study was to identify the structural and compositional features of human gallstones that influence in vitro gallstone dissolution in the cholesterol solvent monooctanoin. Gallstones were obtained from 86 consecutive patients who had at least three morphologically similar stones. One stone from each pa...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(87)90320-9
更新日期：1987-07-01 00:00:00
abstract：:Studies on the natural history of chronic type B hepatitis have shown that loss of hepatitis B e antigen and seroconversion to antibody to hepatitis B e antigen are usually accompanied by remission of disease activity and improvement in serum aminotransferase levels. Twenty-five symptomatic patients with biopsy-docume...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：:If increased gamma-aminobutyric acid (GABA)-mediated neurotransmission contributes to the mediation of hepatic encephalopathy, it may be possible to induce ameliorations of the syndrome by pharmacologically antagonizing a component of the GABA/benzodiazepine receptor complex. To test this possibility we administered t...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(89)90647-1
更新日期：1989-09-01 00:00:00
abstract：:Serum amino acid levels were determined in 29 patients with severe chronic active liver disease before, during, and after administration of prednisone or placebo and in 22 healthy controls. The pretreatment molar ratio of amino acids was less in patients than in controls (p less than 0.001) and was lower in those with...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章
doi：
更新日期：1981-10-01 00:00:00
abstract：BACKGROUND & AIMS:Seroclearance of hepatitis B surface antigen (HBsAg) is one of the most important clinical outcomes for chronic hepatitis B treatment trials. Few studies have explored the incidence and determinants of spontaneous seroclearance using a long-term follow-up study. This study aimed to examine the natural...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.04.048
更新日期：2010-08-01 00:00:00
abstract：:The assimilation of labeled cobalamin and the transport of corrinoids in portal blood, peripheral venous blood, and bile were studied in eight cholecystectomized patients, after ingestion of a dose of cyano[57Co]cobalamin (0.5 microCi). The radioactivity appeared in the portal vein after a delay of 1.5-2 hours and in ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90094-2
更新日期：1991-11-01 00:00:00
abstract：:Antibodies to a membrane-bound antigen, localized to the canalicular structures of the parietal cell, are found in most sera of patients with chronic atrophic gastritis and pernicious anemia. In the present study immunoglobulins containing parietal cell antibodies were found to inhibit the activity of H+,K+-adenosine ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(89)90509-x
更新日期：1989-06-01 00:00:00
abstract：BACKGROUND & AIMS:The molecular mechanisms that contribute to the cholestatic condition in hepatocytes are poorly defined. It has been postulated that a disruption of normal vesicle-based protein trafficking may lead to alterations in hepatocyte polarity. METHODS:To determine if vesicle motility is reduced by cholesta...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2001.28652
更新日期：2001-11-01 00:00:00
abstract：:Spinal cord stimulation is an increasingly popular form of pain treatment. An electrode positioned on the dorsal aspect of the spinal cord at the level of the nerve roots from the painful area stimulates the spinal cord. Current from the electrode is supplied by a pulse generator in the lower anterior abdominal wall. ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(99)70570-6
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND & AIMS:Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia. However, the possible effect these medications may have on the risk of esophageal adenocarcinoma (EAC) in patients w...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.02.045
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND & AIMS:Exposure to biologic and immunosuppressant agents during breastfeeding is controversial, and there are limited data on safety. We investigated whether biologics are detectable in breast milk from women receiving treatment for inflammatory bowel diseases (IBDs) and whether breastfeeding while receiving...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.1053/j.gastro.2018.05.040
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND & AIMS:Therapy with interferon alfa (IFN-alpha) leads to remission of disease in one third of patients with chronic hepatitis B. The aim of this study was to better define the long-term prognosis of this outcome. METHODS:One hundred three patients with chronic hepatitis B who underwent IFN-alpha therapy in ...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/gast.1997.v113.pm9352870
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND & AIMS:Three-dimensional (3D) ultrasound imaging of the total stomach volume has not yet been achieved. The aim of this study was to investigate whether a magnetic position sensor system for acquisition of 3D ultrasonograms could be used to determine gastric emptying rates and intragastric distribution. MET...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(97)70078-7
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND & AIMS:To screen the genetic variants in cyclooxygenase-2 (COX-2), and evaluate their effects on COX-2 expression and risk of gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, Shangdong Province, an area of China, a high-risk area of GC. METHODS:Genotypes were d...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2006.03.021
更新日期：2006-06-01 00:00:00
